STML2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STML2_MOUSE
• UniProt AC: Q99JB2
• Protein Name: Stomatin-like protein 2, mitochondrial
• Gene Name: Stoml2
• Organism: Mus musculus (Mouse).
• Sequence Length: 353
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Mitochondrion . Mitochondrion inner membrane ; Lipid-anchor . Mitochondrion intermembrane space . Membrane raft . Cytoplasm, cytoskeleton . Behaves as an integral membrane protein of the mitochondrion des
• Protein Description: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation..
• Protein Sequence: MLARAARGTGALLLRGSVQASGRVPRRASSGLPRNTVILFVPQQEAWVVERMGRFHRILEPGLNVLIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNANIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAGALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTVLLPSNPSDVTSMVAQAMGVYGALTKAPVPGAQNSSQSRRDVQATDTSIEELGRVKLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	GALLLRGSVQASGRV CCEEEECCCCCCCCC	12.48	-
21	Phosphorylation	LRGSVQASGRVPRRA EECCCCCCCCCCCCC	15.27	23737553
29	Phosphorylation	GRVPRRASSGLPRNT CCCCCCCCCCCCCCE	24.11	28066266
30	Phosphorylation	RVPRRASSGLPRNTV CCCCCCCCCCCCCEE	43.28	28066266
114	Acetylation	LRIMDPYKASYGVED EEECCCCHHHCCCCC	35.92	23236377
114	Succinylation	LRIMDPYKASYGVED EEECCCCHHHCCCCC	35.92	23954790
124	Phosphorylation	YGVEDPEYAVTQLAQ CCCCCHHHHHHHHHH	16.26	-
140	Acetylation	TMRSELGKLSLDKVF HHHHHHHHHCHHHHH	47.75	23201123
142	Phosphorylation	RSELGKLSLDKVFRE HHHHHHHCHHHHHHH	37.70	-
145	Acetylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	23576753
145	Succinylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	-
145	Succinylation	LGKLSLDKVFRERES HHHHCHHHHHHHHHH	48.87	23806337
167	S-palmitoylation	AINQAADCWGIRCLR HHHHHHHHHCCEEEE	2.84	28526873
167	Glutathionylation	AINQAADCWGIRCLR HHHHHHHHHCCEEEE	2.84	24333276
221	Acetylation	AINVAEGKKQAQILA HHHHHHHHHHHHHHH	32.97	23806337
221	Succinylation	AINVAEGKKQAQILA HHHHHHHHHHHHHHH	32.97	23806337
222	Acetylation	INVAEGKKQAQILAS HHHHHHHHHHHHHHH	62.82	2388683
233	Succinylation	ILASEAEKAEQINQA HHHHHHHHHHHHHHH	65.36	23806337
233	Acetylation	ILASEAEKAEQINQA HHHHHHHHHHHHHHH	65.36	23576753
275	Phosphorylation	HNGDAAASLTVAEQY CCCCHHHHHHHHHHH	21.61	-
277	Phosphorylation	GDAAASLTVAEQYVS CCHHHHHHHHHHHHH	18.38	-
288	Acetylation	QYVSAFSKLAKDSNT HHHHHHHHHHCCCCC	46.11	23954790
293	Phosphorylation	FSKLAKDSNTVLLPS HHHHHCCCCCEECCC	33.42	22802335
295	Phosphorylation	KLAKDSNTVLLPSNP HHHCCCCCEECCCCH	19.24	22802335
300	Phosphorylation	SNTVLLPSNPSDVTS CCCEECCCCHHHHHH	62.43	22802335
330	Phosphorylation	PVPGAQNSSQSRRDV CCCCCCCCCCCHHHH	20.06	-
331	Phosphorylation	VPGAQNSSQSRRDVQ CCCCCCCCCCHHHHH	39.46	23684622
333	Phosphorylation	GAQNSSQSRRDVQAT CCCCCCCCHHHHHCC	31.09	23684622
340	Phosphorylation	SRRDVQATDTSIEEL CHHHHHCCCCCHHHH	23.79	29472430
342	Phosphorylation	RDVQATDTSIEELGR HHHHCCCCCHHHHCC	27.52	29472430
343	Phosphorylation	DVQATDTSIEELGRV HHHCCCCCHHHHCCC	30.71	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
17	S	Phosphorylation	Kinase	PRKCZ	Q02956	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STML2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STML2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of STML2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.