dbPTM

RS10_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS10_MOUSE
UniProt AC	P63325
Protein Name	40S ribosomal protein S10
Gene Name	Rps10
Organism	Mus musculus (Mouse).
Sequence Length	165
Subcellular Localization	Cytoplasm. Nucleus, nucleolus. Localized in the granular component (GC) region of the nucleolus. Methylation is required for its localization in the GC region. Colocalizes with NPS1 in the GC region of the nucleolus (By similarity)..
Protein Description	Component of the 40S ribosomal subunit..
Protein Sequence	MLMPKKNRIAIYELLFKEGVMVAKKDVHMPKHPELADKNVPNLHVMKAMQSLKSRGYVKEQFAWRHFYWYLTNEGIQYLRDYLHLPPEIVPATLRRSRPETGRPRPKGPEGERPARFTRGEADRDTYRRSAVPPGADKKAEAGAGSATEFQFRGGFGRGRGQPPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	KKNRIAIYELLFKEG CCCCCHHHHHHHHCC	7.48	26824392
47	Acetylation	VPNLHVMKAMQSLKS CCCHHHHHHHHHHHH	39.35	22826441
59	Acetylation	LKSRGYVKEQFAWRH HHHCCCEEHHHHHHH	37.00	22826441
78	Phosphorylation	LTNEGIQYLRDYLHL HHHHHHHHHHHHHCC	11.20	-
82	Phosphorylation	GIQYLRDYLHLPPEI HHHHHHHHHCCCHHH	6.92	28066266
93	Phosphorylation	PPEIVPATLRRSRPE CHHHHCHHHHCCCCC	18.09	-
97	Phosphorylation	VPATLRRSRPETGRP HCHHHHCCCCCCCCC	45.83	27149854
101	Phosphorylation	LRRSRPETGRPRPKG HHCCCCCCCCCCCCC	40.97	23140645
107	Ubiquitination	ETGRPRPKGPEGERP CCCCCCCCCCCCCCC	84.27	22790023
118	Phosphorylation	GERPARFTRGEADRD CCCCCCCCCCCCCHH	32.01	29514104
119	Methylation	ERPARFTRGEADRDT CCCCCCCCCCCCHHH	37.94	12018797
126	Phosphorylation	RGEADRDTYRRSAVP CCCCCHHHHHHHCCC	21.59	23970565
127	Phosphorylation	GEADRDTYRRSAVPP CCCCHHHHHHHCCCC	14.33	22817900
130	Phosphorylation	DRDTYRRSAVPPGAD CHHHHHHHCCCCCCC	25.31	25521595
138	Malonylation	AVPPGADKKAEAGAG CCCCCCCCCCCCCCC	54.04	26320211
138	Ubiquitination	AVPPGADKKAEAGAG CCCCCCCCCCCCCCC	54.04	-
139	Ubiquitination	VPPGADKKAEAGAGS CCCCCCCCCCCCCCC	52.59	-
139	Malonylation	VPPGADKKAEAGAGS CCCCCCCCCCCCCCC	52.59	26320211
146	Phosphorylation	KAEAGAGSATEFQFR CCCCCCCCCCEEEEC	31.33	26824392
148	Phosphorylation	EAGAGSATEFQFRGG CCCCCCCCEEEECCC	38.74	27742792
153	Methylation	SATEFQFRGGFGRGR CCCEEEECCCCCCCC	33.28	24129315
158	Methylation	QFRGGFGRGRGQPPQ EECCCCCCCCCCCCC	29.40	-
158	Symmetric dimethylarginine	QFRGGFGRGRGQPPQ EECCCCCCCCCCCCC	29.40	-
160	Methylation	RGGFGRGRGQPPQ-- CCCCCCCCCCCCC--	38.93	-
160	Symmetric dimethylarginine	RGGFGRGRGQPPQ-- CCCCCCCCCCCCC--	38.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS10_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS10_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS10_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RS10_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS10_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.	17242355 [Abstract]
"Phosphoproteomic analysis of the developing mouse brain."; Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.; Mol. Cell. Proteomics 3:1093-1101(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND MASSSPECTROMETRY.	15345747 [Abstract]
"Large-scale identification and evolution indexing of tyrosinephosphorylation sites from murine brain."; Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.; J. Proteome Res. 7:311-318(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-12, AND MASSSPECTROMETRY.	18034455 [Abstract]
"Quantitative time-resolved phosphoproteomic analysis of mast cellsignaling."; Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y.,Kawakami T., Salomon A.R.; J. Immunol. 179:5864-5876(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-12, AND MASSSPECTROMETRY.	17947660 [Abstract]