IF5A1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: IF5A1_MOUSE
• UniProt AC: P63242
• Protein Name: Eukaryotic translation initiation factor 5A-1
• Gene Name: Eif5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 154
• Subcellular Localization: Cytoplasm . Nucleus . Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus, nuclear pore complex. The N-terminal extension contributes in signaling this protein to nuclear localization.
• Protein Description: mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity)..
• Protein Sequence: MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADDLDFET ------CCCCCCCCC	21.01	-
9	Phosphorylation	ADDLDFETGDAGASA CCCCCCCCCCCCCCC	40.11	26643407
15	Phosphorylation	ETGDAGASATFPMQC CCCCCCCCCCCCCCC	27.24	26643407
17	Phosphorylation	GDAGASATFPMQCSA CCCCCCCCCCCCCHH	26.27	26643407
23	Phosphorylation	ATFPMQCSALRKNGF CCCCCCCHHHHHCCE	17.28	26643407
27	Ubiquitination	MQCSALRKNGFVVLK CCCHHHHHCCEEEEC	63.37	-
27	Malonylation	MQCSALRKNGFVVLK CCCHHHHHCCEEEEC	63.37	26320211
34	Acetylation	KNGFVVLKGRPCKIV HCCEEEECCCEEEEE	41.06	22826441
38	Glutathionylation	VVLKGRPCKIVEMST EEECCCEEEEEEEEC	4.53	24333276
39	Ubiquitination	VLKGRPCKIVEMSTS EECCCEEEEEEEECC	53.09	-
39	Malonylation	VLKGRPCKIVEMSTS EECCCEEEEEEEECC	53.09	26320211
39	Acetylation	VLKGRPCKIVEMSTS EECCCEEEEEEEECC	53.09	22826441
44	Phosphorylation	PCKIVEMSTSKTGKH EEEEEEEECCCCCCC	18.94	28066266
45	Phosphorylation	CKIVEMSTSKTGKHG EEEEEEECCCCCCCC	32.69	28066266
46	Phosphorylation	KIVEMSTSKTGKHGH EEEEEECCCCCCCCC	22.40	28066266
47	Acetylation	IVEMSTSKTGKHGHA EEEEECCCCCCCCCE	62.48	22826441
50	Other	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
50	Hypusine	MSTSKTGKHGHAKVH EECCCCCCCCCEEEE	52.20	-
65	Phosphorylation	LVGIDIFTGKKYEDI EEEEECCCCCCHHHC	48.72	25367039
67	Malonylation	GIDIFTGKKYEDICP EEECCCCCCHHHCCC	49.47	26320211
67	Ubiquitination	GIDIFTGKKYEDICP EEECCCCCCHHHCCC	49.47	-
67	Acetylation	GIDIFTGKKYEDICP EEECCCCCCHHHCCC	49.47	90401
68	Malonylation	IDIFTGKKYEDICPS EECCCCCCHHHCCCC	56.04	26320211
68	Acetylation	IDIFTGKKYEDICPS EECCCCCCHHHCCCC	56.04	23806337
68	Ubiquitination	IDIFTGKKYEDICPS EECCCCCCHHHCCCC	56.04	-
68	Succinylation	IDIFTGKKYEDICPS EECCCCCCHHHCCCC	56.04	-
69	Phosphorylation	DIFTGKKYEDICPST ECCCCCCHHHCCCCC	23.48	25367039
73	Glutathionylation	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	24333276
73	S-nitrosocysteine	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	-
73	S-nitrosylation	GKKYEDICPSTHNMD CCCHHHCCCCCCCCC	3.17	22178444
85	Acetylation	NMDVPNIKRNDFQLI CCCCCCCCCCCEEEE	52.36	22826441
85	Ubiquitination	NMDVPNIKRNDFQLI CCCCCCCCCCCEEEE	52.36	22790023
98	Phosphorylation	LIGIQDGYLSLLQDS EEEEECCCCHHHCCC	11.04	25266776
121	Succinylation	LPEGDLGKEIEQKYD CCCCCHHHHHHHHHC	63.92	23806337
121	Ubiquitination	LPEGDLGKEIEQKYD CCCCCHHHHHHHHHC	63.92	-
121	Acetylation	LPEGDLGKEIEQKYD CCCCCHHHHHHHHHC	63.92	23806337
127	Phosphorylation	GKEIEQKYDCGEEIL HHHHHHHHCCCCHHH	19.03	-
129	Glutathionylation	EIEQKYDCGEEILIT HHHHHHCCCCHHHHH	7.20	24333276
129	S-palmitoylation	EIEQKYDCGEEILIT HHHHHHCCCCHHHHH	7.20	28526873

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of IF5A1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of IF5A1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of IF5A1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of IF5A1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.