VIGLN_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VIGLN_MOUSE
• UniProt AC: Q8VDJ3
• Protein Name: Vigilin
• Gene Name: Hdlbp
• Organism: Mus musculus (Mouse).
• Sequence Length: 1268
• Subcellular Localization: Cytoplasm. Nucleus.
• Protein Description: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity)..
• Protein Sequence: MSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEENDPPTYKDAFPPLPEKAACLESAQEPAGAWSNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVPIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQALTEVYAKANSFTVSSVSAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKIREESNTKIDLPAENSNSETIIITGKRANCEAARSRILSIQKDLANIAEVEVSIPAKLHNSLIGTKGRLIRSIMEECGGVHIHFPVEGSGSDTVVIRGPSSDVEKAKKQLLHLAEEKQTKSFTVDIRAKPEYHKFLIGKGGGKIRKVRDSTGARIIFPAAEDKDQDLITIIGKEDAVREAQKELEALIQNLENVVEDYMLVDPKHHRHFVIRRGQVLREIAEEYGGVMVSFPRSGTQSDKVTLKGAKDCVEAAKKRIQEIIEDLEAQVTVECAIPQKFHRSVMGPKGSRIQQITRDYNVQIKFPDREENPVHSVEPSIQENGDEAGEGREAKETDPGSPRRCDIIIISGRKEKCEAAKEALEALVPVTIEVEVPFDLHRYIIGQKGSGIRKMMDEFEVNIHVPAPELQSDTIAITGLAANLDRAKAGLLDRVKELQAEQEDRALRSFKLSVTVDPKYHPKIIGRKGAVITQIRLEHEVNIQFPDKDDGNQPQDQITITGYEKNTEAARDAILKIVGELEQMVSEDVPLDHRVHARIIGARGKAIRKIMDEFKVDIRFPQSGAPDPNCVTVTGLPENVEEAIDHILNLEEEYLADVVDSEALQVYMKPPAHEESRAPSKGFVVRDAPWTSNSSEKAPDMSSSEEFPSFGAQVAPKTLPWGPKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSVAVLTQ ------CCCEEEEEH	44.84	-
2	Phosphorylation	------MSSVAVLTQ ------CCCEEEEEH	44.84	30352176
3	Phosphorylation	-----MSSVAVLTQE -----CCCEEEEEHH	26.42	30352176
8	Phosphorylation	MSSVAVLTQESFAEH CCCEEEEEHHHHHHH	24.56	23984901
11	Phosphorylation	VAVLTQESFAEHRSG EEEEEHHHHHHHCCC	21.68	30352176
17	Phosphorylation	ESFAEHRSGLVPQQI HHHHHHCCCCCCCEE	38.08	23984901
28	Phosphorylation	PQQIKVATLNSEEEN CCEEEEEECCCCCCC	29.47	25521595
31	Phosphorylation	IKVATLNSEEENDPP EEEEECCCCCCCCCC	49.88	27087446
39	Phosphorylation	EEENDPPTYKDAFPP CCCCCCCCHHHCCCC	48.90	25619855
40	Phosphorylation	EENDPPTYKDAFPPL CCCCCCCHHHCCCCC	16.79	25619855
41	Ubiquitination	ENDPPTYKDAFPPLP CCCCCCHHHCCCCCC	45.09	-
53	S-palmitoylation	PLPEKAACLESAQEP CCCHHHHHHHHCCCC	5.31	28526873
67	Acetylation	PAGAWSNKIRPIKAS CCCCCCCCCCCCCCH	34.28	22826441
90	Ubiquitination	PLEERKYKDMNQFGE CHHHHCCCCHHHCCC	54.24	-
104	S-palmitoylation	EGEQAKICLEIMQRT CHHHHHHHHHHHHHH	2.48	28526873
130	Phosphorylation	QGLSIMVSGKLDAVM CCCEEEEECCHHHHH	16.90	20531401
132	Acetylation	LSIMVSGKLDAVMKA CEEEEECCHHHHHHH	35.37	7719765
138	Acetylation	GKLDAVMKARKDIVA CCHHHHHHHHHHHHH	38.14	15612653
138	Malonylation	GKLDAVMKARKDIVA CCHHHHHHHHHHHHH	38.14	26320211
149	Phosphorylation	DIVARLQTQASATVP HHHHHHHHHCCCCCC	30.60	29514104
152	Phosphorylation	ARLQTQASATVPIPK HHHHHHCCCCCCCCH	18.04	29514104
154	Phosphorylation	LQTQASATVPIPKEH HHHHCCCCCCCCHHH	25.07	30352176
168	Ubiquitination	HHRFVIGKNGEKLQD HCEEEECCCCCEEEC	51.13	-
168	Malonylation	HHRFVIGKNGEKLQD HCEEEECCCCCEEEC	51.13	26320211
197	Malonylation	DDPSNQIKITGTKEG CCCCCCEEEECCHHH	25.17	26320211
202	Malonylation	QIKITGTKEGIEKAR CEEEECCHHHHHHHH	56.11	26320211
221	Ubiquitination	LISAEQDKRAVERLE EEEHHHHHHHHHHHH	41.78	-
231	Ubiquitination	VERLEVEKAFHPFIA HHHHHHHHHHCHHHC	62.62	-
241	Phosphorylation	HPFIAGPYNRLVGEI CHHHCCHHHHHHHHH	16.40	29514104
274	Ubiquitination	EIVFTGEKEQLAQAV EEEEECCHHHHHHHH	52.70	-
295	Phosphorylation	YEEKKKKTTTIAVEV HHHHCCCCCEEEEEE	37.74	-
296	Phosphorylation	EEKKKKTTTIAVEVK HHHCCCCCEEEEEEE	25.69	-
303	Ubiquitination	TTIAVEVKKSQHKYV CEEEEEEECCCCCEE	32.95	-
314	Ubiquitination	HKYVIGPKGNSLQEI CCEEECCCCCCHHHH	66.56	-
317	Phosphorylation	VIGPKGNSLQEILER EECCCCCCHHHHHHH	39.85	25521595
349	Ubiquitination	ILRGEPEKLGQALTE EECCCHHHHHHHHHH	69.50	-
358	Phosphorylation	GQALTEVYAKANSFT HHHHHHHHHHHCCCE	8.99	29514104
389	Ubiquitination	KKGQNLAKITQQMPK CCCCCHHHHHHCCCC	49.83	-
435	Oxidation	VKDLINRMDYVEINI HHHHHHHCCEEEEEC	3.64	17242355
437	Phosphorylation	DLINRMDYVEINIDH HHHHHCCEEEEECCC	7.22	25521595
453	Acetylation	FHRHLIGKSGANINR HHHHHCCCCCCCHHH	38.43	23806337
453	Malonylation	FHRHLIGKSGANINR HHHHHCCCCCCCHHH	38.43	26320211
454	Phosphorylation	HRHLIGKSGANINRI HHHHCCCCCCCHHHC	37.61	29514104
468	Phosphorylation	IKDQYKVSVRIPPDS CCCEEEEEEECCCCC	11.09	20495213
477	Malonylation	RIPPDSEKSNLIRIE ECCCCCCCCCCEEEE	48.90	26320211
494	Acetylation	PQGVQQAKRELLELA HHHHHHHHHHHHHHH	41.91	23864654
494	Ubiquitination	PQGVQQAKRELLELA HHHHHHHHHHHHHHH	41.91	-
494	Malonylation	PQGVQQAKRELLELA HHHHHHHHHHHHHHH	41.91	26320211
510	Malonylation	RMENERTKDLIIEQR HHCCHHHHHHHHHHH	57.68	26320211
526	Malonylation	HRTIIGQKGERIREI HHHHCCCCCHHHHHH	58.49	26320211
536	Acetylation	RIREIRDKFPEVIIN HHHHHHHHCCCEEEC	53.63	23201123
568	Malonylation	NEVEKCTKYMQKMVA HHHHHHHHHHHHHHH	48.47	26320211
569	Phosphorylation	EVEKCTKYMQKMVAD HHHHHHHHHHHHHHH	6.14	28059163
582	Phosphorylation	ADLVENSYSISVPIF HHHHHCCCCCCHHHH	22.93	29514104
585	Phosphorylation	VENSYSISVPIFKQF HHCCCCCCHHHHHHH	18.85	28059163
599	Ubiquitination	FHKNIIGKGGANIKK HHHHCCCCCCCCHHH	43.70	-
599	Malonylation	FHKNIIGKGGANIKK HHHHCCCCCCCCHHH	43.70	26320211
641	Phosphorylation	ANCEAARSRILSIQK CCHHHHHHHHHHHHH	20.95	29472430
645	Phosphorylation	AARSRILSIQKDLAN HHHHHHHHHHHHHHC	22.17	28725479
663	Ubiquitination	VEVSIPAKLHNSLIG EEEECCHHHHCCCCC	44.95	-
667	Phosphorylation	IPAKLHNSLIGTKGR CCHHHHCCCCCCHHH	15.60	29472430
671	Phosphorylation	LHNSLIGTKGRLIRS HHCCCCCCHHHHHHH	24.27	29176673
672	Ubiquitination	HNSLIGTKGRLIRSI HCCCCCCHHHHHHHH	36.50	-
714	Ubiquitination	SDVEKAKKQLLHLAE CHHHHHHHHHHHHHH	51.54	-
714	Malonylation	SDVEKAKKQLLHLAE CHHHHHHHHHHHHHH	51.54	26320211
723	Acetylation	LLHLAEEKQTKSFTV HHHHHHHHCCCCEEE	55.56	23806337
726	Malonylation	LAEEKQTKSFTVDIR HHHHHCCCCEEEEEE	40.87	26320211
745	Ubiquitination	YHKFLIGKGGGKIRK HHCEEECCCCCCEEE	47.60	-
756	Phosphorylation	KIRKVRDSTGARIIF CEEEEECCCCCEEEE	20.41	23140645
757	Phosphorylation	IRKVRDSTGARIIFP EEEEECCCCCEEEEE	38.87	29550500
769	Acetylation	IFPAAEDKDQDLITI EEECCCCCCCCEEEE	49.12	23954790
779	Ubiquitination	DLITIIGKEDAVREA CEEEEECHHHHHHHH	41.85	-
830	Phosphorylation	LREIAEEYGGVMVSF HHHHHHHHCCEEEEC	15.64	-
840	Phosphorylation	VMVSFPRSGTQSDKV EEEECCCCCCCCCCE	46.56	25777480
842	Phosphorylation	VSFPRSGTQSDKVTL EECCCCCCCCCCEEE	26.58	25777480
844	Phosphorylation	FPRSGTQSDKVTLKG CCCCCCCCCCEEECC	38.96	25777480
848	Phosphorylation	GTQSDKVTLKGAKDC CCCCCCEEECCHHHH	28.61	25777480
853	Ubiquitination	KVTLKGAKDCVEAAK CEEECCHHHHHHHHH	61.40	-
894	Phosphorylation	SVMGPKGSRIQQITR HHCCCCCCHHHHHCC	32.13	29514104
900	Phosphorylation	GSRIQQITRDYNVQI CCHHHHHCCCCCCEE	17.10	18779572
940	Phosphorylation	EGREAKETDPGSPRR CCCCCCCCCCCCCCC	46.95	26824392
944	Phosphorylation	AKETDPGSPRRCDII CCCCCCCCCCCCEEE	22.18	25521595
948	S-nitrosylation	DPGSPRRCDIIIISG CCCCCCCCEEEEEEC	4.68	22178444
948	S-palmitoylation	DPGSPRRCDIIIISG CCCCCCCCEEEEEEC	4.68	26165157
991	Acetylation	HRYIIGQKGSGIRKM HHHHHCCCCCHHHHH	50.24	23806337
991	Ubiquitination	HRYIIGQKGSGIRKM HHHHHCCCCCHHHHH	50.24	-
1039	Ubiquitination	AGLLDRVKELQAEQE HHHHHHHHHHHHHHH	54.31	-
1062	Ubiquitination	LSVTVDPKYHPKIIG EEEEECCCCCCCCCC	52.29	-
1066	Ubiquitination	VDPKYHPKIIGRKGA ECCCCCCCCCCCCCE	33.37	-
1071	Malonylation	HPKIIGRKGAVITQI CCCCCCCCCEEEEEE	46.11	26320211
1108	Ubiquitination	ITITGYEKNTEAARD EEEEHHHCCHHHHHH	61.76	-
1166	Phosphorylation	VDIRFPQSGAPDPNC CEEECCCCCCCCCCE	36.84	25367039
1175	Phosphorylation	APDPNCVTVTGLPEN CCCCCEEEECCCCCC	17.98	25367039
1177	Phosphorylation	DPNCVTVTGLPENVE CCCEEEECCCCCCHH	24.52	25367039
1197	Phosphorylation	ILNLEEEYLADVVDS HHCCCHHHHHHHCCH	15.52	25367039
1204	Phosphorylation	YLADVVDSEALQVYM HHHHHCCHHHHHHHC	17.10	25367039
1210	Phosphorylation	DSEALQVYMKPPAHE CHHHHHHHCCCCCCC	6.10	25367039
1219	Phosphorylation	KPPAHEESRAPSKGF CCCCCCCCCCCCCCE	30.66	25367039
1223	Phosphorylation	HEESRAPSKGFVVRD CCCCCCCCCCEEEEE	44.41	25367039
1224	Ubiquitination	EESRAPSKGFVVRDA CCCCCCCCCEEEEEC	56.14	-
1224	Malonylation	EESRAPSKGFVVRDA CCCCCCCCCEEEEEC	56.14	26320211
1234	Phosphorylation	VVRDAPWTSNSSEKA EEEECCCCCCCCCCC	19.57	23984901
1235	Phosphorylation	VRDAPWTSNSSEKAP EEECCCCCCCCCCCC	30.74	25521595
1237	Phosphorylation	DAPWTSNSSEKAPDM ECCCCCCCCCCCCCC	39.37	25521595
1238	Phosphorylation	APWTSNSSEKAPDMS CCCCCCCCCCCCCCC	47.57	26643407
1245	Phosphorylation	SEKAPDMSSSEEFPS CCCCCCCCCCCCCCC	37.78	26525534
1246	Phosphorylation	EKAPDMSSSEEFPSF CCCCCCCCCCCCCCC	34.82	25521595
1247	Phosphorylation	KAPDMSSSEEFPSFG CCCCCCCCCCCCCCC	33.56	26525534
1252	Phosphorylation	SSSEEFPSFGAQVAP CCCCCCCCCCCCCCC	41.45	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VIGLN_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VIGLN_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VIGLN_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of VIGLN_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Specific phosphopeptide enrichment with immobilized titanium ionaffinity chromatography adsorbent for phosphoproteome analysis.";
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
J. Proteome Res. 7:3957-3967(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 18630941

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND MASSSPECTROMETRY.
PubMed: 17203969