SMD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMD3_MOUSE
• UniProt AC: P62320
• Protein Name: Small nuclear ribonucleoprotein Sm D3
• Gene Name: Snrpd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 126
• Subcellular Localization: Cytoplasm, cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes..
• Protein Description: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing..
• Protein Sequence: MSIGVPIKVLHEAEGHIVTCETNTGEVYRGKLIEAEDNMNCQMSNITVTYRDGRVAQLEQVYIRGSKIRFLILPDMLKNAPMLKSMKNKNQGSGAGRGKAAILKAQVAARGRGRGMGRGNIFQKRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSIGVPIKV ------CCCCCCEEE	28.22	-
2	Phosphorylation	------MSIGVPIKV ------CCCCCCEEE	28.22	28066266
8	Acetylation	MSIGVPIKVLHEAEG CCCCCCEEEEEECCC	32.45	22826441
20	S-nitrosocysteine	AEGHIVTCETNTGEV CCCEEEEEECCCCCE	4.15	-
20	S-nitrosylation	AEGHIVTCETNTGEV CCCEEEEEECCCCCE	4.15	20925432
62	Phosphorylation	VAQLEQVYIRGSKIR EEEEEEEEECCCCEE	5.65	29514104
66	Phosphorylation	EQVYIRGSKIRFLIL EEEEECCCCEEEEEC	18.30	29514104
78	Ubiquitination	LILPDMLKNAPMLKS EECHHHHHCCHHHHH	44.41	22790023
78	Acetylation	LILPDMLKNAPMLKS EECHHHHHCCHHHHH	44.41	23236377
124	Acetylation	GRGNIFQKRR----- CCCCCCCCCC-----	39.12	6568867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SMD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.