dbPTM

FLNA_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FLNA_MOUSE
UniProt AC	Q8BTM8
Protein Name	Filamin-A
Gene Name	Flna
Organism	Mus musculus (Mouse).
Sequence Length	2647
Subcellular Localization	Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Protein Description	Actin binding protein that promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins (By similarity). Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking. Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. [PubMed: 17172441 Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance]
Protein Sequence	MSSSHSRCGQSAAVASPGGSIDSRDAEMPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILHYSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAPGLCPDWDSWDASKPVNNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKAKLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQEEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQGPGLEPSGNIANKTTYFEIFTAGAGMGEVEVVIQDPTGQKGTVEPQLEARGDSTYRCSYQPTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPAACRAIGRGLQPKGVRVKETADFKVYTKGAGSGELKVTVKGPKGEERVKQKDLGDGVYGFEYYPTIPGTYTVTITWGGQNIGRSPFEVKVGTECGNQKVRAWGPGLEGGIVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDKGDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIREAPQDFHPDRVKARGPGLEKTGVAVNKPAEFTVDAKHAGKAPLRVQVQDNEGCSVEATVKDNGNGTYSCSYVPRKPVKHTAMVSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCTEAGQGDVSIGIKCAPGVVGPTEADIDFDIIRNDNDTFTVKYTPCGAGSYTIMVLFADQATPTSPIRVKVEPSHDASKVKAEGPGLNRTGVELGKPTHFTVNAKTAGKGKLDVQFSGLAKGDAVRDVDIIDHHDNTYTVKYIPVQQGPVGVNVTYGGDHIPKSPFSVGVSPSLDLSKIKVSGLGDKVDVGKDQEFTVKSKGAGGQGKVASKIVSPSGAAVPCKVEPGLGADNSVVRFVPREEGPYEVEVTYDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGNAGSPARFTIDTKGAGTGGLGLTVEGPCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVAPCFDASKVKCSGPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCPGAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALTQTGGPHVKARVANPSGNLTDTYVQDCGDGTYKVEYTPYEEGVHSVDVTYDGSPVPSSPFQVPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNKDGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRANLPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGSYSISVLYGEEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITDPEGKPKKTHIQDNHDGTYTVAYVPDVPGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCTVTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPTVQTPLRSQQLAPQYNYPQGSQQTWIPERPMVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPSITDNKDGTVTVRYSPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHITAYGPGLTHGVVNKPATFTVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNDQHIPGSPFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKVTGEGRVKESITRRRRAPSVANIGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGENHTYCIRFVPAEMGMHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEVGVPAEFGIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGALEECYVTEIDQDKYAVRFIPRENGIYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSAYGAGLEGGVTGSPAEFIVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKVATVPQHATSGPGPADVSKVVAKGLGLSKAYVGQKSNFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHMGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRIMVP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSHSRCG ------CCCCCCCCC	52.42	-
8	S-nitrosocysteine	MSSSHSRCGQSAAVA CCCCCCCCCCCCCCC	6.97	-
8	S-nitrosylation	MSSSHSRCGQSAAVA CCCCCCCCCCCCCCC	6.97	21278135
11	Phosphorylation	SHSRCGQSAAVASPG CCCCCCCCCCCCCCC	11.95	29514104
16	Phosphorylation	GQSAAVASPGGSIDS CCCCCCCCCCCCCCC	19.92	27087446
20	Phosphorylation	AVASPGGSIDSRDAE CCCCCCCCCCCCCCC	29.19	26824392
23	Phosphorylation	SPGGSIDSRDAEMPA CCCCCCCCCCCCCCC	30.32	25619855
31	Phosphorylation	RDAEMPATEKDLAED CCCCCCCCHHHHHHC	37.38	26643407
33	Acetylation	AEMPATEKDLAEDAP CCCCCCHHHHHHCCC	54.40	22826441
42	Acetylation	LAEDAPWKKIQQNTF HHHCCCHHHHHHHHH	38.65	7668279
43	Ubiquitination	AEDAPWKKIQQNTFT HHCCCHHHHHHHHHH	41.71	-
48	Phosphorylation	WKKIQQNTFTRWCNE HHHHHHHHHHHHHHH	23.26	25338131
69	Phosphorylation	KRIANLQTDLSDGLR HHHHCCCCCCHHHHH	41.91	18779572
87	Ubiquitination	LLEVLSQKKMHRKHN HHHHHHHHHHHHHHC	49.00	22790023
120	Acetylation	FLDRESIKLVSIDSK HCCHHCCEEEEECCC	52.71	19850019
123	Phosphorylation	RESIKLVSIDSKAIV HHCCEEEEECCCHHC	30.99	25338131
205	Glutathionylation	LGALVDSCAPGLCPD HHHHHHHCCCCCCCC	4.60	24333276
210	Glutathionylation	DSCAPGLCPDWDSWD HHCCCCCCCCCCCCC	3.40	24333276
270	Acetylation	QFPKAKLKPGAPLRP HCCCCCCCCCCCCCC	40.47	23806337
270	Succinylation	QFPKAKLKPGAPLRP HCCCCCCCCCCCCCC	40.47	23806337
299	Acetylation	EPTGNMVKKRAEFTV CCCCCCCEEEEEEEE	26.27	23236377
310	Phosphorylation	EFTVETRSAGQGEVL EEEEEECCCCCCEEE	44.14	26824392
331	Acetylation	AGHQEEAKVTANNDK CCCCEEEEEEECCCC	43.32	7719695
338	Acetylation	KVTANNDKNRTFSVW EEEECCCCCCEEEEE	50.91	23806337
341	Phosphorylation	ANNDKNRTFSVWYVP ECCCCCCEEEEEEEC	29.65	23375375
343	Phosphorylation	NDKNRTFSVWYVPEV CCCCCEEEEEEECCC	15.89	22871156
367	Acetylation	FAGQHIAKSPFEVYV ECCCEECCCCEEEEE	59.04	23236377
368	Phosphorylation	AGQHIAKSPFEVYVD CCCEECCCCEEEEEE	26.29	26824392
373	Phosphorylation	AKSPFEVYVDKSQGD CCCCEEEEEECCCCC	8.85	25367039
376	Acetylation	PFEVYVDKSQGDASK CEEEEEECCCCCHHH	34.33	23806337
376	Succinylation	PFEVYVDKSQGDASK CEEEEEECCCCCHHH	34.33	23806337
382	Phosphorylation	DKSQGDASKVTAQGP ECCCCCHHHCEEECC	32.19	22817900
385	Phosphorylation	QGDASKVTAQGPGLE CCCHHHCEEECCCCC	19.59	22817900
394	Phosphorylation	QGPGLEPSGNIANKT ECCCCCCCCCCCCCC	34.79	26824392
440	Phosphorylation	QLEARGDSTYRCSYQ CEEECCCCCEECCCC	30.11	26824392
478	Glutathionylation	TVTVGQACNPAACRA EEEECCCCCHHHHHH	4.88	24333276
483	S-nitrosocysteine	QACNPAACRAIGRGL CCCCHHHHHHHCCCC	3.07	-
483	Glutathionylation	QACNPAACRAIGRGL CCCCHHHHHHHCCCC	3.07	24333276
483	S-nitrosylation	QACNPAACRAIGRGL CCCCHHHHHHHCCCC	3.07	20925432
504	Acetylation	VKETADFKVYTKGAG EEEECCEEEEECCCC	34.57	23236377
508	Acetylation	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	23806337
508	Succinylation	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	23806337
508	Ubiquitination	ADFKVYTKGAGSGEL CCEEEEECCCCCCEE	29.13	-
518	Phosphorylation	GSGELKVTVKGPKGE CCCEEEEEEECCCCC	18.21	24759943
520	Acetylation	GELKVTVKGPKGEER CEEEEEEECCCCCCE	61.19	23806337
520	Succinylation	GELKVTVKGPKGEER CEEEEEEECCCCCCE	61.19	23806337
569	Acetylation	GRSPFEVKVGTECGN CCCCEEEEEECCCCC	27.96	23806337
574	Glutathionylation	EVKVGTECGNQKVRA EEEEECCCCCCEEEE	6.61	24333276
578	Acetylation	GTECGNQKVRAWGPG ECCCCCCEEEEECCC	37.37	132911
623	S-nitrosocysteine	PSQAKIECDDKGDGS CCCCEEEECCCCCCC	10.51	-
623	S-nitrosylation	PSQAKIECDDKGDGS CCCCEEEECCCCCCC	10.51	20925432
626	Acetylation	AKIECDDKGDGSCDV CEEEECCCCCCCCEE	45.72	23806337
630	Phosphorylation	CDDKGDGSCDVRYWP ECCCCCCCCEEEEEC	16.34	26824392
631	S-nitrosocysteine	DDKGDGSCDVRYWPQ CCCCCCCCEEEEECC	7.39	-
631	S-nitrosylation	DDKGDGSCDVRYWPQ CCCCCCCCEEEEECC	7.39	20925432
649	Glutathionylation	EYAVHVLCNSEDIRL CEEEEEEECCCCCCC	5.25	24333276
684	Acetylation	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	23806337
684	Succinylation	ARGPGLEKTGVAVNK CCCCCCCCCCEECCC	56.47	23806337
691	Acetylation	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	23806337
691	Succinylation	KTGVAVNKPAEFTVD CCCEECCCCEEEEEE	38.72	23806337
700	Acetylation	AEFTVDAKHAGKAPL EEEEEECCCCCCCCE	29.53	23806337
717	Glutathionylation	QVQDNEGCSVEATVK EEECCCCCEEEEEEE	3.16	24333276
718	Phosphorylation	VQDNEGCSVEATVKD EECCCCCEEEEEEEE	33.57	26824392
735	Phosphorylation	NGTYSCSYVPRKPVK CCEEEEEEECCCCCC	20.85	22817900
748	Phosphorylation	VKHTAMVSWGGVSIP CCCEEEEEECCEECC	13.61	26026062
771	Acetylation	GAGSHPNKVKVYGPG CCCCCCCCEEEECCC	48.13	23806337
771	Succinylation	GAGSHPNKVKVYGPG CCCCCCCCEEEECCC	48.13	23806337
775	Phosphorylation	HPNKVKVYGPGVAKT CCCCEEEECCCCCCC	16.34	25195567
781	Acetylation	VYGPGVAKTGLKAHE EECCCCCCCCCCCCC	40.49	23806337
782	Phosphorylation	YGPGVAKTGLKAHEP ECCCCCCCCCCCCCC	37.70	25338131
837	Acetylation	DNDTFTVKYTPCGAG CCCCEEEEEECCCCC	40.11	-
841	Glutathionylation	FTVKYTPCGAGSYTI EEEEEECCCCCCEEE	4.50	24333276
846	Phosphorylation	TPCGAGSYTIMVLFA ECCCCCCEEEEEEEE	10.20	26643407
847	Phosphorylation	PCGAGSYTIMVLFAD CCCCCCEEEEEEEEC	12.32	26643407
857	Phosphorylation	VLFADQATPTSPIRV EEEECCCCCCCCEEE	22.82	26643407
859	Phosphorylation	FADQATPTSPIRVKV EECCCCCCCCEEEEE	42.66	26643407
860	Phosphorylation	ADQATPTSPIRVKVE ECCCCCCCCEEEEEE	21.38	26824392
865	Acetylation	PTSPIRVKVEPSHDA CCCCEEEEEECCCCH	30.91	23806337
874	Acetylation	EPSHDASKVKAEGPG ECCCCHHHCCCCCCC	49.85	23806337
874	Succinylation	EPSHDASKVKAEGPG ECCCCHHHCCCCCCC	49.85	23806337
876	Acetylation	SHDASKVKAEGPGLN CCCHHHCCCCCCCCC	44.44	23806337
876	Succinylation	SHDASKVKAEGPGLN CCCHHHCCCCCCCCC	44.44	23806337
891	Acetylation	RTGVELGKPTHFTVN CCCCCCCCCCEEEEE	60.41	23806337
900	Ubiquitination	THFTVNAKTAGKGKL CEEEEECEECCCCCE	33.43	-
906	Acetylation	AKTAGKGKLDVQFSG CEECCCCCEEEEECC	45.03	23806337
906	Succinylation	AKTAGKGKLDVQFSG CEECCCCCEEEEECC	45.03	23806337
912	Phosphorylation	GKLDVQFSGLAKGDA CCEEEEECCCCCCCC	18.79	26824392
936	Acetylation	HDNTYTVKYIPVQQG CCCEEEEEEEECCCC	29.66	23236377
937	Phosphorylation	DNTYTVKYIPVQQGP CCEEEEEEEECCCCC	13.21	29514104
958	Acetylation	YGGDHIPKSPFSVGV ECCCCCCCCCCCCCC	70.88	23236377
959	Phosphorylation	GGDHIPKSPFSVGVS CCCCCCCCCCCCCCC	26.31	25619855
962	Phosphorylation	HIPKSPFSVGVSPSL CCCCCCCCCCCCCCC	22.73	25619855
966	Phosphorylation	SPFSVGVSPSLDLSK CCCCCCCCCCCCHHH	11.66	26824392
968	Phosphorylation	FSVGVSPSLDLSKIK CCCCCCCCCCHHHEE	27.32	27087446
972	Phosphorylation	VSPSLDLSKIKVSGL CCCCCCHHHEEECCC	31.81	22942356
973	Acetylation	SPSLDLSKIKVSGLG CCCCCHHHEEECCCC	54.57	23806337
973	Succinylation	SPSLDLSKIKVSGLG CCCCCHHHEEECCCC	54.57	23806337
977	Phosphorylation	DLSKIKVSGLGDKVD CHHHEEECCCCCCCC	24.25	26824392
987	Acetylation	GDKVDVGKDQEFTVK CCCCCCCCCCEEEEE	56.96	23806337
987	Succinylation	GDKVDVGKDQEFTVK CCCCCCCCCCEEEEE	56.96	23806337
994	Acetylation	KDQEFTVKSKGAGGQ CCCEEEEEECCCCCC	43.31	23806337
994	Succinylation	KDQEFTVKSKGAGGQ CCCEEEEEECCCCCC	43.31	23806337
1007	Acetylation	GQGKVASKIVSPSGA CCCEEEEEEECCCCC	37.07	23806337
1007	Succinylation	GQGKVASKIVSPSGA CCCEEEEEEECCCCC	37.07	23806337
1010	Phosphorylation	KVASKIVSPSGAAVP EEEEEEECCCCCCCC	19.47	26824392
1012	Phosphorylation	ASKIVSPSGAAVPCK EEEEECCCCCCCCCE	33.29	29472430
1018	S-nitrosocysteine	PSGAAVPCKVEPGLG CCCCCCCCEECCCCC	6.57	-
1018	Glutathionylation	PSGAAVPCKVEPGLG CCCCCCCCEECCCCC	6.57	24333276
1018	S-nitrosylation	PSGAAVPCKVEPGLG CCCCCCCCEECCCCC	6.57	20925432
1019	Acetylation	SGAAVPCKVEPGLGA CCCCCCCEECCCCCC	43.49	23236377
1029	Phosphorylation	PGLGADNSVVRFVPR CCCCCCCCEEEEEEC	23.65	25777480
1055	Phosphorylation	DGVPVPGSPFPLEAV CCEECCCCCCCHHEE	19.80	25619855
1071	Acetylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	23806337
1071	Succinylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	-
1071	Succinylation	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	23806337
1071	Ubiquitination	PTKPSKVKAFGPGLQ CCCCCCCEEECCCCC	41.56	-
1084	Phosphorylation	LQGGNAGSPARFTID CCCCCCCCCEEEEEE	16.99	27087446
1089	Phosphorylation	AGSPARFTIDTKGAG CCCCEEEEEECCCCC	16.64	24453211
1092	Phosphorylation	PARFTIDTKGAGTGG CEEEEEECCCCCCCC	27.77	23984901
1157	Glutathionylation	FKAHVAPCFDASKVK CEEEEECCCCHHHCE	3.30	24333276
1161	Phosphorylation	VAPCFDASKVKCSGP EECCCCHHHCEECCC	39.56	21659605
1162	Acetylation	APCFDASKVKCSGPG ECCCCHHHCEECCCC	47.65	23236377
1165	Glutathionylation	FDASKVKCSGPGLER CCHHHCEECCCCCCC	6.78	24333276
1260	Glutathionylation	VDTSGVQCYGPGIEG CCCCCCEEECCCCCC	3.84	24333276
1286	Phosphorylation	SVDARALTQTGGPHV EEEHHHHHCCCCCCE	24.09	17525332
1288	Phosphorylation	DARALTQTGGPHVKA EHHHHHCCCCCCEEE	38.58	26824392
1294	Acetylation	QTGGPHVKARVANPS CCCCCCEEEEEECCC	27.69	23806337
1294	Succinylation	QTGGPHVKARVANPS CCCCCCEEEEEECCC	27.69	23806337
1294	Ubiquitination	QTGGPHVKARVANPS CCCCCCEEEEEECCC	27.69	-
1301	Phosphorylation	KARVANPSGNLTDTY EEEEECCCCCCCEEE	39.87	-
1338	Phosphorylation	VDVTYDGSPVPSSPF EEEEECCCCCCCCCC	21.59	21189417
1367	Phosphorylation	VHGPGIQSGTTNKPN EECCCCCCCCCCCCC	35.87	26824392
1369	Phosphorylation	GPGIQSGTTNKPNKF CCCCCCCCCCCCCCE	32.23	26824392
1372	Acetylation	IQSGTTNKPNKFTVE CCCCCCCCCCCEEEE	48.12	23806337
1402	Glutathionylation	PSEAKMSCMDNKDGS CCCCCEECCCCCCCC	3.39	24333276
1436	Phosphorylation	GGHQVPGSPFKVPVH CCEECCCCCEECCCC	22.54	23608596
1450	Acetylation	HDVTDASKVKCSGPG CCCCCHHHCCCCCCC	47.65	23806337
1450	Succinylation	HDVTDASKVKCSGPG CCCCCHHHCCCCCCC	47.65	23806337
1452	Acetylation	VTDASKVKCSGPGLS CCCHHHCCCCCCCCC	26.81	23806337
1452	Succinylation	VTDASKVKCSGPGLS CCCHHHCCCCCCCCC	26.81	23806337
1453	S-nitrosocysteine	TDASKVKCSGPGLSP CCHHHCCCCCCCCCC	6.78	-
1453	Glutathionylation	TDASKVKCSGPGLSP CCHHHCCCCCCCCCC	6.78	24333276
1453	S-nitrosylation	TDASKVKCSGPGLSP CCHHHCCCCCCCCCC	6.78	20925432
1454	Phosphorylation	DASKVKCSGPGLSPG CHHHCCCCCCCCCCC	42.16	25619855
1459	Phosphorylation	KCSGPGLSPGMVRAN CCCCCCCCCCCEECC	25.89	27087446
1462	Oxidation	GPGLSPGMVRANLPQ CCCCCCCCEECCCCC	1.78	17242355
1470	Phosphorylation	VRANLPQSFQVDTSK EECCCCCCEECCCCC	18.73	29514104
1477	Acetylation	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	23236377
1477	Ubiquitination	SFQVDTSKAGVAPLQ CEECCCCCCCEECEE	51.78	22790023
1491	Acetylation	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	23806337
1491	Ubiquitination	QVKVQGPKGLVEPVD EEEEECCCCCEEEEE	72.24	22790023
1514	Phosphorylation	QTVNYVPSREGSYSI EEEEEECCCCCEEEE	32.68	-
1518	Phosphorylation	YVPSREGSYSISVLY EECCCCCEEEEEEEE	15.79	26824392
1519	Phosphorylation	VPSREGSYSISVLYG ECCCCCEEEEEEEEC	22.38	29895711
1520	Phosphorylation	PSREGSYSISVLYGE CCCCCEEEEEEEECC	15.30	21454597
1522	Phosphorylation	REGSYSISVLYGEEE CCCEEEEEEEECCCC	10.50	25777480
1525	Phosphorylation	SYSISVLYGEEEVPR EEEEEEEECCCCCCC	21.97	23984901
1533	Phosphorylation	GEEEVPRSPFKVKVL CCCCCCCCCCEEEEE	28.72	26824392
1538	Acetylation	PRSPFKVKVLPTHDA CCCCCEEEEEECCCH	38.35	23806337
1542	Phosphorylation	FKVKVLPTHDASKVK CEEEEEECCCHHHCC	28.38	22817900
1546	Phosphorylation	VLPTHDASKVKASGP EEECCCHHHCCCCCC	44.00	26824392
1547	Acetylation	LPTHDASKVKASGPG EECCCHHHCCCCCCC	49.85	23806337
1551	Phosphorylation	DASKVKASGPGLNTT CHHHCCCCCCCCCCC	39.54	23984901
1557	Phosphorylation	ASGPGLNTTGVPASL CCCCCCCCCCCCCCC	29.94	23984901
1558	Phosphorylation	SGPGLNTTGVPASLP CCCCCCCCCCCCCCC	34.80	23984901
1563	Phosphorylation	NTTGVPASLPVEFTI CCCCCCCCCCEEEEE	27.43	23984901
1594	Phosphorylation	PEGKPKKTHIQDNHD CCCCCCCCCEEECCC	30.27	25338131
1604	Phosphorylation	QDNHDGTYTVAYVPD EECCCCEEEEEECCC	12.54	25195567
1622	Phosphorylation	RYTILIKYGGDEIPF EEEEEEEECCCCCCC	21.24	25777480
1630	Phosphorylation	GGDEIPFSPYRVRAV CCCCCCCCCEEEEEE	18.70	26824392
1632	Phosphorylation	DEIPFSPYRVRAVPT CCCCCCCEEEEEEEC	22.12	26745281
1723	Glutathionylation	QPGKYVICVRFGGEH CCCEEEEEEEECCEE	0.97	24333276
1734	Phosphorylation	GGEHVPNSPFQVTAL CCEECCCCCCEEEEE	22.48	25619855
1739	Phosphorylation	PNSPFQVTALAGDQP CCCCCEEEEECCCCC	12.74	25619855
1747	Phosphorylation	ALAGDQPTVQTPLRS EECCCCCCCCCCCCC	21.44	26824392
1750	Phosphorylation	GDQPTVQTPLRSQQL CCCCCCCCCCCCCCC	21.69	27087446
1805	Phosphorylation	TIKKGEITGEVRMPS EEECCEEEEEEECCC	24.00	28542873
1812	Phosphorylation	TGEVRMPSGKVAQPS EEEEECCCCCEECCE	41.73	18779572
1814	Acetylation	EVRMPSGKVAQPSIT EEECCCCCEECCEEE	38.44	23806337
1814	Succinylation	EVRMPSGKVAQPSIT EEECCCCCEECCEEE	38.44	23806337
1819	Phosphorylation	SGKVAQPSITDNKDG CCCEECCEEECCCCC	26.49	26824392
1821	Phosphorylation	KVAQPSITDNKDGTV CEECCEEECCCCCCE	37.55	29550500
1824	Acetylation	QPSITDNKDGTVTVR CCEEECCCCCCEEEE	61.41	23806337
1824	Ubiquitination	QPSITDNKDGTVTVR CCEEECCCCCCEEEE	61.41	22790023
1829	Phosphorylation	DNKDGTVTVRYSPSE CCCCCCEEEEECCCC	10.09	26824392
1833	Phosphorylation	GTVTVRYSPSEAGLH CCEEEEECCCCCCCC	16.04	26824392
1835	Phosphorylation	VTVRYSPSEAGLHEM EEEEECCCCCCCCEE	33.85	26824392
1899	Phosphorylation	DAGEGGLSLAIEGPS CCCCCCEEEEEECCC	21.01	26824392
1946	Phosphorylation	NDQHIPGSPFTARVT CCCCCCCCCCEEEEE	16.10	26824392
1957	Phosphorylation	ARVTGDDSMRMSHLK EEEECCCCCCCCEEE	17.02	18779572
1961	Phosphorylation	GDDSMRMSHLKVGSA CCCCCCCCEEEECCC	18.46	18779572
1967	Phosphorylation	MSHLKVGSAADIPIN CCEEEECCCCCCCCC	24.22	23649490
1976	Phosphorylation	ADIPINISETDLSLL CCCCCCCCCCCCEEE	29.92	26824392
1978	Phosphorylation	IPINISETDLSLLTA CCCCCCCCCCEEEEE	35.13	28059163
1981	Phosphorylation	NISETDLSLLTATVV CCCCCCCEEEEEEEC	24.92	23649490
1997	S-nitrosocysteine	PSGREEPCLLKRLRN CCCCCCCCHHHHHHC	8.65	-
1997	Glutathionylation	PSGREEPCLLKRLRN CCCCCCCCHHHHHHC	8.65	24333276
1997	S-nitrosylation	PSGREEPCLLKRLRN CCCCCCCCHHHHHHC	8.65	20925432
2000	Acetylation	REEPCLLKRLRNGHV CCCCCHHHHHHCCCC	36.12	22826441
2010	Phosphorylation	RNGHVGISFVPKETG HCCCCEEEEECCCCC	17.79	-
2024	Acetylation	GEHLVHVKKNGQHVA CCEEEEEEECCEEEE	26.16	22826441
2032	Phosphorylation	KNGQHVASSPIPVVI ECCEEEECCCCCEEE	35.24	23684622
2033	Phosphorylation	NGQHVASSPIPVVIS CCEEEECCCCCEEEE	19.67	26824392
2040	Phosphorylation	SPIPVVISQSEIGDA CCCCEEEEHHHCCCC	18.95	23684622
2042	Phosphorylation	IPVVISQSEIGDASR CCEEEEHHHCCCCCC	25.13	21183079
2048	Phosphorylation	QSEIGDASRVRVSGQ HHHCCCCCCEEECCC	35.73	29514104
2053	Phosphorylation	DASRVRVSGQGLHEG CCCCEEECCCCCCCC	18.16	26824392
2081	Phosphorylation	DAGYGGLSLSIEGPS CCCCCCEEEEEECCC	24.28	26824392
2083	Phosphorylation	GYGGLSLSIEGPSKV CCCCEEEEEECCCCE	18.41	26824392
2088	Phosphorylation	SLSIEGPSKVDINTE EEEEECCCCEECCCC	57.05	20531401
2128	Phosphorylation	ADQHVPGSPFSVKVT CCCCCCCCCCEEEEE	19.39	26824392
2131	Phosphorylation	HVPGSPFSVKVTGEG CCCCCCCEEEEECCC	25.14	24068923
2133	Acetylation	PGSPFSVKVTGEGRV CCCCCEEEEECCCCC	32.64	23236377
2143	Phosphorylation	GEGRVKESITRRRRA CCCCCCCCCCCCCCC	24.44	24704852
2145	Phosphorylation	GRVKESITRRRRAPS CCCCCCCCCCCCCCC	27.66	29472430
2152	Phosphorylation	TRRRRAPSVANIGSH CCCCCCCCCCCCCCC	32.64	27087446
2158	Phosphorylation	PSVANIGSHCDLSLK CCCCCCCCCCCEECC	19.69	25521595
2160	Glutathionylation	VANIGSHCDLSLKIP CCCCCCCCCEECCCC	6.36	24333276
2163	Phosphorylation	IGSHCDLSLKIPEIS CCCCCCEECCCCCCE	17.86	24925903
2170	Phosphorylation	SLKIPEISIQDMTAQ ECCCCCCEEEEEEEE	16.73	26239621
2175	Phosphorylation	EISIQDMTAQVTSPS CCEEEEEEEEEECCC	23.40	26239621
2179	Phosphorylation	QDMTAQVTSPSGKTH EEEEEEEECCCCCCE	23.88	23684622
2180	Phosphorylation	DMTAQVTSPSGKTHE EEEEEEECCCCCCEE	20.43	27087446
2182	Phosphorylation	TAQVTSPSGKTHEAE EEEEECCCCCCEEEE	53.33	22942356
2199	S-nitrosocysteine	EGENHTYCIRFVPAE ECCCCEEEEEEEECC	1.57	-
2199	S-nitrosylation	EGENHTYCIRFVPAE ECCCCEEEEEEEECC	1.57	20925432
2217	Acetylation	HTVSVKYKGQHVPGS EEEEEEECCEECCCC	46.51	23806337
2224	Phosphorylation	KGQHVPGSPFQFTVG CCEECCCCCCEEEEE	19.23	26824392
2279	Phosphorylation	AIAVEGPSKAEISFE EEEEECCCCCEEEEC	56.19	26824392
2284	Phosphorylation	GPSKAEISFEDRKDG CCCCCEEEECCCCCC	17.68	28418008
2289	Acetylation	EISFEDRKDGSCGVA EEEECCCCCCCCEEE	77.94	23236377
2293	S-nitrosocysteine	EDRKDGSCGVAYVVQ CCCCCCCCEEEEEEE	6.59	-
2293	S-nitrosylation	EDRKDGSCGVAYVVQ CCCCCCCCEEEEEEE	6.59	20925432
2305	Phosphorylation	VVQEPGDYEVSVKFN EEECCCCEEEEEEEC	24.93	-
2319	Phosphorylation	NEEHIPDSPFVVPVA CHHHCCCCCEEEEEE	18.19	25619855
2327	Phosphorylation	PFVVPVASPSGDARR CEEEEEECCCCCHHE	21.60	27087446
2329	Phosphorylation	VVPVASPSGDARRLT EEEEECCCCCHHEEE	46.97	27087446
2336	Phosphorylation	SGDARRLTVSSLQES CCCHHEEEHHHHHHC	19.27	26824392
2338	Phosphorylation	DARRLTVSSLQESGL CHHEEEHHHHHHCCC	21.79	28833060
2339	Phosphorylation	ARRLTVSSLQESGLK HHEEEHHHHHHCCCC	29.72	28833060
2343	Phosphorylation	TVSSLQESGLKVNQP EHHHHHHCCCCCCCC	36.14	28833060
2352	Phosphorylation	LKVNQPASFAVSLNG CCCCCCCEEEEECCC	22.03	22802335
2356	Phosphorylation	QPASFAVSLNGAKGA CCCEEEEECCCCCCE	16.82	26824392
2370	Phosphorylation	AIDAKVHSPSGALEE EEEEEEECCCCCCEE	24.61	26824392
2372	Phosphorylation	DAKVHSPSGALEECY EEEEECCCCCCEEEE	39.45	19060867
2378	S-nitrosocysteine	PSGALEECYVTEIDQ CCCCCEEEEEEEECC	2.12	-
2378	S-nitrosylation	PSGALEECYVTEIDQ CCCCCEEEEEEEECC	2.12	20925432
2379	Phosphorylation	SGALEECYVTEIDQD CCCCEEEEEEEECCC	17.43	26824392
2387	Acetylation	VTEIDQDKYAVRFIP EEEECCCCEEEEEEE	29.49	22826441
2409	Phosphorylation	IDVKFNGTHIPGSPF EEEEECCEECCCCCC	20.10	24068923
2414	Phosphorylation	NGTHIPGSPFKIRVG CCEECCCCCCEEECC	23.08	26824392
2473	Acetylation	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	23806337
2473	Succinylation	IDGPSKVKMDCQECP EECCCCEEEECCCCC	32.53	23806337
2476	S-nitrosocysteine	PSKVKMDCQECPEGY CCCEEEECCCCCCCE	3.08	-
2476	S-nitrosylation	PSKVKMDCQECPEGY CCCEEEECCCCCCCE	3.08	20925432
2505	Phosphorylation	SIKYGGPYHIGGSPF EEEECCCCEECCCCC	14.89	28066266
2510	Phosphorylation	GPYHIGGSPFKAKVT CCCEECCCCCCCEEC	23.19	21659605
2523	Phosphorylation	VTGPRLVSNHSLHET ECCCEEECCCCCCCC	33.16	22817900
2526	Phosphorylation	PRLVSNHSLHETSSV CEEECCCCCCCCCCE	35.35	30352176
2530	Phosphorylation	SNHSLHETSSVFVDS CCCCCCCCCCEEECC	18.63	23984901
2531	Phosphorylation	NHSLHETSSVFVDSL CCCCCCCCCEEECCC	22.86	23984901
2532	Phosphorylation	HSLHETSSVFVDSLT CCCCCCCCEEECCCC	27.30	23984901
2537	Phosphorylation	TSSVFVDSLTKVATV CCCEEECCCCEEEEC	32.41	26824392
2543	Phosphorylation	DSLTKVATVPQHATS CCCCEEEECCCCCCC	35.39	29514104
2549	Phosphorylation	ATVPQHATSGPGPAD EECCCCCCCCCCCCC	31.90	30635358
2550	Phosphorylation	TVPQHATSGPGPADV ECCCCCCCCCCCCCH	43.72	26824392
2558	Phosphorylation	GPGPADVSKVVAKGL CCCCCCHHHHHHHCC	21.93	30635358
2559	Acetylation	PGPADVSKVVAKGLG CCCCCHHHHHHHCCC	40.34	23806337
2559	Succinylation	PGPADVSKVVAKGLG CCCCCHHHHHHHCCC	40.34	23806337
2563	Acetylation	DVSKVVAKGLGLSKA CHHHHHHHCCCCCHH	42.96	23806337
2563	Succinylation	DVSKVVAKGLGLSKA CHHHHHHHCCCCCHH	42.96	23806337
2569	Acetylation	AKGLGLSKAYVGQKS HHCCCCCHHHCCCCC	49.10	23806337
2569	Malonylation	AKGLGLSKAYVGQKS HHCCCCCHHHCCCCC	49.10	26320211
2569	Succinylation	AKGLGLSKAYVGQKS HHCCCCCHHHCCCCC	49.10	-
2569	Succinylation	AKGLGLSKAYVGQKS HHCCCCCHHHCCCCC	49.10	23806337
2571	Phosphorylation	GLGLSKAYVGQKSNF CCCCCHHHCCCCCCE	14.62	-
2575	Acetylation	SKAYVGQKSNFTVDC CHHHCCCCCCEEEEC	41.25	23806337
2576	Phosphorylation	KAYVGQKSNFTVDCS HHHCCCCCCEEEECH	29.32	23375375
2582	Glutathionylation	KSNFTVDCSKAGNNM CCCEEEECHHCCCCE	3.80	24333276
2599	Phosphorylation	VGVHGPRTPCEEILV EEEECCCCCHHHHHH	35.11	26824392
2601	S-nitrosocysteine	VHGPRTPCEEILVKH EECCCCCHHHHHHHH	7.87	-
2601	S-nitrosylation	VHGPRTPCEEILVKH EECCCCCHHHHHHHH	7.87	20925432
2607	Acetylation	PCEEILVKHMGSRLY CHHHHHHHHCCCCEE	25.16	23806337
2607	Succinylation	PCEEILVKHMGSRLY CHHHHHHHHCCCCEE	25.16	23806337
2611	Phosphorylation	ILVKHMGSRLYSVSY HHHHHCCCCEEEEEE	16.13	28059163
2614	Phosphorylation	KHMGSRLYSVSYLLK HHCCCCEEEEEEEEC	13.10	29514104
2615	Phosphorylation	HMGSRLYSVSYLLKD HCCCCEEEEEEEECC	14.80	18779572
2617	Phosphorylation	GSRLYSVSYLLKDKG CCCEEEEEEEECCCC	12.24	18779572
2618	Phosphorylation	SRLYSVSYLLKDKGE CCEEEEEEEECCCCE	17.56	18779572
2621	Acetylation	YSVSYLLKDKGEYTL EEEEEEECCCCEEEE	55.59	23806337
2623	Acetylation	VSYLLKDKGEYTLVV EEEEECCCCEEEEEE	52.64	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1338	S	Phosphorylation	Kinase	MTOR	Q9JLN9	PSP
2152	S	Phosphorylation	Kinase	RPS6KA1	P18653	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
2152	S	Phosphorylation	19144319
Ligand binding induces a conformational switch triggering phosphorylation at Ser-2152 by PKA.
2152	S	Phosphorylation	19144319
Phosphorylation at Ser-2152 is negatively regulated by the autoinhibited conformation of filamin repeats 19-21.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FLNA_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
FURIN_HUMAN	FURIN	physical	9412467

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FLNA_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1459 AND THR-1750, ANDMASS SPECTROMETRY.	19131326 [Abstract]
"The phagosomal proteome in interferon-gamma-activated macrophages."; Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,Thibault P.; Immunity 30:143-154(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2152, AND MASSSPECTROMETRY.	19144319 [Abstract]
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2152, AND MASSSPECTROMETRY.	19367708 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1286, AND MASSSPECTROMETRY.	17525332 [Abstract]

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