CAH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH2_MOUSE
• UniProt AC: P00920
• Protein Name: Carbonic anhydrase 2
• Gene Name: Ca2
• Organism: Mus musculus (Mouse).
• Sequence Length: 260
• Subcellular Localization: Cytoplasm. Cell membrane. Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cel
• Protein Description: Essential for bone resorption and osteoclast differentiation. Reversible hydration of carbon dioxide. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6..
• Protein Sequence: MSHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPALQPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVLEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSHHWGYSK ------CCCCCCCCC	24.86	29176673
2	Acetylation	------MSHHWGYSK ------CCCCCCCCC	24.86	-
9	Ubiquitination	SHHWGYSKHNGPENW CCCCCCCCCCCCCCC	32.38	22790023
18	Acetylation	NGPENWHKDFPIANG CCCCCCCCCCCCCCC	53.32	23954790
18	Ubiquitination	NGPENWHKDFPIANG CCCCCCCCCCCCCCC	53.32	22790023
29	Phosphorylation	IANGDRQSPVDIDTA CCCCCCCCCCCCCHH	27.99	29899451
50	Phosphorylation	ALQPLLISYDKAASK HHHHEEEECCHHHCH	27.52	25521595
53	Ubiquitination	PLLISYDKAASKSIV HEEEECCHHHCHHHH	37.30	22790023
57	Ubiquitination	SYDKAASKSIVNNGH ECCHHHCHHHHCCCC	39.20	22790023
58	Phosphorylation	YDKAASKSIVNNGHS CCHHHCHHHHCCCCC	29.31	29899451
80	Ubiquitination	SQDNAVLKGGPLSDS CCCCEEEECCCCCHH	56.05	22790023
85	Phosphorylation	VLKGGPLSDSYRLIQ EEECCCCCHHEEEEE	27.87	22817900
87	Phosphorylation	KGGPLSDSYRLIQFH ECCCCCHHEEEEEEE	14.58	22817900
88	Phosphorylation	GGPLSDSYRLIQFHF CCCCCHHEEEEEEEE	17.90	29472430
114	Phosphorylation	HTVNKKKYAAELHLV EECCHHHHEEEEEEE	21.66	25521595
132	Ubiquitination	TKYGDFGKAVQQPDG CCCCCHHHHHCCCCC	45.43	22790023
153	Phosphorylation	FLKIGPASQGLQKVL EEEECCHHHHHHHHH	28.10	-
158	Ubiquitination	PASQGLQKVLEALHS CHHHHHHHHHHHHHH	54.55	22790023
165	Phosphorylation	KVLEALHSIKTKGKR HHHHHHHHHCCCCCC	26.99	25195567
167	Ubiquitination	LEALHSIKTKGKRAA HHHHHHHCCCCCCCC	47.39	22790023
219	Phosphorylation	REPITVSSEQMSHFR CCCEECCHHHHHCEE	27.75	29899451
256	Ubiquitination	PLKNRKIKASFK--- CCCCCCCCCCCC---	40.80	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of CAH2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-87, AND MASSSPECTROMETRY.
PubMed: 17242355