LAP2A_MOUSE - dbPTM
LAP2A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LAP2A_MOUSE
UniProt AC Q61033
Protein Name Lamina-associated polypeptide 2, isoforms alpha/zeta
Gene Name Tmpo
Organism Mus musculus (Mouse).
Sequence Length 693
Subcellular Localization Nucleus. Chromosome. Expressed diffusely throughout the nucleus..
Protein Description May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1 (By similarity)..
Protein Sequence MPEFLEDPSVLTKDKLKSELVANNVTLPAGEQRKDVYVQLYLQHLTARNRPPLAAGANSKGPPDFSSDEEREPTPVLGSGASVGRGRGAVGRKATKKTDKPRLEDKDDLDVTELSNEELLDQLVRYGVNPGPIVGTTRKLYEKKLLKLREQGTESRSSTPLPTVSSSAENTRQNGSNDSDRYSDNDEGKKKEHKKVKSARDCVPFSELASTPSGAFFQGISFPEISTRPPLGRTELQAAKKVQTTKRDPPRETCTDTALPGKGQTHKLAPGRSLFIPSESSYDRCVEKSSSPSSQREFAARLVSAAASPSLIRETTTTYSKDIVENICRGGKSRAQPLRAEEPGVSDQSVFSSEREVLQESERSQVISPPLAQAIRDYVNSLLVQGGVGSLPGTSDSVPTLDVENICKRLSQSSYQDSESLSPPRKVPRLSEKPARGGDSGSCVAFQNTPGSEHRSSFAKSVVSHSLTTLGVEVSKPPPQHDKIEASEPSFPLHESILKVVEEEWQQIDRQLPSVACRYPVSSIEAARILSVPKVDDEILGFISEATPRAATQASSTESCDKHLDLALCRSYEAAASALQIAAHTAFVAKSLQADISQAAQIINSDPSDAQQALRILNRTYDAASYLCDAAFDEVRMSACAMGSSTMGRRYLWLKDCKISPASKNKLTVAPFKGGTLFGGEVHKVIKKRGNKQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
26PhosphorylationELVANNVTLPAGEQR
HHHHCCCEECCCCCH		29.1929514104
59PhosphorylationPLAAGANSKGPPDFS
CCCCCCCCCCCCCCC		38.1526824392
66PhosphorylationSKGPPDFSSDEEREP
CCCCCCCCCCCCCCC		44.2324925903
67PhosphorylationKGPPDFSSDEEREPT
CCCCCCCCCCCCCCC		49.3824925903
71MethylationDFSSDEEREPTPVLG
CCCCCCCCCCCCCCC		53.8216187281
74PhosphorylationSDEEREPTPVLGSGA
CCCCCCCCCCCCCCC		22.6724925903
79PhosphorylationEPTPVLGSGASVGRG
CCCCCCCCCCCCCCC		27.3324925903
82PhosphorylationPVLGSGASVGRGRGA
CCCCCCCCCCCCCCH		28.7324925903
85MethylationGSGASVGRGRGAVGR
CCCCCCCCCCCHHCC		29.4924129315
87MethylationGASVGRGRGAVGRKA
CCCCCCCCCHHCCCC		28.6524129315
92MethylationRGRGAVGRKATKKTD
CCCCHHCCCCCCCCC		20.8815231543
115PhosphorylationDLDVTELSNEELLDQ
CCCHHHCCHHHHHHH		35.6422668510
136PhosphorylationNPGPIVGTTRKLYEK
CCCCCCCHHHHHHHH		16.7225266776
137PhosphorylationPGPIVGTTRKLYEKK
CCCCCCHHHHHHHHH		21.6328066266
153PhosphorylationLKLREQGTESRSSTP
HHHHHCCCCCCCCCC		30.4025521595
155PhosphorylationLREQGTESRSSTPLP
HHHCCCCCCCCCCCC		36.9826824392
157PhosphorylationEQGTESRSSTPLPTV
HCCCCCCCCCCCCCC		48.0924925903
157 (in isoform 2)Phosphorylation-48.0923608596
158PhosphorylationQGTESRSSTPLPTVS
CCCCCCCCCCCCCCC		32.6924925903
158 (in isoform 2)Phosphorylation-32.6923608596
159PhosphorylationGTESRSSTPLPTVSS
CCCCCCCCCCCCCCC		30.0524925903
159 (in isoform 2)Phosphorylation-30.0529899451
163 (in isoform 2)Phosphorylation-40.4823608596
163PhosphorylationRSSTPLPTVSSSAEN
CCCCCCCCCCCCCCC		40.4824925903
165 (in isoform 2)Phosphorylation-22.5125338131
165PhosphorylationSTPLPTVSSSAENTR
CCCCCCCCCCCCCCC		22.5124925903
166 (in isoform 2)Phosphorylation-29.2725338131
166PhosphorylationTPLPTVSSSAENTRQ
CCCCCCCCCCCCCCC		29.2725521595
167 (in isoform 2)Phosphorylation-31.9023608596
167PhosphorylationPLPTVSSSAENTRQN
CCCCCCCCCCCCCCC		31.9024925903
171PhosphorylationVSSSAENTRQNGSND
CCCCCCCCCCCCCCC		25.7424925903
171 (in isoform 2)Phosphorylation-25.7423608596
176 (in isoform 2)Phosphorylation-45.0425521595
176PhosphorylationENTRQNGSNDSDRYS
CCCCCCCCCCCCCCC		45.0425521595
179PhosphorylationRQNGSNDSDRYSDND
CCCCCCCCCCCCCCC		28.3923737553
179 (in isoform 2)Phosphorylation-28.3925521595
182 (in isoform 2)Phosphorylation-25.9325521595
182PhosphorylationGSNDSDRYSDNDEGK
CCCCCCCCCCCCHHH		25.9323608596
183 (in isoform 2)Phosphorylation-30.7225521595
183PhosphorylationSNDSDRYSDNDEGKK
CCCCCCCCCCCHHHH		30.7225521595
189 (in isoform 2)Phosphorylation-59.6327742792
206 (in isoform 2)Acetylation-26.1523806337
206PhosphorylationARDCVPFSELASTPS
HHHCCCHHHHCCCCC		26.1526643407
207 (in isoform 2)Phosphorylation-49.0528725479
210PhosphorylationVPFSELASTPSGAFF
CCHHHHCCCCCCCCC		54.1726643407
210 (in isoform 2)Phosphorylation-54.1728833060
211PhosphorylationPFSELASTPSGAFFQ
CHHHHCCCCCCCCCC		18.8326643407
213PhosphorylationSELASTPSGAFFQGI
HHHCCCCCCCCCCCC		42.7326643407
221PhosphorylationGAFFQGISFPEISTR
CCCCCCCCCCCCCCC		41.39-
226PhosphorylationGISFPEISTRPPLGR
CCCCCCCCCCCCCCH		19.39-
278PhosphorylationGRSLFIPSESSYDRC
CCEEEECCCCHHHHH		45.3425338131
281PhosphorylationLFIPSESSYDRCVEK
EEECCCCHHHHHHHC		27.3129514104
289PhosphorylationYDRCVEKSSSPSSQR
HHHHHHCCCCCHHHH		23.6529895711
290PhosphorylationDRCVEKSSSPSSQRE
HHHHHCCCCCHHHHH		58.2926745281
291PhosphorylationRCVEKSSSPSSQREF
HHHHCCCCCHHHHHH		35.5727149854
293PhosphorylationVEKSSSPSSQREFAA
HHCCCCCHHHHHHHH		40.8426745281
294PhosphorylationEKSSSPSSQREFAAR
HCCCCCHHHHHHHHH		36.3226745281
304PhosphorylationEFAARLVSAAASPSL
HHHHHHHHHHHCHHH		19.4425159016
308PhosphorylationRLVSAAASPSLIRET
HHHHHHHCHHHHHCC		15.4226824392
310PhosphorylationVSAAASPSLIRETTT
HHHHHCHHHHHCCCC		33.6522942356
315PhosphorylationSPSLIRETTTTYSKD
CHHHHHCCCCCCCHH		21.4223984901
316PhosphorylationPSLIRETTTTYSKDI
HHHHHCCCCCCCHHH		16.6423984901
317PhosphorylationSLIRETTTTYSKDIV
HHHHCCCCCCCHHHH		31.0223984901
318PhosphorylationLIRETTTTYSKDIVE
HHHCCCCCCCHHHHH		24.5723984901
319PhosphorylationIRETTTTYSKDIVEN
HHCCCCCCCHHHHHH		16.1923984901
320PhosphorylationRETTTTYSKDIVENI
HCCCCCCCHHHHHHH		23.0423984901
329MethylationDIVENICRGGKSRAQ
HHHHHHHCCCCCCCC		53.7724129315
349PhosphorylationEPGVSDQSVFSSERE
CCCCCCHHHHHHHHH		30.07-
352PhosphorylationVSDQSVFSSEREVLQ
CCCHHHHHHHHHHHH		29.18-
364PhosphorylationVLQESERSQVISPPL
HHHHHHHHCCCCHHH		25.4228066266
368PhosphorylationSERSQVISPPLAQAI
HHHHCCCCHHHHHHH		22.9326643407
411PhosphorylationENICKRLSQSSYQDS
HHHHHHHHHCCCCCH		31.8627149854
413PhosphorylationICKRLSQSSYQDSES
HHHHHHHCCCCCHHH		27.8622942356
414PhosphorylationCKRLSQSSYQDSESL
HHHHHHCCCCCHHHC		21.1221082442
415PhosphorylationKRLSQSSYQDSESLS
HHHHHCCCCCHHHCC		22.9121082442
418PhosphorylationSQSSYQDSESLSPPR
HHCCCCCHHHCCCCC		17.3525619855
420PhosphorylationSSYQDSESLSPPRKV
CCCCCHHHCCCCCCC		37.7921082442
422PhosphorylationYQDSESLSPPRKVPR
CCCHHHCCCCCCCCC		41.9827087446
431PhosphorylationPRKVPRLSEKPARGG
CCCCCCCCCCCCCCC		44.8727149854
440PhosphorylationKPARGGDSGSCVAFQ
CCCCCCCCCCEEEEE		35.5625619855
442PhosphorylationARGGDSGSCVAFQNT
CCCCCCCCEEEEECC		14.9025619855
449PhosphorylationSCVAFQNTPGSEHRS
CEEEEECCCCCCCHH		20.4625619855
452PhosphorylationAFQNTPGSEHRSSFA
EEECCCCCCCHHHHH		31.2825619855
456PhosphorylationTPGSEHRSSFAKSVV
CCCCCCHHHHHHHHH		31.5426643407
457PhosphorylationPGSEHRSSFAKSVVS
CCCCCHHHHHHHHHH		29.2226643407
475PhosphorylationTTLGVEVSKPPPQHD
HHCCEEECCCCCCCC		26.4123140645
517GlutathionylationRQLPSVACRYPVSSI
HHCCCHHCCCCCCHH		3.9224333276
523PhosphorylationACRYPVSSIEAARIL
HCCCCCCHHHHHHHC		25.3623684622
547PhosphorylationLGFISEATPRAATQA
HHHHHHCCCCCCHHC		14.8428066266
655AcetylationGRRYLWLKDCKISPA
CCCEEEEECCEECCC		49.8823806337
660PhosphorylationWLKDCKISPASKNKL
EEECCEECCCCCCCC		10.4225266776
663PhosphorylationDCKISPASKNKLTVA
CCEECCCCCCCCEEE		39.9026745281
673AcetylationKLTVAPFKGGTLFGG
CCEEEECCCCCCCCH		56.2023806337
684AcetylationLFGGEVHKVIKKRGN
CCCHHHHHHHHHCCC		51.3222826441
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LAP2A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LAP2A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LAP2A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LAP2A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LAP2A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-183, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-159; THR-163 ANDSER-422, AND MASS SPECTROMETRY.

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