EIF3K_MOUSE - dbPTM
EIF3K_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID EIF3K_MOUSE
UniProt AC Q9DBZ5
Protein Name Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010}
Gene Name Eif3k
Organism Mus musculus (Mouse).
Sequence Length 218
Subcellular Localization Nucleus . Cytoplasm .
Protein Description Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression..
Protein Sequence MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDNQLKVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAMFEQMRA
------CHHHHHHHH
16.04-
13AcetylationQMRANVGKLLKGIDR
HHHHHHHHHHHCHHH
46.49-
13MalonylationQMRANVGKLLKGIDR
HHHHHHHHHHHCHHH
46.4926320211
28PhosphorylationYNPENLATLERYVET
CCHHHHHHHHHHHHH
32.11-
190GlutathionylationESGQVFICSQEESIK
CCCCEEECCCCCCCC
2.0324333276
204UbiquitinationKPKNIVEKIDFDSVS
CCCCHHHCCCHHHHH
36.36-
209PhosphorylationVEKIDFDSVSSIMAS
HHCCCHHHHHHHHHC
24.7225619855
211PhosphorylationKIDFDSVSSIMASSQ
CCCHHHHHHHHHCCC
20.3525619855
212PhosphorylationIDFDSVSSIMASSQ-
CCHHHHHHHHHCCC-
17.7725619855
216PhosphorylationSVSSIMASSQ-----
HHHHHHHCCC-----
16.3425619855
217PhosphorylationVSSIMASSQ------
HHHHHHCCC------
30.3027087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of EIF3K_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of EIF3K_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of EIF3K_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of EIF3K_MOUSE !!

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of EIF3K_MOUSE

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Related Literatures of Post-Translational Modification

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