dbPTM

PLCB1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PLCB1_RAT
UniProt AC	P10687
Protein Name	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Gene Name	Plcb1
Organism	Rattus norvegicus (Rat).
Sequence Length	1216
Subcellular Localization	Nucleus membrane. Cytoplasm . Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes..
Protein Description	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes..
Protein Sequence	MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETSSEAPSETRTTPAENGVNHTATLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYLRRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMELEQEYQDKFKRLPLEILEFVQEAMKGKVSEDSNHGSAPPSLASDPAKVNLKSPSSEEVQGENAGREFDTPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	S-palmitoylation	ALQLKPVCVSDSLKK EEEEECEEEECHHCC	3.08	-
27	Acetylation	DSLKKGTKFVKWDDD CHHCCCCCEEECCCC	57.75	22902405
85	Acetylation	AKAPKDPKLRELLDV CCCCCCHHHHHHHCC	71.02	22902405
154	Acetylation	SRDAFLEKAYTKLKL CHHHHHHHHHHHHHE	49.17	22902405
158	Acetylation	FLEKAYTKLKLQVTP HHHHHHHHHHEECCC	30.83	22902405
172	Acetylation	PEGRIPLKNIYRLFS CCCCCCHHHHHHHHH	35.62	22902405
193	Phosphorylation	ETALEACSLPSSRND HHHHHHCCCCCCCCC	50.81	24259510
236	Phosphorylation	FSEFGAKSKPYLTVD HHHHCCCCCCEEEHH	38.03	-
239	Phosphorylation	FGAKSKPYLTVDQMM HCCCCCCEEEHHHHH	20.81	-
308	Phosphorylation	GEENGVVSPEKLDLN CCCCCCCCHHHCCCC	25.57	28551015
417	Phosphorylation	SFENHVDSPKQQAKM EEECCCCCHHHHHHH	32.67	25403869
427	Phosphorylation	QQAKMAEYCRLIFGD HHHHHHHHHHHHHCH	3.55	-
465	Acetylation	LMYKILVKNKKKSHK HHHHHHHHCCCCCCC	60.65	22902405
501	Phosphorylation	SSVFEPSSPGAGEAD CCCCCCCCCCCCCCC	37.76	28689409
509	Phosphorylation	PGAGEADTESDDDDD CCCCCCCCCCCCCCC	44.42	28689409
511	Phosphorylation	AGEADTESDDDDDDD CCCCCCCCCCCCCCC	48.72	28689409
568	Phosphorylation	RNKSFEMSSFVETKG HCCCCCCHHHHECCC	17.27	28432305
569	Phosphorylation	NKSFEMSSFVETKGL CCCCCCHHHHECCCH	31.81	28432305
573	Phosphorylation	EMSSFVETKGLEQLT CCHHHHECCCHHHHH	25.72	28432305
582	Phosphorylation	GLEQLTKSPVEFVEY CHHHHHCCCCCHHHH	29.01	22673903
691	Acetylation	SGQFLSDKKVGTYVE ECCCCCCCCEEEEEE	46.08	22902405
755	Acetylation	AAYEEGGKFIGHRIL HHHHCCCEECCCEEE	44.67	22902405
798	Phosphorylation	VYIEVKDYVPDTYAD EEEEEHHHCCCCHHH	14.25	22276854
802	Phosphorylation	VKDYVPDTYADVIEA EHHHCCCCHHHHHHH	17.97	22276854
803	Phosphorylation	KDYVPDTYADVIEAL HHHCCCCHHHHHHHH	14.26	22276854
839	Ubiquitination	LEDEEEVKKEADPGE CCCHHHHHHHCCCCC	48.45	-
847	Phosphorylation	KEADPGETSSEAPSE HHCCCCCCCCCCCCC	43.39	28551015
848	Phosphorylation	EADPGETSSEAPSET HCCCCCCCCCCCCCC	23.14	28551015
849	Phosphorylation	ADPGETSSEAPSETR CCCCCCCCCCCCCCC	45.24	28551015
853	Phosphorylation	ETSSEAPSETRTTPA CCCCCCCCCCCCCCC	59.66	28551015
858	Phosphorylation	APSETRTTPAENGVN CCCCCCCCCCCCCCC	19.74	30240740
876	Phosphorylation	TLAPKPPSQAPHSQP EECCCCCCCCCCCCC	47.72	25575281
881	Phosphorylation	PPSQAPHSQPAPGSV CCCCCCCCCCCCCCC	36.48	25575281
887	Phosphorylation	HSQPAPGSVKAPAKT CCCCCCCCCCCCCCH	21.27	11278470
931	Acetylation	KKHYKEMKDLVKRHH HHHHHHHHHHHHHHH	49.34	22902405
978	Phosphorylation	KKDSKKKSEPSSPDH CCCCCCCCCCCCCCC	64.72	27097102
981	Phosphorylation	SKKKSEPSSPDHGSS CCCCCCCCCCCCCCH	50.91	27097102
982	Phosphorylation	KKKSEPSSPDHGSSA CCCCCCCCCCCCCHH	45.09	27097102
987	Phosphorylation	PSSPDHGSSAIEQDL CCCCCCCCHHHHHHH	17.12	27097102
988	Phosphorylation	SSPDHGSSAIEQDLA CCCCCCCHHHHHHHH	37.55	27097102
1011	Ubiquitination	KLIDLKDKQQQQLLN HHHCCCHHHHHHHHH	48.71	-
1028	Acetylation	QEQYYSEKYQKREHI HHHHHHHHHHHHHHH	47.22	22902405
1055	Ubiquitination	ECQNNQLKKLKEICE HHHHHHHHHHHHHHH	46.42	-
1111	Acetylation	QEVVQYIKRLEEAQS HHHHHHHHHHHHHHH	46.10	22902405
1197	Phosphorylation	PAKVNLKSPSSEEVQ CCCCCCCCCCHHHCC	32.93	30411139
1199	Phosphorylation	KVNLKSPSSEEVQGE CCCCCCCCHHHCCCC	58.43	30411139
1200	Phosphorylation	VNLKSPSSEEVQGEN CCCCCCCHHHCCCCC	40.95	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
887	S	Phosphorylation	Kinase	PRKCA	P17252	GPS
887	S	Phosphorylation	Kinase	PKC	-	Uniprot
982	S	Phosphorylation	Kinase	ERK-SUBFAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
17	C	Palmitoylation		-
Palmitoylation at Cys-17 by ZDHHC21 regulates the signaling activity of PLCB1 and the function of the endothelial barrier.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PLCB1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC20_RAT	Cdc20	physical	19347873
UBC_RAT	Ubc	physical	19347873
ATPA_MOUSE	Atp5a1	physical	23665500
CAH1_MOUSE	Car1	physical	23665500
COF1_MOUSE	Cfl1	physical	23665500
EF1A2_MOUSE	Eef1a2	physical	23665500
EIF3G_MOUSE	Eif3g	physical	23665500
IF5A1_MOUSE	Eif5a	physical	23665500
IF5A2_MOUSE	Eif5a2	physical	23665500
GRP75_MOUSE	Hspa9	physical	23665500
LMNB1_MOUSE	Lmnb1	physical	23665500
LRC59_MOUSE	Lrrc59	physical	23665500
MCM7_MOUSE	Mcm7	physical	23665500
PCBP1_MOUSE	Pcbp1	physical	23665500
HAP28_MOUSE	Pdap1	physical	23665500
PLCB1_MOUSE	Plcb1	physical	23665500
RLA2_MOUSE	Rplp2	physical	23665500
RS10_MOUSE	Rps10	physical	23665500
RS15_MOUSE	Rps15	physical	23665500
RAN_MOUSE	Ran	physical	23665500
PAIRB_MOUSE	Serbp1	physical	23665500
SMD3_MOUSE	Snrpd3	physical	23665500
SRSF2_MOUSE	Srsf2	physical	23665500
SRSF3_MOUSE	Srsf3	physical	23665500
VDAC3_MOUSE	Vdac3	physical	23665500
ALDOA_MOUSE	Aldoa	physical	23665500
ARF3_MOUSE	Arf3	physical	23665500
ARF4_MOUSE	Arf4	physical	23665500
DDX3Y_MOUSE	Ddx3y	physical	23665500
DDX3L_MOUSE	D1Pas1	physical	23665500
DHX9_MOUSE	Dhx9	physical	23665500
IF2A_MOUSE	Eif2s1	physical	23665500
EIF3K_MOUSE	Eif3k	physical	23665500
IF4A2_MOUSE	Eif4a2	physical	23665500
ELAV1_MOUSE	Elavl1	physical	23665500
H2AZ_MOUSE	H2afz	physical	23665500
VIGLN_MOUSE	Hdlbp	physical	23665500
H2B2B_MOUSE	Hist2h2bb	physical	23665500
H2B1A_MOUSE	Hist1h2ba	physical	23665500
H2B2E_MOUSE	Hist2h2be	physical	23665500
H2B3B_MOUSE	Hist3h2bb-ps	physical	23665500
H2B1K_MOUSE	Hist1h2bk	physical	23665500
HMGB1_MOUSE	Hmgb1	physical	23665500
HMGB2_MOUSE	Hmgb2	physical	23665500
ROAA_MOUSE	Hnrnpab	physical	23665500
HNRPK_MOUSE	Hnrnpk	physical	23665500
NACAM_MOUSE	Naca	physical	23665500
NACA_MOUSE	Naca	physical	23665500
NDUV2_MOUSE	Ndufv2	physical	23665500
NPM_MOUSE	Npm1	physical	23665500
PHB2_MOUSE	Phb2	physical	23665500
PPID_MOUSE	Ppid	physical	23665500
RBMX_MOUSE	Rbmx	physical	23665500
RLA1_MOUSE	Rplp1	physical	23665500
RL14_MOUSE	Rpl14	physical	23665500
RL15_MOUSE	Rpl15	physical	23665500
RL3_MOUSE	Rpl3	physical	23665500
RL29_MOUSE	Rpl29	physical	23665500
RL31_MOUSE	Rpl31	physical	23665500
RL4_MOUSE	Rpl4	physical	23665500
RS15A_MOUSE	Rps15a	physical	23665500
RS17_MOUSE	Rps17	physical	23665500
RS24_MOUSE	Rps24	physical	23665500
SET_MOUSE	Set	physical	23665500
ADT2_MOUSE	Slc25a5	physical	23665500
ADT4_MOUSE	Slc25a31	physical	23665500
SUMO2_MOUSE	Sumo2	physical	23665500
HNRPQ_MOUSE	Syncrip	physical	23665500
TADBP_MOUSE	Tardbp	physical	23665500
TCP4_MOUSE	Sub1	physical	23665500
TPM3_MOUSE	Tpm3	physical	23665500
VDAC2_MOUSE	Vdac2	physical	23665500
ACL6A_MOUSE	Actl6a	physical	23665500
AHSA1_MOUSE	Ahsa1	physical	23665500
AN32B_MOUSE	Anp32b	physical	23665500
ANXA5_MOUSE	Anxa5	physical	23665500
APEX1_MOUSE	Apex1	physical	23665500
ATAD1_MOUSE	Atad1	physical	23665500
AT5F1_MOUSE	Atp5f1	physical	23665500
ATP5H_MOUSE	Atp5h	physical	23665500
BTF3_MOUSE	Btf3	physical	23665500
CAH2_MOUSE	Car2	physical	23665500
TCPB_MOUSE	Cct2	physical	23665500
TCPH_MOUSE	Cct7	physical	23665500
CDC42_MOUSE	Cdc42	physical	23665500
CHD4_MOUSE	Chd4	physical	23665500
CHD5_MOUSE	Chd5	physical	23665500
CNOT1_MOUSE	Cnot1	physical	23665500
CPSF6_MOUSE	Cpsf6	physical	23665500
CSK21_MOUSE	Csnk2a1	physical	23665500
CSTF3_MOUSE	Cstf3	physical	23665500
DNJC2_MOUSE	Dnajc2	physical	23665500
EIF3I_MOUSE	Eif3i	physical	23665500
EIF3M_MOUSE	Eif3m	physical	23665500
IF4B_MOUSE	Eif4b	physical	23665500
FLNA_MOUSE	Flna	physical	23665500
CHTOP_MOUSE	Chtop	physical	23665500
G3BP1_MOUSE	G3bp1	physical	23665500
G6PI_MOUSE	Gpi1	physical	23665500
HEM3_MOUSE	Hmbs	physical	23665500
HMGB3_MOUSE	Hmgb3	physical	23665500
ROA3_MOUSE	Hnrnpa3	physical	23665500
ROA1_MOUSE	Hnrnpa1	physical	23665500
HNRPC_MOUSE	Hnrnpc	physical	23665500
HP1B3_MOUSE	Hp1bp3	physical	23665500
IMA1_MOUSE	Kpna2	physical	23665500
IMA3_MOUSE	Kpna4	physical	23665500
IMB1_MOUSE	Kpnb1	physical	23665500
LYAR_MOUSE	Lyar	physical	23665500
MBD3_MOUSE	Mbd3	physical	23665500
MDHM_MOUSE	Mdh2	physical	23665500
NDUA9_MOUSE	Ndufa9	physical	23665500
NDUS3_MOUSE	Ndufs3	physical	23665500
NDKA_MOUSE	Nme1	physical	23665500
NPM3_MOUSE	Npm3	physical	23665500
NXF1_MOUSE	Nxf1	physical	23665500
OLA1_MOUSE	Ola1	physical	23665500
PCBP2_MOUSE	Pcbp2	physical	23665500
PELP1_MOUSE	Pelp1	physical	23665500
PGAM1_MOUSE	Pgam1	physical	23665500
PGAM2_MOUSE	Pgam2	physical	23665500
PPIA_MOUSE	Ppia	physical	23665500
PP1A_MOUSE	Ppp1ca	physical	23665500
PRDX1_MOUSE	Prdx1	physical	23665500
PRDX4_MOUSE	Prdx4	physical	23665500
PRDX2_MOUSE	Prdx2	physical	23665500
PRDX6_MOUSE	Prdx6	physical	23665500
RAGP1_MOUSE	Rangap1	physical	23665500
RL10_MOUSE	Rpl10	physical	23665500
RL18A_MOUSE	Rpl18a	physical	23665500
RL27_MOUSE	Rpl27	physical	23665500
RL30_MOUSE	Rpl30	physical	23665500
RL32_MOUSE	Rpl32	physical	23665500
RL9_MOUSE	Rpl9	physical	23665500
RS20_MOUSE	Rps20	physical	23665500
RS23_MOUSE	Rps23	physical	23665500
RIR1_MOUSE	Rrm1	physical	23665500
MPCP_MOUSE	Slc25a3	physical	23665500
SMCA4_MOUSE	Smarca4	physical	23665500
SMC1A_MOUSE	Smc1a	physical	23665500
SMD1_MOUSE	Snrpd1	physical	23665500
SMD2_MOUSE	Snrpd2	physical	23665500
SRP68_MOUSE	Srp68	physical	23665500
LA_MOUSE	Ssb	physical	23665500
SSRD_MOUSE	Ssr4	physical	23665500
STML2_MOUSE	Stoml2	physical	23665500
TLN1_MOUSE	Tln1	physical	23665500
LAP2B_MOUSE	Tmpo	physical	23665500
LAP2A_MOUSE	Tmpo	physical	23665500
TOM22_MOUSE	Tomm22	physical	23665500
TPIS_MOUSE	Tpi1	physical	23665500
TPR_MOUSE	Tpr	physical	23665500
TCTP_MOUSE	Tpt1	physical	23665500
SR140_MOUSE	U2surp	physical	23665500
QCR1_MOUSE	Uqcrc1	physical	23665500
VPS35_MOUSE	Vps35	physical	23665500
YBOX1_MOUSE	Ybx1	physical	23665500

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PLCB1_RAT

Related Literatures of Post-Translational Modification

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