TCP4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TCP4_MOUSE
• UniProt AC: P11031
• Protein Name: Activated RNA polymerase II transcriptional coactivator p15
• Gene Name: Sub1
• Organism: Mus musculus (Mouse).
• Sequence Length: 127
• Subcellular Localization: Nucleus.
• Protein Description: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)..
• Protein Sequence: MPKSKELVSSSSSGSDSDSEVEKKLKRKKQAVPEKPVKKQKPGETSRALASSKQSSSSRDDNMFQIGKMRYVSVRDFKGKILIDIREYWMDSEGEMKPGRKGISLNMEQWSQLKEQISDIDDAVRKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MPKSKELVSS -----CCCCHHHHCC	73.24	22826441
4	Phosphorylation	----MPKSKELVSSS ----CCCCHHHHCCC	26.03	-
5	Acetylation	---MPKSKELVSSSS ---CCCCHHHHCCCC	62.28	22826441
9	Phosphorylation	PKSKELVSSSSSGSD CCCHHHHCCCCCCCC	36.81	25619855
10	Phosphorylation	KSKELVSSSSSGSDS CCHHHHCCCCCCCCC	27.10	25619855
11	Phosphorylation	SKELVSSSSSGSDSD CHHHHCCCCCCCCCH	22.48	25619855
12	Phosphorylation	KELVSSSSSGSDSDS HHHHCCCCCCCCCHH	40.44	25293948
13	Phosphorylation	ELVSSSSSGSDSDSE HHHCCCCCCCCCHHH	44.24	23984901
15	Phosphorylation	VSSSSSGSDSDSEVE HCCCCCCCCCHHHHH	35.57	26824392
17	Phosphorylation	SSSSGSDSDSEVEKK CCCCCCCCHHHHHHH	44.74	25521595
19	Phosphorylation	SSGSDSDSEVEKKLK CCCCCCHHHHHHHHH	47.71	22942356
35	Acetylation	KKQAVPEKPVKKQKP HHCCCCCCCCCCCCC	49.38	23201123
45	Phosphorylation	KKQKPGETSRALASS CCCCCCHHHHHHHHH	29.45	25338131
51	Phosphorylation	ETSRALASSKQSSSS HHHHHHHHHCCCCCC	38.63	26643407
52	Phosphorylation	TSRALASSKQSSSSR HHHHHHHHCCCCCCC	29.16	26643407
53	Succinylation	SRALASSKQSSSSRD HHHHHHHCCCCCCCC	52.26	23806337
53	Ubiquitination	SRALASSKQSSSSRD HHHHHHHCCCCCCCC	52.26	-
53	Acetylation	SRALASSKQSSSSRD HHHHHHHCCCCCCCC	52.26	23806337
55	Phosphorylation	ALASSKQSSSSRDDN HHHHHCCCCCCCCCC	35.60	25521595
56	Phosphorylation	LASSKQSSSSRDDNM HHHHCCCCCCCCCCC	29.82	25521595
57	Phosphorylation	ASSKQSSSSRDDNMF HHHCCCCCCCCCCCE	34.34	25521595
58	Phosphorylation	SSKQSSSSRDDNMFQ HHCCCCCCCCCCCEE	41.50	24453211
68	Ubiquitination	DNMFQIGKMRYVSVR CCCEEECCEEEEEEE	23.10	22790023
68	Acetylation	DNMFQIGKMRYVSVR CCCEEECCEEEEEEE	23.10	23236377
71	Phosphorylation	FQIGKMRYVSVRDFK EEECCEEEEEEECCC	8.12	29514104
80	Malonylation	SVRDFKGKILIDIRE EEECCCCCEEEEEHH	34.62	26320211
92	Phosphorylation	IREYWMDSEGEMKPG EHHHEECCCCCCCCC	31.25	25266776
104	Phosphorylation	KPGRKGISLNMEQWS CCCCCCCCCCHHHHH	23.51	26643407
118	Phosphorylation	SQLKEQISDIDDAVR HHHHHHHHCHHHHHH	28.36	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TCP4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TCP4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TCP4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TCP4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A differential phosphoproteomic analysis of retinoic acid-treated P19cells.";
Smith J.C., Duchesne M.A., Tozzi P., Ethier M., Figeys D.;
J. Proteome Res. 6:3174-3186(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-9; SER-10; SER-11;SER-12; SER-13; SER-15; SER-17 AND SER-19, AND MASS SPECTROMETRY.
PubMed: 17622165