| UniProt ID | PRDX4_MOUSE | |
|---|---|---|
| UniProt AC | O08807 | |
| Protein Name | Peroxiredoxin-4 | |
| Gene Name | Prdx4 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 274 | |
| Subcellular Localization | Cytoplasm . Endoplasmic reticulum . Not secreted. | |
| Protein Description | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. [PubMed: 11229364 Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation (By similarity] | |
| Protein Sequence | MEARSKLLDGTTASRRWTRKLVLLLPPLLLFLLRTESLQGLESDERFRTRENECHFYAGGQVYPGEASRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 6 | Ubiquitination | --MEARSKLLDGTTA --CCCHHHHCCCCCC | 47.73 | 27667366 | |
| 54 | Glutathionylation | FRTRENECHFYAGGQ HHCCCCCCEEEECCE | 3.97 | 24333276 | |
| 54 | S-nitrosylation | FRTRENECHFYAGGQ HHCCCCCCEEEECCE | 3.97 | 22178444 | |
| 85 | Phosphorylation | HLSKAKISKPAPYWE EECCCCCCCCCCCCE | 31.70 | 21454597 | |
| 90 | Phosphorylation | KISKPAPYWEGTAVI CCCCCCCCCEEEEEE | 20.42 | 21454597 | |
| 94 | Phosphorylation | PAPYWEGTAVINGEF CCCCCEEEEEECCEE | 13.26 | 21454597 | |
| 151 | S-nitrosocysteine | INTEVVACSVDSQFT CCCEEEEEEECCCCE | 2.48 | - | |
| 151 | Glutathionylation | INTEVVACSVDSQFT CCCEEEEEEECCCCE | 2.48 | 24333276 | |
| 151 | S-nitrosylation | INTEVVACSVDSQFT CCCEEEEEEECCCCE | 2.48 | 20925432 | |
| 151 | S-palmitoylation | INTEVVACSVDSQFT CCCEEEEEEECCCCE | 2.48 | 28526873 | |
| 211 | Methylation | GLFIIDDKGVLRQIT EEEEECCCCEEEEEE | 47.36 | - | |
| 211 | Acetylation | GLFIIDDKGVLRQIT EEEEECCCCEEEEEE | 47.36 | 22826441 | |
| 243 | Ubiquitination | QAFQYTDKHGEVCPA HHHHCCCCCCCCCCC | 45.79 | - | |
| 253 | Acetylation | EVCPAGWKPGSETII CCCCCCCCCCCCEEC | 38.29 | 22826441 | |
| 268 | Ubiquitination | PDPAGKLKYFDKLN- CCCCCCCCEECCCC- | 47.56 | - | |
| 272 | Ubiquitination | GKLKYFDKLN----- CCCCEECCCC----- | 39.78 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of PRDX4_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of PRDX4_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of PRDX4_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of PRDX4_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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