HEM3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM3_MOUSE
• UniProt AC: P22907
• Protein Name: Porphobilinogen deaminase
• Gene Name: Hmbs
• Organism: Mus musculus (Mouse).
• Sequence Length: 361
• Protein Description: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps..
• Protein Sequence: MSGNGGAATTAEENGSKMRVIRVGTRKSQLARIQTDTVVAMLKALYPGIQFEIIAMSTTGDKILDTALSKIGEKSLFTKELENALEKNEVDLVVHSLKDVPTILPPGFTIGAICKRENPCDAVVFHPKFIGKTLETLPEKSAVGTSSLRRVAQLQRKFPHLEFKSIRGNLNTRLRKLDELQEFSAIVLAVAGLQRMGWQNRVGQILHPEECMYAVGQGALAVEVRAKDQDILDLVSVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTVMKDGQLYLTGGVWSLDGSDSMQETMQATIQVPVQQEDGPEDDPQLVGITARNIPRGAQLAAENLGISLASLLLNKGAKNILDVARQLNDVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGNGGAAT ------CCCCCCCCC	40.75	-
35	Phosphorylation	SQLARIQTDTVVAML HHHHHHHHHHHHHHH	31.13	-
69	Phosphorylation	KILDTALSKIGEKSL HHHHHHHHHHCHHHH	21.55	27841257
70	Ubiquitination	ILDTALSKIGEKSLF HHHHHHHHHCHHHHH	56.43	22790023
74	Acetylation	ALSKIGEKSLFTKEL HHHHHCHHHHHHHHH	47.44	23806337
79	Ubiquitination	GEKSLFTKELENALE CHHHHHHHHHHHHHH	53.63	22790023
87	Acetylation	ELENALEKNEVDLVV HHHHHHHHCCCCEEE	60.29	23954790
128	Ubiquitination	DAVVFHPKFIGKTLE CEEEECHHHCCCCHH	40.83	22790023
132	Acetylation	FHPKFIGKTLETLPE ECHHHCCCCHHCCCC	45.16	22826441
136	Phosphorylation	FIGKTLETLPEKSAV HCCCCHHCCCCCCCC	51.21	24719451
140	Ubiquitination	TLETLPEKSAVGTSS CHHCCCCCCCCCHHH	41.60	22790023
147	Phosphorylation	KSAVGTSSLRRVAQL CCCCCHHHHHHHHHH	26.23	23140645
227	Ubiquitination	LAVEVRAKDQDILDL EEEEEEECCCCHHHH	45.41	-
261	S-(dipyrrolylmethanemethyl)cysteine	LRHLEGGCSVPVAVH HHHHCCCCCCCEEEE	5.65	-
261	Pyrrolylation	LRHLEGGCSVPVAVH HHHHCCCCCCCEEEE	5.65	-
348	Ubiquitination	LLLNKGAKNILDVAR HHHCHHHHHHHHHHH	53.87	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RANB9_MOUSE	Ranbp9	physical	12917623

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.