RL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL4_MOUSE
• UniProt AC: Q9D8E6
• Protein Name: 60S ribosomal protein L4
• Gene Name: Rpl4
• Organism: Mus musculus (Mouse).
• Sequence Length: 419
• Protein Sequence: MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVQLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMMNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVKKLEAAATALATKSEKVVPEKGTADKKPAVGKKGKKVDAKKQKPAGKKVVAKKPAEKKPTTEEKKPAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACARPLIS ------CCCCCCCEE	8.83	-
11	Phosphorylation	ARPLISVYSEKGESS CCCCEEEEECCCCCC	12.34	25367039
12	Phosphorylation	RPLISVYSEKGESSG CCCEEEEECCCCCCC	30.58	29176673
14	Acetylation	LISVYSEKGESSGKN CEEEEECCCCCCCCC	63.14	23806337
14	Ubiquitination	LISVYSEKGESSGKN CEEEEECCCCCCCCC	63.14	-
14	Malonylation	LISVYSEKGESSGKN CEEEEECCCCCCCCC	63.14	26320211
14	Succinylation	LISVYSEKGESSGKN CEEEEECCCCCCCCC	63.14	23954790
20	Ubiquitination	EKGESSGKNVTLPAV CCCCCCCCCCCCCEE	50.63	-
23	Phosphorylation	ESSGKNVTLPAVFKA CCCCCCCCCCEEECC	36.10	22006019
29	Acetylation	VTLPAVFKAPIRPDI CCCCEEECCCCCHHH	46.80	23201123
52	Phosphorylation	RKNNRQPYAVSELAG CCCCCCCCCHHHHCC	15.99	29514104
55	Phosphorylation	NRQPYAVSELAGHQT CCCCCCHHHHCCCCC	20.79	29514104
62	Phosphorylation	SELAGHQTSAESWGT HHHCCCCCCHHHHCC	24.99	26525534
96	S-palmitoylation	QGAFGNMCRGGRMFA CCCCCCCCCCCCCCC	4.19	28526873
96	Glutathionylation	QGAFGNMCRGGRMFA CCCCCCCCCCCCCCC	4.19	24333276
96	S-nitrosylation	QGAFGNMCRGGRMFA CCCCCCCCCCCCCCC	4.19	24926564
96	S-nitrosocysteine	QGAFGNMCRGGRMFA CCCCCCCCCCCCCCC	4.19	-
97	Methylation	GAFGNMCRGGRMFAP CCCCCCCCCCCCCCC	39.57	24129315
100	Methylation	GNMCRGGRMFAPTKT CCCCCCCCCCCCHHH	21.62	26542237
106	Acetylation	GRMFAPTKTWRRWHR CCCCCCHHHHHHHHH	45.06	23806337
106	Ubiquitination	GRMFAPTKTWRRWHR CCCCCCHHHHHHHHH	45.06	-
125	Glutathionylation	TQKRYAICSALAASA HHHHHHHHHHHHHHH	1.16	24333276
125	S-palmitoylation	TQKRYAICSALAASA HHHHHHHHHHHHHHH	1.16	28526873
140	Acetylation	LPALVMSKGHRIEEV HHHHHHCCCCCCEEC	40.41	22826441
157	Succinylation	LPLVVEDKVEGYKKT CCEEEECCCCCCHHH	28.78	23954790
157	Acetylation	LPLVVEDKVEGYKKT CCEEEECCCCCCHHH	28.78	23954790
157	Ubiquitination	LPLVVEDKVEGYKKT CCEEEECCCCCCHHH	28.78	-
162	Ubiquitination	EDKVEGYKKTKEAVQ ECCCCCCHHHHHHHH	65.90	-
162	Acetylation	EDKVEGYKKTKEAVQ ECCCCCCHHHHHHHH	65.90	23201123
163	Ubiquitination	DKVEGYKKTKEAVQL CCCCCCHHHHHHHHH	57.24	-
163	Acetylation	DKVEGYKKTKEAVQL CCCCCCHHHHHHHHH	57.24	130549
172	Succinylation	KEAVQLLKKLKAWND HHHHHHHHHHHHHHH	65.73	23954790
173	Ubiquitination	EAVQLLKKLKAWNDI HHHHHHHHHHHHHHH	56.01	-
175	Ubiquitination	VQLLKKLKAWNDIKK HHHHHHHHHHHHHHH	61.30	-
181	Acetylation	LKAWNDIKKVYASQR HHHHHHHHHHHHHHH	38.76	23864654
208	Glutathionylation	RIQRRGPCIIYNEDN HHHHHCCEEEEECCC	3.09	24333276
208	S-nitrosylation	RIQRRGPCIIYNEDN HHHHHCCEEEEECCC	3.09	24926564
208	S-palmitoylation	RIQRRGPCIIYNEDN HHHHHCCEEEEECCC	3.09	28526873
219	Acetylation	NEDNGIIKAFRNIPG ECCCCHHHHHHCCCC	39.28	22826441
219	Ubiquitination	NEDNGIIKAFRNIPG ECCCCHHHHHHCCCC	39.28	-
228	Phosphorylation	FRNIPGITLLNVSKL HHCCCCEEEEEHHHC	30.98	22006019
233	Phosphorylation	GITLLNVSKLNILKL CEEEEEHHHCCEEEC	30.28	29514104
234	Ubiquitination	ITLLNVSKLNILKLA EEEEEHHHCCEEECC	41.07	-
234	Acetylation	ITLLNVSKLNILKLA EEEEEHHHCCEEECC	41.07	22733758
239	Acetylation	VSKLNILKLAPGGHV HHHCCEEECCCCCCH	38.51	22826441
239	Ubiquitination	VSKLNILKLAPGGHV HHHCCEEECCCCCCH	38.51	-
250	Glutathionylation	GGHVGRFCIWTESAF CCCHHHEEEECHHHH	2.15	24333276
250	S-nitrosylation	GGHVGRFCIWTESAF CCCHHHEEEECHHHH	2.15	21278135
250	S-palmitoylation	GGHVGRFCIWTESAF CCCHHHEEEECHHHH	2.15	28526873
250	S-nitrosocysteine	GGHVGRFCIWTESAF CCCHHHEEEECHHHH	2.15	-
253	Phosphorylation	VGRFCIWTESAFRKL HHHEEEECHHHHHHH	10.51	26643407
255	Phosphorylation	RFCIWTESAFRKLDE HEEEECHHHHHHHHH	25.90	26643407
259	Acetylation	WTESAFRKLDELYGT ECHHHHHHHHHHHHH	54.56	23806337
259	Ubiquitination	WTESAFRKLDELYGT ECHHHHHHHHHHHHH	54.56	-
264	Phosphorylation	FRKLDELYGTWRKAA HHHHHHHHHHHHHHH	15.51	22817900
266	Phosphorylation	KLDELYGTWRKAASL HHHHHHHHHHHHHHC	14.45	25367039
274	Ubiquitination	WRKAASLKSNYNLPM HHHHHHCCCCCCCCH	33.87	-
277	Phosphorylation	AASLKSNYNLPMHKM HHHCCCCCCCCHHHH	25.76	29514104
283	Ubiquitination	NYNLPMHKMMNTDLS CCCCCHHHHHCCCHH	33.32	-
283	Acetylation	NYNLPMHKMMNTDLS CCCCCHHHHHCCCHH	33.32	22826441
287	Phosphorylation	PMHKMMNTDLSRILK CHHHHHCCCHHHHHC	22.03	22324799
290	Phosphorylation	KMMNTDLSRILKSPE HHHCCCHHHHHCCHH	21.78	22817900
294	Ubiquitination	TDLSRILKSPEIQRA CCHHHHHCCHHHHHH	62.69	-
294	Malonylation	TDLSRILKSPEIQRA CCHHHHHCCHHHHHH	62.69	26320211
295	Phosphorylation	DLSRILKSPEIQRAL CHHHHHCCHHHHHHH	25.07	26824392
300	Citrullination	LKSPEIQRALRAPRK HCCHHHHHHHHCCHH	41.05	-
300	Citrullination	LKSPEIQRALRAPRK HCCHHHHHHHHCCHH	41.05	24463520
320	Ubiquitination	VLKKNPLKNLRIMLK HHHHCCCCCHHHHHH	56.01	-
327	Ubiquitination	KNLRIMLKLNPYAKT CCHHHHHHHCHHHHH	28.92	-
327	Acetylation	KNLRIMLKLNPYAKT CCHHHHHHHCHHHHH	28.92	23806337
333	Ubiquitination	LKLNPYAKTMRRNTI HHHCHHHHHHHHHHH	36.69	-
333	Acetylation	LKLNPYAKTMRRNTI HHHCHHHHHHHHHHH	36.69	23864654
339	Phosphorylation	AKTMRRNTILRQARN HHHHHHHHHHHHHHH	21.41	-
352	Ubiquitination	RNHKLRVKKLEAAAT HHCCCHHHHHHHHHH	45.25	-
353	Succinylation	NHKLRVKKLEAAATA HCCCHHHHHHHHHHH	49.02	23806337
353	Ubiquitination	NHKLRVKKLEAAATA HCCCHHHHHHHHHHH	49.02	-
353	Acetylation	NHKLRVKKLEAAATA HCCCHHHHHHHHHHH	49.02	23806337
359	Phosphorylation	KKLEAAATALATKSE HHHHHHHHHHHHCCC	19.92	28066266
363	Phosphorylation	AAATALATKSEKVVP HHHHHHHHCCCCCCC	35.63	28066266
364	Malonylation	AATALATKSEKVVPE HHHHHHHCCCCCCCC	51.51	26320211
364	Acetylation	AATALATKSEKVVPE HHHHHHHCCCCCCCC	51.51	23806337
364	Ubiquitination	AATALATKSEKVVPE HHHHHHHCCCCCCCC	51.51	-
365	Phosphorylation	ATALATKSEKVVPEK HHHHHHCCCCCCCCC	37.99	26824392
367	Acetylation	ALATKSEKVVPEKGT HHHHCCCCCCCCCCC	56.47	23806337
367	Ubiquitination	ALATKSEKVVPEKGT HHHHCCCCCCCCCCC	56.47	-
367	Malonylation	ALATKSEKVVPEKGT HHHHCCCCCCCCCCC	56.47	26073543
372	Acetylation	SEKVVPEKGTADKKP CCCCCCCCCCCCCCC	56.33	23954790
372	Ubiquitination	SEKVVPEKGTADKKP CCCCCCCCCCCCCCC	56.33	-
372	Malonylation	SEKVVPEKGTADKKP CCCCCCCCCCCCCCC	56.33	26320211
374	Phosphorylation	KVVPEKGTADKKPAV CCCCCCCCCCCCCCC	42.63	28066266
377	Acetylation	PEKGTADKKPAVGKK CCCCCCCCCCCCCCC	59.18	23806337
378	Acetylation	EKGTADKKPAVGKKG CCCCCCCCCCCCCCC	38.46	23201123
391	Acetylation	KGKKVDAKKQKPAGK CCCCCCHHHCCCCCC	51.80	24062335
392	Acetylation	GKKVDAKKQKPAGKK CCCCCHHHCCCCCCC	66.33	24062335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RL4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry.";
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
Mol. Cell. Proteomics 8:904-912(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.
PubMed: 19131326