TCPH_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPH_MOUSE
• UniProt AC: P80313
• Protein Name: T-complex protein 1 subunit eta
• Gene Name: Cct7
• Organism: Mus musculus (Mouse).
• Sequence Length: 544
• Subcellular Localization: Cytoplasm.
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MMPTPVILLKEGTDSSQGIPQLVSNISACQVIAEAVRTTLGPRGMDKLIVDGRGKATISNDGATILKLLDVVHPAAKTLVDIAKSQDAEVGDGTTSVTLLAAEFLKQVKPYVEEGLHPQIIIRAFRTATQLAVNKIKEIAVTVKKQDKVEQRKMLEKCAMTALSSKLISQQKVFFAKMVVDAVMMLDELLQLKMIGIKKVQGGALEESQLVAGVAFKKTFSYAGFEMQPKKYKNPKIALLNVELELKAEKDNAEIRVHTVEDYQAIVDAEWNILYDKLEKIHQSGAKVILSKLPIGDVATQYFADRDMFCAGRVPEEDLKRTMMACGGSIQTSVNALVPDVLGHCQVFEETQIGGERYNFFTGCPKAKTCTIILRGGAEQFMEETERSLHDAIMIVRRAIKNDSVVAGGGAIEMELSKYLRDYSRTIPGKQQLLIGAYAKALEIIPRQLCDNAGFDATNILNKLRARHAQGGMWYGVDINNENIADNFQAFVWEPAMVRINALTAASEAACLIVSVDETIKNPRSTVDPPAPSAGRGRGQARFH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MMPTPVIL -------CCCCCEEE	7.01	-
4	Phosphorylation	----MMPTPVILLKE ----CCCCCEEEEEC	16.58	24719451
29	Glutathionylation	LVSNISACQVIAEAV HHHHHHHHHHHHHHH	2.37	24333276
47	Ubiquitination	LGPRGMDKLIVDGRG CCCCCCCEEEECCCC	31.08	22790023
55	Ubiquitination	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	-
55	Malonylation	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	26320211
55	Succinylation	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	-
55	Acetylation	LIVDGRGKATISNDG EEECCCCCEEECCCH	40.78	23806337
67	Acetylation	NDGATILKLLDVVHP CCHHHHHHHHHHHCH	43.06	22826441
67	Ubiquitination	NDGATILKLLDVVHP CCHHHHHHHHHHHCH	43.06	22790023
77	Ubiquitination	DVVHPAAKTLVDIAK HHHCHHHHHHHHHHH	44.49	22790023
85	Phosphorylation	TLVDIAKSQDAEVGD HHHHHHHCCCCCCCC	25.03	-
109	Acetylation	AEFLKQVKPYVEEGL HHHHHHHHHHHHCCC	28.30	23806337
129	Phosphorylation	IRAFRTATQLAVNKI HHHHHHHHHHHHHHH	24.41	22006019
137	Ubiquitination	QLAVNKIKEIAVTVK HHHHHHHHHHEEEEE	44.68	-
137	Malonylation	QLAVNKIKEIAVTVK HHHHHHHHHHEEEEE	44.68	26320211
144	Ubiquitination	KEIAVTVKKQDKVEQ HHHEEEEECCCHHHH	35.04	-
144	Malonylation	KEIAVTVKKQDKVEQ HHHEEEEECCCHHHH	35.04	26320211
145	Ubiquitination	EIAVTVKKQDKVEQR HHEEEEECCCHHHHH	60.43	-
157	Acetylation	EQRKMLEKCAMTALS HHHHHHHHHHHHHHH	24.27	22826441
157	Malonylation	EQRKMLEKCAMTALS HHHHHHHHHHHHHHH	24.27	26320211
158	S-nitrosylation	QRKMLEKCAMTALSS HHHHHHHHHHHHHHH	1.98	24926564
158	Glutathionylation	QRKMLEKCAMTALSS HHHHHHHHHHHHHHH	1.98	24333276
158	S-nitrosocysteine	QRKMLEKCAMTALSS HHHHHHHHHHHHHHH	1.98	-
172	Malonylation	SKLISQQKVFFAKMV HHHHHHCHHHHHHHH	33.11	26320211
172	Succinylation	SKLISQQKVFFAKMV HHHHHHCHHHHHHHH	33.11	23806337
172	Acetylation	SKLISQQKVFFAKMV HHHHHHCHHHHHHHH	33.11	23806337
217	Acetylation	LVAGVAFKKTFSYAG EEEEEEEEEECCCCC	40.96	129773
218	Ubiquitination	VAGVAFKKTFSYAGF EEEEEEEEECCCCCC	48.63	22790023
218	Acetylation	VAGVAFKKTFSYAGF EEEEEEEEECCCCCC	48.63	22826441
219	Phosphorylation	AGVAFKKTFSYAGFE EEEEEEEECCCCCCC	20.57	24719451
221	Phosphorylation	VAFKKTFSYAGFEMQ EEEEEECCCCCCCCC	21.21	29514104
230	Ubiquitination	AGFEMQPKKYKNPKI CCCCCCCCCCCCCEE	52.41	22790023
247	Ubiquitination	LNVELELKAEKDNAE EEEEEEEEECCCCCE	45.16	22790023
250	Acetylation	ELELKAEKDNAEIRV EEEEEECCCCCEEEE	62.23	23806337
275	Phosphorylation	DAEWNILYDKLEKIH CCCHHHHHHHHHHHH	13.77	22345495
292	Acetylation	GAKVILSKLPIGDVA CCEEEEECCCCCCHH	55.63	22826441
310	S-nitrosocysteine	FADRDMFCAGRVPEE HCCCCCCCCCCCCHH	2.93	-
310	S-nitrosylation	FADRDMFCAGRVPEE HCCCCCCCCCCCCHH	2.93	21278135
320	Acetylation	RVPEEDLKRTMMACG CCCHHHHHHHHHHCC	59.13	-
362	Phosphorylation	GERYNFFTGCPKAKT CEEEEECCCCCCCCE	33.46	22006019
364	S-nitrosylation	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	21278135
364	Glutathionylation	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	24333276
364	S-palmitoylation	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	28526873
364	S-nitrosocysteine	RYNFFTGCPKAKTCT EEEECCCCCCCCEEE	2.58	-
366	Acetylation	NFFTGCPKAKTCTII EECCCCCCCCEEEEE	67.60	23806337
366	Succinylation	NFFTGCPKAKTCTII EECCCCCCCCEEEEE	67.60	23806337
368	Malonylation	FTGCPKAKTCTIILR CCCCCCCCEEEEEEC	50.70	26320211
370	S-nitrosylation	GCPKAKTCTIILRGG CCCCCCEEEEEECCC	2.25	20925432
370	Glutathionylation	GCPKAKTCTIILRGG CCCCCCEEEEEECCC	2.25	24333276
370	S-palmitoylation	GCPKAKTCTIILRGG CCCCCCEEEEEECCC	2.25	28526873
370	S-nitrosocysteine	GCPKAKTCTIILRGG CCCCCCEEEEEECCC	2.25	-
418	Ubiquitination	AIEMELSKYLRDYSR HHHHHHHHHHHHHCC	62.01	22790023
430	Ubiquitination	YSRTIPGKQQLLIGA HCCCCCCHHHHHHHH	29.53	22790023
440	Ubiquitination	LLIGAYAKALEIIPR HHHHHHHHHHHHCHH	40.61	-
463	Ubiquitination	DATNILNKLRARHAQ CHHHHHHHHHHHHCC	35.59	22790023
463	Acetylation	DATNILNKLRARHAQ CHHHHHHHHHHHHCC	35.59	23864654
511	S-palmitoylation	TAASEAACLIVSVDE HHHHHHHHEEEECCH	3.25	28526873
511	S-nitrosylation	TAASEAACLIVSVDE HHHHHHHHEEEECCH	3.25	21278135
511	Glutathionylation	TAASEAACLIVSVDE HHHHHHHHEEEECCH	3.25	24333276
511	S-nitrosocysteine	TAASEAACLIVSVDE HHHHHHHHEEEECCH	3.25	-
521	Ubiquitination	VSVDETIKNPRSTVD EECCHHCCCCCCCCC	69.21	-
533	Phosphorylation	TVDPPAPSAGRGRGQ CCCCCCCCCCCCCCC	45.52	28066266
536	Methylation	PPAPSAGRGRGQARF CCCCCCCCCCCCCCC	31.21	24129315
538	Methylation	APSAGRGRGQARFH- CCCCCCCCCCCCCC-	32.46	-
542	Methylation	GRGRGQARFH----- CCCCCCCCCC-----	23.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCPH_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPH_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPH_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TCPA_MOUSE	Tcp1	physical	9250675
TCPD_MOUSE	Cct4	physical	9250675
PDCL3_HUMAN	PDCL3	physical	20360068
PDCD5_HUMAN	PDCD5	physical	20360068
TCPZ_HUMAN	CCT6A	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
PDCD5_HUMAN	PDCD5	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
TXND9_HUMAN	TXNDC9	physical	26496610
TBA1B_HUMAN	TUBA1B	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPB_HUMAN	CCT2	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
ZN281_HUMAN	ZNF281	physical	26496610
HGH1_HUMAN	HGH1	physical	26496610
DTL_HUMAN	DTL	physical	26496610
UGGG1_HUMAN	UGGT1	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
TBB5_HUMAN	TUBB	physical	26496610
WDR92_HUMAN	WDR92	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.