RL3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL3_MOUSE
• UniProt AC: P27659
• Protein Name: 60S ribosomal protein L3
• Gene Name: Rpl3
• Organism: Mus musculus (Mouse).
• Sequence Length: 403
• Subcellular Localization: Nucleus, nucleolus. Cytoplasm.
• Protein Description: The L3 protein is a component of the large subunit of cytoplasmic ribosomes..
• Protein Sequence: MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDASKPVHLTAFLGYKAGMTHIVREVDRPGSKVNKKEVVEAVTIVETPPMVVVGIVGYVETPRGLRTFKTVFAEHISDECKRRFYKNWHKSKKKAFTKYCKKWQDDTGKKQLEKDFNSMKKYCQVIRIIAHTQMRLLPLRQKKAHLMEIQVNGGTVAEKLDWARERLEQQVPVNQVFGQDEMIDVIGVTKGKGYKGVTSRWHTKKLPRKTHRGLRKVACIGAWHPARVAFSVARAGQKGYHHRTEINKKIYKIGQGYLIKDGKLIKNNASTDYDLSDKSINPLGGFVHYGEVTNDFIMLKGCVVGTKKRVLTLRKSLLVQTKRRALEKIDLKFIDTTSKFGHGRFQTMEEKKAFMGPLKKDRIAKEEGA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MSHRKFSAPRHGSL -CCCCCCCCCCCCCC	40.16	21183079
13	Phosphorylation	FSAPRHGSLGFLPRK CCCCCCCCCCCCCCC	21.13	26824392
39	Acetylation	FPKDDASKPVHLTAF CCCCCCCCCCEEHEE	53.43	23954790
44	Phosphorylation	ASKPVHLTAFLGYKA CCCCCEEHEEECHHH	10.65	19854140
49	Phosphorylation	HLTAFLGYKAGMTHI EEHEEECHHHCCCEE	10.38	19854140
65	Phosphorylation	REVDRPGSKVNKKEV EECCCCCCCCCHHHH	35.79	24719451
66	Acetylation	EVDRPGSKVNKKEVV ECCCCCCCCCHHHHE	56.60	23864654
103	Acetylation	PRGLRTFKTVFAEHI CCCCCHHHHHHHHHC	43.07	22826441
114	S-nitrosocysteine	AEHISDECKRRFYKN HHHCCHHHHHHHHHH	5.08	-
114	S-palmitoylation	AEHISDECKRRFYKN HHHCCHHHHHHHHHH	5.08	28526873
114	S-nitrosylation	AEHISDECKRRFYKN HHHCCHHHHHHHHHH	5.08	22178444
114	Glutathionylation	AEHISDECKRRFYKN HHHCCHHHHHHHHHH	5.08	24333276
134	Ubiquitination	KKAFTKYCKKWQDDT HHHHHHHHHHHCCCH	3.78	27667366
136	Acetylation	AFTKYCKKWQDDTGK HHHHHHHHHCCCHHH	46.67	23806337
142	Ubiquitination	KKWQDDTGKKQLEKD HHHCCCHHHHHHHHH	42.00	27667366
143	Acetylation	KWQDDTGKKQLEKDF HHCCCHHHHHHHHHH	39.16	23864654
144	Acetylation	WQDDTGKKQLEKDFN HCCCHHHHHHHHHHH	62.55	7385607
148	Ubiquitination	TGKKQLEKDFNSMKK HHHHHHHHHHHHHHH	75.98	27667366
148	Succinylation	TGKKQLEKDFNSMKK HHHHHHHHHHHHHHH	75.98	23954790
148	Acetylation	TGKKQLEKDFNSMKK HHHHHHHHHHHHHHH	75.98	23864654
154	Succinylation	EKDFNSMKKYCQVIR HHHHHHHHHHHHHHH	40.17	23954790
155	Ubiquitination	KDFNSMKKYCQVIRI HHHHHHHHHHHHHHH	42.49	-
166	Phosphorylation	VIRIIAHTQMRLLPL HHHHHHHHHHHHCCH	18.29	22817900
189	Phosphorylation	EIQVNGGTVAEKLDW EEEECCCHHHHHHHH	20.24	29895711
204	Ubiquitination	ARERLEQQVPVNQVF HHHHHHHHCCHHHHH	31.91	27667366
210	Ubiquitination	QQVPVNQVFGQDEMI HHCCHHHHHCCCCEE	4.99	27667366
214	Ubiquitination	VNQVFGQDEMIDVIG HHHHHCCCCEEEEEE	48.05	27667366
229	Succinylation	VTKGKGYKGVTSRWH ECCCCCCCCCCCCCC	56.42	23806337
229	Acetylation	VTKGKGYKGVTSRWH ECCCCCCCCCCCCCC	56.42	23806337
253	Glutathionylation	RGLRKVACIGAWHPA CCCCCEEEEECCCHH	3.10	24333276
253	S-nitrosylation	RGLRKVACIGAWHPA CCCCCEEEEECCCHH	3.10	24926564
253	S-nitrosocysteine	RGLRKVACIGAWHPA CCCCCEEEEECCCHH	3.10	-
253	S-palmitoylation	RGLRKVACIGAWHPA CCCCCEEEEECCCHH	3.10	28526873
265	Phosphorylation	HPARVAFSVARAGQK CHHHHHHHHHHCCCC	12.72	24719451
283	Ubiquitination	HRTEINKKIYKIGQG CCHHHHHHHEEECCC	46.94	22790023
286	Succinylation	EINKKIYKIGQGYLI HHHHHHEEECCCEEE	43.78	23806337
286	Ubiquitination	EINKKIYKIGQGYLI HHHHHHEEECCCEEE	43.78	27667366
286	Acetylation	EINKKIYKIGQGYLI HHHHHHEEECCCEEE	43.78	23806337
291	Phosphorylation	IYKIGQGYLIKDGKL HEEECCCEEEECCCE	9.43	18779572
294	Acetylation	IGQGYLIKDGKLIKN ECCCEEEECCCEECC	58.81	22826441
294	Ubiquitination	IGQGYLIKDGKLIKN ECCCEEEECCCEECC	58.81	27667366
294	Malonylation	IGQGYLIKDGKLIKN ECCCEEEECCCEECC	58.81	26320211
300	Acetylation	IKDGKLIKNNASTDY EECCCEECCCCCCCC	55.36	23954790
300	Ubiquitination	IKDGKLIKNNASTDY EECCCEECCCCCCCC	55.36	27667366
300	Malonylation	IKDGKLIKNNASTDY EECCCEECCCCCCCC	55.36	26320211
304	Phosphorylation	KLIKNNASTDYDLSD CEECCCCCCCCCCCC	24.76	25159016
305	Phosphorylation	LIKNNASTDYDLSDK EECCCCCCCCCCCCC	35.85	25159016
307	Phosphorylation	KNNASTDYDLSDKSI CCCCCCCCCCCCCCC	20.90	25159016
310	Phosphorylation	ASTDYDLSDKSINPL CCCCCCCCCCCCCCC	39.84	30635358
336	Glutathionylation	DFIMLKGCVVGTKKR CEEEEECCEECCCHH	1.83	24333276
350	Phosphorylation	RVLTLRKSLLVQTKR HHHHHHHHHHHHHHH	22.09	29176673
356	Succinylation	KSLLVQTKRRALEKI HHHHHHHHHHHHHHC	23.85	23806337
356	Ubiquitination	KSLLVQTKRRALEKI HHHHHHHHHHHHHHC	23.85	27667366
356	Acetylation	KSLLVQTKRRALEKI HHHHHHHHHHHHHHC	23.85	23806337
362	Acetylation	TKRRALEKIDLKFID HHHHHHHHCCEEEEE	42.23	23864654
362	Ubiquitination	TKRRALEKIDLKFID HHHHHHHHCCEEEEE	42.23	27667366
366	Succinylation	ALEKIDLKFIDTTSK HHHHCCEEEEECCCC	36.20	23806337
366	Acetylation	ALEKIDLKFIDTTSK HHHHCCEEEEECCCC	36.20	23864654
366	Ubiquitination	ALEKIDLKFIDTTSK HHHHCCEEEEECCCC	36.20	27667366
373	Acetylation	KFIDTTSKFGHGRFQ EEEECCCCCCCCCCC	53.96	23806337
381	Phosphorylation	FGHGRFQTMEEKKAF CCCCCCCCHHHHHHH	24.68	29514104
386	Malonylation	FQTMEEKKAFMGPLK CCCHHHHHHHCCCCH	50.57	26320211
393	Acetylation	KAFMGPLKKDRIAKE HHHCCCCHHHHHHHH	56.62	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.