dbPTM

MPCP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MPCP_MOUSE
UniProt AC	Q8VEM8
Protein Name	Phosphate carrier protein, mitochondrial
Gene Name	Slc25a3
Organism	Mus musculus (Mouse).
Sequence Length	357
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Transport of phosphate groups from the cytosol to mitochondrial matrix. Phosphate is cotransported with H(+). May play a role regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)..
Protein Sequence	MFSSVAHLARANPFNAPHLQLVHDGLSGPRSPPAPPRRSRHLAAAAVEEYSCEFGSMKYYALCGFGGVLSCGLTHTAVVPLDLVKCRMQVDPQKYKGIFNGFSITLKEDGVRGLAKGWAPTLIGYSMQGLCKFGFYEVFKALYSNILGEENTYLWRTSLYLASSASAEFFADIALAPMEAAKVRIQTQPGYANTLREAVPKMYKEEGLNAFYKGVAPLWMRQIPYTMMKFACFERTVEALYKFVVPKPRSECTKAEQLVVTFVAGYIAGVFCAIVSHPADSVVSVLNKEKGSTASQVLQRLGFRGVWKGLFARIIMIGTLTALQWFIYDSVKVYFRLPRPPPPEMPESLKKKLGLTE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
27	Phosphorylation	QLVHDGLSGPRSPPA EEECCCCCCCCCCCC	52.89	23140645
31	Phosphorylation	DGLSGPRSPPAPPRR CCCCCCCCCCCCCCH	38.07	22817900
39	Phosphorylation	PPAPPRRSRHLAAAA CCCCCCHHHHHHHHH	25.90	22817900
50	Phosphorylation	AAAAVEEYSCEFGSM HHHHHHHHHCCCCCC	12.71	-
52	S-nitrosylation	AAVEEYSCEFGSMKY HHHHHHHCCCCCCCC	5.00	22178444
86	S-nitrosocysteine	VPLDLVKCRMQVDPQ EEHHHHCCCCCCCHH	3.23	-
86	S-nitrosylation	VPLDLVKCRMQVDPQ EEHHHHCCCCCCCHH	3.23	21278135
94	Acetylation	RMQVDPQKYKGIFNG CCCCCHHHCCEECCC	55.08	23864654
94	Ubiquitination	RMQVDPQKYKGIFNG CCCCCHHHCCEECCC	55.08	-
96	Acetylation	QVDPQKYKGIFNGFS CCCHHHCCEECCCEE	53.19	23864654
96	Succinylation	QVDPQKYKGIFNGFS CCCHHHCCEECCCEE	53.19	24315375
107	Methylation	NGFSITLKEDGVRGL CCEEEEEECCCCCHH	45.14	-
107	Acetylation	NGFSITLKEDGVRGL CCEEEEEECCCCCHH	45.14	23576753
107	Succinylation	NGFSITLKEDGVRGL CCEEEEEECCCCCHH	45.14	26388266
131	S-palmitoylation	GYSMQGLCKFGFYEV CCCHHHHHHHHHHHH	4.37	28526873
131	S-nitrosylation	GYSMQGLCKFGFYEV CCCHHHHHHHHHHHH	4.37	21278135
131	S-nitrosocysteine	GYSMQGLCKFGFYEV CCCHHHHHHHHHHHH	4.37	-
132	Acetylation	YSMQGLCKFGFYEVF CCHHHHHHHHHHHHH	54.27	23576753
132	Malonylation	YSMQGLCKFGFYEVF CCHHHHHHHHHHHHH	54.27	26073543
136	Phosphorylation	GLCKFGFYEVFKALY HHHHHHHHHHHHHHH	16.15	25195567
152	Phosphorylation	NILGEENTYLWRTSL HHCCCCCCCHHHHHH	24.22	29899451
153	Phosphorylation	ILGEENTYLWRTSLY HCCCCCCCHHHHHHH	18.82	22817900
191	Phosphorylation	RIQTQPGYANTLREA HHCCCCCHHHHHHHH	11.89	25195567
201	Acetylation	TLREAVPKMYKEEGL HHHHHHHHHHHHHCH	48.54	23864654
204	Succinylation	EAVPKMYKEEGLNAF HHHHHHHHHHCHHHH	45.87	23806337
204	Ubiquitination	EAVPKMYKEEGLNAF HHHHHHHHHHCHHHH	45.87	-
204	Acetylation	EAVPKMYKEEGLNAF HHHHHHHHHHCHHHH	45.87	23806337
212	Phosphorylation	EEGLNAFYKGVAPLW HHCHHHHHHCCHHHH	12.38	25195567
213	Acetylation	EGLNAFYKGVAPLWM HCHHHHHHCCHHHHH	40.22	23864654
213	Succinylation	EGLNAFYKGVAPLWM HCHHHHHHCCHHHHH	40.22	23954790
225	Phosphorylation	LWMRQIPYTMMKFAC HHHHHCCHHHHHHHH	14.64	25195567
229	Acetylation	QIPYTMMKFACFERT HCCHHHHHHHHHHHH	20.98	23864654
229	Succinylation	QIPYTMMKFACFERT HCCHHHHHHHHHHHH	20.98	24315375
229	Ubiquitination	QIPYTMMKFACFERT HCCHHHHHHHHHHHH	20.98	-
232	S-nitrosylation	YTMMKFACFERTVEA HHHHHHHHHHHHHHH	4.02	21278135
232	S-nitrosocysteine	YTMMKFACFERTVEA HHHHHHHHHHHHHHH	4.02	-
242	Acetylation	RTVEALYKFVVPKPR HHHHHHHHHHCCCCH	32.31	24062335
242	Succinylation	RTVEALYKFVVPKPR HHHHHHHHHHCCCCH	32.31	23954790
272	S-nitrosylation	GYIAGVFCAIVSHPA HHHHHHHHHHHCCCC	2.04	22178444
290	Acetylation	VSVLNKEKGSTASQV HHHHCCCCCCCHHHH	60.82	23864654
290	Malonylation	VSVLNKEKGSTASQV HHHHCCCCCCCHHHH	60.82	26320211
290	Succinylation	VSVLNKEKGSTASQV HHHHCCCCCCCHHHH	60.82	24315375
290	Ubiquitination	VSVLNKEKGSTASQV HHHHCCCCCCCHHHH	60.82	-
295	Phosphorylation	KEKGSTASQVLQRLG CCCCCCHHHHHHHHC	22.40	28464351
308	Acetylation	LGFRGVWKGLFARII HCCCHHHHHHHHHHH	43.24	23806337
308	Succinylation	LGFRGVWKGLFARII HCCCHHHHHHHHHHH	43.24	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MPCP_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MPCP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MPCP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MPCP_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MPCP_MOUSE

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-94 AND LYS-204, AND MASSSPECTROMETRY.	16916647 [Abstract]