SRP68_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SRP68_MOUSE
• UniProt AC: Q8BMA6
• Protein Name: Signal recognition particle subunit SRP68
• Gene Name: Srp68
• Organism: Mus musculus (Mouse).
• Sequence Length: 625
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus.
• Protein Description: Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function (By similarity)..
• Protein Sequence: MAAEKQIPGGGSGGGGSGSGGGGGGSGGGRSAGGDENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKSAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDALQAVREELKPDQKQRDYALDGESGKVSNLQYLHSYLTYIKLSTAIRRNENMAKGLHRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDRTFQKEISLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVSSHGGASKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDSHQTDTSSQVKDNTPLVERFESFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Acetylation	---MAAEKQIPGGGS ---CCCCCCCCCCCC	49.12	23954790
12	Phosphorylation	KQIPGGGSGGGGSGS CCCCCCCCCCCCCCC	37.22	23684622
17	Phosphorylation	GGSGGGGSGSGGGGG CCCCCCCCCCCCCCC	32.82	25521595
19	Phosphorylation	SGGGGSGSGGGGGGS CCCCCCCCCCCCCCC	35.64	29514104
26	Phosphorylation	SGGGGGGSGGGRSAG CCCCCCCCCCCCCCC	37.22	29233185
31	Phosphorylation	GGSGGGRSAGGDENK CCCCCCCCCCCCCCC	34.24	25338131
38	Ubiquitination	SAGGDENKENERPSA CCCCCCCCCCCCCCC	60.93	27667366
47	Phosphorylation	NERPSAGSKANKEFG CCCCCCCHHHHHHHH	28.45	-
141	Ubiquitination	WSYAMQLKQEANTEP HHHHHHHHHHHCCCH	29.24	22790023
219	Ubiquitination	KCKTIYEKLASAFTE HHHHHHHHHHHCCCH	32.17	-
240	Phosphorylation	NQRVEEISPNIRYCA HHHHHHCCCCCCEEH	18.38	28066266
266	Phosphorylation	LMQMRLRSGGTEGLL HHHHHHHCCCCCHHH	46.28	25521595
269	Phosphorylation	MRLRSGGTEGLLAEK HHHHCCCCCHHHHHH	30.33	26745281
276	Ubiquitination	TEGLLAEKLEALITQ CCHHHHHHHHHHHHH	46.12	22790023
305	Malonylation	RGRTVPVKIDKVRIF CCCEECEEECEEEEE	38.83	26320211
305	Ubiquitination	RGRTVPVKIDKVRIF CCCEECEEECEEEEE	38.83	-
363	Phosphorylation	PDQKQRDYALDGESG CCHHHHCHHHCCCCC	15.97	29514104
451	Acetylation	EEDRTFQKEISLKTL CCCCCHHHHHHHHHH	53.47	-
451	Malonylation	EEDRTFQKEISLKTL CCCCCHHHHHHHHHH	53.47	26320211
490	Malonylation	VLYDRVLKYANEVSS HHHHHHHHHHHHHHH	39.19	26320211
490	Acetylation	VLYDRVLKYANEVSS HHHHHHHHHHHHHHH	39.19	23954790
491	Phosphorylation	LYDRVLKYANEVSSH HHHHHHHHHHHHHHC	15.53	-
496	Phosphorylation	LKYANEVSSHGGASK HHHHHHHHHCCCCCC	15.50	-
497	Phosphorylation	KYANEVSSHGGASKN HHHHHHHHCCCCCCC	31.18	-
502	Phosphorylation	VSSHGGASKNSLKDL HHHCCCCCCCCCCCC	35.33	27841257
503	Ubiquitination	SSHGGASKNSLKDLP HHCCCCCCCCCCCCC	50.45	-
503	Malonylation	SSHGGASKNSLKDLP HHCCCCCCCCCCCCC	50.45	26320211
505	Phosphorylation	HGGASKNSLKDLPDV CCCCCCCCCCCCCCH	40.30	29514104
558	Phosphorylation	PLVERFESFCLDPSL HHHHHHHHHHCCHHH	20.67	28066266
616	Phosphorylation	TKSGLTGYIKGIFGF HHCCHHHHHHHHCCC	8.33	29514104
625	Phosphorylation	KGIFGFRS------- HHHCCCCC-------	42.17	19060867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SRP68_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SRP68_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SRP68_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SRP68_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.