TCTP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCTP_MOUSE
• UniProt AC: P63028
• Protein Name: Translationally-controlled tumor protein
• Gene Name: Tpt1
• Organism: Mus musculus (Mouse).
• Sequence Length: 172
• Subcellular Localization: Cytoplasm.
• Protein Description: Involved in calcium binding and microtubule stabilization..
• Protein Sequence: MIIYRDLISHDELFSDIYKIREIADGLCLEVEGKMVSRTEGAIDDSLIGGNASAEGPEGEGTESTVVTGVDIVMNHHLQETSFTKEAYKKYIKDYMKSLKGKLEEQKPERVKPFMTGAAEQIKHILANFNNYQFFIGENMNPDGMVALLDYREDGVTPFMIFFKDGLEMEKC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	IIYRDLISHDELFSD CEEHHCCCCHHHHHH	31.98	26370283
19	Ubiquitination	ELFSDIYKIREIADG HHHHHHHHHHHHHHC	35.30	22790023
19	Acetylation	ELFSDIYKIREIADG HHHHHHHHHHHHHHC	35.30	22826441
28	S-nitrosocysteine	REIADGLCLEVEGKM HHHHHCCEEEEECEE	3.58	-
28	S-nitrosylation	REIADGLCLEVEGKM HHHHHCCEEEEECEE	3.58	21278135
28	Glutathionylation	REIADGLCLEVEGKM HHHHHCCEEEEECEE	3.58	24333276
39	Phosphorylation	EGKMVSRTEGAIDDS ECEEEECCCCCCCCC	31.12	25619855
46	Phosphorylation	TEGAIDDSLIGGNAS CCCCCCCCCCCCCCC	20.38	21082442
53	Phosphorylation	SLIGGNASAEGPEGE CCCCCCCCCCCCCCC	30.74	25619855
62	Phosphorylation	EGPEGEGTESTVVTG CCCCCCCCCCEEEEE	23.59	25619855
64	Phosphorylation	PEGEGTESTVVTGVD CCCCCCCCEEEEECC	26.75	25619855
65	Phosphorylation	EGEGTESTVVTGVDI CCCCCCCEEEEECCE	16.86	25619855
68	Phosphorylation	GTESTVVTGVDIVMN CCCCEEEEECCEEEC	27.44	25619855
93	Acetylation	EAYKKYIKDYMKSLK HHHHHHHHHHHHHHC	39.45	23201123
93	Malonylation	EAYKKYIKDYMKSLK HHHHHHHHHHHHHHC	39.45	26320211
97	Malonylation	KYIKDYMKSLKGKLE HHHHHHHHHHCCHHH	46.54	26320211
97	Acetylation	KYIKDYMKSLKGKLE HHHHHHHHHHCCHHH	46.54	22826441
102	Acetylation	YMKSLKGKLEEQKPE HHHHHCCHHHHCCCH	51.65	22826441
107	Ubiquitination	KGKLEEQKPERVKPF CCHHHHCCCHHCCCC	52.72	-
107	Acetylation	KGKLEEQKPERVKPF CCHHHHCCCHHCCCC	52.72	23806337
112	Ubiquitination	EQKPERVKPFMTGAA HCCCHHCCCCCCCHH	38.47	27667366
112	Malonylation	EQKPERVKPFMTGAA HCCCHHCCCCCCCHH	38.47	26320211
112	Acetylation	EQKPERVKPFMTGAA HCCCHHCCCCCCCHH	38.47	22826441
164	Ubiquitination	TPFMIFFKDGLEMEK CCEEEEECCCCCEEC	39.89	22790023
172	S-nitrosocysteine	DGLEMEKC------- CCCCEECC-------	4.26	-
172	Glutathionylation	DGLEMEKC------- CCCCEECC-------	4.26	24333276
172	S-nitrosylation	DGLEMEKC------- CCCCEECC-------	4.26	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
46	S	Phosphorylation	Kinase	PLK1	P53350	PSP
46	S	Phosphorylation	Kinase	PLK1	Q07832	PSP
46	S	Phosphorylation	Kinase	PLK-FAMILY	-	GPS
64	S	Phosphorylation	Kinase	PLK1	P53350	PSP
64	S	Phosphorylation	Kinase	PLK1	Q07832	Uniprot
64	S	Phosphorylation	Kinase	PLK-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCTP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCTP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NUCL_MOUSE	Ncl	physical	21048921

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.