NDUV2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUV2_MOUSE
• UniProt AC: Q9D6J6
• Protein Name: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
• Gene Name: Ndufv2
• Organism: Mus musculus (Mouse).
• Sequence Length: 248
• Subcellular Localization: Mitochondrion inner membrane.
• Protein Description: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)..
• Protein Sequence: MFSLALRARATGLAAQWGRHARNLHKTAVHNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHQAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRDSDSILETLQRKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTPKDIEEIIDELKAGKVPKPGPRSGRFCCEPAGGLTSLTEPPKGPGFGVQAGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSLALRARA -----CCCHHHHHHH	16.07	29895711
60	Acetylation	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	23576753
60	Ubiquitination	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	-
60	Succinylation	DFTPENYKRIEAIVK CCCHHHHHHHHHHHH	59.49	26388266
69	Nitration	IEAIVKNYPEGHQAA HHHHHHHCCCHHHHH	9.28	-
128	Acetylation	YNRKPVGKYHIQVCT CCCCCCCEEEEEEEC	33.61	24062335
192	Phosphorylation	VQINDNYYEDLTPKD EEECCCCCCCCCHHH	14.82	-
208	Acetylation	EEIIDELKAGKVPKP HHHHHHHHCCCCCCC	53.71	23864654
208	Ubiquitination	EEIIDELKAGKVPKP HHHHHHHHCCCCCCC	53.71	-
208	Succinylation	EEIIDELKAGKVPKP HHHHHHHHCCCCCCC	53.71	23954790
214	Acetylation	LKAGKVPKPGPRSGR HHCCCCCCCCCCCCC	66.64	2374327
223	S-nitrosylation	GPRSGRFCCEPAGGL CCCCCCCCEECCCCC	2.18	24895380
224	S-nitrosylation	PRSGRFCCEPAGGLT CCCCCCCEECCCCCC	6.89	24895380

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
192	Y	Phosphorylation	Kinase	SRC	P05480	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUV2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUV2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUV2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.