dbPTM

TLN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TLN1_MOUSE
UniProt AC	P26039
Protein Name	Talin-1
Gene Name	Tln1
Organism	Mus musculus (Mouse).
Sequence Length	2541
Subcellular Localization	Cell projection, ruffle membrane Peripheral membrane protein Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface . Cell junction, focal adhesion . Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal
Protein Description	Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts..
Protein Sequence	MVALSLKISIGNVVKTMQFEPSTMVYDACRMIRERIPEALAGPPNDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKDEGTGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWSLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFETLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGNGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDVLMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASAPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEIKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAKLLGEIAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKASGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPASPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRQLETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAIATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSVPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGDPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASQAKPAAVAAENEEIGAHIKHRVQELGHGCSALVTKAGALQCSPSDVYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGAETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAFHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPNPDLKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEDQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Ubiquitination	ISIGNVVKTMQFEPS EEECCCEECCCCCCC	33.72	-
16	Phosphorylation	SIGNVVKTMQFEPST EECCCEECCCCCCCH	12.47	21183079
17	Oxidation	IGNVVKTMQFEPSTM ECCCEECCCCCCCHH	3.39	17242355
22	Phosphorylation	KTMQFEPSTMVYDAC ECCCCCCCHHHHHHH	23.18	22499769
23	Phosphorylation	TMQFEPSTMVYDACR CCCCCCCHHHHHHHH	22.75	22499769
24	Oxidation	MQFEPSTMVYDACRM CCCCCCHHHHHHHHH	2.85	17242355
26	Phosphorylation	FEPSTMVYDACRMIR CCCCHHHHHHHHHHH	6.23	28418008
57	Acetylation	FLSDDDPKKGIWLEA CCCCCCCCCCEEEEH	71.30	15605895
70	Phosphorylation	EAGKALDYYMLRNGD EHHHHHHEEEHHCCC	7.51	21082442
71	Phosphorylation	AGKALDYYMLRNGDT HHHHHHEEEHHCCCC	6.85	22499769
72	Oxidation	GKALDYYMLRNGDTM HHHHHEEEHHCCCCC	2.00	17242355
78	Phosphorylation	YMLRNGDTMEYRKKQ EEHHCCCCCHHHHHC	17.19	22817900
99	Phosphorylation	MLDGTVKTIMVDDSK ECCCCEEEEEECCCH	15.23	22802335
105	Phosphorylation	KTIMVDDSKTVTDML EEEEECCCHHHHHHH	26.26	22802335
107	Phosphorylation	IMVDDSKTVTDMLMT EEECCCHHHHHHHHH	32.37	22802335
109	Phosphorylation	VDDSKTVTDMLMTIC ECCCHHHHHHHHHHH	22.41	22802335
114	Phosphorylation	TVTDMLMTICARIGI HHHHHHHHHHHHHCC	14.67	22802335
116	Glutathionylation	TDMLMTICARIGITN HHHHHHHHHHHCCCC	1.21	24333276
127	Phosphorylation	GITNHDEYSLVRELM CCCCCHHHHHHHHHH	17.23	25263469
128	Phosphorylation	ITNHDEYSLVRELME CCCCHHHHHHHHHHH	20.52	25263469
142	Phosphorylation	EEKKDEGTGTLRKDK HHHCCCCCCCCCCCH	25.58	24899341
144	Phosphorylation	KKDEGTGTLRKDKTL HCCCCCCCCCCCHHH	24.19	26824392
150	Phosphorylation	GTLRKDKTLLRDEKK CCCCCCHHHHCCHHH	40.95	22324799
167	Phosphorylation	KLKQKLHTDDELNWL HHHHHCCCCCCCHHH	56.43	-
190	Phosphorylation	QGVEEHETLLLRRKF CCHHHHHHHHHHCHH	25.31	26824392
196	Acetylation	ETLLLRRKFFYSDQN HHHHHHCHHHCCCCC	33.13	22826441
199	Phosphorylation	LLRRKFFYSDQNVDS HHHCHHHCCCCCCCC	17.92	29514104
256	Succinylation	PHNEQKHKAGFLDLK CCCHHHCCCCCCCHH	58.18	23954790
286	S-nitrosocysteine	IFQAHKNCGQMSEIE HHHHHCCCCCHHHHH	4.83	-
286	S-nitrosylation	IFQAHKNCGQMSEIE HHHHHCCCCCHHHHH	4.83	21278135
334	Acetylation	PRLLGITKECVMRVD HHHHCCCHHHHHCCC	47.39	22826441
405	Phosphorylation	IILKKKKSKDHFGLE HHCCCCCCCCCCCCC	52.80	26824392
406	Ubiquitination	ILKKKKSKDHFGLEG HCCCCCCCCCCCCCC	65.19	-
417	Phosphorylation	GLEGDEESTMLEDSV CCCCCHHHCCCCCCC	19.64	23984901
418	Phosphorylation	LEGDEESTMLEDSVS CCCCHHHCCCCCCCC	29.11	23984901
423	Phosphorylation	ESTMLEDSVSPKKST HHCCCCCCCCCCHHH	18.34	27566939
425	Phosphorylation	TMLEDSVSPKKSTVL CCCCCCCCCCHHHHH	34.65	27087446
428	Acetylation	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	23806337
428	Malonylation	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	26320211
428	Succinylation	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	23806337
428	Ubiquitination	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	-
429	Phosphorylation	DSVSPKKSTVLQQQY CCCCCCHHHHHHHHH	29.85	22499769
430	Phosphorylation	SVSPKKSTVLQQQYN CCCCCHHHHHHHHHH	33.83	-
436	Phosphorylation	STVLQQQYNRVGKVE HHHHHHHHHCCCCCC	10.70	22499769
446	Phosphorylation	VGKVEHGSVALPAIM CCCCCCCCCHHHHHH	13.21	27180971
455	Phosphorylation	ALPAIMRSGASGPEN HHHHHHCCCCCCCCC	22.72	29472430
458	Phosphorylation	AIMRSGASGPENFQV HHHCCCCCCCCCCCC	59.41	23684622
467	Phosphorylation	PENFQVGSMPPAQQQ CCCCCCCCCCHHHHC	29.29	23684622
568	Phosphorylation	TAGDPAETDYTAVGC CCCCCCCCCCCEEEE	36.09	25367039
570	Phosphorylation	GDPAETDYTAVGCAV CCCCCCCCCEEEEEE	12.20	25367039
571	Phosphorylation	DPAETDYTAVGCAVT CCCCCCCCEEEEEEH	20.06	25367039
578	Phosphorylation	TAVGCAVTTISSNLT CEEEEEEHHHHCCHH	10.41	25367039
579	Phosphorylation	AVGCAVTTISSNLTE EEEEEEHHHHCCHHH	16.56	25367039
581	Phosphorylation	GCAVTTISSNLTEMS EEEEHHHHCCHHHHH	15.87	25367039
582	Phosphorylation	CAVTTISSNLTEMSR EEEHHHHCCHHHHHH	31.82	25367039
585	Phosphorylation	TTISSNLTEMSRGVK HHHHCCHHHHHHHHH	33.61	25367039
588	Phosphorylation	SSNLTEMSRGVKLLA HCCHHHHHHHHHHHH	21.46	25367039
620	Phosphorylation	KGLAGAVSELLRSAQ HHHHHHHHHHHHHCC	23.22	26824392
677	Phosphorylation	QLAKAVASAAAALVL HHHHHHHHHHHHHHH	16.31	26824392
709	Glutathionylation	VIAAATQCALSTSQL HHHHHHHHHHCHHHH	3.41	24333276
714	Phosphorylation	TQCALSTSQLVACTK HHHHHCHHHHHHHCE	20.38	-
719	Glutathionylation	STSQLVACTKVVAPT CHHHHHHHCEEECCC	2.70	24333276
726	Phosphorylation	CTKVVAPTISSPVCQ HCEEECCCCCCCCHH	24.61	29233185
728	Phosphorylation	KVVAPTISSPVCQEQ EEECCCCCCCCHHHH	30.94	26824392
729	Phosphorylation	VVAPTISSPVCQEQL EECCCCCCCCHHHHH	19.94	27087446
732	Glutathionylation	PTISSPVCQEQLVEA CCCCCCCHHHHHHHH	4.12	24333276
745	Acetylation	EAGRLVAKAVEGCVS HHHHHHHHHHHHHCC	45.55	22826441
834	Phosphorylation	RILAQATSDLVNAIK HHHHHHHHHHHHHHH	31.78	26824392
841	Ubiquitination	SDLVNAIKADAEGES HHHHHHHHHCCCCCC	37.49	-
848	Phosphorylation	KADAEGESDLENSRK HHCCCCCCCCHHHHH	59.35	26525534
858	Phosphorylation	ENSRKLLSAAKILAD HHHHHHHHHHHHHHH	36.29	25338131
861	Ubiquitination	RKLLSAAKILADATA HHHHHHHHHHHHHHH	37.66	-
869	Acetylation	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	23806337
869	Succinylation	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	23806337
869	Ubiquitination	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	-
883	Phosphorylation	GAAAHPDSEEQQQRL HHHCCCCCHHHHHHH	47.70	26824392
910	Acetylation	AAAQNAIKKKLVQRL HHHHHHHHHHHHHHH	41.25	7609165
910	Ubiquitination	AAAQNAIKKKLVQRL HHHHHHHHHHHHHHH	41.25	-
956	Glutathionylation	QPLLVQSCKAVAEQI CCCHHHHHHHHHHHC	1.51	24333276
973	Phosphorylation	LVQGVRGSQAQPDSP HHHCCCCCCCCCCCH	16.27	25619855
979	Phosphorylation	GSQAQPDSPSAQLAL CCCCCCCCHHHHHHH	27.69	27087446
981	Phosphorylation	QAQPDSPSAQLALIA CCCCCCHHHHHHHHH	32.38	27087446
990	Phosphorylation	QLALIAASQSFLQPG HHHHHHHCHHHCCCC	19.82	25619855
992	Phosphorylation	ALIAASQSFLQPGGK HHHHHCHHHCCCCCE	25.98	25619855
999	Ubiquitination	SFLQPGGKMVAAAKA HHCCCCCEEHHHHHC	35.80	-
1021	Phosphorylation	QASAMQLSQCAKNLG HHHHHHHHHHHHHHH	13.30	29472430
1023	Glutathionylation	SAMQLSQCAKNLGTA HHHHHHHHHHHHHHH	5.38	24333276
1045	Glutathionylation	AQKAQEACGPLEMDS HHHHHHHHCCCCHHH	5.92	24333276
1052	Phosphorylation	CGPLEMDSALSVVQN HCCCCHHHHHHHHHH	29.78	28638064
1055	Phosphorylation	LEMDSALSVVQNLEK CCHHHHHHHHHHHHH	21.69	26824392
1068	Ubiquitination	EKDLQEIKAAARDGK HHHHHHHHHHHHCCC	31.08	-
1083	Phosphorylation	LKPLPGETMEKCTQD CCCCCCCHHHHHHHH	36.22	29514104
1087	Glutathionylation	PGETMEKCTQDLGNS CCCHHHHHHHHCCHH	2.35	24333276
1096	Ubiquitination	QDLGNSTKAVSSAIA HHCCHHHHHHHHHHH	46.76	-
1116	Phosphorylation	IAQGNENYAGIAARD HHHCCCCCCHHHHHH	10.46	26824392
1142	Phosphorylation	ARGVAALTSDPAVQA HHHHHHHCCCHHHHH	26.76	23984901
1143	Phosphorylation	RGVAALTSDPAVQAI HHHHHHCCCHHHHHH	42.31	26824392
1154	Phosphorylation	VQAIVLDTASDVLDK HHHHEEECHHHHHHH	24.73	21183079
1156	Phosphorylation	AIVLDTASDVLDKAS HHEEECHHHHHHHHH	30.28	26824392
1163	Phosphorylation	SDVLDKASSLIEEAK HHHHHHHHHHHHHHH	31.27	26824392
1164	Phosphorylation	DVLDKASSLIEEAKK HHHHHHHHHHHHHHH	37.92	25521595
1190	Acetylation	QRLAQVAKAVTQALN HHHHHHHHHHHHHHH	44.53	22826441
1190	Ubiquitination	QRLAQVAKAVTQALN HHHHHHHHHHHHHHH	44.53	-
1199	S-nitrosocysteine	VTQALNRCVSCLPGQ HHHHHHHHHHCCCCC	2.28	-
1199	S-nitrosylation	VTQALNRCVSCLPGQ HHHHHHHHHHCCCCC	2.28	20925432
1201	Phosphorylation	QALNRCVSCLPGQRD HHHHHHHHCCCCCCC	17.35	24453211
1225	Phosphorylation	DASKRLLSDSLPPST HHHHHHHHCCCCCCC	29.73	27180971
1227	Phosphorylation	SKRLLSDSLPPSTGT HHHHHHCCCCCCCCH	39.12	26824392
1234	Phosphorylation	SLPPSTGTFQEAQSR CCCCCCCHHHHHHHH	23.41	22942356
1254	Phosphorylation	AGLNQAATELVQASR HHHHHHHHHHHHHCC	32.63	28638064
1260	Phosphorylation	ATELVQASRGTPQDL HHHHHHHCCCCHHHH	17.72	27087446
1263	Phosphorylation	LVQASRGTPQDLARA HHHHCCCCHHHHHHH	19.37	26824392
1271	Phosphorylation	PQDLARASGRFGQDF HHHHHHHCCCCCCCH	25.58	29514104
1303	Phosphorylation	EDRAQVVSNLKGISM HHHHHHHHHHCCCCC	37.27	25338131
1306	Acetylation	AQVVSNLKGISMSSS HHHHHHHCCCCCCHH	59.45	23806337
1306	Succinylation	AQVVSNLKGISMSSS HHHHHHHCCCCCCHH	59.45	23806337
1306	Ubiquitination	AQVVSNLKGISMSSS HHHHHHHCCCCCCHH	59.45	-
1313	Phosphorylation	KGISMSSSKLLLAAK CCCCCCHHHHHHHHH	21.73	25195567
1314	Acetylation	GISMSSSKLLLAAKA CCCCCHHHHHHHHHH	45.14	22826441
1323	Phosphorylation	LLAAKALSTDPASPN HHHHHHHCCCCCCCC	35.31	27180971
1324	Phosphorylation	LAAKALSTDPASPNL HHHHHHCCCCCCCCH	47.02	28833060
1328	Phosphorylation	ALSTDPASPNLKSQL HHCCCCCCCCHHHHH	21.51	25521595
1332	Ubiquitination	DPASPNLKSQLAAAA CCCCCCHHHHHHHHH	42.68	-
1353	Glutathionylation	INQLITMCTQQAPGQ HHHHHHHHHCCCCCH	2.02	24333276
1392	Glutathionylation	NDMSYFGCLDSVMEN CCCCCCCCHHHHHHC	2.46	24333276
1445	Phosphorylation	EAAAQAAYLVGVSDP HHHHHHHHHHCCCCC	12.63	-
1503	Phosphorylation	TIVAKHTSALCNSCR HHHHHHHHHHHHHHH	20.97	26824392
1506	Glutathionylation	AKHTSALCNSCRLAS HHHHHHHHHHHHHCC	3.35	24333276
1509	Glutathionylation	TSALCNSCRLASART HHHHHHHHHHCCCCC	2.29	24333276
1535	Phosphorylation	SAKEVANSTANLVKT HHHHHHHHHHHHHHH	21.11	29514104
1541	Acetylation	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	23236377
1541	Ubiquitination	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	-
1544	Acetylation	ANLVKTIKALDGDFT HHHHHHHHHHCCCCC	48.40	23806337
1544	Ubiquitination	ANLVKTIKALDGDFT HHHHHHHHHHCCCCC	48.40	-
1558	Glutathionylation	TEENRAQCRAATAPL CHHHHHHHHHHHHHH	2.89	24333276
1589	Phosphorylation	SSVPAQISPEGRAAM CCCCCCCCCCCHHCC	12.57	27180971
1631	Phosphorylation	PRDPPRWSVLAGHSR CCCCCCCHHHHCCCC	14.45	26824392
1637	Phosphorylation	WSVLAGHSRTVSDSI CHHHHCCCCCHHHHH	28.82	23984901
1639	Phosphorylation	VLAGHSRTVSDSIKK HHHCCCCCHHHHHHH	27.63	28285833
1641	Phosphorylation	AGHSRTVSDSIKKLI HCCCCCHHHHHHHHH	25.65	30352176
1643	Phosphorylation	HSRTVSDSIKKLITS CCCCHHHHHHHHHHH	28.89	21743459
1661	S-nitrosocysteine	KAPGQLECETAIAAL CCCCCCHHHHHHHHH	8.39	-
1661	Glutathionylation	KAPGQLECETAIAAL CCCCCCHHHHHHHHH	8.39	24333276
1661	S-nitrosylation	KAPGQLECETAIAAL CCCCCCHHHHHHHHH	8.39	20925432
1679	Phosphorylation	LRDLDQASLAAVSQQ HHCHHHHHHHHHHHH	16.95	26824392
1694	Phosphorylation	LAPREGISQEALHTQ HCCCCCCCHHHHHHH	32.59	24719451
1742	Phosphorylation	AQYFEPLTLAAVGAA HHHHHHHHHHHHHHH	25.68	22802335
1750	Phosphorylation	LAAVGAASKTLSHPQ HHHHHHHHHCCCCHH	26.16	22802335
1767	Phosphorylation	ALLDQTKTLAESALQ HHHHHHHHHHHHHHH	34.29	-
1771	Phosphorylation	QTKTLAESALQLLYT HHHHHHHHHHHHHHH	28.77	-
1777	Phosphorylation	ESALQLLYTAKEAGG HHHHHHHHHHHHCCC	17.16	22817900
1778	Phosphorylation	SALQLLYTAKEAGGN HHHHHHHHHHHCCCC	31.09	22345495
1780	Acetylation	LQLLYTAKEAGGNPK HHHHHHHHHCCCCHH	40.05	22826441
1849	Phosphorylation	PMGDPEGSFVDYQTT CCCCCCCCCCCCHHH	22.04	-
1855	Phosphorylation	GSFVDYQTTMVRTAK CCCCCCHHHHHHHHH	15.61	-
1875	Phosphorylation	VQEMVTKSNTSPEEL HHHHHHCCCCCHHHH	35.65	27180971
1877	Phosphorylation	EMVTKSNTSPEELGP HHHHCCCCCHHHHHH	53.39	23737553
1878	Phosphorylation	MVTKSNTSPEELGPL HHHCCCCCHHHHHHH	34.27	23737553
1893	Phosphorylation	ANQLTSDYGRLASQA HHHHHHHHHHHHHCC	12.15	25338131
1917	Acetylation	EEIGAHIKHRVQELG CCHHHHHHHHHHHHC	18.58	22826441
1927	Glutathionylation	VQELGHGCSALVTKA HHHHCCCCCEEHHHC	1.46	24333276
1939	Glutathionylation	TKAGALQCSPSDVYT HHCCCCCCCHHHCCC	7.22	24333276
1940	Phosphorylation	KAGALQCSPSDVYTK HCCCCCCCHHHCCCH	17.93	25195567
1942	Phosphorylation	GALQCSPSDVYTKKE CCCCCCHHHCCCHHH	24.34	29472430
1945	Phosphorylation	QCSPSDVYTKKELIE CCCHHHCCCHHHHHH	20.17	29472430
1946	Phosphorylation	CSPSDVYTKKELIEC CCHHHCCCHHHHHHH	35.17	29472430
1960	Malonylation	CARRVSEKVSHVLAA HHHHHHHHHHHHHHH	41.34	26320211
1960	Ubiquitination	CARRVSEKVSHVLAA HHHHHHHHHHHHHHH	41.34	-
2021	Ubiquitination	DHREGILKTAKVLVE HHHCHHHHHHHHHHC	44.51	-
2024	Malonylation	EGILKTAKVLVEDTK CHHHHHHHHHHCCHH	41.14	26320211
2031	Acetylation	KVLVEDTKVLVQNAA HHHHCCHHHHHHCCC	45.99	23236377
2031	Malonylation	KVLVEDTKVLVQNAA HHHHCCHHHHHHCCC	45.99	26320211
2040	Phosphorylation	LVQNAAGSQEKLAQA HHHCCCCCHHHHHHH	30.36	25521595
2043	Acetylation	NAAGSQEKLAQAAQS CCCCCHHHHHHHHHH	41.30	23236377
2043	Ubiquitination	NAAGSQEKLAQAAQS CCCCCHHHHHHHHHH	41.30	-
2068	Phosphorylation	VVKLGAASLGAEDPE HHHHCHHHCCCCCCC	27.14	26824392
2089	Ubiquitination	NAVKDVAKALGDLIS HHHHHHHHHHHHHHH	43.95	-
2098	O-linked_Glycosylation	LGDLISATKAAAGKV HHHHHHHHHHHCCCC	17.90	29187734
2099	Acetylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	23806337
2099	Malonylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	26320211
2099	Succinylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	23806337
2099	Ubiquitination	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	-
2115	Acetylation	DPAVWQLKNSAKVMV CHHHHHCCCCCEEEE	33.48	23236377
2117	Phosphorylation	AVWQLKNSAKVMVTN HHHHCCCCCEEEEEE	28.07	19854140
2123	Phosphorylation	NSAKVMVTNVTSLLK CCCEEEEEEHHHHHH	13.08	29233185
2126	Phosphorylation	KVMVTNVTSLLKTVK EEEEEEHHHHHHHHH	18.74	19854140
2127	Phosphorylation	VMVTNVTSLLKTVKA EEEEEHHHHHHHHHH	27.67	27180971
2130	Acetylation	TNVTSLLKTVKAVED EEHHHHHHHHHHHHH	57.47	23236377
2130	Ubiquitination	TNVTSLLKTVKAVED EEHHHHHHHHHHHHH	57.47	-
2131	Phosphorylation	NVTSLLKTVKAVEDE EHHHHHHHHHHHHHH	27.49	22418434
2133	Malonylation	TSLLKTVKAVEDEAT HHHHHHHHHHHHHCH	52.53	26320211
2140	Phosphorylation	KAVEDEATKGTRALE HHHHHHCHHCHHHHH	28.14	22418434
2150	Phosphorylation	TRALEATTEHIRQEL HHHHHHHHHHHHHHH	32.39	28059163
2162	Phosphorylation	QELAVFCSPEPPAKT HHHHHHCCCCCCCCC	22.34	26745281
2169	Phosphorylation	SPEPPAKTSTPEDFI CCCCCCCCCCHHHHH	39.68	24759943
2170	Phosphorylation	PEPPAKTSTPEDFIR CCCCCCCCCHHHHHH	41.06	25195567
2171	Phosphorylation	EPPAKTSTPEDFIRM CCCCCCCCHHHHHHH	35.61	27180971
2188	Ubiquitination	GITMATAKAVAAGNS CCHHHHHHHHHCCCC	38.75	-
2196	Glutathionylation	AVAAGNSCRQEDVIA HHHCCCCCCHHHHHH	6.37	24333276
2270	Phosphorylation	PDLKQQLTGHSKRVA CCHHHHHHCCCHHHH	28.63	27149854
2273	Phosphorylation	KQQLTGHSKRVAGSV HHHHHCCCHHHHHHH	24.41	19144319
2333	Ubiquitination	LKPRAKPKEADESLN CCCCCCCCCCCCCCC	65.90	-
2338	Phosphorylation	KPKEADESLNFEEQI CCCCCCCCCCHHHHH	29.21	25159016
2351	Phosphorylation	QILEAAKSIAAATSA HHHHHHHHHHHHHHH	16.84	26824392
2408	S-nitrosocysteine	AAATNNLCEAANAAV HHHHCCHHHHHHHHH	3.48	-
2408	S-nitrosylation	AAATNNLCEAANAAV HHHHCCHHHHHHHHH	3.48	20925432
2426	Phosphorylation	ASQEKLISSAKQVAA CCHHHHHHHHHHHHH	34.38	20139300
2450	Phosphorylation	KVKADQDSEAMKRLQ HCCCCCCHHHHHHHH	22.94	22802335
2454	Trimethylation	DQDSEAMKRLQAAGN CCCHHHHHHHHHHHH	57.94	-
2454	Methylation	DQDSEAMKRLQAAGN CCCHHHHHHHHHHHH	57.94	-
2464	Acetylation	QAAGNAVKRASDNLV HHHHHHHHHHHHHHH	39.58	23806337
2464	Succinylation	QAAGNAVKRASDNLV HHHHHHHHHHHHHHH	39.58	23806337
2467	Phosphorylation	GNAVKRASDNLVKAA HHHHHHHHHHHHHHH	30.94	18779572
2476	Ubiquitination	NLVKAAQKAAAFEDQ HHHHHHHHHHHCCCC	34.95	-
2491	Ubiquitination	ENETVVVKEKMVGGI CCCEEEEEEEHHHHH	39.75	-
2530	Phosphorylation	AQIRQQQYKFLPSEL HHHHHHHHCCCCHHH	10.20	29514104
2535	Phosphorylation	QQYKFLPSELRDEH- HHHCCCCHHHCCCC-	51.95	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TLN1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TLN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TLN1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
PI51C_HUMAN	PIP5K1C	physical	12782621

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TLN1_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2273, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2040, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis."; Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.; J. Proteome Res. 7:3957-3967(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2040, AND MASSSPECTROMETRY.	18630941 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1116, AND MASSSPECTROMETRY.	18034455 [Abstract]