TCPD_MOUSE - dbPTM
TCPD_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TCPD_MOUSE
UniProt AC P80315
Protein Name T-complex protein 1 subunit delta
Gene Name Cct4
Organism Mus musculus (Mouse).
Sequence Length 539
Subcellular Localization Cytoplasm . Melanosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body .
Protein Description Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity)..
Protein Sequence MPENVASRSGAPTAGPGSRGKSAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDVEREDIEFICKTIGTKPVAHIDQFTADMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
7Phosphorylation-MPENVASRSGAPTA
-CCCCCCCCCCCCCC		23.7725338131
9PhosphorylationPENVASRSGAPTAGP
CCCCCCCCCCCCCCC		36.4929514104
13PhosphorylationASRSGAPTAGPGSRG
CCCCCCCCCCCCCCC		43.6523375375
18PhosphorylationAPTAGPGSRGKSAYQ
CCCCCCCCCCCCCCC		40.7827149854
19MethylationPTAGPGSRGKSAYQD
CCCCCCCCCCCCCCC		63.57-
21AcetylationAGPGSRGKSAYQDRD
CCCCCCCCCCCCCCC		30.7023806337
22PhosphorylationGPGSRGKSAYQDRDK
CCCCCCCCCCCCCCC		34.7223684622
24PhosphorylationGSRGKSAYQDRDKPA
CCCCCCCCCCCCCCC		20.3129514104
36PhosphorylationKPAQIRFSNISAAKA
CCCCEECCCHHHHHH		24.3328066266
39PhosphorylationQIRFSNISAAKAVAD
CEECCCHHHHHHHHH		26.8228066266
55UbiquitinationIRTSLGPKGMDKMIQ
HHHCCCCCCHHHCCC		66.13-
55MalonylationIRTSLGPKGMDKMIQ
HHHCCCCCCHHHCCC		66.1326320211
55AcetylationIRTSLGPKGMDKMIQ
HHHCCCCCCHHHCCC		66.1323806337
65UbiquitinationDKMIQDGKGDVTITN
HHCCCCCCCCEEEEC		61.2922790023
79UbiquitinationNDGATILKQMQVLHP
CCHHHHHHHHHHHCH		39.6122790023
120GlutathionylationAGSLLDSCTKLLQKG
EHHHHHHHHHHHHCC		3.7724333276
139UbiquitinationIISESFQKALEKGLE
HHCHHHHHHHHHHHH		53.5922790023
162PhosphorylationVQLSDRETLLNSATT
CCCCCHHHHHHHHCH		37.1222802335
166PhosphorylationDRETLLNSATTSLNS
CHHHHHHHHCHHHHH		27.2820415495
168PhosphorylationETLLNSATTSLNSKV
HHHHHHHCHHHHHHH		19.4220415495
169PhosphorylationTLLNSATTSLNSKVV
HHHHHHCHHHHHHHH		30.8220415495
170PhosphorylationLLNSATTSLNSKVVS
HHHHHCHHHHHHHHH		22.6220415495
173PhosphorylationSATTSLNSKVVSQYS
HHCHHHHHHHHHHHH		31.9220415495
177PhosphorylationSLNSKVVSQYSSLLS
HHHHHHHHHHHHHHC		26.7922802335
179PhosphorylationNSKVVSQYSSLLSPM
HHHHHHHHHHHHCCC		7.8522802335
180PhosphorylationSKVVSQYSSLLSPMS
HHHHHHHHHHHCCCC		13.5822802335
181PhosphorylationKVVSQYSSLLSPMSV
HHHHHHHHHHCCCCH		28.5322802335
184PhosphorylationSQYSSLLSPMSVNAV
HHHHHHHCCCCHHHH		24.6922802335
187PhosphorylationSSLLSPMSVNAVMKV
HHHHCCCCHHHHHHH		18.6622802335
202PhosphorylationIDPATATSVDLRDIK
CCHHHCCCCCHHHHH		15.9226824392
221GlutathionylationLGGTIDDCELVEGLV
CCCCCCCCEEEEHHH		3.7524333276
232MalonylationEGLVLTQKVANSGIT
EHHHHCHHHHHCCCC		37.7726073543
236PhosphorylationLTQKVANSGITRVEK
HCHHHHHCCCCCCHH		23.1026824392
239PhosphorylationKVANSGITRVEKAKI
HHHHCCCCCCHHHHH		31.9928066266
252S-nitrosylationKIGLIQFCLSAPKTD
HHCHHHHHHCCCCCC		1.3621278135
252S-palmitoylationKIGLIQFCLSAPKTD
HHCHHHHHHCCCCCC		1.3628526873
252S-nitrosocysteineKIGLIQFCLSAPKTD
HHCHHHHHHCCCCCC		1.36-
252GlutathionylationKIGLIQFCLSAPKTD
HHCHHHHHHCCCCCC		1.3624333276
267PhosphorylationMDNQIVVSDYAQMDR
CCCCEEECCHHHHHH		17.6325159016
269PhosphorylationNQIVVSDYAQMDRVL
CCEEECCHHHHHHHH		7.3924224561
288AcetylationAYILNLVKQIKKTGC
HHHHHHHHHHHHHCC		49.8523236377
288UbiquitinationAYILNLVKQIKKTGC
HHHHHHHHHHHHHCC		49.85-
288MalonylationAYILNLVKQIKKTGC
HHHHHHHHHHHHHCC		49.8526073543
292MalonylationNLVKQIKKTGCNVLL
HHHHHHHHHCCCEEE		52.3526320211
295S-palmitoylationKQIKKTGCNVLLIQK
HHHHHHCCCEEEEEH		3.7328526873
302AcetylationCNVLLIQKSILRDAL
CCEEEEEHHHHHHHH		32.2522826441
303PhosphorylationNVLLIQKSILRDALS
CEEEEEHHHHHHHHH		15.5226643407
310PhosphorylationSILRDALSDLALHFL
HHHHHHHHHHHHHHH		32.0926745281
319UbiquitinationLALHFLNKMKIMVVK
HHHHHHHHCCEEEEE		43.66-
319MalonylationLALHFLNKMKIMVVK
HHHHHHHHCCEEEEE		43.6626073543
319AcetylationLALHFLNKMKIMVVK
HHHHHHHHCCEEEEE		43.6623806337
321MalonylationLHFLNKMKIMVVKDV
HHHHHHCCEEEEECC		29.2926320211
321AcetylationLHFLNKMKIMVVKDV
HHHHHHCCEEEEECC		29.2922826441
326MalonylationKMKIMVVKDVEREDI
HCCEEEEECCCHHHH		44.6526320211
326AcetylationKMKIMVVKDVEREDI
HCCEEEEECCCHHHH		44.6522826441
375UbiquitinationNGSGKLFKITGCTSP
CCCCCEEEEEECCCC		50.2022790023
375AcetylationNGSGKLFKITGCTSP
CCCCCEEEEEECCCC		50.2023806337
377PhosphorylationSGKLFKITGCTSPGK
CCCEEEEEECCCCCC		27.1325168779
379S-nitrosylationKLFKITGCTSPGKTV
CEEEEEECCCCCCEE		2.2620925432
379S-nitrosocysteineKLFKITGCTSPGKTV
CEEEEEECCCCCCEE		2.26-
379GlutathionylationKLFKITGCTSPGKTV
CEEEEEECCCCCCEE		2.2624333276
380PhosphorylationLFKITGCTSPGKTVT
EEEEEECCCCCCEEE		39.0228066266
381PhosphorylationFKITGCTSPGKTVTI
EEEEECCCCCCEEEE		35.4126745281
384AcetylationTGCTSPGKTVTIVVR
EECCCCCCEEEEEEE		43.1122826441
385PhosphorylationGCTSPGKTVTIVVRG
ECCCCCCEEEEEEEC		28.8825168779
387PhosphorylationTSPGKTVTIVVRGSN
CCCCCEEEEEEECCC		17.1825168779
395AcetylationIVVRGSNKLVIEEAE
EEEECCCCEEECHHH		45.9222826441
395MalonylationIVVRGSNKLVIEEAE
EEEECCCCEEECHHH		45.9226320211
410S-palmitoylationRSIHDALCVIRCLVK
HHHHHHHHHHHHHHH		2.2828526873
410GlutathionylationRSIHDALCVIRCLVK
HHHHHHHHHHHHHHH		2.2824333276
410S-nitrosocysteineRSIHDALCVIRCLVK
HHHHHHHHHHHHHHH		2.28-
410S-nitrosylationRSIHDALCVIRCLVK
HHHHHHHHHHHHHHH		2.2824926564
444PhosphorylationTEYSRTLSGMESYCV
HHHHHHHCCHHHHHH		35.17-
449PhosphorylationTLSGMESYCVRAFAD
HHCCHHHHHHHHHHH		5.01-
450S-palmitoylationLSGMESYCVRAFADA
HCCHHHHHHHHHHHH		2.0228526873
450S-nitrosylationLSGMESYCVRAFADA
HCCHHHHHHHHHHHH		2.0224926564
531UbiquitinationETVRSILKIDDVVNT
HHHHHHHCHHHHCCC		42.28-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TCPD_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TCPD_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TCPD_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TCPZ_HUMANCCT6Aphysical
26496610
DIC_HUMANSLC25A10physical
26496610
CSTF1_HUMANCSTF1physical
26496610
GBB1_HUMANGNB1physical
26496610
GBB2_HUMANGNB2physical
26496610
IGBP1_HUMANIGBP1physical
26496610
LIMS1_HUMANLIMS1physical
26496610
PHLP_HUMANPDCLphysical
26496610
PFD1_HUMANPFDN1physical
26496610
PPP6_HUMANPPP6Cphysical
26496610
TCPA_HUMANTCP1physical
26496610
TCPG_HUMANCCT3physical
26496610
VAV2_HUMANVAV2physical
26496610
GEMI2_HUMANGEMIN2physical
26496610
EIF3I_HUMANEIF3Iphysical
26496610
DPM1_HUMANDPM1physical
26496610
PIAS2_HUMANPIAS2physical
26496610
PDCD5_HUMANPDCD5physical
26496610
VAMP3_HUMANVAMP3physical
26496610
RHG32_HUMANARHGAP32physical
26496610
ARP2_HUMANACTR2physical
26496610
ACTZ_HUMANACTR1Aphysical
26496610
CMC2_HUMANSLC25A13physical
26496610
TXND9_HUMANTXNDC9physical
26496610
TCPH_HUMANCCT7physical
26496610
TCPB_HUMANCCT2physical
26496610
TCPQ_HUMANCCT8physical
26496610
TCPE_HUMANCCT5physical
26496610
INT7_HUMANINTS7physical
26496610
HGH1_HUMANHGH1physical
26496610
DTL_HUMANDTLphysical
26496610
PPIL3_HUMANPPIL3physical
26496610
OCAD1_HUMANOCIAD1physical
26496610
RFWD3_HUMANRFWD3physical
26496610
CCD47_HUMANCCDC47physical
26496610
RPTOR_HUMANRPTORphysical
26496610
RIC8A_HUMANRIC8Aphysical
26496610
LST8_HUMANMLST8physical
26496610
PDCL3_HUMANPDCL3physical
26496610
MEP50_HUMANWDR77physical
26496610
INT5_HUMANINTS5physical
26496610
ACTL8_HUMANACTL8physical
26496610
TXD17_HUMANTXNDC17physical
26496610
ESCO1_HUMANESCO1physical
26496610
CDYL2_HUMANCDYL2physical
26496610
WDR92_HUMANWDR92physical
26496610
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TCPD_MOUSE

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Related Literatures of Post-Translational Modification

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