LA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LA_MOUSE
• UniProt AC: P32067
• Protein Name: Lupus La protein homolog
• Gene Name: Ssb
• Organism: Mus musculus (Mouse).
• Sequence Length: 415
• Subcellular Localization: Nucleus .
• Protein Description: Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation..
• Protein Sequence: MAENGDNEKMTALEAKICHQIEYYFGDFNLPRDKFLKEQIKLDEGWVPLETMIKFNRLNRLTTDFNVIVQALSKSKAKLMEVSADKTKIRRSPSRPLPEVTDEYKNDVKNRSVYIKGFPTDATLDDIKEWLDDKGQILNIQMRRTLHKTFKGSIFAVFDSIQSAKKFVEIPGQKYKDTNLLILFKEDYFAKKNEERKQSKVEAKLKAKQEHEGRHKPGSTETRALEGKMGCLLKFSGDLDDQTCREDLHFLFSNHGEIKWVDFARGAKEGIILFKEKAKEALEKARNANNGNLLLRNKKVTWKVLEGHAEKEALKKITDDQQESLNKWKSKGGHAGGRFKGSHVFTAARRFKGKGKGNRPGYAGAPKGRGQFHGRRTRFDDDDRRRGPMKRGRDGRDREEPASKHKKRENGARDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Glutathionylation	TALEAKICHQIEYYF HHHHHHHHHHHHHHH	1.58	24333276
18	S-nitrosylation	TALEAKICHQIEYYF HHHHHHHHHHHHHHH	1.58	20925432
18	S-nitrosocysteine	TALEAKICHQIEYYF HHHHHHHHHHHHHHH	1.58	-
92	Phosphorylation	DKTKIRRSPSRPLPE CCHHCCCCCCCCCCC	19.85	25521595
94	Phosphorylation	TKIRRSPSRPLPEVT HHCCCCCCCCCCCCC	48.02	27742792
114	Phosphorylation	DVKNRSVYIKGFPTD HCCCCEEEEECCCCC	9.73	29514104
116	Ubiquitination	KNRSVYIKGFPTDAT CCCEEEEECCCCCCC	36.49	22790023
116	Acetylation	KNRSVYIKGFPTDAT CCCEEEEECCCCCCC	36.49	-
120	Phosphorylation	VYIKGFPTDATLDDI EEEECCCCCCCHHHH	35.68	-
128	Acetylation	DATLDDIKEWLDDKG CCCHHHHHHHHCCCC	50.24	23954790
153	Phosphorylation	LHKTFKGSIFAVFDS HHHHHCCHHHHHHHH	18.34	21454597
160	Phosphorylation	SIFAVFDSIQSAKKF HHHHHHHHHHHHHHH	15.86	21454597
165	Ubiquitination	FDSIQSAKKFVEIPG HHHHHHHHHHHCCCC	52.57	22790023
199	Phosphorylation	KNEERKQSKVEAKLK CCHHHHHHHHHHHHH	41.52	22817900
219	Phosphorylation	EGRHKPGSTETRALE CCCCCCCCHHHHHHC	31.43	25266776
220	Phosphorylation	GRHKPGSTETRALEG CCCCCCCHHHHHHCC	47.49	30635358
222	Phosphorylation	HKPGSTETRALEGKM CCCCCHHHHHHCCCC	22.72	30635358
228	Ubiquitination	ETRALEGKMGCLLKF HHHHHCCCCEEEEEE	23.81	22790023
268	Acetylation	VDFARGAKEGIILFK EEECCCCCCEEEEEH	60.33	22826441
275	Acetylation	KEGIILFKEKAKEAL CCEEEEEHHHHHHHH	55.66	22826441
301	Phosphorylation	LLRNKKVTWKVLEGH EECCCCEEHHHHCCH	28.57	22817900
303	Ubiquitination	RNKKVTWKVLEGHAE CCCCEEHHHHCCHHH	27.81	22790023
311	Ubiquitination	VLEGHAEKEALKKIT HHCCHHHHHHHHHCC	49.42	22790023
327	Ubiquitination	DQQESLNKWKSKGGH HHHHHHHHHHHCCCC	62.38	22790023
327	Acetylation	DQQESLNKWKSKGGH HHHHHHHHHHHCCCC	62.38	23806337
340	Ubiquitination	GHAGGRFKGSHVFTA CCCCCCCCCCHHHHC	59.13	-
340	Malonylation	GHAGGRFKGSHVFTA CCCCCCCCCCHHHHC	59.13	26320211
342	Phosphorylation	AGGRFKGSHVFTAAR CCCCCCCCHHHHCCH	19.64	25266776
356	Acetylation	RRFKGKGKGNRPGYA HHCCCCCCCCCCCCC	57.40	23806337
369	Dimethylation	YAGAPKGRGQFHGRR CCCCCCCCCCCCCCC	41.69	-
369	Methylation	YAGAPKGRGQFHGRR CCCCCCCCCCCCCCC	41.69	7495491
377	Phosphorylation	GQFHGRRTRFDDDDR CCCCCCCCCCCCCCC	34.04	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
199	S	Phosphorylation	Kinase	PRKACA	P17612	GPS
199	S	Phosphorylation	Kinase	PRKG1	Q13976	GPS
301	T	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LA_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LA_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of LA_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.