H2B1A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H2B1A_MOUSE
• UniProt AC: P70696
• Protein Name: Histone H2B type 1-A
• Gene Name: Hist1h2ba {ECO:0000312|MGI:MGI:2448375}
• Organism: Mus musculus (Mouse).
• Sequence Length: 127
• Subcellular Localization: Nucleus . Chromosome .
• Protein Description: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. [PubMed: 23884607]
• Protein Sequence: MPEVAVKGATISKKGFKKAVTKTQKKEGRKRKRCRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTDIFERIASEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MPEVAVKGA ------CCCCCCCCC	44.78	-
7	Crotonylation	-MPEVAVKGATISKK -CCCCCCCCCEECHH	32.84	21925322
7	Sumoylation	-MPEVAVKGATISKK -CCCCCCCCCEECHH	32.84	28289178
7	N6-crotonyl-L-lysine	-MPEVAVKGATISKK -CCCCCCCCCEECHH	32.84	-
7	Lactoylation	-MPEVAVKGATISKK -CCCCCCCCCEECHH	32.84	31645732
7	Acetylation	-MPEVAVKGATISKK -CCCCCCCCCEECHH	32.84	-
13	N6-crotonyl-L-lysine	VKGATISKKGFKKAV CCCCEECHHHHHHHH	53.73	-
13	Crotonylation	VKGATISKKGFKKAV CCCCEECHHHHHHHH	53.73	21925322
13	Lactoylation	VKGATISKKGFKKAV CCCCEECHHHHHHHH	53.73	31645732
13	Acetylation	VKGATISKKGFKKAV CCCCEECHHHHHHHH	53.73	-
14	Acetylation	KGATISKKGFKKAVT CCCEECHHHHHHHHH	63.89	164399
14	Crotonylation	KGATISKKGFKKAVT CCCEECHHHHHHHHH	63.89	21925322
14	N6-crotonyl-L-lysine	KGATISKKGFKKAVT CCCEECHHHHHHHHH	63.89	-
17	Acetylation	TISKKGFKKAVTKTQ EECHHHHHHHHHHHH	48.79	164403
17	Lactoylation	TISKKGFKKAVTKTQ EECHHHHHHHHHHHH	48.79	31645732
17	N6-crotonyl-L-lysine	TISKKGFKKAVTKTQ EECHHHHHHHHHHHH	48.79	-
17	Crotonylation	TISKKGFKKAVTKTQ EECHHHHHHHHHHHH	48.79	21925322
18	Acetylation	ISKKGFKKAVTKTQK ECHHHHHHHHHHHHH	45.91	164407
18	Lactoylation	ISKKGFKKAVTKTQK ECHHHHHHHHHHHHH	45.91	31645732
18	Crotonylation	ISKKGFKKAVTKTQK ECHHHHHHHHHHHHH	45.91	21925322
18	N6-crotonyl-L-lysine	ISKKGFKKAVTKTQK ECHHHHHHHHHHHHH	45.91	-
22	Lactoylation	GFKKAVTKTQKKEGR HHHHHHHHHHHHHCC	42.22	31645732
22	Crotonylation	GFKKAVTKTQKKEGR HHHHHHHHHHHHHCC	42.22	21925322
22	Sumoylation	GFKKAVTKTQKKEGR HHHHHHHHHHHHHCC	42.22	28289178
22	N6-crotonyl-L-lysine	GFKKAVTKTQKKEGR HHHHHHHHHHHHHCC	42.22	-
22	Acetylation	GFKKAVTKTQKKEGR HHHHHHHHHHHHHCC	42.22	164411
25	Crotonylation	KAVTKTQKKEGRKRK HHHHHHHHHHCCCCH	59.01	21925322
25	Lactoylation	KAVTKTQKKEGRKRK HHHHHHHHHHCCCCH	59.01	-
25	Acetylation	KAVTKTQKKEGRKRK HHHHHHHHHHCCCCH	59.01	19864931
25	N6-crotonyl-L-lysine	KAVTKTQKKEGRKRK HHHHHHHHHHCCCCH	59.01	-
36	Succinylation	RKRKRCRKESYSIYI CCCHHHCHHHHHHHH	55.42	-
36	Crotonylation	RKRKRCRKESYSIYI CCCHHHCHHHHHHHH	55.42	21925322
36	N6-crotonyl-L-lysine	RKRKRCRKESYSIYI CCCHHHCHHHHHHHH	55.42	-
38	Phosphorylation	RKRCRKESYSIYIYK CHHHCHHHHHHHHHH	27.50	-
45	Lactoylation	SYSIYIYKVLKQVHP HHHHHHHHHHHHHCC	31.37	-
48	Methylation	IYIYKVLKQVHPDTG HHHHHHHHHHCCCCC	53.94	-
48	Ubiquitination	IYIYKVLKQVHPDTG HHHHHHHHHHCCCCC	53.94	-
48	Acetylation	IYIYKVLKQVHPDTG HHHHHHHHHHCCCCC	53.94	22631103
54	Phosphorylation	LKQVHPDTGISSKAM HHHHCCCCCCCHHHH	40.65	23737553
57	Phosphorylation	VHPDTGISSKAMSIM HCCCCCCCHHHHHHH	27.42	25521595
58	Phosphorylation	HPDTGISSKAMSIMN CCCCCCCHHHHHHHH	23.63	25521595
59	Methylation	PDTGISSKAMSIMNS CCCCCCHHHHHHHHH	41.12	-
59	"N6,N6-dimethyllysine"	PDTGISSKAMSIMNS CCCCCCHHHHHHHHH	41.12	-
77	Phosphorylation	DIFERIASEASRLAH HHHHHHHHHHHHHHH	31.18	24453211
80	Phosphorylation	ERIASEASRLAHYNK HHHHHHHHHHHHHCC	24.63	28066266
81	Methylation	RIASEASRLAHYNKR HHHHHHHHHHHHCCC	42.83	-
85	Phosphorylation	EASRLAHYNKRSTIT HHHHHHHHCCCCCCC	19.44	22499769
87	Lactoylation	SRLAHYNKRSTITSR HHHHHHCCCCCCCHH	40.33	31645732
87	Methylation	SRLAHYNKRSTITSR HHHHHHCCCCCCCHH	40.33	-
87	Acetylation	SRLAHYNKRSTITSR HHHHHHCCCCCCCHH	40.33	7609931
87	"N6,N6,N6-trimethyllysine"	SRLAHYNKRSTITSR HHHHHHCCCCCCCHH	40.33	-
87	Ubiquitination	SRLAHYNKRSTITSR HHHHHHCCCCCCCHH	40.33	27667366
88	Methylation	RLAHYNKRSTITSRE HHHHHCCCCCCCHHH	35.08	-
89	Phosphorylation	LAHYNKRSTITSREI HHHHCCCCCCCHHHH	26.27	26643407
90	Phosphorylation	AHYNKRSTITSREIQ HHHCCCCCCCHHHHH	32.10	26643407
92	Phosphorylation	YNKRSTITSREIQTA HCCCCCCCHHHHHHH	23.09	26643407
93	Phosphorylation	NKRSTITSREIQTAV CCCCCCCHHHHHHHH	24.86	30352176
94	Methylation	KRSTITSREIQTAVR CCCCCCHHHHHHHHH	36.07	-
98	Phosphorylation	ITSREIQTAVRLLLP CCHHHHHHHHHHHCC	32.55	26745281
110	Acetylation	LLPGELAKHAVSEGT HCCHHHHHHHHHHHC	44.73	163937
110	Lactoylation	LLPGELAKHAVSEGT HCCHHHHHHHHHHHC	44.73	31645732
110	Ubiquitination	LLPGELAKHAVSEGT HCCHHHHHHHHHHHC	44.73	27667366
110	Methylation	LLPGELAKHAVSEGT HCCHHHHHHHHHHHC	44.73	-
114	Phosphorylation	ELAKHAVSEGTKAVT HHHHHHHHHHCHHHH	30.96	26824392
117	Phosphorylation	KHAVSEGTKAVTKYT HHHHHHHCHHHHHHC	16.27	22817900
118	Succinylation	HAVSEGTKAVTKYTS HHHHHHCHHHHHHCC	52.28	-
118	Lactoylation	HAVSEGTKAVTKYTS HHHHHHCHHHHHHCC	52.28	31645732
118	Ubiquitination	HAVSEGTKAVTKYTS HHHHHHCHHHHHHCC	52.28	27667366
118	Methylation	HAVSEGTKAVTKYTS HHHHHHCHHHHHHCC	52.28	-
121	Phosphorylation	SEGTKAVTKYTSSK- HHHCHHHHHHCCCC-	24.16	17488778
122	Succinylation	EGTKAVTKYTSSK-- HHCHHHHHHCCCC--	39.67	-
122	Lactoylation	EGTKAVTKYTSSK-- HHCHHHHHHCCCC--	39.67	-
122	Acetylation	EGTKAVTKYTSSK-- HHCHHHHHHCCCC--	39.67	1919683
122	Ubiquitination	EGTKAVTKYTSSK-- HHCHHHHHHCCCC--	39.67	27667366
124	Phosphorylation	TKAVTKYTSSK---- CHHHHHHCCCC----	28.25	-
126	Phosphorylation	AVTKYTSSK------ HHHHHCCCC------	34.29	29514104
127	Acetylation	VTKYTSSK------- HHHHCCCC-------	65.21	7431179

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H2B1A_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
4	K	Methylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	-
4	K	Methylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-
4	K	ubiquitylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	-
4	K	ubiquitylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-
36	K	Methylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	21925322
36	K	ubiquitylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	21925322
79	K	Methylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	-
79	K	Methylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-
79	K	ubiquitylation	Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci.	-
79	K	ubiquitylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-
117	T	Phosphorylation	Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids.	-
118	K	Methylation	Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids.	-
122	K	Methylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-
122	K	ubiquitylation	Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H2B1A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of H2B1A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.