| UniProt ID | AKA12_HUMAN | |
|---|---|---|
| UniProt AC | Q02952 | |
| Protein Name | A-kinase anchor protein 12 | |
| Gene Name | AKAP12 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1782 | |
| Subcellular Localization |
Cytoplasm, cell cortex . Cytoplasm, cytoskeleton . Membrane Lipid-anchor . May be part of the cortical cytoskeleton. |
|
| Protein Description | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC).. | |
| Protein Sequence | MGAGSSTEQRSPEQPPEGSSTPAEPEPSGGGPSAEAAPDTTADPAIAASDPATKLLQKNGQLSTINGVAEQDELSLQEGDLNGQKGALNGQGALNSQEEEEVIVTEVGQRDSEDVSKRDSDKEMATKSAVVHDITDDGQEETPEIIEQIPSSESNLEELTQPTESQANDIGFKKVFKFVGFKFTVKKDKTEKPDTVQLLTVKKDEGEGAAGAGDHKDPSLGAGEAASKESEPKQSTEKPEETLKREQSHAEISPPAESGQAVEECKEEGEEKQEKEPSKSAESPTSPVTSETGSTFKKFFTQGWAGWRKKTSFRKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAEYEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKTEVEETAGSVPAEELVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQKGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAEEGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEMQEEMKGSVEEPKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEEGGPKAMGGDHQKADEAGKDKETGTDGILAGSQEHDPGQGSSSPEQAGSPTEGEGVSTWESFKRLVTPRKKSKSKLEEKSEDSIAGSGVEHSTPDTEPGKEESWVSIKKFIPGRRKKRPDGKQEQAPVEDAGPTGANEDDSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADGTRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPPTVTEPLPENREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDSPDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGTGGPEDVLQPVQRAEAERPEEQAEASGLKKETDVVLKVDAQEAKTEPFTQGKVVGQTTPESFEKAPQVTESIESSELVTTCQAETLAGVKSQEMVMEQAIPPDSVETPTDSETDGSTPVADFDAPGTTQKDEIVEIHEENEVASGTQSGGTEAEAVPAQKERPPAPSSFVFQEETKEQSKMEDTLEHTDKEVSVETVSILSKTEGTQEADQYADEKTKDVPFFEGLEGSIDTGITVSREKVTEVALKGEGTEEAECKKDDALELQSHAKSPPSPVEREMVVQVEREKTEAEPTHVNEEKLEHETAVTVSEEVSKQLLQTVNVPIIDGAKEVSSLEGSPPPCLGQEEAVCTKIQVQSSEASFTLTAAAEEEKVLGETANILETGETLEPAGAHLVLEEKSSEKNEDFAAHPGEDAVPTGPDCQAKSTPVIVSATTKKGLSSDLEGEKTTSLKWKSDEVDEQVACQEVKVSVAIEDLEPENGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEKEGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKTMTVEVEGSTVNDQQLEEVVLPSEEEGGGAGTKSVPEDDGHALLAERIEKSLVEPKEDEKGDDVDDPENQNSALADTDASGGLTKESPDTNGPKQKEKEDAQEVELQEGKVHSESDKAITPQAQEELQKQERESAKSELTES | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | N-myristoyl glycine | ------MGAGSSTEQ ------CCCCCCCCC | 50.37 | - | |
| 2 | Myristoylation | ------MGAGSSTEQ ------CCCCCCCCC | 50.37 | 25807930 | |
| 6 | Phosphorylation | --MGAGSSTEQRSPE --CCCCCCCCCCCCC | 34.74 | 23403867 | |
| 7 | Phosphorylation | -MGAGSSTEQRSPEQ -CCCCCCCCCCCCCC | 37.52 | 54291399 | |
| 11 | Phosphorylation | GSSTEQRSPEQPPEG CCCCCCCCCCCCCCC | 32.27 | 23403867 | |
| 19 | Phosphorylation | PEQPPEGSSTPAEPE CCCCCCCCCCCCCCC | 29.40 | 28857561 | |
| 20 | Phosphorylation | EQPPEGSSTPAEPEP CCCCCCCCCCCCCCC | 49.63 | 23403867 | |
| 21 | Phosphorylation | QPPEGSSTPAEPEPS CCCCCCCCCCCCCCC | 28.37 | 28985074 | |
| 24 (in isoform 2) | Ubiquitination | - | 51.94 | 21890473 | |
| 28 | Phosphorylation | TPAEPEPSGGGPSAE CCCCCCCCCCCCCCC | 48.70 | 27251275 | |
| 33 | Phosphorylation | EPSGGGPSAEAAPDT CCCCCCCCCCCCCCC | 41.85 | 27251275 | |
| 40 | Phosphorylation | SAEAAPDTTADPAIA CCCCCCCCCCCHHHH | 23.87 | 27251275 | |
| 41 | Phosphorylation | AEAAPDTTADPAIAA CCCCCCCCCCHHHHC | 36.12 | 27251275 | |
| 54 | Ubiquitination | AASDPATKLLQKNGQ HCCCHHHHHHHHCCC | 49.67 | 21906983 | |
| 54 (in isoform 1) | Ubiquitination | - | 49.67 | 21890473 | |
| 63 | Phosphorylation | LQKNGQLSTINGVAE HHHCCCEEEECCCCC | 21.25 | 30624053 | |
| 64 | Phosphorylation | QKNGQLSTINGVAEQ HHCCCEEEECCCCCH | 27.36 | 23403867 | |
| 72 (in isoform 3) | Ubiquitination | - | 50.76 | 21890473 | |
| 75 | Phosphorylation | VAEQDELSLQEGDLN CCCHHHHHHCCCCCC | 26.42 | 30266825 | |
| 75 (in isoform 2) | Ubiquitination | - | 26.42 | - | |
| 77 (in isoform 3) | Ubiquitination | - | 49.61 | 21890473 | |
| 79 (in isoform 2) | Ubiquitination | - | 31.57 | 21890473 | |
| 84 (in isoform 2) | Ubiquitination | - | 39.68 | 21890473 | |
| 91 (in isoform 2) | Ubiquitination | - | 32.67 | 21890473 | |
| 94 (in isoform 2) | Ubiquitination | - | 8.95 | 21890473 | |
| 96 | Phosphorylation | NGQGALNSQEEEEVI CCCCCCCCCCCEEEE | 39.56 | 22617229 | |
| 105 | Phosphorylation | EEEEVIVTEVGQRDS CCEEEEEEECCCCCC | 17.52 | 25278378 | |
| 105 (in isoform 2) | Ubiquitination | - | 17.52 | 21890473 | |
| 112 | Phosphorylation | TEVGQRDSEDVSKRD EECCCCCCCCHHHCC | 37.57 | 28787133 | |
| 116 | Phosphorylation | QRDSEDVSKRDSDKE CCCCCCHHHCCCCHH | 34.00 | 26657352 | |
| 120 | Phosphorylation | EDVSKRDSDKEMATK CCHHHCCCCHHHHHH | 55.40 | 26657352 | |
| 122 | Ubiquitination | VSKRDSDKEMATKSA HHHCCCCHHHHHHHE | 54.03 | 21906983 | |
| 122 (in isoform 1) | Ubiquitination | - | 54.03 | 21890473 | |
| 128 | Phosphorylation | DKEMATKSAVVHDIT CHHHHHHHEEEEECC | 23.18 | 22468782 | |
| 129 (in isoform 2) | Phosphorylation | - | 14.65 | - | |
| 130 (in isoform 2) | Ubiquitination | - | 5.19 | 21890473 | |
| 135 | Phosphorylation | SAVVHDITDDGQEET HEEEEECCCCCCCCC | 33.81 | 22468782 | |
| 151 | Phosphorylation | EIIEQIPSSESNLEE HHHHHCCCCCCCHHH | 48.65 | 27251275 | |
| 152 | Phosphorylation | IIEQIPSSESNLEEL HHHHCCCCCCCHHHH | 39.42 | 27251275 | |
| 154 | Phosphorylation | EQIPSSESNLEELTQ HHCCCCCCCHHHHHC | 48.97 | 27251275 | |
| 155 (in isoform 2) | Phosphorylation | - | 47.63 | - | |
| 173 | Ubiquitination | QANDIGFKKVFKFVG HHHHCCHHHHEEECE | 42.70 | - | |
| 177 | Ubiquitination | IGFKKVFKFVGFKFT CCHHHHEEECEEEEE | 41.97 | 21890473 | |
| 177 (in isoform 1) | Ubiquitination | - | 41.97 | 21890473 | |
| 181 (in isoform 2) | Ubiquitination | - | 5.03 | 21890473 | |
| 182 | Ubiquitination | VFKFVGFKFTVKKDK HEEECEEEEEECCCC | 33.91 | 21890473 | |
| 182 (in isoform 1) | Ubiquitination | - | 33.91 | 21890473 | |
| 182 (in isoform 2) | Phosphorylation | - | 33.91 | - | |
| 184 | Phosphorylation | KFVGFKFTVKKDKTE EECEEEEEECCCCCC | 31.82 | 113313587 | |
| 185 (in isoform 2) | Phosphorylation | - | 9.03 | - | |
| 187 | Ubiquitination | GFKFTVKKDKTEKPD EEEEEECCCCCCCCC | 61.18 | - | |
| 187 (in isoform 2) | Phosphorylation | - | 61.18 | - | |
| 188 (in isoform 2) | Phosphorylation | - | 58.34 | - | |
| 189 | Ubiquitination | KFTVKKDKTEKPDTV EEEECCCCCCCCCCE | 68.42 | 21906983 | |
| 189 (in isoform 1) | Ubiquitination | - | 68.42 | 21890473 | |
| 191 (in isoform 2) | Phosphorylation | - | 69.22 | - | |
| 192 | Ubiquitination | VKKDKTEKPDTVQLL ECCCCCCCCCCEEEE | 54.12 | 21906983 | |
| 192 (in isoform 1) | Ubiquitination | - | 54.12 | 21890473 | |
| 193 (in isoform 3) | Ubiquitination | - | 35.95 | 21890473 | |
| 199 (in isoform 2) | Ubiquitination | - | 2.64 | 21890473 | |
| 200 (in isoform 2) | Ubiquitination | - | 38.58 | 21890473 | |
| 203 | Ubiquitination | VQLLTVKKDEGEGAA EEEEEEECCCCCCCC | 57.59 | 21906983 | |
| 203 (in isoform 1) | Ubiquitination | - | 57.59 | 21890473 | |
| 213 (in isoform 2) | Phosphorylation | - | 36.32 | - | |
| 214 (in isoform 2) | Phosphorylation | - | 45.16 | - | |
| 217 (in isoform 2) | Ubiquitination | - | 34.30 | 21890473 | |
| 219 | Phosphorylation | AGDHKDPSLGAGEAA CCCCCCCCCCCCHHC | 49.95 | 29255136 | |
| 219 (in isoform 2) | Ubiquitination | - | 49.95 | 21890473 | |
| 227 | Phosphorylation | LGAGEAASKESEPKQ CCCCHHCCCCCCCCC | 43.96 | 25850435 | |
| 228 | Ubiquitination | GAGEAASKESEPKQS CCCHHCCCCCCCCCC | 61.61 | 21906983 | |
| 228 (in isoform 1) | Ubiquitination | - | 61.61 | 21890473 | |
| 230 | Phosphorylation | GEAASKESEPKQSTE CHHCCCCCCCCCCCC | 64.04 | 24961811 | |
| 235 | Phosphorylation | KESEPKQSTEKPEET CCCCCCCCCCCHHHH | 44.66 | 37006795 | |
| 236 | Phosphorylation | ESEPKQSTEKPEETL CCCCCCCCCCHHHHH | 45.60 | 54291403 | |
| 242 | Phosphorylation | STEKPEETLKREQSH CCCCHHHHHHHHHHC | 35.60 | 24719451 | |
| 244 (in isoform 2) | Ubiquitination | - | 62.40 | 21890473 | |
| 248 | Phosphorylation | ETLKREQSHAEISPP HHHHHHHHCCCCCCC | 21.66 | 30266825 | |
| 253 | Phosphorylation | EQSHAEISPPAESGQ HHHCCCCCCCCHHCH | 19.14 | 30266825 | |
| 258 | Phosphorylation | EISPPAESGQAVEEC CCCCCCHHCHHHHHH | 38.01 | 23403867 | |
| 276 (in isoform 2) | Phosphorylation | - | 54.79 | - | |
| 278 | Phosphorylation | EKQEKEPSKSAESPT HHCCCCCCCCCCCCC | 40.09 | 30576142 | |
| 278 (in isoform 2) | Ubiquitination | - | 40.09 | 21890473 | |
| 279 | Ubiquitination | KQEKEPSKSAESPTS HCCCCCCCCCCCCCC | 65.48 | 21906983 | |
| 279 (in isoform 1) | Ubiquitination | - | 65.48 | 21890473 | |
| 280 | Phosphorylation | QEKEPSKSAESPTSP CCCCCCCCCCCCCCC | 41.42 | 29255136 | |
| 283 | Phosphorylation | EPSKSAESPTSPVTS CCCCCCCCCCCCCCC | 32.94 | 19664994 | |
| 283 (in isoform 2) | Phosphorylation | - | 32.94 | - | |
| 285 | Phosphorylation | SKSAESPTSPVTSET CCCCCCCCCCCCCCC | 55.75 | 29255136 | |
| 286 | Phosphorylation | KSAESPTSPVTSETG CCCCCCCCCCCCCCC | 22.28 | 29255136 | |
| 289 | Phosphorylation | ESPTSPVTSETGSTF CCCCCCCCCCCCHHH | 24.99 | 30266825 | |
| 290 | Phosphorylation | SPTSPVTSETGSTFK CCCCCCCCCCCHHHH | 33.14 | 17525332 | |
| 290 (in isoform 2) | Phosphorylation | - | 33.14 | - | |
| 292 | Phosphorylation | TSPVTSETGSTFKKF CCCCCCCCCHHHHHH | 35.88 | 30266825 | |
| 294 | Phosphorylation | PVTSETGSTFKKFFT CCCCCCCHHHHHHHH | 37.78 | 23911959 | |
| 295 | Phosphorylation | VTSETGSTFKKFFTQ CCCCCCHHHHHHHHC | 40.60 | 21712546 | |
| 297 | Acetylation | SETGSTFKKFFTQGW CCCCHHHHHHHHCCC | 49.08 | 24431223 | |
| 297 | Ubiquitination | SETGSTFKKFFTQGW CCCCHHHHHHHHCCC | 49.08 | 21906983 | |
| 297 (in isoform 1) | Ubiquitination | - | 49.08 | 21890473 | |
| 297 (in isoform 2) | Ubiquitination | - | 49.08 | 21890473 | |
| 298 | Acetylation | ETGSTFKKFFTQGWA CCCHHHHHHHHCCCC | 41.33 | 24469455 | |
| 298 | Ubiquitination | ETGSTFKKFFTQGWA CCCHHHHHHHHCCCC | 41.33 | 21890473 | |
| 298 (in isoform 1) | Ubiquitination | - | 41.33 | 21890473 | |
| 311 | Phosphorylation | WAGWRKKTSFRKPKE CCCCCCCCCCCCCCH | 35.81 | 23403867 | |
| 312 | Phosphorylation | AGWRKKTSFRKPKED CCCCCCCCCCCCCHH | 31.75 | 17081983 | |
| 315 | Ubiquitination | RKKTSFRKPKEDEVE CCCCCCCCCCHHHHH | 59.43 | 21906983 | |
| 315 (in isoform 1) | Ubiquitination | - | 59.43 | 21890473 | |
| 317 | Ubiquitination | KTSFRKPKEDEVEAS CCCCCCCCHHHHHHH | 79.44 | 21906983 | |
| 317 (in isoform 1) | Ubiquitination | - | 79.44 | 21890473 | |
| 334 (in isoform 2) | Ubiquitination | - | 57.01 | 21890473 | |
| 337 | Phosphorylation | QEPEKVDTEEDGKAE CCCCCCCCCCCCCHH | 44.24 | 26657352 | |
| 342 | Ubiquitination | VDTEEDGKAEVASEK CCCCCCCCHHHHHHH | 54.41 | 21906983 | |
| 342 (in isoform 1) | Ubiquitination | - | 54.41 | 21890473 | |
| 347 | Phosphorylation | DGKAEVASEKLTASE CCCHHHHHHHCCHHC | 40.20 | 29255136 | |
| 351 | Phosphorylation | EVASEKLTASEQAHP HHHHHHCCHHCCCCC | 38.92 | 30266825 | |
| 353 | Phosphorylation | ASEKLTASEQAHPQE HHHHCCHHCCCCCCC | 25.63 | 30266825 | |
| 363 (in isoform 2) | Ubiquitination | - | 60.21 | 21890473 | |
| 364 | Phosphorylation | HPQEPAESAHEPRLS CCCCCHHHCCCCCCC | 36.71 | 30266825 | |
| 369 (in isoform 2) | Ubiquitination | - | 37.99 | 21890473 | |
| 371 | Phosphorylation | SAHEPRLSAEYEKVE HCCCCCCCEEEEEEE | 21.97 | 29255136 | |
| 374 | Phosphorylation | EPRLSAEYEKVELPS CCCCCEEEEEEECCC | 22.29 | 27273156 | |
| 376 | Ubiquitination | RLSAEYEKVELPSEE CCCEEEEEEECCCHH | 39.86 | 21906983 | |
| 376 (in isoform 1) | Ubiquitination | - | 39.86 | 21890473 | |
| 381 | Phosphorylation | YEKVELPSEEQVSGS EEEEECCCHHHCCCC | 67.40 | 19664994 | |
| 385 (in isoform 2) | Phosphorylation | - | 8.72 | - | |
| 386 | Phosphorylation | LPSEEQVSGSQGPSE CCCHHHCCCCCCCCC | 32.21 | 22167270 | |
| 388 | Phosphorylation | SEEQVSGSQGPSEEK CHHHCCCCCCCCCCC | 25.18 | 17525332 | |
| 392 | Phosphorylation | VSGSQGPSEEKPAPL CCCCCCCCCCCCCCC | 66.27 | 22167270 | |
| 393 (in isoform 2) | Ubiquitination | - | 73.50 | 21890473 | |
| 395 | Ubiquitination | SQGPSEEKPAPLATE CCCCCCCCCCCCHHH | 42.29 | 21906983 | |
| 395 (in isoform 1) | Ubiquitination | - | 42.29 | 21890473 | |
| 401 | Phosphorylation | EKPAPLATEVFDEKI CCCCCCHHHHHCCCC | 40.12 | 29632367 | |
| 407 (in isoform 2) | Phosphorylation | - | 46.11 | - | |
| 428 | Phosphorylation | VSTVEERTEEQKTEV EHHHHHHCHHHHCHH | 47.34 | 25002506 | |
| 432 | Ubiquitination | EERTEEQKTEVEETA HHHCHHHHCHHHHCC | 50.35 | 21906983 | |
| 432 (in isoform 1) | Ubiquitination | - | 50.35 | 21890473 | |
| 433 | Phosphorylation | ERTEEQKTEVEETAG HHCHHHHCHHHHCCC | 44.98 | 29978859 | |
| 438 | Phosphorylation | QKTEVEETAGSVPAE HHCHHHHCCCCCCHH | 23.86 | 29978859 | |
| 441 | Phosphorylation | EVEETAGSVPAEELV HHHHCCCCCCHHHHH | 23.59 | 26657352 | |
| 456 (in isoform 2) | Phosphorylation | - | 66.76 | - | |
| 459 (in isoform 2) | Phosphorylation | - | 56.53 | - | |
| 461 | Ubiquitination | PQEAEPAKELVKLKE CCCCCCHHHHHHHHH | 63.40 | 21906983 | |
| 461 (in isoform 1) | Ubiquitination | - | 63.40 | 21890473 | |
| 467 | Ubiquitination | AKELVKLKETCVSGE HHHHHHHHHHHCCCC | 45.30 | 21906983 | |
| 467 (in isoform 1) | Ubiquitination | - | 45.30 | 21890473 | |
| 467 (in isoform 2) | Phosphorylation | - | 45.30 | - | |
| 468 (in isoform 2) | Phosphorylation | - | 58.85 | - | |
| 469 | Phosphorylation | ELVKLKETCVSGEDP HHHHHHHHHCCCCCC | 19.34 | 28985074 | |
| 470 (in isoform 2) | Phosphorylation | - | 2.11 | - | |
| 471 (in isoform 2) | Phosphorylation | - | 12.29 | - | |
| 472 | Phosphorylation | KLKETCVSGEDPTQG HHHHHHCCCCCCCCC | 38.31 | 27050516 | |
| 477 | Phosphorylation | CVSGEDPTQGADLSP HCCCCCCCCCCCCCC | 52.54 | 29691806 | |
| 483 | Phosphorylation | PTQGADLSPDEKVLS CCCCCCCCCCCCHHC | 30.74 | 19664994 | |
| 490 | Phosphorylation | SPDEKVLSKPPEGVV CCCCCHHCCCCCCCE | 46.21 | 23403867 | |
| 491 | Ubiquitination | PDEKVLSKPPEGVVS CCCCHHCCCCCCCEE | 61.50 | 21906983 | |
| 491 (in isoform 1) | Ubiquitination | - | 61.50 | 21890473 | |
| 498 | Phosphorylation | KPPEGVVSEVEMLSS CCCCCCEEHHEECCC | 33.25 | 23403867 | |
| 500 (in isoform 2) | Phosphorylation | - | 4.00 | - | |
| 504 | Phosphorylation | VSEVEMLSSQERMKV EEHHEECCCCHHHHC | 28.76 | 30266825 | |
| 504 (in isoform 2) | Ubiquitination | - | 28.76 | 21890473 | |
| 505 | Phosphorylation | SEVEMLSSQERMKVQ EHHEECCCCHHHHCC | 31.90 | 17525332 | |
| 510 (in isoform 2) | Phosphorylation | - | 37.31 | - | |
| 514 | Phosphorylation | ERMKVQGSPLKKLFT HHHHCCCCHHHHHHH | 15.23 | 19664994 | |
| 514 (in isoform 2) | Phosphorylation | - | 15.23 | - | |
| 521 | Phosphorylation | SPLKKLFTSTGLKKL CHHHHHHHHHCHHHH | 35.50 | 26657352 | |
| 522 | Phosphorylation | PLKKLFTSTGLKKLS HHHHHHHHHCHHHHC | 17.10 | 23403867 | |
| 523 | Phosphorylation | LKKLFTSTGLKKLSG HHHHHHHHCHHHHCC | 43.40 | 23403867 | |
| 526 | Acetylation | LFTSTGLKKLSGKKQ HHHHHCHHHHCCCCC | 53.68 | 156147 | |
| 526 | Ubiquitination | LFTSTGLKKLSGKKQ HHHHHCHHHHCCCCC | 53.68 | - | |
| 529 | Phosphorylation | STGLKKLSGKKQKGK HHCHHHHCCCCCCCC | 58.40 | 18707149 | |
| 529 (in isoform 2) | Phosphorylation | - | 58.40 | - | |
| 531 (in isoform 2) | Phosphorylation | - | 48.97 | - | |
| 537 | Methylation | GKKQKGKRGGGDEES CCCCCCCCCCCCCCC | 58.62 | - | |
| 541 (in isoform 2) | Ubiquitination | - | 60.82 | 21890473 | |
| 542 (in isoform 2) | Phosphorylation | - | 58.29 | - | |
| 544 | Phosphorylation | RGGGDEESGEHTQVP CCCCCCCCCCCCCCC | 47.65 | 21082442 | |
| 544 (in isoform 2) | Phosphorylation | - | 47.65 | - | |
| 546 (in isoform 2) | Phosphorylation | - | 53.71 | - | |
| 547 (in isoform 2) | Phosphorylation | - | 25.73 | - | |
| 548 | Phosphorylation | DEESGEHTQVPADSP CCCCCCCCCCCCCCC | 27.28 | 19413330 | |
| 548 (in isoform 2) | Phosphorylation | - | 27.28 | - | |
| 550 (in isoform 2) | Phosphorylation | - | 4.42 | - | |
| 551 (in isoform 2) | Phosphorylation | - | 22.11 | - | |
| 553 (in isoform 2) | Phosphorylation | - | 55.42 | - | |
| 554 | Phosphorylation | HTQVPADSPDSQEEQ CCCCCCCCCCCHHHH | 32.48 | 25159151 | |
| 557 | Phosphorylation | VPADSPDSQEEQKGE CCCCCCCCHHHHCCC | 42.76 | 28355574 | |
| 565 | Phosphorylation | QEEQKGESSASSPEE HHHHCCCCCCCCCCC | 39.61 | 30631047 | |
| 566 | Phosphorylation | EEQKGESSASSPEEP HHHCCCCCCCCCCCH | 28.06 | 25159151 | |
| 568 | Phosphorylation | QKGESSASSPEEPEE HCCCCCCCCCCCHHH | 48.66 | 25159151 | |
| 569 | Phosphorylation | KGESSASSPEEPEEI CCCCCCCCCCCHHHH | 35.73 | 30631047 | |
| 572 (in isoform 2) | Ubiquitination | - | 62.49 | 21890473 | |
| 574 (in isoform 2) | Ubiquitination | - | 66.37 | 21890473 | |
| 577 | Phosphorylation | PEEPEEITCLEKGLA CCCHHHHHHHHHHHH | 17.83 | 21406692 | |
| 591 (in isoform 2) | Ubiquitination | - | 62.29 | 21890473 | |
| 597 | Phosphorylation | GEAEEGATSDGEKKR CCCCCCCCCCCCHHC | 37.90 | 29255136 | |
| 598 | Phosphorylation | EAEEGATSDGEKKRE CCCCCCCCCCCHHCC | 42.98 | 19664994 | |
| 598 (in isoform 2) | Phosphorylation | - | 42.98 | - | |
| 599 (in isoform 2) | Phosphorylation | - | 65.99 | - | |
| 600 (in isoform 2) | Phosphorylation | - | 48.68 | - | |
| 602 | Ubiquitination | GATSDGEKKREGVTP CCCCCCCHHCCCCCC | 63.76 | 21906983 | |
| 602 (in isoform 1) | Ubiquitination | - | 63.76 | 21890473 | |
| 608 | Phosphorylation | EKKREGVTPWASFKK CHHCCCCCCHHHHHH | 24.78 | 30266825 | |
| 612 | Phosphorylation | EGVTPWASFKKMVTP CCCCCHHHHHHCCCC | 33.46 | 19664994 | |
| 614 | Acetylation | VTPWASFKKMVTPKK CCCHHHHHHCCCCCC | 37.15 | 21339330 | |
| 615 | Acetylation | TPWASFKKMVTPKKR CCHHHHHHCCCCCCC | 36.27 | 24471123 | |
| 618 | Phosphorylation | ASFKKMVTPKKRVRR HHHHHCCCCCCCCCC | 26.37 | 22817900 | |
| 627 | Phosphorylation | KKRVRRPSESDKEDE CCCCCCCCCCCCHHH | 48.17 | 29255136 | |
| 629 | Phosphorylation | RVRRPSESDKEDELD CCCCCCCCCCHHHHH | 59.32 | 29255136 | |
| 634 (in isoform 2) | Phosphorylation | - | 61.02 | - | |
| 639 | Ubiquitination | EDELDKVKSATLSST HHHHHHHHHHCCCCC | 39.86 | 21906983 | |
| 639 (in isoform 1) | Ubiquitination | - | 39.86 | 21890473 | |
| 640 | Phosphorylation | DELDKVKSATLSSTE HHHHHHHHHCCCCCC | 29.49 | 22617229 | |
| 642 | Phosphorylation | LDKVKSATLSSTEST HHHHHHHCCCCCCHH | 33.97 | 9570613 | |
| 644 | Phosphorylation | KVKSATLSSTESTAS HHHHHCCCCCCHHHH | 30.75 | 28355574 | |
| 645 | Phosphorylation | VKSATLSSTESTASE HHHHCCCCCCHHHHH | 39.03 | 28355574 | |
| 646 | Phosphorylation | KSATLSSTESTASEM HHHCCCCCCHHHHHH | 30.49 | 21712546 | |
| 648 | Phosphorylation | ATLSSTESTASEMQE HCCCCCCHHHHHHHH | 29.39 | 22617229 | |
| 649 | Phosphorylation | TLSSTESTASEMQEE CCCCCCHHHHHHHHH | 28.15 | 30631047 | |
| 651 | Phosphorylation | SSTESTASEMQEEMK CCCCHHHHHHHHHHC | 33.42 | 28355574 | |
| 660 | Phosphorylation | MQEEMKGSVEEPKPE HHHHHCCCCCCCCCC | 22.34 | 54886577 | |
| 665 (in isoform 2) | Ubiquitination | - | 69.23 | 21890473 | |
| 670 | Ubiquitination | EPKPEEPKRKVDTSV CCCCCCCCCCCCCCC | 69.04 | 21906983 | |
| 670 (in isoform 1) | Ubiquitination | - | 69.04 | 21890473 | |
| 672 | Ubiquitination | KPEEPKRKVDTSVSW CCCCCCCCCCCCCCE | 51.06 | 21906983 | |
| 672 (in isoform 1) | Ubiquitination | - | 51.06 | 21890473 | |
| 675 | Phosphorylation | EPKRKVDTSVSWEAL CCCCCCCCCCCEEEE | 33.73 | 27251275 | |
| 676 | Phosphorylation | PKRKVDTSVSWEALI CCCCCCCCCCEEEEE | 15.08 | 27251275 | |
| 678 | Phosphorylation | RKVDTSVSWEALICV CCCCCCCCEEEEEEE | 20.97 | 27251275 | |
| 687 | Phosphorylation | EALICVGSSKKRARR EEEEEECCHHHCCCC | 20.70 | 63724951 | |
| 688 | Phosphorylation | ALICVGSSKKRARRG EEEEECCHHHCCCCC | 35.95 | 24275569 | |
| 689 | Ubiquitination | LICVGSSKKRARRGS EEEECCHHHCCCCCC | 48.23 | 21906983 | |
| 689 (in isoform 1) | Ubiquitination | - | 48.23 | 21890473 | |
| 696 | Phosphorylation | KKRARRGSSSDEEGG HHCCCCCCCCCCCCC | 25.51 | 30266825 | |
| 697 | Phosphorylation | KRARRGSSSDEEGGP HCCCCCCCCCCCCCC | 44.63 | 30266825 | |
| 698 | Phosphorylation | RARRGSSSDEEGGPK CCCCCCCCCCCCCCC | 51.22 | 30266825 | |
| 702 (in isoform 2) | Ubiquitination | - | 56.51 | 21890473 | |
| 710 (in isoform 2) | Ubiquitination | - | 35.00 | 21890473 | |
| 723 | Phosphorylation | EAGKDKETGTDGILA HCCCCCCCCCCCEEE | 51.64 | 29514088 | |
| 725 | Phosphorylation | GKDKETGTDGILAGS CCCCCCCCCCEEECC | 38.17 | 29514088 | |
| 732 | Phosphorylation | TDGILAGSQEHDPGQ CCCEEECCCCCCCCC | 27.13 | 17525332 | |
| 741 | Phosphorylation | EHDPGQGSSSPEQAG CCCCCCCCCCHHHCC | 21.54 | 29514088 | |
| 742 | Phosphorylation | HDPGQGSSSPEQAGS CCCCCCCCCHHHCCC | 57.65 | 20363803 | |
| 743 | Phosphorylation | DPGQGSSSPEQAGSP CCCCCCCCHHHCCCC | 33.87 | 20363803 | |
| 749 | Phosphorylation | SSPEQAGSPTEGEGV CCHHHCCCCCCCCCC | 31.50 | 22617229 | |
| 751 | Phosphorylation | PEQAGSPTEGEGVST HHHCCCCCCCCCCCH | 59.32 | 29514088 | |
| 757 | Phosphorylation | PTEGEGVSTWESFKR CCCCCCCCHHHHHHH | 38.36 | 21406692 | |
| 758 | Phosphorylation | TEGEGVSTWESFKRL CCCCCCCHHHHHHHH | 30.74 | 21406692 | |
| 761 | Phosphorylation | EGVSTWESFKRLVTP CCCCHHHHHHHHCCC | 27.85 | 21406692 | |
| 761 (in isoform 2) | Ubiquitination | - | 27.85 | 21890473 | |
| 763 | Ubiquitination | VSTWESFKRLVTPRK CCHHHHHHHHCCCCC | 54.85 | 21906983 | |
| 763 (in isoform 1) | Ubiquitination | - | 54.85 | 21890473 | |
| 767 | Phosphorylation | ESFKRLVTPRKKSKS HHHHHHCCCCCCCHH | 23.20 | 23312004 | |
| 769 (in isoform 2) | Ubiquitination | - | 50.06 | 21890473 | |
| 771 | Acetylation | RLVTPRKKSKSKLEE HHCCCCCCCHHHHHH | 65.48 | 70887 | |
| 772 | Phosphorylation | LVTPRKKSKSKLEEK HCCCCCCCHHHHHHH | 45.24 | 69326199 | |
| 775 | Acetylation | PRKKSKSKLEEKSED CCCCCHHHHHHHCCC | 64.75 | 70889 | |
| 777 (in isoform 2) | Ubiquitination | - | 68.09 | 21890473 | |
| 780 | Phosphorylation | KSKLEEKSEDSIAGS HHHHHHHCCCCCCCC | 50.33 | 28355574 | |
| 783 | Phosphorylation | LEEKSEDSIAGSGVE HHHHCCCCCCCCCCC | 15.41 | 21712546 | |
| 784 (in isoform 2) | Ubiquitination | - | 8.55 | 21890473 | |
| 787 | Phosphorylation | SEDSIAGSGVEHSTP CCCCCCCCCCCCCCC | 30.55 | 25159151 | |
| 789 (in isoform 2) | Phosphorylation | - | 6.83 | - | |
| 792 | Phosphorylation | AGSGVEHSTPDTEPG CCCCCCCCCCCCCCC | 28.29 | 25159151 | |
| 793 | Phosphorylation | GSGVEHSTPDTEPGK CCCCCCCCCCCCCCC | 27.39 | 25159151 | |
| 796 | Phosphorylation | VEHSTPDTEPGKEES CCCCCCCCCCCCCCC | 45.33 | 21712546 | |
| 800 | Ubiquitination | TPDTEPGKEESWVSI CCCCCCCCCCCCEEH | 69.86 | 21906983 | |
| 800 (in isoform 1) | Ubiquitination | - | 69.86 | 21890473 | |
| 803 | Phosphorylation | TEPGKEESWVSIKKF CCCCCCCCCEEHHHH | 33.59 | 21712546 | |
| 806 | Phosphorylation | GKEESWVSIKKFIPG CCCCCCEEHHHHCCC | 23.56 | 28355574 | |
| 806 (in isoform 2) | Phosphorylation | - | 23.56 | - | |
| 808 | Ubiquitination | EESWVSIKKFIPGRR CCCCEEHHHHCCCCC | 33.84 | 21906983 | |
| 808 (in isoform 1) | Ubiquitination | - | 33.84 | 21890473 | |
| 812 (in isoform 2) | Phosphorylation | - | 33.11 | - | |
| 834 | Phosphorylation | PVEDAGPTGANEDDS CHHHCCCCCCCCCCC | 48.27 | 30242111 | |
| 841 | Phosphorylation | TGANEDDSDVPAVVP CCCCCCCCCCCCEEE | 53.48 | 26657352 | |
| 850 | Phosphorylation | VPAVVPLSEYDAVER CCCEEEHHHHHHHHH | 28.21 | 29978859 | |
| 852 | Phosphorylation | AVVPLSEYDAVEREK CEEEHHHHHHHHHHH | 13.06 | 29978859 | |
| 859 | Ubiquitination | YDAVEREKMEAQQAQ HHHHHHHHHHHHHHH | 48.54 | 21906983 | |
| 859 (in isoform 1) | Ubiquitination | - | 48.54 | 21890473 | |
| 860 | Sulfoxidation | DAVEREKMEAQQAQK HHHHHHHHHHHHHHH | 4.40 | 30846556 | |
| 867 | Ubiquitination | MEAQQAQKSAEQPEQ HHHHHHHHHHCCHHH | 55.43 | 21906983 | |
| 867 (in isoform 1) | Ubiquitination | - | 55.43 | 21890473 | |
| 868 | Phosphorylation | EAQQAQKSAEQPEQK HHHHHHHHHCCHHHH | 25.59 | 28985074 | |
| 875 | Ubiquitination | SAEQPEQKAATEVSK HHCCHHHHHHHHHHH | 38.02 | 21906983 | |
| 875 (in isoform 1) | Ubiquitination | - | 38.02 | 21890473 | |
| 881 | Phosphorylation | QKAATEVSKELSESQ HHHHHHHHHHHCHHH | 17.74 | 28985074 | |
| 882 | Ubiquitination | KAATEVSKELSESQV HHHHHHHHHHCHHHH | 68.78 | 21906983 | |
| 882 (in isoform 1) | Ubiquitination | - | 68.78 | 21890473 | |
| 885 | Phosphorylation | TEVSKELSESQVHMM HHHHHHHCHHHHHHH | 35.97 | 30266825 | |
| 887 | Phosphorylation | VSKELSESQVHMMAA HHHHHCHHHHHHHHH | 33.84 | 17525332 | |
| 891 | Sulfoxidation | LSESQVHMMAAAVAD HCHHHHHHHHHHHHC | 1.73 | 30846556 | |
| 892 | Sulfoxidation | SESQVHMMAAAVADG CHHHHHHHHHHHHCC | 1.07 | 30846556 | |
| 900 | Phosphorylation | AAAVADGTRAATIIE HHHHHCCCEEEEEEE | 20.06 | 23403867 | |
| 904 | Phosphorylation | ADGTRAATIIEERSP HCCCEEEEEEECCCC | 22.85 | 28857561 | |
| 910 | Phosphorylation | ATIIEERSPSWISAS EEEEECCCCCCEECC | 26.94 | 21406692 | |
| 912 | Phosphorylation | IIEERSPSWISASVT EEECCCCCCEECCCC | 37.98 | 21406692 | |
| 915 | Phosphorylation | ERSPSWISASVTEPL CCCCCCEECCCCCCH | 14.29 | 21406692 | |
| 917 | Phosphorylation | SPSWISASVTEPLEQ CCCCEECCCCCCHHH | 23.84 | 21406692 | |
| 919 | Phosphorylation | SWISASVTEPLEQVE CCEECCCCCCHHHHH | 29.41 | 21406692 | |
| 951 (in isoform 2) | Ubiquitination | - | 34.07 | 21890473 | |
| 953 (in isoform 2) | Ubiquitination | - | 43.80 | 21890473 | |
| 967 | Phosphorylation | ARGDTVVSEAELTPE CCCCEEEEEEECCHH | 27.10 | 22468782 | |
| 989 (in isoform 2) | Ubiquitination | - | 71.52 | 21890473 | |
| 1004 (in isoform 2) | Ubiquitination | - | 22.95 | 21890473 | |
| 1010 | Phosphorylation | VSAVSQLTDSPDTTE HHHHHHHCCCCCCCC | 27.13 | 24275569 | |
| 1012 | Phosphorylation | AVSQLTDSPDTTEEA HHHHHCCCCCCCCCC | 21.31 | 68997761 | |
| 1012 (in isoform 2) | Ubiquitination | - | 21.31 | 21890473 | |
| 1016 | Phosphorylation | LTDSPDTTEEATPVQ HCCCCCCCCCCCCHH | 38.93 | 68997575 | |
| 1018 (in isoform 2) | Phosphorylation | - | 56.61 | - | |
| 1020 | Phosphorylation | PDTTEEATPVQEVEG CCCCCCCCCHHHCCC | 27.54 | 24275569 | |
| 1021 (in isoform 2) | Phosphorylation | - | 32.61 | - | |
| 1039 | Phosphorylation | IEEQERRTQEVLQAV HHHHHHHHHHHHHHH | 34.99 | 30242111 | |
| 1049 | Ubiquitination | VLQAVAEKVKEESQL HHHHHHHHHHHHHCC | 49.20 | 21906983 | |
| 1049 (in isoform 1) | Ubiquitination | - | 49.20 | 21890473 | |
| 1051 | Sumoylation | QAVAEKVKEESQLPG HHHHHHHHHHHCCCC | 67.82 | 25114211 | |
| 1051 | Ubiquitination | QAVAEKVKEESQLPG HHHHHHHHHHHCCCC | 67.82 | 21906983 | |
| 1051 (in isoform 1) | Ubiquitination | - | 67.82 | 21890473 | |
| 1054 | Phosphorylation | AEKVKEESQLPGTGG HHHHHHHHCCCCCCC | 37.80 | 54291409 | |
| 1059 | Phosphorylation | EESQLPGTGGPEDVL HHHCCCCCCCCHHHH | 36.71 | 28555341 | |
| 1087 | Acetylation | QAEASGLKKETDVVL HHHHCCCCCCCCEEE | 52.68 | 24469465 | |
| 1087 | Ubiquitination | QAEASGLKKETDVVL HHHHCCCCCCCCEEE | 52.68 | 21906983 | |
| 1087 (in isoform 1) | Ubiquitination | - | 52.68 | 21890473 | |
| 1088 | Acetylation | AEASGLKKETDVVLK HHHCCCCCCCCEEEE | 71.53 | 12437765 | |
| 1102 | Ubiquitination | KVDAQEAKTEPFTQG EEECCCCCCCCCCCC | 53.31 | 21906983 | |
| 1102 (in isoform 1) | Ubiquitination | - | 53.31 | 21890473 | |
| 1103 | Phosphorylation | VDAQEAKTEPFTQGK EECCCCCCCCCCCCC | 56.81 | 29888752 | |
| 1107 | Phosphorylation | EAKTEPFTQGKVVGQ CCCCCCCCCCCCCCC | 47.31 | 29888752 | |
| 1110 | Ubiquitination | TEPFTQGKVVGQTTP CCCCCCCCCCCCCCH | 24.75 | 21906983 | |
| 1110 (in isoform 1) | Ubiquitination | - | 24.75 | 21890473 | |
| 1115 | Phosphorylation | QGKVVGQTTPESFEK CCCCCCCCCHHHHHH | 38.09 | 30266825 | |
| 1116 | Phosphorylation | GKVVGQTTPESFEKA CCCCCCCCHHHHHHC | 19.71 | 19664994 | |
| 1119 | Phosphorylation | VGQTTPESFEKAPQV CCCCCHHHHHHCCCC | 39.65 | 30266825 | |
| 1127 | Phosphorylation | FEKAPQVTESIESSE HHHCCCCCCCCCCCC | 20.83 | 54291401 | |
| 1136 (in isoform 2) | Ubiquitination | - | 3.50 | 21890473 | |
| 1149 | Phosphorylation | ETLAGVKSQEMVMEQ HHHCCCCCHHHHHHC | 29.03 | 22468782 | |
| 1162 | Phosphorylation | EQAIPPDSVETPTDS HCCCCCCCCCCCCCC | 27.85 | 29460479 | |
| 1162 (in isoform 2) | Ubiquitination | - | 27.85 | 21890473 | |
| 1166 (in isoform 2) | Phosphorylation | - | 22.24 | - | |
| 1174 | Phosphorylation | TDSETDGSTPVADFD CCCCCCCCCCCCCCC | 32.14 | 29460479 | |
| 1176 (in isoform 2) | Ubiquitination | - | 22.46 | 21890473 | |
| 1206 | Phosphorylation | EVASGTQSGGTEAEA CCCCCCCCCCCCEEE | 38.74 | 24719451 | |
| 1209 | Phosphorylation | SGTQSGGTEAEAVPA CCCCCCCCCEEECCC | 35.23 | 28985074 | |
| 1218 (in isoform 2) | Ubiquitination | - | 58.77 | 21890473 | |
| 1225 | Phosphorylation | KERPPAPSSFVFQEE CCCCCCCCCCCCCHH | 38.22 | 30266825 | |
| 1226 | Phosphorylation | ERPPAPSSFVFQEET CCCCCCCCCCCCHHH | 25.11 | 30266825 | |
| 1233 (in isoform 2) | Phosphorylation | - | 38.85 | - | |
| 1234 | Ubiquitination | FVFQEETKEQSKMED CCCCHHHHHHHHHHH | 57.97 | 21906983 | |
| 1234 (in isoform 1) | Ubiquitination | - | 57.97 | 21890473 | |
| 1237 | Phosphorylation | QEETKEQSKMEDTLE CHHHHHHHHHHHHHH | 34.75 | 28555341 | |
| 1242 | Phosphorylation | EQSKMEDTLEHTDKE HHHHHHHHHHHCCCE | 22.27 | 29255136 | |
| 1246 | Phosphorylation | MEDTLEHTDKEVSVE HHHHHHHCCCEEEEE | 39.12 | 28985074 | |
| 1251 | Phosphorylation | EHTDKEVSVETVSIL HHCCCEEEEEEEEEE | 18.48 | 30266825 | |
| 1254 | Phosphorylation | DKEVSVETVSILSKT CCEEEEEEEEEEECC | 19.87 | 30266825 | |
| 1256 | Phosphorylation | EVSVETVSILSKTEG EEEEEEEEEEECCCC | 25.82 | 30266825 | |
| 1259 | Phosphorylation | VETVSILSKTEGTQE EEEEEEEECCCCCHH | 35.54 | 30266825 | |
| 1260 | Ubiquitination | ETVSILSKTEGTQEA EEEEEEECCCCCHHH | 47.34 | 21906983 | |
| 1260 (in isoform 1) | Ubiquitination | - | 47.34 | 21890473 | |
| 1261 | Phosphorylation | TVSILSKTEGTQEAD EEEEEECCCCCHHHH | 35.95 | 23403867 | |
| 1264 | Phosphorylation | ILSKTEGTQEADQYA EEECCCCCHHHHHHC | 19.60 | 21712546 | |
| 1270 | Phosphorylation | GTQEADQYADEKTKD CCHHHHHHCCHHCCC | 19.30 | 27273156 | |
| 1274 | Ubiquitination | ADQYADEKTKDVPFF HHHHCCHHCCCCCCC | 62.51 | 21906983 | |
| 1274 (in isoform 1) | Ubiquitination | - | 62.51 | 21890473 | |
| 1287 | Phosphorylation | FFEGLEGSIDTGITV CCCCCCCCCCCCCEE | 14.12 | 113313607 | |
| 1290 | Phosphorylation | GLEGSIDTGITVSRE CCCCCCCCCCEEEHH | 28.90 | 30301811 | |
| 1292 (in isoform 2) | Phosphorylation | - | 3.59 | - | |
| 1293 | Phosphorylation | GSIDTGITVSREKVT CCCCCCCEEEHHHEE | 17.49 | 27732954 | |
| 1293 (in isoform 2) | Phosphorylation | - | 17.49 | - | |
| 1295 | Phosphorylation | IDTGITVSREKVTEV CCCCCEEEHHHEEEE | 26.52 | 30624053 | |
| 1297 (in isoform 2) | Phosphorylation | - | 44.35 | - | |
| 1316 | Ubiquitination | TEEAECKKDDALELQ CCCHHCCCCCHHHHH | 72.93 | 21906983 | |
| 1316 (in isoform 1) | Ubiquitination | - | 72.93 | 21890473 | |
| 1324 | Phosphorylation | DDALELQSHAKSPPS CCHHHHHHHCCCCCC | 37.73 | 28985074 | |
| 1328 | Phosphorylation | ELQSHAKSPPSPVER HHHHHCCCCCCCCCH | 42.71 | 23401153 | |
| 1331 | Phosphorylation | SHAKSPPSPVEREMV HHCCCCCCCCCHHEE | 44.99 | 19664994 | |
| 1337 | Sulfoxidation | PSPVEREMVVQVERE CCCCCHHEEEEEEHH | 4.48 | 30846556 | |
| 1358 (in isoform 2) | Ubiquitination | - | 10.32 | 21890473 | |
| 1362 | Phosphorylation | EEKLEHETAVTVSEE HHHHCCCEEEECCHH | 28.47 | 23663014 | |
| 1365 | Phosphorylation | LEHETAVTVSEEVSK HCCCEEEECCHHHHH | 18.82 | 23663014 | |
| 1367 | Phosphorylation | HETAVTVSEEVSKQL CCEEEECCHHHHHHH | 20.76 | 23663014 | |
| 1371 | Phosphorylation | VTVSEEVSKQLLQTV EECCHHHHHHHHHHC | 20.26 | 23663014 | |
| 1377 | Phosphorylation | VSKQLLQTVNVPIID HHHHHHHHCCCCEEC | 17.64 | 25841592 | |
| 1390 | Phosphorylation | IDGAKEVSSLEGSPP ECCCCHHHHCCCCCC | 30.23 | 30266825 | |
| 1391 | Phosphorylation | DGAKEVSSLEGSPPP CCCCHHHHCCCCCCC | 35.30 | 30266825 | |
| 1395 | Phosphorylation | EVSSLEGSPPPCLGQ HHHHCCCCCCCCCCC | 25.51 | 19664994 | |
| 1395 (in isoform 2) | Ubiquitination | - | 25.51 | 21890473 | |
| 1408 | Phosphorylation | GQEEAVCTKIQVQSS CCCCEEEEEEEEECC | 25.28 | 29632367 | |
| 1415 | Phosphorylation | TKIQVQSSEASFTLT EEEEEECCCCEEEEE | 21.79 | 113313611 | |
| 1418 | Phosphorylation | QVQSSEASFTLTAAA EEECCCCEEEEEEHH | 18.08 | 28674419 | |
| 1420 | Phosphorylation | QSSEASFTLTAAAEE ECCCCEEEEEEHHHH | 22.24 | 27251275 | |
| 1450 (in isoform 2) | Ubiquitination | - | 18.62 | - | |
| 1456 | Ubiquitination | AHLVLEEKSSEKNED CEEEEEECCCCCCCC | 50.32 | 21906983 | |
| 1456 (in isoform 1) | Ubiquitination | - | 50.32 | 21890473 | |
| 1457 | Phosphorylation | HLVLEEKSSEKNEDF EEEEEECCCCCCCCC | 47.19 | 29460479 | |
| 1458 | Phosphorylation | LVLEEKSSEKNEDFA EEEEECCCCCCCCCC | 64.75 | 26657352 | |
| 1483 | Phosphorylation | GPDCQAKSTPVIVSA CCCCCCCCCCEEEEC | 40.74 | 23403867 | |
| 1484 | Phosphorylation | PDCQAKSTPVIVSAT CCCCCCCCCEEEECC | 22.37 | 25159151 | |
| 1486 (in isoform 2) | Ubiquitination | - | 7.36 | 21890473 | |
| 1493 | 2-Hydroxyisobutyrylation | VIVSATTKKGLSSDL EEEECCCCCCCCCCC | 40.25 | - | |
| 1493 | Acetylation | VIVSATTKKGLSSDL EEEECCCCCCCCCCC | 40.25 | 24431233 | |
| 1493 | Ubiquitination | VIVSATTKKGLSSDL EEEECCCCCCCCCCC | 40.25 | 21906983 | |
| 1493 (in isoform 1) | Ubiquitination | - | 40.25 | 21890473 | |
| 1497 | Phosphorylation | ATTKKGLSSDLEGEK CCCCCCCCCCCCCCC | 30.40 | 29514088 | |
| 1498 | Phosphorylation | TTKKGLSSDLEGEKT CCCCCCCCCCCCCCC | 51.78 | 21815630 | |
| 1505 | Phosphorylation | SDLEGEKTTSLKWKS CCCCCCCCCCCEECC | 19.81 | 23312004 | |
| 1506 | Phosphorylation | DLEGEKTTSLKWKSD CCCCCCCCCCEECCC | 43.03 | 30624053 | |
| 1507 | Phosphorylation | LEGEKTTSLKWKSDE CCCCCCCCCEECCCC | 32.93 | 30624053 | |
| 1512 | Phosphorylation | TTSLKWKSDEVDEQV CCCCEECCCCCCHHH | 37.58 | 28985074 | |
| 1548 | Ubiquitination | ELETKSSKLVQNIIQ EEEECCHHHHHHHHH | 60.82 | - | |
| 1556 | Phosphorylation | LVQNIIQTAVDQFVR HHHHHHHHHHHHHHC | 20.45 | 21406692 | |
| 1564 | Phosphorylation | AVDQFVRTEETATEM HHHHHHCCHHHHHHH | 32.63 | 46161257 | |
| 1567 | Phosphorylation | QFVRTEETATEMLTS HHHCCHHHHHHHHHH | 32.42 | 21406692 | |
| 1569 | Phosphorylation | VRTEETATEMLTSEL HCCHHHHHHHHHHHH | 29.37 | 21406692 | |
| 1573 | Phosphorylation | ETATEMLTSELQTQA HHHHHHHHHHHHHCC | 20.88 | 21406692 | |
| 1574 | Phosphorylation | TATEMLTSELQTQAH HHHHHHHHHHHHCCE | 32.14 | 21406692 | |
| 1578 | Phosphorylation | MLTSELQTQAHVIKA HHHHHHHHCCEEEEC | 40.11 | 21406692 | |
| 1584 | Ubiquitination | QTQAHVIKADSQDAG HHCCEEEECCCCCCC | 45.08 | 21906983 | |
| 1584 (in isoform 1) | Ubiquitination | - | 45.08 | 21890473 | |
| 1587 | Phosphorylation | AHVIKADSQDAGQET CEEEECCCCCCCHHC | 34.52 | 21712546 | |
| 1592 (in isoform 2) | Ubiquitination | - | 57.04 | 21890473 | |
| 1594 | Phosphorylation | SQDAGQETEKEGEEP CCCCCHHCCCCCCCC | 44.46 | 26657352 | |
| 1602 (in isoform 2) | Ubiquitination | - | 51.75 | 21890473 | |
| 1618 | Phosphorylation | ITSAKEESESTAVGQ CCCCCHHHHCCCHHH | 37.63 | 21406692 | |
| 1620 | Phosphorylation | SAKEESESTAVGQAH CCCHHHHCCCHHHHH | 30.83 | 21406692 | |
| 1621 | Phosphorylation | AKEESESTAVGQAHS CCHHHHCCCHHHHHH | 22.70 | 21406692 | |
| 1627 (in isoform 2) | Ubiquitination | - | 20.37 | 21890473 | |
| 1628 | Phosphorylation | TAVGQAHSDISKDMS CCHHHHHHHHCCCHH | 39.39 | 28985074 | |
| 1631 | Phosphorylation | GQAHSDISKDMSEAS HHHHHHHCCCHHHHH | 27.82 | 25159151 | |
| 1635 | Phosphorylation | SDISKDMSEASEKTM HHHCCCHHHHHCCEE | 39.89 | 63711655 | |
| 1652 (in isoform 2) | Ubiquitination | - | 41.27 | 21890473 | |
| 1662 (in isoform 2) | Phosphorylation | - | 28.25 | - | |
| 1663 | Phosphorylation | LEEVVLPSEEEGGGA HEEEECCCCCCCCCC | 54.18 | 30624053 | |
| 1674 | Phosphorylation | GGGAGTKSVPEDDGH CCCCCCCCCCCCCCH | 42.62 | 30266825 | |
| 1678 (in isoform 2) | Ubiquitination | - | 62.21 | 21890473 | |
| 1690 | Ubiquitination | LLAERIEKSLVEPKE HHHHHHHHHCCCCCC | 46.87 | 21906983 | |
| 1690 (in isoform 1) | Ubiquitination | - | 46.87 | 21890473 | |
| 1691 | Phosphorylation | LAERIEKSLVEPKED HHHHHHHHCCCCCCC | 25.51 | 27050516 | |
| 1700 | Ubiquitination | VEPKEDEKGDDVDDP CCCCCCCCCCCCCCC | 78.82 | 21906983 | |
| 1700 (in isoform 1) | Ubiquitination | - | 78.82 | 21890473 | |
| 1712 | Phosphorylation | DDPENQNSALADTDA CCCCHHCCCCCCCCC | 18.20 | 27050516 | |
| 1717 | Phosphorylation | QNSALADTDASGGLT HCCCCCCCCCCCCCC | 28.05 | 29978859 | |
| 1720 | Phosphorylation | ALADTDASGGLTKES CCCCCCCCCCCCCCC | 35.88 | 26657352 | |
| 1724 | Phosphorylation | TDASGGLTKESPDTN CCCCCCCCCCCCCCC | 35.72 | 26657352 | |
| 1725 | Ubiquitination | DASGGLTKESPDTNG CCCCCCCCCCCCCCC | 62.33 | 21906983 | |
| 1725 (in isoform 1) | Ubiquitination | - | 62.33 | 21890473 | |
| 1727 | Phosphorylation | SGGLTKESPDTNGPK CCCCCCCCCCCCCCC | 29.63 | 9571241 | |
| 1730 | Phosphorylation | LTKESPDTNGPKQKE CCCCCCCCCCCCCCC | 45.52 | 21406692 | |
| 1750 | Ubiquitination | EVELQEGKVHSESDK HHCCCCCCCCCCCCC | 35.70 | 21906983 | |
| 1750 (in isoform 1) | Ubiquitination | - | 35.70 | 21890473 | |
| 1753 | Phosphorylation | LQEGKVHSESDKAIT CCCCCCCCCCCCCCC | 41.61 | 23312004 | |
| 1755 | Phosphorylation | EGKVHSESDKAITPQ CCCCCCCCCCCCCHH | 47.64 | 29978859 | |
| 1760 | Phosphorylation | SESDKAITPQAQEEL CCCCCCCCHHHHHHH | 17.76 | 30266825 | |
| 1769 | Ubiquitination | QAQEELQKQERESAK HHHHHHHHHHHHHHH | 67.75 | - | |
| 1774 | Phosphorylation | LQKQERESAKSELTE HHHHHHHHHHHHHHC | 47.41 | 23312004 | |
| 1776 | Ubiquitination | KQERESAKSELTES- HHHHHHHHHHHHCC- | 54.46 | 21906983 | |
| 1776 (in isoform 1) | Ubiquitination | - | 54.46 | 21890473 | |
| 1777 | Phosphorylation | QERESAKSELTES-- HHHHHHHHHHHCC-- | 37.24 | 23312004 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 618 | T | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 627 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 696 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 698 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| 732 | S | Phosphorylation | Kinase | ATR | Q13535 | PSP |
| 767 | T | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 772 | S | Phosphorylation | Kinase | PRKACA | P17612 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of AKA12_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of AKA12_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KPCA_HUMAN | PRKCA | physical | 11316952 | |
| KAP2_HUMAN | PRKAR2A | physical | 11316952 | |
| HDAC7_HUMAN | HDAC7 | genetic | 22584896 | |
| DC1L1_HUMAN | DYNC1LI1 | physical | 22863883 | |
| DLRB1_HUMAN | DYNLRB1 | physical | 22863883 | |
| STK4_HUMAN | STK4 | physical | 27173435 | |
| KIF3C_HUMAN | KIF3C | physical | 27173435 | |
| DYRK2_HUMAN | DYRK2 | physical | 27173435 | |
| KIF3B_HUMAN | KIF3B | physical | 27173435 | |
| SAV1_HUMAN | SAV1 | physical | 27173435 | |
| NECT2_HUMAN | PVRL2 | physical | 27173435 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Myristoylation | |
| Reference | PubMed |
| "Strategy for comprehensive identification of human N-myristoylatedproteins using an insect cell-free protein synthesis system."; Suzuki T., Moriya K., Nagatoshi K., Ota Y., Ezure T., Ando E.,Tsunasawa S., Utsumi T.; Proteomics 10:1780-1793(2010). Cited for: MYRISTOYLATION AT GLY-2. | |
| Phosphorylation | |
| Reference | PubMed |
| "Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-597; SER-598; SER-627;SER-696 AND SER-1395, AND MASS SPECTROMETRY. | |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283; THR-285; SER-286;THR-289; SER-388; SER-483; SER-554; SER-557; SER-566; SER-568;SER-598; SER-612; THR-642; SER-644; SER-645; THR-646; SER-651;THR-1116; SER-1331; SER-1390; SER-1391; SER-1395 AND THR-1760, ANDMASS SPECTROMETRY. | |
| "ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-388; SER-505; SER-732AND SER-887, AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-253; SER-283; SER-286;SER-627; SER-629 AND SER-1331, AND MASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-312; SER-565;SER-566; SER-568; SER-569; SER-598 AND SER-612, AND MASS SPECTROMETRY. | |
