NDUA9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUA9_MOUSE
• UniProt AC: Q9DC69
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
• Gene Name: Ndufa9
• Organism: Mus musculus (Mouse).
• Sequence Length: 377
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAAAVRFRVVRALPMSRPAITAAATSVFCGSSHRQLHHAVIPHGKGGRSSVSGVVATVFGATGFLGRYVVNHLGRMGSQVIIPYRCDVYDIMHLRLMGDLGQLTFLEWDARDKDSIRKAVQHSNVVINLIGREWETRNFDFEDVFVNIPRAIAQASKEAGVERFIHVSHLNASMKSSSKSLRSKAVGEKEVRSVFPEAIIIRPSDIFGREDRFLNHFANYRWFLAVPLVSLGFKTVKQPVYVADVSKGIVNATKDPDAVGKTFAFTGPNRYLLFHLVKYIFGMTHRTFIPYPLPLFVYSWIGKLFGLSPFEPWTTKDKVERIHISDVMPTDLPGLEDLGVQPTPLELKSIEVLRRHRTYRWLSSEIEETKPAKTVNY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	VVRALPMSRPAITAA EEECCCCCCHHHHHH	32.92	22802335
21	Phosphorylation	PMSRPAITAAATSVF CCCCHHHHHHHCEEC	16.61	22802335
68	Phosphorylation	ATGFLGRYVVNHLGR CCCHHHHHHHHHHHC	13.62	27180971
86	S-palmitoylation	QVIIPYRCDVYDIMH EEEEEECCCHHHHHH	3.24	26165157
86	S-nitrosocysteine	QVIIPYRCDVYDIMH EEEEEECCCHHHHHH	3.24	-
86	S-nitrosylation	QVIIPYRCDVYDIMH EEEEEECCCHHHHHH	3.24	21278135
113	Acetylation	LEWDARDKDSIRKAV EEECCCCHHHHHHHH	48.07	23201123
156	O-linked_Glycosylation	PRAIAQASKEAGVER HHHHHHHHHHHCCCE	20.96	15066235
157	Acetylation	RAIAQASKEAGVERF HHHHHHHHHHCCCEE	55.38	23806337
157	Succinylation	RAIAQASKEAGVERF HHHHHHHHHHCCCEE	55.38	23806337
173	Phosphorylation	HVSHLNASMKSSSKS EHHHHCHHHCCCCHH	26.18	-
175	Succinylation	SHLNASMKSSSKSLR HHHCHHHCCCCHHHH	44.69	-
175	Acetylation	SHLNASMKSSSKSLR HHHCHHHCCCCHHHH	44.69	23806337
175	Succinylation	SHLNASMKSSSKSLR HHHCHHHCCCCHHHH	44.69	23806337
189	Acetylation	RSKAVGEKEVRSVFP HHHHHCHHHHHHHCC	56.43	23576753
189	Succinylation	RSKAVGEKEVRSVFP HHHHHCHHHHHHHCC	56.43	26388266
193	Phosphorylation	VGEKEVRSVFPEAII HCHHHHHHHCCCEEE	33.03	24719451
237	Ubiquitination	SLGFKTVKQPVYVAD HCCCCCCCCCEEEEE	54.86	27667366
254	Ubiquitination	KGIVNATKDPDAVGK CCCCCCCCCCCCCCC	65.93	22790023
254	Acetylation	KGIVNATKDPDAVGK CCCCCCCCCCCCCCC	65.93	23201123
261	Succinylation	KDPDAVGKTFAFTGP CCCCCCCCEEEECCC	33.59	23954790
316	Acetylation	PFEPWTTKDKVERIH CCCCCCCCCCEEEEE	48.45	23954790
370	Acetylation	SSEIEETKPAKTVNY HHHHCCCCCCCCCCC	46.38	23576753
373	Acetylation	IEETKPAKTVNY--- HCCCCCCCCCCC---	62.63	24062335

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUA9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUA9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUA9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NDUA9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-370, AND MASS SPECTROMETRY.
PubMed: 16916647