IF4A2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF4A2_MOUSE
• UniProt AC: P10630
• Protein Name: Eukaryotic initiation factor 4A-II
• Gene Name: Eif4a2
• Organism: Mus musculus (Mouse).
• Sequence Length: 407
• Protein Description: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon..
• Protein Sequence: MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	52.43	30352176
2	Phosphorylation	------MSGGSADYN ------CCCCCCCCC	52.43	23684622
5	Phosphorylation	---MSGGSADYNREH ---CCCCCCCCCHHC	22.84	27818261
5 (in isoform 2)	Phosphorylation	-	22.84	27841257
49	Phosphorylation	ESLLRGIYAYGFEKP HHHHHHHHHCCCCCC	9.15	22499769
51	Phosphorylation	LLRGIYAYGFEKPSA HHHHHHHCCCCCCCH	12.84	22499769
55	Acetylation	IYAYGFEKPSAIQQR HHHCCCCCCCHHHHH	41.85	22826441
55	Ubiquitination	IYAYGFEKPSAIQQR HHHCCCCCCCHHHHH	41.85	-
55	Succinylation	IYAYGFEKPSAIQQR HHHCCCCCCCHHHHH	41.85	23806337
69	Ubiquitination	RAIIPCIKGYDVIAQ HCHHCCCCCCEEEEE	59.12	-
71	Phosphorylation	IIPCIKGYDVIAQAQ HHCCCCCCEEEEEEC	11.31	29514104
81	Phosphorylation	IAQAQSGTGKTATFA EEEECCCCCHHHHHH	40.53	29514104
119	Ubiquitination	ELAQQIQKVILALGD HHHHHHHHHHHHHHH	32.64	-
147 (in isoform 2)	Ubiquitination	-	41.05	22790023
147	Ubiquitination	NVRNEMQKLQAEAPH HHHHHHHHHHHCCCE	41.05	22790023
148 (in isoform 2)	Ubiquitination	-	3.08	-
159	Phosphorylation	APHIVVGTPGRVFDM CCEEEECCCHHHHHH	15.80	-
173	Phosphorylation	MLNRRYLSPKWIKMF HHCCCCCCHHHHHEE	18.59	18779572
175 (in isoform 2)	Ubiquitination	-	59.17	22790023
175	Ubiquitination	NRRYLSPKWIKMFVL CCCCCCHHHHHEEEC	59.17	22790023
176 (in isoform 2)	Ubiquitination	-	9.98	-
194	Acetylation	EMLSRGFKDQIYEIF HHHHCCCHHHHHHHH	52.10	23954790
227	Ubiquitination	DVLEVTKKFMRDPIR CHHHHHHHHHCCCEE	34.72	-
239	Acetylation	PIRILVKKEELTLEG CEEEEEECCEECHHH	49.28	23806337
251	Phosphorylation	LEGIKQFYINVEREE HHHHHHEEEEECCCC	6.78	25367039
285	Ubiquitination	IFLNTRRKVDWLTEK HHHCCCCCCHHHHHH	41.05	-
292	Acetylation	KVDWLTEKMHARDFT CCHHHHHHHHHCCCC	30.65	23236377
292	Ubiquitination	KVDWLTEKMHARDFT CCHHHHHHHHHCCCC	30.65	-
310	Ubiquitination	LHGDMDQKERDVIMR HCCCCCHHHHHHHHH	50.91	-
310	Malonylation	LHGDMDQKERDVIMR HCCCCCHHHHHHHHH	50.91	26320211
310 (in isoform 2)	Ubiquitination	-	50.91	22790023
311 (in isoform 2)	Ubiquitination	-	48.78	-
321	Phosphorylation	VIMREFRSGSSRVLI HHHHHHHCCCCCEEE	48.63	22871156
323	Phosphorylation	MREFRSGSSRVLITT HHHHHCCCCCEEEEH	19.06	22871156
330	Phosphorylation	SSRVLITTDLLARGI CCCEEEEHHHHHCCC	20.04	22006019
382	Ubiquitination	NFVTEEDKRILRDIE EEECHHHHHHHHHHH	44.62	22790023
382 (in isoform 2)	Ubiquitination	-	44.62	22790023
383 (in isoform 2)	Ubiquitination	-	45.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF4A2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF4A2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF4A2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IF4A2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.