RT17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RT17_HUMAN
• UniProt AC: Q9Y2R5
• Protein Name: 28S ribosomal protein S17, mitochondrial
• Gene Name: MRPS17
• Organism: Homo sapiens (Human).
• Sequence Length: 130
• Subcellular Localization: Mitochondrion .
• Protein Sequence: MSVVRSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFNKRKTYFAHDALQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAGTTYLESPLSSETTQLSKNLEELNISSAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MSVVRSSVHARWI --CCCCCCHHHHHHH	25.71	22617229
21	Acetylation	VGKVIGTKMQKTAKV HHHHHCCCCHHCCCE	33.83	25953088
21	Ubiquitination	VGKVIGTKMQKTAKV HHHHHCCCCHHCCCE	33.83	29967540
38	Phosphorylation	TRLVLDPYLLKYFNK HHHHHCHHHHHHHCC	25.08	21406692
41	Ubiquitination	VLDPYLLKYFNKRKT HHCHHHHHHHCCCCC	45.24	23000965
42	Phosphorylation	LDPYLLKYFNKRKTY HCHHHHHHHCCCCCC	16.62	29083192
45	Ubiquitination	YLLKYFNKRKTYFAH HHHHHHCCCCCCCHH	45.43	23000965
47	Ubiquitination	LKYFNKRKTYFAHDA HHHHCCCCCCCHHHH	49.54	23000965
48	Phosphorylation	KYFNKRKTYFAHDAL HHHCCCCCCCHHHHH	28.09	29496907
78	2-Hydroxyisobutyrylation	VPRAKHVKHELAEIV CCCCHHHHHHHHHHH	30.95	-
90	Ubiquitination	EIVFKVGKVIDPVTG HHHHHHCCEECCCCC	38.72	29967540
90	Acetylation	EIVFKVGKVIDPVTG HHHHHHCCEECCCCC	38.72	26051181
98	Ubiquitination	VIDPVTGKPCAGTTY EECCCCCCCCCCCCE	27.79	29967540
100	Glutathionylation	DPVTGKPCAGTTYLE CCCCCCCCCCCCEEC	6.59	22555962
108	Phosphorylation	AGTTYLESPLSSETT CCCCEECCCCCCHHH	28.66	-
111	Phosphorylation	TYLESPLSSETTQLS CEECCCCCCHHHHHH	29.52	-
127	Phosphorylation	NLEELNISSAQ---- HHHHHCCCCCC----	20.67	30266825
128	Phosphorylation	LEELNISSAQ----- HHHHCCCCCC-----	27.22	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RT17_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RT17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RT17_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIFA3_HUMAN	KIFAP3	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.
PubMed: 19413330

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND MASSSPECTROMETRY.
PubMed: 17081983