NDKA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDKA_MOUSE
• UniProt AC: P15532
• Protein Name: Nucleoside diphosphate kinase A
• Gene Name: Nme1
• Organism: Mus musculus (Mouse).
• Sequence Length: 152
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair (By similarity)..
• Protein Sequence: MANSERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFLQASEDLLKEHYTDLKDRPFFTGLVKYMHSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFQPEELVEYKSCAQNWIYE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Ubiquitination	ERTFIAIKPDGVQRG CCEEEEECCCCHHCC	28.21	-
12	Succinylation	ERTFIAIKPDGVQRG CCEEEEECCCCHHCC	28.21	23806337
12	Acetylation	ERTFIAIKPDGVQRG CCEEEEECCCCHHCC	28.21	23806337
26	Acetylation	GLVGEIIKRFEQKGF CHHHHHHHHHHHCCC	57.61	23806337
26	Ubiquitination	GLVGEIIKRFEQKGF CHHHHHHHHHHHCCC	57.61	-
26	Succinylation	GLVGEIIKRFEQKGF CHHHHHHHHHHHCCC	57.61	23806337
31	Acetylation	IIKRFEQKGFRLVGL HHHHHHHCCCEEEEH	53.47	22826441
39	Ubiquitination	GFRLVGLKFLQASED CCEEEEHHHHHHCHH	37.79	-
39	Acetylation	GFRLVGLKFLQASED CCEEEEHHHHHHCHH	37.79	22826441
44	Phosphorylation	GLKFLQASEDLLKEH EHHHHHHCHHHHHHH	20.77	22499769
49	Ubiquitination	QASEDLLKEHYTDLK HHCHHHHHHHCCCCC	50.14	-
49	Acetylation	QASEDLLKEHYTDLK HHCHHHHHHHCCCCC	50.14	23236377
52	Phosphorylation	EDLLKEHYTDLKDRP HHHHHHHCCCCCCCC	11.75	22499769
53	Phosphorylation	DLLKEHYTDLKDRPF HHHHHHCCCCCCCCC	36.44	22499769
56	Ubiquitination	KEHYTDLKDRPFFTG HHHCCCCCCCCCHHH	55.27	-
56	Acetylation	KEHYTDLKDRPFFTG HHHCCCCCCCCCHHH	55.27	22826441
85	Acetylation	WEGLNVVKTGRVMLG EECCCEEEECCEEEC	40.76	22826441
94	Phosphorylation	GRVMLGETNPADSKP CCEEECCCCCCCCCC	44.71	26824392
99	Phosphorylation	GETNPADSKPGTIRG CCCCCCCCCCCCCCC	42.74	23984901
100	Malonylation	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	26320211
100	Ubiquitination	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	-
100	Acetylation	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	22826441
100	Succinylation	ETNPADSKPGTIRGD CCCCCCCCCCCCCCC	48.27	23806337
103	Phosphorylation	PADSKPGTIRGDFCI CCCCCCCCCCCCEEE	18.94	24068923
109	Glutathionylation	GTIRGDFCIQVGRNI CCCCCCEEEEECCCE	2.24	24333276
109	S-nitrosylation	GTIRGDFCIQVGRNI CCCCCCEEEEECCCE	2.24	24895380
109	S-nitrosocysteine	GTIRGDFCIQVGRNI CCCCCCEEEEECCCE	2.24	-
120	Phosphorylation	GRNIIHGSDSVKSAE CCCEEECCCHHHCCH	16.73	26824392
122	Phosphorylation	NIIHGSDSVKSAEKE CEEECCCHHHCCHHE	32.89	26824392
124	Acetylation	IHGSDSVKSAEKEIS EECCCHHHCCHHEEE	48.15	23806337
124	Malonylation	IHGSDSVKSAEKEIS EECCCHHHCCHHEEE	48.15	26320211
124	Ubiquitination	IHGSDSVKSAEKEIS EECCCHHHCCHHEEE	48.15	-
125	Phosphorylation	HGSDSVKSAEKEISL ECCCHHHCCHHEEEC	39.23	27681418
128	Acetylation	DSVKSAEKEISLWFQ CHHHCCHHEEECEEC	61.13	23954790
128	Ubiquitination	DSVKSAEKEISLWFQ CHHHCCHHEEECEEC	61.13	-
131	Phosphorylation	KSAEKEISLWFQPEE HCCHHEEECEECHHH	22.19	26643407
145	S-nitrosylation	ELVEYKSCAQNWIYE HHHCCHHHHHHCCCC	3.85	24895380
151	Phosphorylation	SCAQNWIYE------ HHHHHCCCC------	13.75	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDKA_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDKA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDKA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDKA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.