dbPTM

SR140_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SR140_MOUSE
UniProt AC	Q6NV83
Protein Name	U2 snRNP-associated SURP motif-containing protein
Gene Name	U2surp
Organism	Mus musculus (Mouse).
Sequence Length	1029
Subcellular Localization	Nucleus.
Protein Description
Protein Sequence	MADKTPGGSQKASSKNRSSDVHSSGSSDAHMDASGPSDSDMPSRTRPKSPRKHNYRNESSRESLCDSPHQNLSRPLLENKLKAFSIGKMSTAKRTLSKKEQEELKKKEDEKAAAEIYEEFLAAFEGSDGNKVKTFVRGGVVNAAKDEHETDEKRGKIYKPSSRFADQKNPPNQSSNERPPSLLVIETKKPPLKKGEKEKKKSNLELFKEELKQIQEERDERHKTKGRLSRFEPPQSDSDGQRRSMDVPSRRNRSSGVLDDYAPGSHDVGDPSTTNLYLGNINPQMNEEMLCQEFGRFGPLASVKIMWPRTDEERARERNCGFVAFMNRRDAERALKNLNGKMIMSFEMKLGWGKAVPIPPHPIYIPPSMMEHTLPPPPSGLPFNAQPRERLKNPNAPMLPPPKNKEDFEKTLSQAIVKVVIPTERNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPVREEATESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDASKKAKRSPSGSRTPKRSRRSRSRSPKKSGKKSRSQSRSPHRSHKKSKKNKH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADKTPGGS ------CCCCCCCCC	38.01	-
5	Phosphorylation	---MADKTPGGSQKA ---CCCCCCCCCCCC	27.93	25266776
9	Phosphorylation	ADKTPGGSQKASSKN CCCCCCCCCCCCCCC	34.13	25266776
18	Phosphorylation	KASSKNRSSDVHSSG CCCCCCCCCCCCCCC	40.04	27717184
34	Phosphorylation	SDAHMDASGPSDSDM CCCCCCCCCCCCCCC	47.15	29895711
37	Phosphorylation	HMDASGPSDSDMPSR CCCCCCCCCCCCCCC	53.95	27087446
49	Phosphorylation	PSRTRPKSPRKHNYR CCCCCCCCCCCCCCC	32.40	23384938
63	Phosphorylation	RNESSRESLCDSPHQ CCHHHHHHHCCCCCC	32.94	25159016
67	Phosphorylation	SRESLCDSPHQNLSR HHHHHCCCCCCCCCH	24.24	25521595
73	Phosphorylation	DSPHQNLSRPLLENK CCCCCCCCHHHHHHH	39.13	25159016
80	Acetylation	SRPLLENKLKAFSIG CHHHHHHHHHHHHHH	41.82	23806337
85	Phosphorylation	ENKLKAFSIGKMSTA HHHHHHHHHHHHHHH	34.98	29176673
97	Phosphorylation	STAKRTLSKKEQEEL HHHHHHCCHHHHHHH	40.86	29176673
117	Phosphorylation	EKAAAEIYEEFLAAF HHHHHHHHHHHHHHH	10.83	25159016
127	Phosphorylation	FLAAFEGSDGNKVKT HHHHHCCCCCCEEEE	34.84	25159016
145	Acetylation	GGVVNAAKDEHETDE CCCCCCCCCCCCCHH	62.33	22826441
158	Phosphorylation	DEKRGKIYKPSSRFA HHCCCCEECCHHHCC	21.97	22807455
175	Phosphorylation	KNPPNQSSNERPPSL CCCCCCCCCCCCCCE	32.71	28285833
202	Phosphorylation	GEKEKKKSNLELFKE CHHHHHHHHHHHHHH	56.37	25521595
236	Phosphorylation	SRFEPPQSDSDGQRR HHCCCCCCCCCCCCC	44.87	22817900
238	Phosphorylation	FEPPQSDSDGQRRSM CCCCCCCCCCCCCCC	49.22	27149854
244	Phosphorylation	DSDGQRRSMDVPSRR CCCCCCCCCCCCCCC	22.86	29176673
254 (in isoform 2)	Phosphorylation	-	34.69	25338131
345	Phosphorylation	LNGKMIMSFEMKLGW CCCCEEEEEEEECCC	13.71	25338131
347	Ubiquitination	GKMIMSFEMKLGWGK CCEEEEEEEECCCCC	28.27	27667366
348	Ubiquitination	KMIMSFEMKLGWGKA CEEEEEEEECCCCCC	4.01	27667366
391	Ubiquitination	NAQPRERLKNPNAPM CCCHHHHCCCCCCCC	5.57	27667366
392	Ubiquitination	AQPRERLKNPNAPML CCHHHHCCCCCCCCC	76.27	27667366
392	Acetylation	AQPRERLKNPNAPML CCHHHHCCCCCCCCC	76.27	23806337
485	Phosphorylation	YSILQGDSPTKWRTE HHHHCCCCCCCCCCC	41.09	26824392
487	Phosphorylation	ILQGDSPTKWRTEDF HHCCCCCCCCCCCCC	47.38	22942356
541	Ubiquitination	LKEEQRDKLEEILRG CCHHHHHHHHHHHHC	61.05	22790023
719	Phosphorylation	DGIPIDATPIDDLDG CCCCCCCCCCCCCCC	19.61	-
755	Acetylation	KKNEPIFKVAPSKWE HCCCCCEEECCCCCE	37.90	23806337
760	Acetylation	IFKVAPSKWEAVDES CEEECCCCCEECCHH	48.25	22826441
767	Phosphorylation	KWEAVDESELEAQAV CCEECCHHHHHHHEE	42.91	26525534
788	Phosphorylation	LFDQHEESEEEENQN HHHHHHHHHHHHHHC	47.53	26525534
800	Phosphorylation	NQNQEEESEDEEDTQ HHCHHHHCCCHHHHH	54.34	26525534
806	Phosphorylation	ESEDEEDTQSSKSEE HCCCHHHHHHCHHHH	33.36	25195567
808	Phosphorylation	EDEEDTQSSKSEEHH CCHHHHHHCHHHHHH	41.65	25338131
809	Phosphorylation	DEEDTQSSKSEEHHL CHHHHHHCHHHHHHH	30.31	25338131
811	Phosphorylation	EDTQSSKSEEHHLYS HHHHHCHHHHHHHHC	50.60	25521595
817	Phosphorylation	KSEEHHLYSNPVREE HHHHHHHHCCCCCHH	11.31	28066266
850	Acetylation	KLREIELKVMKFQDE HHHHHHHHHHHHHHH	27.74	23236377
919	Phosphorylation	KKEKDECTPTRKERK HHHCCCCCCCHHHHH	26.16	26824392
921	Phosphorylation	EKDECTPTRKERKRR HCCCCCCCHHHHHHH	35.90	25159016
930	Phosphorylation	KERKRRHSTSPSPSR HHHHHHCCCCCCCCC	28.86	27087446
931	Phosphorylation	ERKRRHSTSPSPSRS HHHHHCCCCCCCCCC	38.23	27087446
932	Phosphorylation	RKRRHSTSPSPSRSS HHHHCCCCCCCCCCC	26.79	27087446
934	Phosphorylation	RRHSTSPSPSRSSSG HHCCCCCCCCCCCCC	34.96	27087446
936	Phosphorylation	HSTSPSPSRSSSGRR CCCCCCCCCCCCCCC	49.48	23684622
938	Phosphorylation	TSPSPSRSSSGRRVK CCCCCCCCCCCCCCC	32.94	29899451
939	Phosphorylation	SPSPSRSSSGRRVKS CCCCCCCCCCCCCCC	35.38	21183079
940	Phosphorylation	PSPSRSSSGRRVKSP CCCCCCCCCCCCCCC	37.25	21183079
946	Phosphorylation	SSGRRVKSPSPKSER CCCCCCCCCCCCCHH	27.96	26824392
948	Phosphorylation	GRRVKSPSPKSERSE CCCCCCCCCCCHHHH	52.64	26824392
951	Phosphorylation	VKSPSPKSERSERSE CCCCCCCCHHHHHHH	41.44	23684622
954	Phosphorylation	PSPKSERSERSERSH CCCCCHHHHHHHHHH	33.05	27841257
957	Phosphorylation	KSERSERSERSHKES CCHHHHHHHHHHHHH	33.05	29899451
967	Phosphorylation	SHKESSRSRSSHKDS HHHHHHHHHCCCCCC	38.16	23737553
969	Phosphorylation	KESSRSRSSHKDSPR HHHHHHHCCCCCCHH	37.73	23970565
970	Phosphorylation	ESSRSRSSHKDSPRD HHHHHHCCCCCCHHH	33.18	23737553
974	Phosphorylation	SRSSHKDSPRDASKK HHCCCCCCHHHHHHH	27.00	25266776
985	Phosphorylation	ASKKAKRSPSGSRTP HHHHHHCCCCCCCCC	23.78	23684622
998	Phosphorylation	TPKRSRRSRSRSPKK CCCCCHHCCCCCCCC	33.23	19367708
1000	Phosphorylation	KRSRRSRSRSPKKSG CCCHHCCCCCCCCCC	38.05	19367708
1002	Phosphorylation	SRRSRSRSPKKSGKK CHHCCCCCCCCCCCC	42.17	23384938
1012	Phosphorylation	KSGKKSRSQSRSPHR CCCCCCCCCCCCCCH	39.33	19367708
1014	Phosphorylation	GKKSRSQSRSPHRSH CCCCCCCCCCCCHHC	35.65	19367708
1016	Phosphorylation	KSRSQSRSPHRSHKK CCCCCCCCCCHHCCH	30.24	19367708

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SR140_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SR140_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SR140_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SR140_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SR140_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-811, AND MASSSPECTROMETRY.	19367708 [Abstract]