| UniProt ID | RIR1_MOUSE | |
|---|---|---|
| UniProt AC | P07742 | |
| Protein Name | Ribonucleoside-diphosphate reductase large subunit | |
| Gene Name | Rrm1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 792 | |
| Subcellular Localization | Cytoplasm. | |
| Protein Description | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.. | |
| Protein Sequence | MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLDIVMANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSEKWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFESPEAQLLNKQIFETIYYGALEASCELAKEYGPYETYEGSPVSKGILQYDMWNVAPTDLWDWKPLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWNEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKALKEEEEKERNTAAMVCSLENREECLMCGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Acetylation | QERVMFDKITSRIQK CHHHCHHHHHHHHHH | 36.30 | - | |
| 26 | Glutathionylation | TSRIQKLCYGLNMDF HHHHHHHHHCCCCCC | 3.05 | 24333276 | |
| 102 | Phosphorylation | SDVMEDLYNYINPHN HHHHHHHHHHHCCCC | 20.45 | 22817900 | |
| 254 | S-nitrosocysteine | GIGVAVSCIRATGSY CCHHHHEEEEECCCE | 1.64 | - | |
| 254 | S-nitrosylation | GIGVAVSCIRATGSY CCHHHHEEEEECCCE | 1.64 | 20925432 | |
| 254 | Glutathionylation | GIGVAVSCIRATGSY CCHHHHEEEEECCCE | 1.64 | 24333276 | |
| 376 | Acetylation | KLYESYEKQGRVRKV HHHHHHHHCCCHHHH | 50.23 | - | |
| 471 | Ubiquitination | EKLAEVTKVIVRNLN HHHHHHHHHHHHHCH | 34.83 | - | |
| 471 | Acetylation | EKLAEVTKVIVRNLN HHHHHHHHHHHHHCH | 34.83 | 22826441 | |
| 553 | Phosphorylation | LAKEYGPYETYEGSP HHHHHCCCCCCCCCC | 19.28 | 28285833 | |
| 590 | Acetylation | PLKEKIAKYGIRNSL HHHHHHHHHCCCCCE | 47.70 | 7844321 | |
| 631 | Phosphorylation | IYTRRVLSGEFQIVN CCEECCCCCCCEEEC | 33.16 | 26824392 | |
| 721 | Phosphorylation | EPNYGKLTSMHFYGW CCCCCCCEEEEECCC | 27.73 | 26643407 | |
| 722 | Phosphorylation | PNYGKLTSMHFYGWK CCCCCCEEEEECCCC | 22.24 | 26643407 | |
| 741 | Phosphorylation | TGMYYLRTRPAANPI CEEEEECCCCCCCCE | 38.11 | 18846507 | |
| 751 | Phosphorylation | AANPIQFTLNKEKLK CCCCEEEEECHHHHH | 17.04 | 22817900 | |
| 780 | Phosphorylation | NTAAMVCSLENREEC HHHHHHHCCCCHHHH | 27.58 | 22006019 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RIR1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RIR1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RIR1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| KAT5_MOUSE | Kat5 | physical | 20159953 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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