PRDX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDX2_MOUSE
• UniProt AC: Q61171
• Protein Name: Peroxiredoxin-2
• Gene Name: Prdx2
• Organism: Mus musculus (Mouse).
• Sequence Length: 198
• Subcellular Localization: Cytoplasm .
• Protein Description: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)..
• Protein Sequence: MASGNAQIGKSAPDFTATAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASGNAQIG ------CCCCCCCCC	26.58	-
10	Succinylation	SGNAQIGKSAPDFTA CCCCCCCCCCCCCEE	45.10	23954790
11	Phosphorylation	GNAQIGKSAPDFTAT CCCCCCCCCCCCEEE	39.56	26643407
16	Phosphorylation	GKSAPDFTATAVVDG CCCCCCCEEEEEEEC	30.40	25521595
26	Ubiquitination	AVVDGAFKEIKLSDY EEEECCCEEEECHHC	58.98	22790023
26	Acetylation	AVVDGAFKEIKLSDY EEEECCCEEEECHHC	58.98	22826441
29	Ubiquitination	DGAFKEIKLSDYRGK ECCCEEEECHHCCCC	42.92	22790023
89	Phosphorylation	THLAWINTPRKEGGL CEEEEECCCCCCCCC	18.48	17610816
92	Ubiquitination	AWINTPRKEGGLGPL EEECCCCCCCCCCCC	63.01	22790023
108	Phosphorylation	IPLLADVTKSLSQNY CHHHHHHHHHHHHHC	18.57	23984901
110	Phosphorylation	LLADVTKSLSQNYGV HHHHHHHHHHHHCCE	24.72	25521595
112	Phosphorylation	ADVTKSLSQNYGVLK HHHHHHHHHHCCEEE	24.38	23737553
115	Phosphorylation	TKSLSQNYGVLKNDE HHHHHHHCCEEECCC	10.85	-
119	Succinylation	SQNYGVLKNDEGIAY HHHCCEEECCCCCEE	61.00	23954790
119	Acetylation	SQNYGVLKNDEGIAY HHHCCEEECCCCCEE	61.00	22826441
119	Ubiquitination	SQNYGVLKNDEGIAY HHHCCEEECCCCCEE	61.00	-
135	Ubiquitination	GLFIIDAKGVLRQIT EEEEEECCCEEEEEE	45.89	22790023
142	Phosphorylation	KGVLRQITVNDLPVG CCEEEEEECCCCCCC	12.62	20139300
177	Ubiquitination	EVCPAGWKPGSDTIK CCCCCCCCCCCCCCC	38.29	22790023
182	Phosphorylation	GWKPGSDTIKPNVDD CCCCCCCCCCCCCCC	32.37	-
184	Acetylation	KPGSDTIKPNVDDSK CCCCCCCCCCCCCHH	32.41	23954790
190	Phosphorylation	IKPNVDDSKEYFSKH CCCCCCCHHHHHHHC	23.95	25367039
193	Phosphorylation	NVDDSKEYFSKHN-- CCCCHHHHHHHCC--	19.52	22499769
195	Phosphorylation	DDSKEYFSKHN---- CCHHHHHHHCC----	31.91	25367039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
89	T	Phosphorylation	Kinase	CDK5	P49615	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRDX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDX2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRDX2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.