ANXA5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANXA5_MOUSE
• UniProt AC: P48036
• Protein Name: Annexin A5
• Gene Name: Anxa5
• Organism: Mus musculus (Mouse).
• Sequence Length: 319
• Protein Description: This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade..
• Protein Sequence: MATRGTVTDFPGFDGRADAEVLRKAMKGLGTDEDSILNLLTSRSNAQRQEIAQEFKTLFGRDLVDDLKSELTGKFEKLIVAMMKPSRLYDAYELKHALKGAGTDEKVLTEIIASRTPEELSAIKQVYEEEYGSNLEDDVVGDTSGYYQRMLVVLLQANRDPDTAIDDAQVELDAQALFQAGELKWGTDEEKFITIFGTRSVSHLRRVFDKYMTISGFQIEETIDRETSGNLEQLLLAVVKSIRSIPAYLAETLYYAMKGAGTDDHTLIRVVVSRSEIDLFNIRKEFRKNFATSLYSMIKGDTSGDYKKALLLLCGGEDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATRGTVTD ------CCCCCCCCC	13.15	-
3	Phosphorylation	-----MATRGTVTDF -----CCCCCCCCCC	28.47	25338131
8	Phosphorylation	MATRGTVTDFPGFDG CCCCCCCCCCCCCCC	31.59	26525534
27	Ubiquitination	EVLRKAMKGLGTDED HHHHHHHCCCCCCHH	56.71	22790023
31	Phosphorylation	KAMKGLGTDEDSILN HHHCCCCCCHHHHHH	41.06	29899451
35	Phosphorylation	GLGTDEDSILNLLTS CCCCCHHHHHHHHHC	27.25	27180971
56	Acetylation	QEIAQEFKTLFGRDL HHHHHHHHHHHCCHH	43.49	22826441
56	Ubiquitination	QEIAQEFKTLFGRDL HHHHHHHHHHHCCHH	43.49	22790023
68	Succinylation	RDLVDDLKSELTGKF CHHHHHHHHHHCCHH	49.21	23954790
68	Ubiquitination	RDLVDDLKSELTGKF CHHHHHHHHHHCCHH	49.21	-
68	Acetylation	RDLVDDLKSELTGKF CHHHHHHHHHHCCHH	49.21	23806337
72	Phosphorylation	DDLKSELTGKFEKLI HHHHHHHCCHHHHHH	33.98	25338131
74	Acetylation	LKSELTGKFEKLIVA HHHHHCCHHHHHHHH	45.15	23236377
74	Malonylation	LKSELTGKFEKLIVA HHHHHCCHHHHHHHH	45.15	26320211
74	Ubiquitination	LKSELTGKFEKLIVA HHHHHCCHHHHHHHH	45.15	27667366
77	Acetylation	ELTGKFEKLIVAMMK HHCCHHHHHHHHHHC	46.80	22733758
77	Malonylation	ELTGKFEKLIVAMMK HHCCHHHHHHHHHHC	46.80	26320211
84	Ubiquitination	KLIVAMMKPSRLYDA HHHHHHHCHHHHHHH	27.10	22790023
84	Acetylation	KLIVAMMKPSRLYDA HHHHHHHCHHHHHHH	27.10	23236377
89	Phosphorylation	MMKPSRLYDAYELKH HHCHHHHHHHHHHHH	9.45	22499769
92	Phosphorylation	PSRLYDAYELKHALK HHHHHHHHHHHHHHC	20.92	26824392
95	Acetylation	LYDAYELKHALKGAG HHHHHHHHHHHCCCC	18.19	23806337
95	Ubiquitination	LYDAYELKHALKGAG HHHHHHHHHHHCCCC	18.19	22790023
99	Acetylation	YELKHALKGAGTDEK HHHHHHHCCCCCCHH	47.72	22826441
99	Ubiquitination	YELKHALKGAGTDEK HHHHHHHCCCCCCHH	47.72	22790023
106	Acetylation	KGAGTDEKVLTEIIA CCCCCCHHHHHHHHH	45.41	22826441
106	Ubiquitination	KGAGTDEKVLTEIIA CCCCCCHHHHHHHHH	45.41	22790023
114	Phosphorylation	VLTEIIASRTPEELS HHHHHHHCCCHHHHH	26.69	23984901
116	Phosphorylation	TEIIASRTPEELSAI HHHHHCCCHHHHHHH	32.34	23984901
121	Phosphorylation	SRTPEELSAIKQVYE CCCHHHHHHHHHHHH	31.09	23984901
127	Phosphorylation	LSAIKQVYEEEYGSN HHHHHHHHHHHHCCC	18.35	23984901
131	Phosphorylation	KQVYEEEYGSNLEDD HHHHHHHHCCCCCCC	29.18	23984901
133	Phosphorylation	VYEEEYGSNLEDDVV HHHHHHCCCCCCCCC	37.02	27087446
187	Phosphorylation	AGELKWGTDEEKFIT CCCCCCCCCHHHEEE	38.84	20469934
191	Acetylation	KWGTDEEKFITIFGT CCCCCHHHEEEEEEC	39.76	22826441
240	Acetylation	QLLLAVVKSIRSIPA HHHHHHHHHHHCHHH	33.30	22826441
244	Phosphorylation	AVVKSIRSIPAYLAE HHHHHHHCHHHHHHH	31.11	22345495
248	Phosphorylation	SIRSIPAYLAETLYY HHHCHHHHHHHHHHH	10.90	22345495
252	Phosphorylation	IPAYLAETLYYAMKG HHHHHHHHHHHHHHC	17.91	22345495
254	Phosphorylation	AYLAETLYYAMKGAG HHHHHHHHHHHHCCC	9.15	75343
255	Phosphorylation	YLAETLYYAMKGAGT HHHHHHHHHHHCCCC	11.88	22345495
258	Acetylation	ETLYYAMKGAGTDDH HHHHHHHHCCCCCCC	37.12	23954790
262	Phosphorylation	YAMKGAGTDDHTLIR HHHHCCCCCCCCEEE	37.41	22345495
288	Succinylation	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	-
288	Succinylation	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	23806337
288	Acetylation	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	23806337
288	Ubiquitination	NIRKEFRKNFATSLY HHCHHHHHHHHHHHH	62.83	27667366
295	Phosphorylation	KNFATSLYSMIKGDT HHHHHHHHHHHHCCC	8.92	22817900
296	Phosphorylation	NFATSLYSMIKGDTS HHHHHHHHHHHCCCC	21.23	25367039
299	Acetylation	TSLYSMIKGDTSGDY HHHHHHHHCCCCCCH	41.93	23236377
307	Acetylation	GDTSGDYKKALLLLC CCCCCCHHHEEHHHC	35.99	23954790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANXA5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANXA5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANXA5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ANXA5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.