EIF3K_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIF3K_MOUSE
• UniProt AC: Q9DBZ5
• Protein Name: Eukaryotic translation initiation factor 3 subunit K {ECO:0000255|HAMAP-Rule:MF_03010}
• Gene Name: Eif3k
• Organism: Mus musculus (Mouse).
• Sequence Length: 218
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression..
• Protein Sequence: MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLTDNQLKVWMSKYGWSADESGQVFICSQEESIKPKNIVEKIDFDSVSSIMASSQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAMFEQMRA ------CHHHHHHHH	16.04	-
13	Acetylation	QMRANVGKLLKGIDR HHHHHHHHHHHCHHH	46.49	-
13	Malonylation	QMRANVGKLLKGIDR HHHHHHHHHHHCHHH	46.49	26320211
28	Phosphorylation	YNPENLATLERYVET CCHHHHHHHHHHHHH	32.11	-
190	Glutathionylation	ESGQVFICSQEESIK CCCCEEECCCCCCCC	2.03	24333276
204	Ubiquitination	KPKNIVEKIDFDSVS CCCCHHHCCCHHHHH	36.36	-
209	Phosphorylation	VEKIDFDSVSSIMAS HHCCCHHHHHHHHHC	24.72	25619855
211	Phosphorylation	KIDFDSVSSIMASSQ CCCHHHHHHHHHCCC	20.35	25619855
212	Phosphorylation	IDFDSVSSIMASSQ- CCHHHHHHHHHCCC-	17.77	25619855
216	Phosphorylation	SVSSIMASSQ----- HHHHHHHCCC-----	16.34	25619855
217	Phosphorylation	VSSIMASSQ------ HHHHHHCCC------	30.30	27087446

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIF3K_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIF3K_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIF3K_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of EIF3K_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.