IF5A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A2_MOUSE
• UniProt AC: Q8BGY2
• Protein Name: Eukaryotic translation initiation factor 5A-2
• Gene Name: Eif5a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 153
• Subcellular Localization: Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the loca
• Protein Description: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity)..
• Protein Sequence: MADEIDFTTGDAGASSTYPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDYQLICIQDGYLSLLTETGEVREDLKLPEGELGKEIEGKYNAGEDVQVSVMCAMSEEYAVAIKPCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADEIDFTT ------CCCCCEECC	24.12	-
27	Ubiquitination	MQCSALRKNGFVVLK CCCHHEECCCEEEEC	63.37	-
38	S-nitrosocysteine	VVLKGRPCKIVEMST EEECCCEEEEEEEEC	4.53	-
38	S-nitrosylation	VVLKGRPCKIVEMST EEECCCEEEEEEEEC	4.53	21278135
39	Ubiquitination	VLKGRPCKIVEMSTS EECCCEEEEEEEECC	53.09	-
44	Phosphorylation	PCKIVEMSTSKTGKH EEEEEEEECCCCCCC	18.94	28066266
45	Phosphorylation	CKIVEMSTSKTGKHG EEEEEEECCCCCCCC	32.69	28066266
46	Phosphorylation	KIVEMSTSKTGKHGH EEEEEECCCCCCCCC	22.40	28066266
47	Acetylation	IVEMSTSKTGKHGHA EEEEECCCCCCCCCE	62.48	37418437
50	Hypusine	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
50	Other	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
65	Phosphorylation	LVGIDIFTGKKYEDI EEEEECCCCCCHHHC	48.72	25367039
67	Ubiquitination	GIDIFTGKKYEDICP EEECCCCCCHHHCCC	49.47	-
68	Ubiquitination	IDIFTGKKYEDICPS EECCCCCCHHHCCCC	56.04	-
69	Phosphorylation	DIFTGKKYEDICPST ECCCCCCHHHCCCCC	23.48	25367039
73	S-palmitoylation	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	28526873
73	S-nitrosylation	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	24926564
73	S-nitrosocysteine	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	-
85	Ubiquitination	NMDVPNIKRNDYQLI CCCCCCCCCCCEEEE	52.36	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IF5A2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.