RL18A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL18A_MOUSE
• UniProt AC: P62717
• Protein Name: 60S ribosomal protein L18a
• Gene Name: Rpl18a
• Organism: Mus musculus (Mouse).
• Sequence Length: 176
• Protein Sequence: MKASGTLREYKVVGRCLPTPKCHTPPLYRMRIFAPNHVVAKSRFWYFVSQLKKMKKSSGEIVYCGQVFEKSPLRVKNFGIWLRYDSRSGTHNMYREYRDLTTAGAVTQCYRDMGARHRARAHSIQIMKVEEIAAGKCRRPAVKQFHDSKIKFPLPHRVLRRQHKPRFTTKRPNTFF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MKASGTLREYK ----CCCCCCCEEEE	27.13	25338131
6	Phosphorylation	--MKASGTLREYKVV --CCCCCCCEEEEEE	21.83	29550500
10	Phosphorylation	ASGTLREYKVVGRCL CCCCCEEEEEEEEEC	11.58	29514104
11	Ubiquitination	SGTLREYKVVGRCLP CCCCEEEEEEEEECC	26.20	27667366
11	Acetylation	SGTLREYKVVGRCLP CCCCEEEEEEEEECC	26.20	23806337
11	Malonylation	SGTLREYKVVGRCLP CCCCEEEEEEEEECC	26.20	26320211
11	Succinylation	SGTLREYKVVGRCLP CCCCEEEEEEEEECC	26.20	-
16	S-nitrosylation	EYKVVGRCLPTPKCH EEEEEEEECCCCCCC	4.37	24926564
22	S-nitrosylation	RCLPTPKCHTPPLYR EECCCCCCCCCCEEE	4.56	24926564
22	Glutathionylation	RCLPTPKCHTPPLYR EECCCCCCCCCCEEE	4.56	24333276
24	Phosphorylation	LPTPKCHTPPLYRMR CCCCCCCCCCEEEEE	35.75	26745281
49	Phosphorylation	SRFWYFVSQLKKMKK HHHHHHHHHHHHHHC	21.64	-
52	Acetylation	WYFVSQLKKMKKSSG HHHHHHHHHHHCCCC	43.09	22826441
57	Phosphorylation	QLKKMKKSSGEIVYC HHHHHHCCCCCEEEE	37.75	23984901
58	Phosphorylation	LKKMKKSSGEIVYCG HHHHHCCCCCEEEEC	49.69	23984901
63	Phosphorylation	KSSGEIVYCGQVFEK CCCCCEEEECEEEEC	9.12	22817900
64	Glutathionylation	SSGEIVYCGQVFEKS CCCCEEEECEEEECC	1.81	24333276
64	S-nitrosylation	SSGEIVYCGQVFEKS CCCCEEEECEEEECC	1.81	24895380
64	S-palmitoylation	SSGEIVYCGQVFEKS CCCCEEEECEEEECC	1.81	28526873
64	S-nitrosocysteine	SSGEIVYCGQVFEKS CCCCEEEECEEEECC	1.81	-
70	Ubiquitination	YCGQVFEKSPLRVKN EECEEEECCCEEEEE	46.00	22790023
70	Acetylation	YCGQVFEKSPLRVKN EECEEEECCCEEEEE	46.00	22826441
71	Phosphorylation	CGQVFEKSPLRVKNF ECEEEECCCEEEEEE	23.20	26824392
76	Succinylation	EKSPLRVKNFGIWLR ECCCEEEEEEEEEEE	39.87	23806337
76	Succinylation	EKSPLRVKNFGIWLR ECCCEEEEEEEEEEE	39.87	-
76	Acetylation	EKSPLRVKNFGIWLR ECCCEEEEEEEEEEE	39.87	23806337
84	Phosphorylation	NFGIWLRYDSRSGTH EEEEEEEEECCCCCC	18.99	25168779
86	Phosphorylation	GIWLRYDSRSGTHNM EEEEEEECCCCCCHH	21.29	25168779
88	Phosphorylation	WLRYDSRSGTHNMYR EEEEECCCCCCHHHH	52.58	25168779
90	Phosphorylation	RYDSRSGTHNMYREY EEECCCCCCHHHHHH	16.01	25168779
109	S-nitrosylation	TAGAVTQCYRDMGAR HHHHHHHHHHHHCHH	1.88	24895380
109	Glutathionylation	TAGAVTQCYRDMGAR HHHHHHHHHHHHCHH	1.88	24333276
109	S-palmitoylation	TAGAVTQCYRDMGAR HHHHHHHHHHHHCHH	1.88	28526873
109	S-nitrosocysteine	TAGAVTQCYRDMGAR HHHHHHHHHHHHCHH	1.88	-
111	Methylation	GAVTQCYRDMGARHR HHHHHHHHHHCHHHH	34.76	16287717
116	Methylation	CYRDMGARHRARAHS HHHHHCHHHHHHHCE	17.69	16287727
123	Phosphorylation	RHRARAHSIQIMKVE HHHHHHCEEEEEEHH	18.40	26824392
128	Acetylation	AHSIQIMKVEEIAAG HCEEEEEEHHHHHCC	48.39	22826441
136	Succinylation	VEEIAAGKCRRPAVK HHHHHCCCCCCHHHH	21.60	23806337
136	Acetylation	VEEIAAGKCRRPAVK HHHHHCCCCCCHHHH	21.60	23806337
136	Ubiquitination	VEEIAAGKCRRPAVK HHHHHCCCCCCHHHH	21.60	-
137	Glutathionylation	EEIAAGKCRRPAVKQ HHHHCCCCCCHHHHH	4.34	24333276
143	Ubiquitination	KCRRPAVKQFHDSKI CCCCHHHHHHCCCCC	49.72	-
151	Acetylation	QFHDSKIKFPLPHRV HHCCCCCCCCCCHHH	44.67	23806337
151	Succinylation	QFHDSKIKFPLPHRV HHCCCCCCCCCCHHH	44.67	23806337
151	Ubiquitination	QFHDSKIKFPLPHRV HHCCCCCCCCCCHHH	44.67	-
170	Acetylation	HKPRFTTKRPNTFF- CCCCCCCCCCCCCC-	63.90	23201123

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL18A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL18A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL18A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL18A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-123, AND MASSSPECTROMETRY.
PubMed: 19367708