PCBP2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCBP2_MOUSE
• UniProt AC: Q61990
• Protein Name: Poly(rC)-binding protein 2
• Gene Name: Pcbp2
• Organism: Mus musculus (Mouse).
• Sequence Length: 362
• Subcellular Localization: Nucleus. Cytoplasm.
• Protein Description: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitinationa and degradation (By similarity)..
• Protein Sequence: MDTGVIEGGLNVTLTIRLLMHGKEVGSIIGKKGESVKKMREESGARINISEGNCPERIITLAGPTNAIFKAFAMIIDKLEEDISSSMTNSTAASRPPVTLRLVVPASQCGSLIGKGGCKIKEIRESTGAQVQVAGDMLPNSTERAITIAGIPQSIIECVKQICVVMLESPPKGVTIPYRPKPSSSPVIFAGGQDRYSTGSDSASFPHTTPSMCLNPDLEGPPLEAYTIQGQYAIPQPDLTKLHQLAMQQSHFPMTHGNTGFSGIESSSPEVKGYWAGLDASAQTTSHELTIPNDLIGCIIGRQGAKINEIRQMSGAQIKIANPVEGSTDRQVTITGSAASISLAQYLINVRLSSETGGMGSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	IRLLMHGKEVGSIIG EEHHHCCHHHHHHHC	34.25	-
23	Acetylation	IRLLMHGKEVGSIIG EEHHHCCHHHHHHHC	34.25	21680727
50	Phosphorylation	SGARINISEGNCPER HCCCEEECCCCCCCC	34.66	-
54	S-nitrosocysteine	INISEGNCPERIITL EEECCCCCCCCEEEE	5.64	-
54	S-nitrosylation	INISEGNCPERIITL EEECCCCCCCCEEEE	5.64	20925432
109	S-palmitoylation	LVVPASQCGSLIGKG EEEEHHHHHHHHCCC	3.56	28526873
109	S-nitrosylation	LVVPASQCGSLIGKG EEEEHHHHHHHHCCC	3.56	22178444
109	Glutathionylation	LVVPASQCGSLIGKG EEEEHHHHHHHHCCC	3.56	24333276
109	S-nitrosocysteine	LVVPASQCGSLIGKG EEEEHHHHHHHHCCC	3.56	-
111	Phosphorylation	VPASQCGSLIGKGGC EEHHHHHHHHCCCCC	25.17	27566939
115	Ubiquitination	QCGSLIGKGGCKIKE HHHHHHCCCCCEEEH	45.17	-
115	Malonylation	QCGSLIGKGGCKIKE HHHHHHCCCCCEEEH	45.17	26320211
115	Acetylation	QCGSLIGKGGCKIKE HHHHHHCCCCCEEEH	45.17	-
119	Ubiquitination	LIGKGGCKIKEIRES HHCCCCCEEEHHHHH	61.15	-
154	Phosphorylation	TIAGIPQSIIECVKQ HHCCCCHHHHHHHHH	21.85	22006019
158	S-palmitoylation	IPQSIIECVKQICVV CCHHHHHHHHHHHEE	3.06	28526873
158	S-nitrosylation	IPQSIIECVKQICVV CCHHHHHHHHHHHEE	3.06	22178444
158	S-nitrosocysteine	IPQSIIECVKQICVV CCHHHHHHHHHHHEE	3.06	-
160	Ubiquitination	QSIIECVKQICVVML HHHHHHHHHHHEEEE	45.67	-
169	Phosphorylation	ICVVMLESPPKGVTI HHEEEECCCCCCCCC	42.41	26643407
175	Phosphorylation	ESPPKGVTIPYRPKP CCCCCCCCCCCCCCC	25.55	27742792
175 (in isoform 2)	Phosphorylation	-	25.55	26239621
178	Phosphorylation	PKGVTIPYRPKPSSS CCCCCCCCCCCCCCC	35.38	27742792
178 (in isoform 2)	Phosphorylation	-	35.38	25777480
181	Ubiquitination	VTIPYRPKPSSSPVI CCCCCCCCCCCCCEE	48.83	-
181	Malonylation	VTIPYRPKPSSSPVI CCCCCCCCCCCCCEE	48.83	26320211
181	Acetylation	VTIPYRPKPSSSPVI CCCCCCCCCCCCCEE	48.83	23806337
183	Phosphorylation	IPYRPKPSSSPVIFA CCCCCCCCCCCEEEE	49.96	27742792
183 (in isoform 2)	Phosphorylation	-	49.96	25777480
184	Phosphorylation	PYRPKPSSSPVIFAG CCCCCCCCCCEEEEC	47.38	26824392
184 (in isoform 2)	Phosphorylation	-	47.38	25777480
185 (in isoform 2)	Phosphorylation	-	27.76	25777480
185	Phosphorylation	YRPKPSSSPVIFAGG CCCCCCCCCEEEECC	27.76	26824392
195 (in isoform 2)	Phosphorylation	-	21.29	25777480
196 (in isoform 2)	Phosphorylation	-	20.90	25777480
201 (in isoform 2)	Phosphorylation	-	49.95	25777480
209 (in isoform 2)	Phosphorylation	-	15.44	25777480
232	Phosphorylation	AYTIQGQYAIPQPDL EEEEECCCCCCCCCH	17.21	22817900
250	Phosphorylation	HQLAMQQSHFPMTHG HHHHHHHCCCCCCCC	15.37	25619855
255	Phosphorylation	QQSHFPMTHGNTGFS HHCCCCCCCCCCCCC	27.20	25619855
259	Phosphorylation	FPMTHGNTGFSGIES CCCCCCCCCCCCCCC	44.17	25619855
262	Phosphorylation	THGNTGFSGIESSSP CCCCCCCCCCCCCCC	39.96	25619855
266	Phosphorylation	TGFSGIESSSPEVKG CCCCCCCCCCCCCCC	33.91	23984901
267	Phosphorylation	GFSGIESSSPEVKGY CCCCCCCCCCCCCCE	36.80	25521595
268	Phosphorylation	FSGIESSSPEVKGYW CCCCCCCCCCCCCEE	34.07	26824392
298	Glutathionylation	IPNDLIGCIIGRQGA CCCCHHHHHHCCCCC	1.30	24333276
306	Malonylation	IIGRQGAKINEIRQM HHCCCCCCHHHHHHH	53.54	26320211
314	Phosphorylation	INEIRQMSGAQIKIA HHHHHHHCCCEEEEC	23.73	29514104
319	Ubiquitination	QMSGAQIKIANPVEG HHCCCEEEECCCCCC	24.56	22790023
353	Phosphorylation	YLINVRLSSETGGMG HHHHCCCCCCCCCCC	18.63	20415495
354	Phosphorylation	LINVRLSSETGGMGS HHHCCCCCCCCCCCC	43.71	20415495
356	Phosphorylation	NVRLSSETGGMGSS- HCCCCCCCCCCCCC-	40.77	29233185
361	Phosphorylation	SETGGMGSS------ CCCCCCCCC------	24.79	25521595
362	Phosphorylation	ETGGMGSS------- CCCCCCCC-------	38.21	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCBP2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCBP2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCBP2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRIC3_HUMAN	PRICKLE3	physical	26496610
UBP11_HUMAN	USP11	physical	26496610
FARP1_HUMAN	FARP1	physical	26496610
ARIP4_HUMAN	RAD54L2	physical	26496610
ZFY26_HUMAN	ZFYVE26	physical	26496610
PLPL8_HUMAN	PNPLA8	physical	26496610
NOP58_HUMAN	NOP58	physical	26496610
SAV1_HUMAN	SAV1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.