PHB2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHB2_MOUSE
• UniProt AC: O35129
• Protein Name: Prohibitin-2
• Gene Name: Phb2 {ECO:0000250|UniProtKB:Q99623}
• Organism: Mus musculus (Mouse).
• Sequence Length: 299
• Subcellular Localization: Mitochondrion inner membrane . Cytoplasm . Nucleus .
• Protein Description: Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging..
• Protein Sequence: MAQNLKDLAGRLPAGPRGMGTALKLLLGAGAVAYGVRESVFTVEGGHRAIFFNRIGGVQQDTILAEGLHFRIPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEERVLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSREYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSKNPGYIKLRKIRAAQNISKTIATSQNRIYLTADNLVLNLQDESFTRGSDSLIKGKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQNLKDLA ------CCCCHHHHC	13.63	-
6	Ubiquitination	--MAQNLKDLAGRLP --CCCCHHHHCCCCC	59.24	-
6	Acetylation	--MAQNLKDLAGRLP --CCCCHHHHCCCCC	59.24	23576753
6	Malonylation	--MAQNLKDLAGRLP --CCCCHHHHCCCCC	59.24	26320211
77	Phosphorylation	FRIPWFQYPIIYDIR EECCCCCCCEEEEEC	6.21	-
89	Acetylation	DIRARPRKISSPTGS EECCCCCCCCCCCCC	50.01	23806337
89	Malonylation	DIRARPRKISSPTGS EECCCCCCCCCCCCC	50.01	26320211
89	Succinylation	DIRARPRKISSPTGS EECCCCCCCCCCCCC	50.01	23806337
91	Phosphorylation	RARPRKISSPTGSKD CCCCCCCCCCCCCCC	33.04	26824392
92	Phosphorylation	ARPRKISSPTGSKDL CCCCCCCCCCCCCCC	29.92	26745281
94	Phosphorylation	PRKISSPTGSKDLQM CCCCCCCCCCCCCEE	56.91	29895711
96	Phosphorylation	KISSPTGSKDLQMVN CCCCCCCCCCCEEEE	26.02	25890499
97	Malonylation	ISSPTGSKDLQMVNI CCCCCCCCCCEEEEE	64.90	26320211
97	Succinylation	ISSPTGSKDLQMVNI CCCCCCCCCCEEEEE	64.90	23954790
97	Acetylation	ISSPTGSKDLQMVNI CCCCCCCCCCEEEEE	64.90	23864654
105	Phosphorylation	DLQMVNISLRVLSRP CCEEEEEEEEEHHCC	12.62	27742792
110	Phosphorylation	NISLRVLSRPNAQEL EEEEEEHHCCCHHHC	42.72	29895711
121	Phosphorylation	AQELPSMYQRLGLDY HHHCCHHHHHHCCCH	8.53	25195567
128	Phosphorylation	YQRLGLDYEERVLPS HHHHCCCHHHCHHHH	25.40	-
147	Acetylation	VLKSVVAKFNASQLI HHHHHHHHCCHHHHH	27.78	23576753
151	Phosphorylation	VVAKFNASQLITQRA HHHHCCHHHHHHHHH	26.99	23737553
155	Phosphorylation	FNASQLITQRAQVSL CCHHHHHHHHHHHHH	22.16	22817900
161	Phosphorylation	ITQRAQVSLLIRREL HHHHHHHHHHHHHHH	12.84	22817900
200	Acetylation	YTAAVEAKQVAQQEA HHHHHHHHHHHHHHH	31.62	23576753
200	Malonylation	YTAAVEAKQVAQQEA HHHHHHHHHHHHHHH	31.62	26320211
216	Acetylation	RAQFLVEKAKQEQRQ HHHHHHHHHHHHHHH	54.10	23864654
216	Malonylation	RAQFLVEKAKQEQRQ HHHHHHHHHHHHHHH	54.10	26320211
224	Ubiquitination	AKQEQRQKIVQAEGE HHHHHHHHHHHHHHH	47.21	22790023
224	Acetylation	AKQEQRQKIVQAEGE HHHHHHHHHHHHHHH	47.21	23201123
236	Acetylation	EGEAEAAKMLGEALS HHHHHHHHHHHHHHH	41.53	23576753
244	Acetylation	MLGEALSKNPGYIKL HHHHHHHHCCCCCHH	68.93	23864654
244	Malonylation	MLGEALSKNPGYIKL HHHHHHHHCCCCCHH	68.93	26320211
248	Phosphorylation	ALSKNPGYIKLRKIR HHHHCCCCCHHHHHH	8.99	20116462
250	Acetylation	SKNPGYIKLRKIRAA HHCCCCCHHHHHHHH	33.48	23806337
250	Succinylation	SKNPGYIKLRKIRAA HHCCCCCHHHHHHHH	33.48	23806337
262	Malonylation	RAAQNISKTIATSQN HHHHHHCHHHHCCCC	39.90	26320211
262	Ubiquitination	RAAQNISKTIATSQN HHHHHHCHHHHCCCC	39.90	-
262	Acetylation	RAAQNISKTIATSQN HHHHHHCHHHHCCCC	39.90	23576753
267	Phosphorylation	ISKTIATSQNRIYLT HCHHHHCCCCEEEEE	19.21	27841257
286	Phosphorylation	VLNLQDESFTRGSDS EEECCCCCCCCCCCC	39.96	26745281
288	Phosphorylation	NLQDESFTRGSDSLI ECCCCCCCCCCCCCC	43.32	26745281
291	Phosphorylation	DESFTRGSDSLIKGK CCCCCCCCCCCCCCC	22.27	28066266
293	Phosphorylation	SFTRGSDSLIKGKK- CCCCCCCCCCCCCC-	33.42	26745281
296	Malonylation	RGSDSLIKGKK---- CCCCCCCCCCC----	70.71	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PHB2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHB2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHB2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYOD1_MOUSE	Myod1	physical	15173318
MEF2C_MOUSE	Mef2c	physical	15173318
PLCB1_RAT	Plcb1	physical	23665500
SRSF3_MOUSE	Srsf3	physical	23665500
PHB2_MOUSE	Phb2	physical	23665500

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.