CHD5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CHD5_MOUSE
• UniProt AC: A2A8L1
• Protein Name: Chromodomain-helicase-DNA-binding protein 5
• Gene Name: Chd5
• Organism: Mus musculus (Mouse).
• Sequence Length: 1946
• Subcellular Localization: Nucleus . Associates with heterochromatin.
• Protein Description: Chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa..
• Protein Sequence: MRGPLGTEEELPRLFAEEMENEEEMSEEEDGGLEGFEDFFPAEPVSLPKKKPKKLKESKSSKGKRKKKEGSNDEMSDNEEDLEEKSESEGSDYSPTKKKKKKLKEKKEKKEKKEKRKKRGEDEDDNDDGGLKEPKSSGQLMAEWGLDDVDYLFSEDDYHTLTNYKAFSQFLRPLIAKKNPKIPMSKMMTVLGAKWREFSANNPFKGSSAAAAAAAVAAAVETVTIAPPLAISPQQVPQTLPIRKAKTKEGKGPGVRKKNKGAKDSKKKGRGKRVAGLKFRFGGISKRKKGSSSEEDEREDSDLDNASIHSSSVRSECSAALGKKNKRRRKKKRIDDGDGYETDHQDYCEVCQQGGEIILCDTCPRAYHLVCLDPELEKAPEGKWSCPHCEKEGIQWEPKDDDEEEEEGGCEEEEDDHMEFCRVCKDGGELLCCDACPSSYHLHCLNPPLPEIPNGEWLCPRCTCPPLKGKVQRILHWRWTEPPAPFVVGLPGPEVEPGMPPPRPLEGIPEREFFVKWAGLSYWHCSWVKELQLELYHTVMYRNYQRKNDMDEPPPFDYGSGDEDGKSEKRKNKDPLYAKMEERFYRYGIKPEWMMVHRILNHSFDKKGDIHYLIKWKDLPYDQCTWEIDEIDIPYYDNLKQAYWGHRELMLGEDARLPKRLVKKGKKLKDDKQEKPPDTPIVDPTVKFDKQPWYIDATGGTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFEDNAIRGGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADISKEDQIKKLHDLLGPHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQVSLLNIMMDLKKCCNHPYLFPVAAVEAPVLPNGSYDGSSLVKSSGKLMLLQKMLKKLRDEGHRVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEELFKDDVEGMMSQGQRPTTPIPDIQSTKGGSLTAGAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATDDTELQNMNEYLSSFKVAQYVVREEDGVEEVEREVIKQEENVDPDYWEKLLRHHYEQQQEDLARNLGKGKRIRKQVNYNDASQEDQEWQDELSDNQSEYSIGSEDEDEDFEERPEGQSGRRQSRRQLKSDRDKPLPPLLARVGGNIEVLGFNARQRKAFLNAIMRWGMPPQDAFNSHWLVRDLRGKSEKEFRAYVSLFMRHLCEPGADGAETFADGVPREGLSRQHVLTRIGVMSLVRKKVQEFEHVNGKYSTPDLVPEGAEGKKPGEVISSDPNTPVPASPAQLPPAPLGLTDKMEAQLGYTDEKESGMQKPKKSLEIQTLPTALDRVEGEDKHQSSDSKDRAREERTEEVEKAQGSPEQPLKEEVLPDKEPIPDKPELSLGHSGDFRPDDPKTEEKEPGETQQNGDREEDEEGKKEDKNGKFKFMFNIADGGFTELHTLWQNEERAAVSSGKIYEIWHRRHDYWLLAGIVTHGYARWQDIQNDPRYMILNEPFKSEIHKGNYLEMKNKFLARRFKLLEQALVIEEQLRRAAYLNMTQDPNHPAMALNARLAEVECLAESHQHLSKESLAGNKPANAVLHKVLNQLEELLSDMKADVTRLPSMLSRIPPVAARLQMSERSILSRLTNRAGDPTIQQTSSRRRDFPLFQRSFPAEPSHLPNPRGREKLQPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	KKLKESKSSKGKRKK CCCCCCCCCCCCCCC		-
71	Phosphorylation	KRKKKEGSNDEMSDN CCCCCCCCCCCCCCC		27180971
76	Phosphorylation	EGSNDEMSDNEEDLE CCCCCCCCCCHHHHH		27180971
86	Phosphorylation	EEDLEEKSESEGSDY HHHHHHHHHHCCCCC		21149613
88	Phosphorylation	DLEEKSESEGSDYSP HHHHHHHHCCCCCCC		21149613
91	Phosphorylation	EKSESEGSDYSPTKK HHHHHCCCCCCCCHH		21149613
93	Phosphorylation	SESEGSDYSPTKKKK HHHCCCCCCCCHHHH		21149613
94	Phosphorylation	ESEGSDYSPTKKKKK HHCCCCCCCCHHHHH		21149613
160	Phosphorylation	FSEDDYHTLTNYKAF CCCCCCCCCCCHHHH		18779572
162	Phosphorylation	EDDYHTLTNYKAFSQ CCCCCCCCCHHHHHH		18779572
232	Phosphorylation	IAPPLAISPQQVPQT ECCCCCCCCCCCCCC		29899451
291	Phosphorylation	ISKRKKGSSSEEDER CCCCCCCCCCHHHHC		-
292	Phosphorylation	SKRKKGSSSEEDERE CCCCCCCCCHHHHCC		-
293	Phosphorylation	KRKKGSSSEEDERED CCCCCCCCHHHHCCC		-
301	Phosphorylation	EEDEREDSDLDNASI HHHHCCCCCCCCHHH		-
342	Phosphorylation	DDGDGYETDHQDYCE CCCCCCCCCCHHHHH		29899451
558	Phosphorylation	DEPPPFDYGSGDEDG CCCCCCCCCCCCCCC		25293948
560	Phosphorylation	PPPFDYGSGDEDGKS CCCCCCCCCCCCCCC		25293948
716	Phosphorylation	GLNWLRFSWAQGTDT CCCCEEEEECCCCCE		-
721	Phosphorylation	RFSWAQGTDTILADE EEEECCCCCEEEEHH		-
798	Phosphorylation	VIRENEFSFEDNAIR EECCCCCCCCCCCCC		-
1019	Phosphorylation	PNGSYDGSSLVKSSG CCCCCCCHHHHHHHH		-
1049	Phosphorylation	GHRVLIFSQMTKMLD CCCEEEEHHHHHHHH		-
1183	Phosphorylation	RPGLGSKSGSMTKQE CCCCCCCCCCCCHHH		29899451
1185	Phosphorylation	GLGSKSGSMTKQELD CCCCCCCCCCHHHHH		-
1212	Phosphorylation	DDVEGMMSQGQRPTT HCHHHHHHCCCCCCC		25293948
1218	Phosphorylation	MSQGQRPTTPIPDIQ HHCCCCCCCCCCCCC		25293948
1219	Phosphorylation	SQGQRPTTPIPDIQS HCCCCCCCCCCCCCC		25521595
1392	Methylation	FEERPEGQSGRRQSR HHHCCCCCCCCHHHH		-
1546	Phosphorylation	KKPGEVISSDPNTPV CCCCCCCCCCCCCCC		21183079
1547	Phosphorylation	KPGEVISSDPNTPVP CCCCCCCCCCCCCCC		20415495
1551	Phosphorylation	VISSDPNTPVPASPA CCCCCCCCCCCCCCC		22807455
1556	Phosphorylation	PNTPVPASPAQLPPA CCCCCCCCCCCCCCC		23318260
1633	Phosphorylation	EVEKAQGSPEQPLKE HHHHHCCCCCCCCCC		25521595
1836	Phosphorylation	EVECLAESHQHLSKE HHHHHHHHHHHCCHH		-
1867	Phosphorylation	NQLEELLSDMKADVT HHHHHHHHHHHCCHH		-
1870	Ubiquitination	EELLSDMKADVTRLP HHHHHHHHCCHHHHH		-
1874	Phosphorylation	SDMKADVTRLPSMLS HHHHCCHHHHHHHHH		25777480
1878	Phosphorylation	ADVTRLPSMLSRIPP CCHHHHHHHHHCCCH		25777480
1881	Phosphorylation	TRLPSMLSRIPPVAA HHHHHHHHCCCHHHH		25777480

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CHD5_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1392	Q	Methylation	Methylated at Gln-1392 by N6AMT1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CHD5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MTA3_MOUSE	Mta3	physical	21931736
SYN2_MOUSE	Syn2	physical	21931736
HDAC2_MOUSE	Hdac2	physical	21931736
HDAC1_MOUSE	Hdac1	physical	21931736

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.