LRC59_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRC59_MOUSE
• UniProt AC: Q922Q8
• Protein Name: Leucine-rich repeat-containing protein 59
• Gene Name: Lrrc59
• Organism: Mus musculus (Mouse).
• Sequence Length: 307
• Subcellular Localization: Microsome membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus envelope. Localization in the nuclear envelope depends upon the nuclear import machinery, including KPNB1..
• Protein Description: Required for nuclear import of FGF1, but not that of FGF2. Might regulate nuclear import of exogenous FGF1 by facilitating interaction with the nuclear import machinery and by transporting cytosolic FGF1 to, and possibly through, the nuclear pores (By similarity)..
• Protein Sequence: MTKAGSKGGNLRDKLDGNELDLSLSDLNEVPVKELAALPKATVLDLSCNKLSTLPSDFCGLTHLVKLDLSKNKLQQLPADFGRLVNLQHLDLLNNRLVTLPVSFAQLKNLKWLDLKDNPLDPVLAKVAGDCLDEKQCKQCANKVLQHMKAVQADQERERQRRLEVEREAEKKREAKQQAKEAKERELRKREKAEEKERRRKEYDAQKASKREQEKKPKKEANQAPKSKSGSRPRKPPPRKHTRSWAVLKVLLLLLLLCVAGGLVVCRVTGLHQQPLCTSVNTIYDNAVQGLRHHEILQWVLQTDSQQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTKAGSKG -------CCCCCCCC	8.60	-
2	Phosphorylation	------MTKAGSKGG ------CCCCCCCCC	29.60	19854140
2	Acetylation	------MTKAGSKGG ------CCCCCCCCC	29.60	-
23	Phosphorylation	DGNELDLSLSDLNEV CCCEECCCHHHHCCC	26.03	26643407
25	Phosphorylation	NELDLSLSDLNEVPV CEECCCHHHHCCCCH	36.35	26643407
33	Ubiquitination	DLNEVPVKELAALPK HHCCCCHHHHHHCCC	40.72	-
40	Ubiquitination	KELAALPKATVLDLS HHHHHCCCCEEEECC	58.50	-
40	Malonylation	KELAALPKATVLDLS HHHHHCCCCEEEECC	58.50	26320211
48	S-nitrosylation	ATVLDLSCNKLSTLP CEEEECCCCCCCCCC	7.28	20925432
48	S-palmitoylation	ATVLDLSCNKLSTLP CEEEECCCCCCCCCC	7.28	28526873
48	Glutathionylation	ATVLDLSCNKLSTLP CEEEECCCCCCCCCC	7.28	24333276
48	S-nitrosocysteine	ATVLDLSCNKLSTLP CEEEECCCCCCCCCC	7.28	-
56	Phosphorylation	NKLSTLPSDFCGLTH CCCCCCCCCCCCCHH	46.56	30352176
59	S-nitrosocysteine	STLPSDFCGLTHLVK CCCCCCCCCCHHHHH	5.39	-
59	S-palmitoylation	STLPSDFCGLTHLVK CCCCCCCCCCHHHHH	5.39	28526873
59	S-nitrosylation	STLPSDFCGLTHLVK CCCCCCCCCCHHHHH	5.39	20925432
59	Glutathionylation	STLPSDFCGLTHLVK CCCCCCCCCCHHHHH	5.39	24333276
71	Malonylation	LVKLDLSKNKLQQLP HHHHCCCCCHHHCCC	66.45	26320211
73	Malonylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	26320211
73	Succinylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	23806337
73	Ubiquitination	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	27667366
73	Succinylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	-
73	Acetylation	KLDLSKNKLQQLPAD HHCCCCCHHHCCCCC	51.95	23864654
108	Ubiquitination	PVSFAQLKNLKWLDL CCCHHHHCCCCCCCC	48.42	22790023
108	Acetylation	PVSFAQLKNLKWLDL CCCHHHHCCCCCCCC	48.42	23201123
111	Malonylation	FAQLKNLKWLDLKDN HHHHCCCCCCCCCCC	55.92	26320211
111	Acetylation	FAQLKNLKWLDLKDN HHHHCCCCCCCCCCC	55.92	22826441
116	Acetylation	NLKWLDLKDNPLDPV CCCCCCCCCCCCCHH	55.94	22826441
116	Ubiquitination	NLKWLDLKDNPLDPV CCCCCCCCCCCCCHH	55.94	22790023
126	Ubiquitination	PLDPVLAKVAGDCLD CCCHHHHHHHHHCCC	28.58	22790023
131	S-palmitoylation	LAKVAGDCLDEKQCK HHHHHHHCCCHHHHH	5.16	28526873
135	Acetylation	AGDCLDEKQCKQCAN HHHCCCHHHHHHHHH	61.74	23806337
135	Ubiquitination	AGDCLDEKQCKQCAN HHHCCCHHHHHHHHH	61.74	-
135	Malonylation	AGDCLDEKQCKQCAN HHHCCCHHHHHHHHH	61.74	26320211
137	S-nitrosocysteine	DCLDEKQCKQCANKV HCCCHHHHHHHHHHH	4.94	-
137	S-nitrosylation	DCLDEKQCKQCANKV HCCCHHHHHHHHHHH	4.94	20925432
140	S-nitrosocysteine	DEKQCKQCANKVLQH CHHHHHHHHHHHHHH	2.49	-
140	S-nitrosylation	DEKQCKQCANKVLQH CHHHHHHHHHHHHHH	2.49	20925432
143	Acetylation	QCKQCANKVLQHMKA HHHHHHHHHHHHHHH	26.29	23201123
143	Malonylation	QCKQCANKVLQHMKA HHHHHHHHHHHHHHH	26.29	32601280
149	Acetylation	NKVLQHMKAVQADQE HHHHHHHHHHHHHHH	43.19	23806337
149	Succinylation	NKVLQHMKAVQADQE HHHHHHHHHHHHHHH	43.19	23806337
149	Malonylation	NKVLQHMKAVQADQE HHHHHHHHHHHHHHH	43.19	26320211
277	S-palmitoylation	GLHQQPLCTSVNTIY CCCCCCCCCCHHHHH	3.20	28526873
305	Phosphorylation	QWVLQTDSQQ----- HHHHHHCCCC-----	33.59	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRC59_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRC59_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRC59_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LRC59_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.