CHTOP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHTOP_MOUSE
• UniProt AC: Q9CY57
• Protein Name: Chromatin target of PRMT1 protein
• Gene Name: Chtop
• Organism: Mus musculus (Mouse).
• Sequence Length: 249
• Subcellular Localization: Nucleus . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus speckle . Mostly associated with facultative heterochromatin. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By simi
• Protein Description: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (By similarity). May play a role in the silencing of fetal globin genes. [PubMed: 20688955 Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes]
• Protein Sequence: MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQKSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAQSAPKV ------CCCCCCCEE		-
13	Phosphorylation	APKVVLKSTTKMSLN CCEEEEECCCCCCHH		25338131
40	Phosphorylation	MPVNIRASMQQQQQL CCCCHHHHHHHHHHH		21930439
49	Phosphorylation	QQQQQLASARNRRLA HHHHHHHHHHHHHHH		29514104
64	Phosphorylation	QQMENRPSVQAALKL HHHHCCHHHHHHHHH		29514104
70	Ubiquitination	PSVQAALKLKQKSLK HHHHHHHHHHHHHHH		22790023
82	Ubiquitination	SLKQRLGKSNIQARL HHHHHHCHHHHHHHH		22790023
98	Dimethylation	RPIGALARGAIGGRG CCHHHHHHHCCCCCC		-
104	Dimethylation	ARGAIGGRGLPIIQR HHHCCCCCCCCCCCC		-
111	Dimethylation	RGLPIIQRGLPRGGL CCCCCCCCCCCCCCC		-
115	Dimethylation	IIQRGLPRGGLRGGR CCCCCCCCCCCCCCH		-
119	Dimethylation	GLPRGGLRGGRATRT CCCCCCCCCCHHHHH		-
122	Dimethylation	RGGLRGGRATRTLLR CCCCCCCHHHHHHHH		-
129	Dimethylation	RATRTLLRGGMSLRG HHHHHHHHCCCCCCC		-
135	Dimethylation	LRGGMSLRGQNLLRG HHCCCCCCCCCHHCC		-
141	Dimethylation	LRGQNLLRGGRAVAP CCCCCHHCCCCCCCC		-
144	Dimethylation	QNLLRGGRAVAPRMG CCHHCCCCCCCCCCC		-
149	Dimethylation	GGRAVAPRMGLRRGG CCCCCCCCCCCCCCC		-
204	Dimethylation	GRGRGRGRGALTRPV CCCCCCCCCCCCCCC		-
208	Phosphorylation	GRGRGALTRPVLTKE CCCCCCCCCCCCCHH		-
214	Ubiquitination	LTRPVLTKEQLDNQL CCCCCCCHHHHHHHH		22790023
227	Ubiquitination	QLDAYMSKTKGHLDA HHHHHHHHCCCCHHH		22790023
229	Ubiquitination	DAYMSKTKGHLDAEL HHHHHHCCCCHHHHH		22790023
239	Phosphorylation	LDAELDAYMAQTDPE HHHHHHHHHHHCCCC		25619855
243	Phosphorylation	LDAYMAQTDPETND- HHHHHHHCCCCCCC-		27087446
247	Phosphorylation	MAQTDPETND----- HHHCCCCCCC-----		27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHTOP_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CHTOP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHTOP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM1_MOUSE	Prmt1	physical	19858291

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.