AHSA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AHSA1_MOUSE
• UniProt AC: Q8BK64
• Protein Name: Activator of 90 kDa heat shock protein ATPase homolog 1
• Gene Name: Ahsa1
• Organism: Mus musculus (Mouse).
• Sequence Length: 338
• Subcellular Localization: Cytoplasm, cytosol . Endoplasmic reticulum . May transiently interact with the endoplasmic reticulum.
• Protein Description: Acts as a co-chaperone of HSP90AA1. [PubMed: 29127155 Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity]
• Protein Sequence: MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTEKLKTLFLAVRVENEEGKCEVTEVNKLDGEASINNRKGKLIFFYEWTIKLNWTGTSKSGVQYKGHVEIPNLSDENSVDEVEISVSLAKDEPDTNLVALMKEDGVKLLREAVGIYISTLKTEFTQGMILPTVNGESVDPVGQPALKTETCKAKSAPSKSQAKPVGVKIPTCKITLKETFLTSPEELYRVFTTQELVQAFTHAPAALEADRGGKFHMVDGNVTGEFTDLVPEKHIAMKWRFKSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYGARLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKWGEGDPR -----CCCCCCCCCC	55.20	23806337
56	S-nitrosocysteine	VENEEGKCEVTEVNK EECCCCCEEEEEEEE	8.16	-
56	S-nitrosylation	VENEEGKCEVTEVNK EECCCCCEEEEEEEE	8.16	21278135
69	Phosphorylation	NKLDGEASINNRKGK EECCCEEEECCCCCE	22.88	25159016
193	Phosphorylation	CKAKSAPSKSQAKPV CCCCCCCCHHHCCCC	44.66	-
194	Acetylation	KAKSAPSKSQAKPVG CCCCCCCHHHCCCCC	45.59	23806337
195	Phosphorylation	AKSAPSKSQAKPVGV CCCCCCHHHCCCCCC	39.44	81018081
198	Malonylation	APSKSQAKPVGVKIP CCCHHHCCCCCCCCC	32.38	26320211
203	Malonylation	QAKPVGVKIPTCKIT HCCCCCCCCCCCEEE	36.72	26320211
208	Malonylation	GVKIPTCKITLKETF CCCCCCCEEEEEEEC	41.00	26320211
212	Acetylation	PTCKITLKETFLTSP CCCEEEEEEECCCCH	46.16	23236377
217	Phosphorylation	TLKETFLTSPEELYR EEEEECCCCHHHHHH	37.74	29899451
218	Phosphorylation	LKETFLTSPEELYRV EEEECCCCHHHHHHH	32.25	25338131
223	Phosphorylation	LTSPEELYRVFTTQE CCCHHHHHHHCCHHH	14.17	-
249	Acetylation	LEADRGGKFHMVDGN EECCCCCCEEEECCC	34.61	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
223	Y	Phosphorylation	Kinase	ABL	P00520	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AHSA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AHSA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of AHSA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.