BTF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BTF3_MOUSE
• UniProt AC: Q64152
• Protein Name: Transcription factor BTF3
• Gene Name: Btf3
• Organism: Mus musculus (Mouse).
• Sequence Length: 204
• Subcellular Localization: Cytoplasm. Nucleus. The heterodimer with NACA is cytoplasmic..
• Protein Description: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription (By similarity)..
• Protein Sequence: MRRTGAPTQADSRGRGRARGGWPGAEATPSLPLGGSRGRESQMKETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	GAPTQADSRGRGRAR CCCCCCCCCCCCCCC	39.38	20531401
19	Methylation	SRGRGRARGGWPGAE CCCCCCCCCCCCCCC	42.68	24129315
30	Phosphorylation	PGAEATPSLPLGGSR CCCCCCCCCCCCCCC	37.96	-
36	Phosphorylation	PSLPLGGSRGRESQM CCCCCCCCCCCHHHH	29.75	28066266
44	Methylation	RGRESQMKETIMNQE CCCHHHHHHHHHCHH	44.03	-
52	Methylation	ETIMNQEKLAKLQAQ HHHHCHHHHHHHHHH	43.94	-
52	Ubiquitination	ETIMNQEKLAKLQAQ HHHHCHHHHHHHHHH	43.94	22790023
55	Malonylation	MNQEKLAKLQAQVRI HCHHHHHHHHHHHCC	52.12	26320211
55	Succinylation	MNQEKLAKLQAQVRI HCHHHHHHHHHHHCC	52.12	-
55	Acetylation	MNQEKLAKLQAQVRI HCHHHHHHHHHHHCC	52.12	23806337
55	Ubiquitination	MNQEKLAKLQAQVRI HCHHHHHHHHHHHCC	52.12	-
65	Acetylation	AQVRIGGKGTARRKK HHHCCCCCCHHHHCC	48.12	23806337
67	Phosphorylation	VRIGGKGTARRKKKV HCCCCCCHHHHCCEE	22.07	-
80	Phosphorylation	KVVHRTATADDKKLQ EEEEEECCCCHHHHH	29.97	18779572
85	Ubiquitination	TATADDKKLQFSLKK ECCCCHHHHHHHHHH	55.29	22790023
91	Ubiquitination	KKLQFSLKKLGVNNI HHHHHHHHHHCCCCC	44.76	22790023
99	Phosphorylation	KLGVNNISGIEEVNM HHCCCCCCCCEEEEE	35.52	26643407
142	Phosphorylation	HAETKQLTEMLPSIL CHHHHHHHHHHHHHH	19.49	22817900
147	Phosphorylation	QLTEMLPSILNQLGA HHHHHHHHHHHHHCC	35.43	21149613
156	Phosphorylation	LNQLGADSLTSLRRL HHHHCCHHHHHHHHH	32.77	28507225
158	Phosphorylation	QLGADSLTSLRRLAE HHCCHHHHHHHHHHH	29.66	21149613
159	Phosphorylation	LGADSLTSLRRLAEA HCCHHHHHHHHHHHH	25.77	21149613
169	Ubiquitination	RLAEALPKQSVDGKA HHHHHCCCCCCCCCC	56.93	-
169	Malonylation	RLAEALPKQSVDGKA HHHHHCCCCCCCCCC	56.93	26320211
171	Phosphorylation	AEALPKQSVDGKAPL HHHCCCCCCCCCCCC	28.44	26824392
175	Ubiquitination	PKQSVDGKAPLATGE CCCCCCCCCCCCCCC	42.22	-
180	Phosphorylation	DGKAPLATGEDDDDE CCCCCCCCCCCCCCC	49.11	25338131
199	Phosphorylation	VENFDEASKNEAN-- HHHHHHHHHHCCC--	33.69	30352176
200	Ubiquitination	ENFDEASKNEAN--- HHHHHHHHHCCC---	66.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BTF3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BTF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BTF3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BTF3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.