LYAR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LYAR_MOUSE
• UniProt AC: Q08288
• Protein Name: Cell growth-regulating nucleolar protein
• Gene Name: Lyar
• Organism: Mus musculus (Mouse).
• Sequence Length: 388
• Subcellular Localization: Nucleus, nucleolus . Cytoplasm . Cell projection, cilium, photoreceptor outer segment . Component of pre-ribosomal particles, including pre-40S, pre-60S and pre-90S (By similarity). Associated with cytoplasmic ribosomes, but not polysomes, as a compo
• Protein Description: Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (By similarity). Also acts at the level of transcription regulation. Along with PRMT5, binds embryonic globin promoter (By similarity). Represses the expression of embryonic globin Hbb-y gene. [PubMed: 25092918 In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and that encoding the small nucleolar RNA SNORD41 (By similarity Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (By similarity Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells]
• Protein Sequence: MVFFTCNACGESVKKIQVEKHVSNCRNCECLSCIDCGKDFWGDDYKSHVKCISEGQKYGGKGYEAKTHKGDAKQQAWIQKINELIKKPNVSPKVRELLQQISAFDNVPRKKAKFQNWMKNSLKVHSDSVLEQVWDIFSEASSSEQDQQQPPSHTAKPHAEMPITKVPSAKTNGTTEEQTEAKKNKRERKEERQKNRKKEKKELKLENHQENLRGQKPKKRKKNQEAGHEAAGEEAAEASGPPEKKKAQGGQASEEGADRNGGPGEDAAEGQTKTAAGKRKRPKHSGAESGYKKKKMKLPEQPEEGEAKDHEAPSKGKFNWKGTIKAVLKQAPDNEISVKKLKKKVIAQYHAVMNDHHTSEEELLAIFNRKISRNPTFKVLKDRVKLLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Acetylation	EGQKYGGKGYEAKTH CCCCCCCCCCCCCCC	54.69	8275731
66	Acetylation	GGKGYEAKTHKGDAK CCCCCCCCCCCCCHH	38.94	23806337
91	Phosphorylation	LIKKPNVSPKVRELL HHHCCCCCHHHHHHH	26.16	28066266
285	Phosphorylation	KRKRPKHSGAESGYK CCCCCCCCCCCCCCC	45.91	20139300
325	Ubiquitination	FNWKGTIKAVLKQAP CCCHHHHHHHHHHCC	32.07	-
329	Ubiquitination	GTIKAVLKQAPDNEI HHHHHHHHHCCCCCC	37.50	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LYAR_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LYAR_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LYAR_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LYAR_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.