TCPB_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCPB_MOUSE
• UniProt AC: P80314
• Protein Name: T-complex protein 1 subunit beta
• Gene Name: Cct2
• Organism: Mus musculus (Mouse).
• Sequence Length: 535
• Subcellular Localization: Cytoplasm .
• Protein Description: Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin..
• Protein Sequence: MASLSLAPVNIFKAGADEERAETARLSSFIGAIAIGDLVKSTLGPKGMDKILLSSGRDAALMVTNDGATILKNIGVDNPAAKVLVDMSRVQDDEVGDGTTSVTVLAAELLREAESLIAKKIHPQTIISGWREATKAAREALLSSAVDHGSDEARFWQDLMNIAGTTLSSKLLTHHKDHFTKLAVEAVLRLKGSGNLEAIHVIKKLGGSLADSYLDEGFLLDKKIGVNQPKRIENAKILIANTGMDTDKIKIFGSRVRVDSTAKVAEIEHAEKEKMKEKVERILKHGINCFINRQLIYNYPEQLFGAAGVMAIEHADFAGVERLALVTGGEIASTFDHPELVKLGSCKLIEEVMIGEDKLIHFSGVALGEACTIVLRGATQQILDEAERSLHDALCVLAQTVKDPRTVYGGGCSEMLMAHAVTQLANRTPGKEAVAMESFAKALRMLPTIIADNAGYDSADLVAQLRAAHSEGHITAGLDMKEGTIGDMAVLGITESFQVKRQVLLSAAEAAEVILRVDNIIKAAPRKRVPDHHPC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASLSLAPV ------CCCCCCCCH	21.12	-
3	Phosphorylation	-----MASLSLAPVN -----CCCCCCCCHH	19.72	26824392
5	Phosphorylation	---MASLSLAPVNIF ---CCCCCCCCHHHC	21.71	30352176
13	Ubiquitination	LAPVNIFKAGADEER CCCHHHCCCCCCHHH	41.96	22790023
13	Acetylation	LAPVNIFKAGADEER CCCHHHCCCCCCHHH	41.96	22826441
28	Phosphorylation	AETARLSSFIGAIAI HHHHHHHHHHHHHHH	26.02	28059163
40	Ubiquitination	IAIGDLVKSTLGPKG HHHHHHHHHCCCCCC	45.05	-
50	Acetylation	LGPKGMDKILLSSGR CCCCCCCEEEECCCC	26.76	22826441
50	Ubiquitination	LGPKGMDKILLSSGR CCCCCCCEEEECCCC	26.76	22790023
69	Phosphorylation	MVTNDGATILKNIGV EEECCCCHHHHHHCC	32.16	20469934
72	Ubiquitination	NDGATILKNIGVDNP CCCCHHHHHHCCCCH	42.54	22790023
119	Succinylation	EAESLIAKKIHPQTI HHHHHHHHHHCHHHH	45.31	23954790
134	Phosphorylation	ISGWREATKAAREAL HHCHHHHHHHHHHHH	19.23	22871156
150	Phosphorylation	SSAVDHGSDEARFWQ HHHHHCCCHHHHHHH	28.94	25338131
181	Acetylation	HHKDHFTKLAVEAVL CCHHHHHHHHHHHHH	33.24	-
191	Ubiquitination	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	22790023
191	Acetylation	VEAVLRLKGSGNLEA HHHHHHHCCCCCHHH	44.59	22826441
203	Acetylation	LEAIHVIKKLGGSLA HHHHHHHHHHCCCHH	40.64	22826441
204	Ubiquitination	EAIHVIKKLGGSLAD HHHHHHHHHCCCHHH	41.04	22790023
208	Phosphorylation	VIKKLGGSLADSYLD HHHHHCCCHHHHHHC	20.70	23984901
212	Phosphorylation	LGGSLADSYLDEGFL HCCCHHHHHHCCCCC	23.22	23984901
213	Phosphorylation	GGSLADSYLDEGFLL CCCHHHHHHCCCCCC	20.79	23984901
222	Ubiquitination	DEGFLLDKKIGVNQP CCCCCCCCCCCCCCC	46.38	22790023
222	Acetylation	DEGFLLDKKIGVNQP CCCCCCCCCCCCCCC	46.38	23236377
223	Malonylation	EGFLLDKKIGVNQPK CCCCCCCCCCCCCCC	44.34	26320211
242	Phosphorylation	AKILIANTGMDTDKI CEEEEECCCCCHHHE	25.51	28066266
246	Phosphorylation	IANTGMDTDKIKIFG EECCCCCHHHEEECC	30.24	28066266
248	Acetylation	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	23236377
248	Ubiquitination	NTGMDTDKIKIFGSR CCCCCHHHEEECCCC	48.25	22790023
250	Acetylation	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	22826441
250	Ubiquitination	GMDTDKIKIFGSRVR CCCHHHEEECCCCEE	37.41	22790023
254	Phosphorylation	DKIKIFGSRVRVDST HHEEECCCCEEECCC	19.49	25338131
260	Phosphorylation	GSRVRVDSTAKVAEI CCCEEECCCCHHHHH	27.66	26824392
261	Phosphorylation	SRVRVDSTAKVAEIE CCEEECCCCHHHHHH	26.49	25266776
284	Acetylation	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	22826441
284	Ubiquitination	EKVERILKHGINCFI HHHHHHHHHCCCCEE	37.10	22790023
289	S-palmitoylation	ILKHGINCFINRQLI HHHHCCCCEECCHHH	3.24	28526873
297	Phosphorylation	FINRQLIYNYPEQLF EECCHHHHCCHHHHH	19.75	22817900
299	Phosphorylation	NRQLIYNYPEQLFGA CCHHHHCCHHHHHCC	7.38	22345495
327	Phosphorylation	VERLALVTGGEIAST CCEEEEEECCCHHHC	40.08	-
342	Ubiquitination	FDHPELVKLGSCKLI CCCHHHHCCCCCCEE	60.81	22790023
389	Phosphorylation	ILDEAERSLHDALCV HHHHHHHHHHHHHHH	22.89	25293948
395	Glutathionylation	RSLHDALCVLAQTVK HHHHHHHHHHHCCCC	2.24	24333276
395	S-palmitoylation	RSLHDALCVLAQTVK HHHHHHHHHHHCCCC	2.24	28526873
395	S-nitrosylation	RSLHDALCVLAQTVK HHHHHHHHHHHCCCC	2.24	20925432
395	S-nitrosocysteine	RSLHDALCVLAQTVK HHHHHHHHHHHCCCC	2.24	-
402	Acetylation	CVLAQTVKDPRTVYG HHHHCCCCCCCCCCC	66.46	22826441
408	Phosphorylation	VKDPRTVYGGGCSEM CCCCCCCCCCCHHHH	14.94	19854140
412	S-palmitoylation	RTVYGGGCSEMLMAH CCCCCCCHHHHHHHH	3.35	26165157
412	Glutathionylation	RTVYGGGCSEMLMAH CCCCCCCHHHHHHHH	3.35	24333276
413	Phosphorylation	TVYGGGCSEMLMAHA CCCCCCHHHHHHHHH	29.34	19854140
422	Phosphorylation	MLMAHAVTQLANRTP HHHHHHHHHHHHCCC	20.74	22817900
441	Acetylation	VAMESFAKALRMLPT HHHHHHHHHHHHHCH	46.04	22826441
441	Ubiquitination	VAMESFAKALRMLPT HHHHHHHHHHHHHCH	46.04	22790023
470	Phosphorylation	AQLRAAHSEGHITAG HHHHHHHHCCCEEEC	40.31	26824392
475	Phosphorylation	AHSEGHITAGLDMKE HHHCCCEEECCCCCC	14.70	28066266
522	Acetylation	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	22826441
522	Ubiquitination	LRVDNIIKAAPRKRV HCHHHHHHHCCCCCC	34.40	22790023
527	Ubiquitination	IIKAAPRKRVPDHHP HHHHCCCCCCCCCCC	57.60	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
260	S	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCPB_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCPB_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDCL3_HUMAN	PDCL3	physical	20360068
TCPZ_HUMAN	CCT6A	physical	26496610
CDC20_HUMAN	CDC20	physical	26496610
CSTF1_HUMAN	CSTF1	physical	26496610
GBB2_HUMAN	GNB2	physical	26496610
IGBP1_HUMAN	IGBP1	physical	26496610
PHLP_HUMAN	PDCL	physical	26496610
PDPK1_HUMAN	PDPK1	physical	26496610
TCPA_HUMAN	TCP1	physical	26496610
TCPG_HUMAN	CCT3	physical	26496610
RAE1L_HUMAN	RAE1	physical	26496610
TNKS1_HUMAN	TNKS	physical	26496610
EIF3I_HUMAN	EIF3I	physical	26496610
PDCD5_HUMAN	PDCD5	physical	26496610
BUB3_HUMAN	BUB3	physical	26496610
ARP2_HUMAN	ACTR2	physical	26496610
ACTZ_HUMAN	ACTR1A	physical	26496610
TXND9_HUMAN	TXNDC9	physical	26496610
DCAF7_HUMAN	DCAF7	physical	26496610
SSA27_HUMAN	SSSCA1	physical	26496610
TCPH_HUMAN	CCT7	physical	26496610
TCPD_HUMAN	CCT4	physical	26496610
TCPQ_HUMAN	CCT8	physical	26496610
TCPE_HUMAN	CCT5	physical	26496610
HGH1_HUMAN	HGH1	physical	26496610
KI21A_HUMAN	KIF21A	physical	26496610
RPTOR_HUMAN	RPTOR	physical	26496610
LST8_HUMAN	MLST8	physical	26496610
PDCL3_HUMAN	PDCL3	physical	26496610
ERI3_HUMAN	ERI3	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
OSBL9_HUMAN	OSBPL9	physical	26496610
TIM14_HUMAN	DNAJC19	physical	26496610
ESCO2_HUMAN	ESCO2	physical	26496610
TBB5_HUMAN	TUBB	physical	26496610
WDR92_HUMAN	WDR92	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.