TADBP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TADBP_MOUSE
• UniProt AC: Q921F2
• Protein Name: TAR DNA-binding protein 43
• Gene Name: Tardbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 414
• Subcellular Localization: Nucleus .
• Protein Description: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR..
• Protein Sequence: MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Glutathionylation	TAQFPGACGLRYRNP EECCCCCCCCEECCH	6.99	24333276
50	Glutathionylation	YRNPVSQCMRGVRLV ECCHHHHHHHHHEEE	1.24	24333276
50	S-palmitoylation	YRNPVSQCMRGVRLV ECCHHHHHHHHHEEE	1.24	28526873
88	Phosphorylation	NKRKMDETDASSAVK CCCCCCCCCHHHHHH	32.38	29550500
91	Phosphorylation	KMDETDASSAVKVKR CCCCCCHHHHHHHHH	22.95	28066266
92	Phosphorylation	MDETDASSAVKVKRA CCCCCHHHHHHHHHH	38.51	25266776
95	Ubiquitination	TDASSAVKVKRAVQK CCHHHHHHHHHHHHH	41.58	-
102	Ubiquitination	KVKRAVQKTSDLIVL HHHHHHHHCCCEEEE	43.32	-
103	Phosphorylation	VKRAVQKTSDLIVLG HHHHHHHCCCEEEEC	15.47	21454597
104	Phosphorylation	KRAVQKTSDLIVLGL HHHHHHCCCEEEECC	37.14	21454597
114	Ubiquitination	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	-
114	Acetylation	IVLGLPWKTTEQDLK EEECCCCCCCHHHHH	43.56	8277349
121	Acetylation	KTTEQDLKDYFSTFG CCCHHHHHHHHHHHC	59.68	8277361
137	Acetylation	VLMVQVKKDLKTGHS EEEEEEECCCCCCCC	70.23	8277373
144	Phosphorylation	KDLKTGHSKGFGFVR CCCCCCCCCCCCEEE	35.50	28285833
155	Phosphorylation	GFVRFTEYETQVKVM CEEEEEEEEEHHHEE	22.63	25177544
160	Ubiquitination	TEYETQVKVMSQRHM EEEEEHHHEEECCCC	23.54	-
173	S-nitrosocysteine	HMIDGRWCDCKLPNS CCCCCCCCCCCCCCC	4.19	-
173	S-nitrosylation	HMIDGRWCDCKLPNS CCCCCCCCCCCCCCC	4.19	20925432
173	Glutathionylation	HMIDGRWCDCKLPNS CCCCCCCCCCCCCCC	4.19	24333276
175	Glutathionylation	IDGRWCDCKLPNSKQ CCCCCCCCCCCCCCC	4.40	24333276
176	Ubiquitination	DGRWCDCKLPNSKQS CCCCCCCCCCCCCCC	54.45	-
180	Phosphorylation	CDCKLPNSKQSPDEP CCCCCCCCCCCCCCC	30.08	26239621
181	Malonylation	DCKLPNSKQSPDEPL CCCCCCCCCCCCCCH	62.53	26320211
181	Ubiquitination	DCKLPNSKQSPDEPL CCCCCCCCCCCCCCH	62.53	-
183	Phosphorylation	KLPNSKQSPDEPLRS CCCCCCCCCCCCHHC	37.75	25521595
238	Ubiquitination	FVTFADDKVAQSLCG EEEECCHHHHHHHHC	39.76	-
242	Phosphorylation	ADDKVAQSLCGEDLI CCHHHHHHHHCCCEE	18.85	26370283
244	Glutathionylation	DKVAQSLCGEDLIIK HHHHHHHHCCCEEEE	7.31	24333276
244	S-palmitoylation	DKVAQSLCGEDLIIK HHHHHHHHCCCEEEE	7.31	28526873
266	Phosphorylation	NAEPKHNSNRQLERS CCCCCCCCCCCHHHC	32.86	22817900
273	Phosphorylation	SNRQLERSGRFGGNP CCCCHHHCCCCCCCC	25.58	26745281
292	Phosphorylation	NQGGFGNSRGGGAGL CCCCCCCCCCCCCCC	32.45	23684622
293	Methylation	QGGFGNSRGGGAGLG CCCCCCCCCCCCCCC	52.34	24129315
379	Phosphorylation	NSYSGSNSGAPLGWG CCCCCCCCCCCCCCC	37.72	22802335
387	Phosphorylation	GAPLGWGSASNAGSG CCCCCCCCCCCCCCC	23.24	22802335
389	Phosphorylation	PLGWGSASNAGSGSG CCCCCCCCCCCCCCC	28.98	22802335
393	Phosphorylation	GSASNAGSGSGFNGG CCCCCCCCCCCCCCC	27.63	22802335
395	Phosphorylation	ASNAGSGSGFNGGFG CCCCCCCCCCCCCCC	41.74	22802335
403	Phosphorylation	GFNGGFGSSMDSKSS CCCCCCCCCCCCCCC	21.89	22802335
404	Phosphorylation	FNGGFGSSMDSKSSG CCCCCCCCCCCCCCC	27.30	-
409	Phosphorylation	GSSMDSKSSGWGM-- CCCCCCCCCCCCC--	37.73	-
410	Phosphorylation	SSMDSKSSGWGM--- CCCCCCCCCCCC---	42.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TADBP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TADBP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TADBP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TADBP_MOUSE	Tardbp	physical	20211142
NACC1_MOUSE	Nacc1	physical	23022214
RBBP5_HUMAN	RBBP5	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.