CNOT1_MOUSE - dbPTM
CNOT1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CNOT1_MOUSE
UniProt AC Q6ZQ08
Protein Name CCR4-NOT transcription complex subunit 1
Gene Name Cnot1
Organism Mus musculus (Mouse).
Sequence Length 2375
Subcellular Localization Cytoplasm, P-body . Nucleus. Cytoplasm. NANOS2 promotes its localization to P-body.
Protein Description Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages..
Protein Sequence MNLDSLSLALSQISYLVDNLTKKNYRASQQEIQHIVNRHGPEADRHLLRCLFSHVDFSGDGKSSGKDFHQTQFLIQECASLITKPNFISTLSYAIDNPLHYQKSLKPAPHLFAQLSKVLKLSKVQEVIFGLALLNSSSPDLRGFAAQFIKQKLPDLLRSYIDADVSGNQEGGFQDIAIEVLHLLLSHLLFGQKGAFGVGQEQIDAFLKTLRRDFPQERCPVVLAPLLYPEKRDILMDRILPDSGGVAKTMMESSLADFMQEVGYGFCASIEECRNIIMQFGVREVTAAQVARVLGMMARTHSGLTDGIPLQSISAPGSGIWSDGKDKSEGAQAHTWNVEVLIDVLKELNPSLNFKEVTYELDHPGFQIRDSKGLHNVVYGIQRGLGMEVFPVDFIYRPWKHAEGQLSFIQHSLINPEVFCFADYPCHTVATDILKAPPEDDNREIATWKSLDLIESLLRLAEVGQYEQVKQLFSFPIKHCPDMLVLALLQINTSWHTLRHELISTLMPIFLGNHPNSAIILHYAWHGQGQSPSIRQLIMHAMAEWYMRGEQYDQAKLSRILDVAQDLKALSMLLNGTPFAFVIDLAALASRREYLKLDKWLTDKIREHGEPFIQACMTFLKRRCPSILGGLAPEKDQPKSAQLPAETLATMLACLQACAGSVSQELSETILTMVANCSNVMNKARQPPPGVMPKGRPPSASSLDAISPVQIDPLAGMASLSIGGSAAPHTQSMQGFPPNLGSAFSTPQSPAKAFPPLSTPNQTTAFSGIGGLSSQLPGGLGTGSLTGIGTGALGLPAVNNDPFVQRKLGTSGLNQPTFQQSKMKPSDLSQVWPEANQHFSKEIDDEANSYFQRIYNHPPHPTMSVDEVLEMLQRFKDSTIKREREVFNCMLRNLFEEYRFFPQYPDKELHITACLFGGIIEKGLVTYMALGLALRYVLEALRKPFGSKMYYFGIAALDRFKNRLKDYPQYCQHLASISHFMQFPHHLQEYIEYGQQSRDPPVKMQGSITTPGSIALAQAQAQAQVPAKAPLAGQVNTMVTTSTTTTVAKTVTVTKPTGVSFKKDVPPSINTTNIDTLLVATDQTERIVEPPENIQEKIAFIFNNLSQSNMTQKVEELKETVKEEFMPWVSQYLVMKRVSIEPNFHSLYSNFLDTLKNPEFNKMVLNETYRNIKVLLTSDKAAANFSDRSLLKNLGHWLGMITLAKNKPILHTDLDVKSLLLEAYVKGQQELLYVVPFVAKVLESSIRSLVFRPPNPWTMAIMNVLAELHQEHDLKLNLKFEIEVLCKNLALDINELKPGNLLKDKDRLKNLDEQLSAPKKDVKQPEELPAITTTTTSTTPATSTTCTATVPPQPQYSYHDINVYSLAGLAPHITLNPTIPLFQAHPQLKQCVRQAIERAVQELVHPVVDRSIKIAMTTCEQIVRKDFALDSEESRMRIAAHHMMRNLTAGMAMITCREPLLMSISTNLKNSFASALRTASPQQREMMDQAAAQLAQDNCELACCFIQKTAVEKAGPEMDKRLATEFELRKHARQEGRRYCDPVVLTYQAERMPEQIRLKVGGVDPKQLAVYEEFARNVPGFLPTNDLSQPTGFLAQPMKQAWATDDVAQIYDKCITELEQHLHAIPPTLAMNPQAQALRSLLEVVVLSRNSRDAIAALGLLQKAVEGLLDATSGADADLLLRYRECHLLVLKALQDGRAYGSPWCNKQITRCLIECRDEYKYNVEAVELLIRNHLVNMQQYDLHLAQSMENGLNYMAVAFAMQLVKILLVDERSVAHITEADLFHTIETLMRINAHSRGNAPEGLPQLMEVVRSNYEAMIDRAHGGPNFMMHSGISQASEYDDPPGLREKAEYLLREWVNLYHSAAAGRDSTKAFSAFVGQMHQQGILKTDDLITRFFRLCTEMCVEISYRAQAEQQHNPAANPTMIRAKCYHNLDAFVRLIALLVKHSGEATNTVTKINLLNKVLGIVVGVLLQDHDVRQSEFQQLPYHRIFIMLLLELNAPEHVLETINFQTLTAFCNTFHILRPTKAPGFVYAWLELISHRIFIARMLAHTPQQKGWPMYAQLLIDLFKYLAPFLRNVELTKPMQILYKGTLRVLLVLLHDFPEFLCDYHYGFCDVIPPNCIQLRNLILSAFPRNMRLPDPFTPNLKVDMLSEINIAPRILTNFTGVMPPQFKKDLDSYLKTRSPVTFLSDLRSNLQVSNEPGNRYNLQLINALVLYVGTQAIAHIHNKGSTPSMSTITHSAHMDIFQNLAVDLDTEGRYLFLNAIANQLRYPNSHTHYFSCTMLYLFAEANTEAIQEQITRVLLERLIVNRPHPWGLLITFIELIKNPAFKFWNHEFVHCAPEIEKLFQSVAQCCMGQKQAQQVMEGTGAS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
231UbiquitinationAPLLYPEKRDILMDR
CCCCCHHHHCHHHHH		51.3622790023
231 (in isoform 4)Ubiquitination-51.3622790023
243PhosphorylationMDRILPDSGGVAKTM
HHHCCCCCCCHHHHH		35.1925338131
314PhosphorylationGIPLQSISAPGSGIW
CCCCCCCCCCCCCCC		33.3923984901
318PhosphorylationQSISAPGSGIWSDGK
CCCCCCCCCCCCCCC		26.5023984901
322PhosphorylationAPGSGIWSDGKDKSE
CCCCCCCCCCCCCCC		34.2723984901
355 (in isoform 4)Ubiquitination-50.6422790023
355UbiquitinationLNPSLNFKEVTYELD
HCCCCCCEEEEEECC		50.6422790023
449UbiquitinationNREIATWKSLDLIES
CCHHCHHHHHHHHHH		36.46-
626PhosphorylationFLKRRCPSILGGLAP
HHHHHCHHHHCCCCC		33.79-
699PhosphorylationMPKGRPPSASSLDAI
CCCCCCCCCHHCCCC		43.3925338131
701PhosphorylationKGRPPSASSLDAISP
CCCCCCCHHCCCCCC		35.4525338131
702PhosphorylationGRPPSASSLDAISPV
CCCCCCHHCCCCCCC		29.9525338131
707PhosphorylationASSLDAISPVQIDPL
CHHCCCCCCCCCCCC		22.2725338131
807UbiquitinationNDPFVQRKLGTSGLN
CCHHHHHHHCCCCCC		33.8922790023
807 (in isoform 4)Ubiquitination-33.8922790023
808 (in isoform 4)Ubiquitination-11.16-
1037O-linked_GlycosylationPLAGQVNTMVTTSTT
CCCCCEEEEEEECCC		17.7322517741
1040O-linked_GlycosylationGQVNTMVTTSTTTTV
CCEEEEEEECCCCEE		12.2822517741
1041O-linked_GlycosylationQVNTMVTTSTTTTVA
CEEEEEEECCCCEEE		16.8055412941
1042O-linked_GlycosylationVNTMVTTSTTTTVAK
EEEEEEECCCCEEEE		17.8722517741
1043O-linked_GlycosylationNTMVTTSTTTTVAKT
EEEEEECCCCEEEEE		26.5222517741
1045O-linked_GlycosylationMVTTSTTTTVAKTVT
EEEECCCCEEEEEEE		21.2522517741
1050O-linked_GlycosylationTTTTVAKTVTVTKPT
CCCEEEEEEEECCCC		16.2110733299
1050PhosphorylationTTTTVAKTVTVTKPT
CCCEEEEEEEECCCC		16.21-
1052PhosphorylationTTVAKTVTVTKPTGV
CEEEEEEEECCCCCC		27.91-
1054O-linked_GlycosylationVAKTVTVTKPTGVSF
EEEEEEECCCCCCCC		23.1822517741
1054PhosphorylationVAKTVTVTKPTGVSF
EEEEEEECCCCCCCC		23.1826643407
1057PhosphorylationTVTVTKPTGVSFKKD
EEEECCCCCCCCCCC		52.3423984901
1060PhosphorylationVTKPTGVSFKKDVPP
ECCCCCCCCCCCCCC		32.4726643407
1106PhosphorylationAFIFNNLSQSNMTQK
HHHHHCCCCCCCHHH		33.4228059163
1148PhosphorylationEPNFHSLYSNFLDTL
CCCHHHHHHHHHHHH		12.4628576409
1417PhosphorylationRSIKIAMTTCEQIVR
CHHHHHHHCHHHHHH		21.1922871156
1418PhosphorylationSIKIAMTTCEQIVRK
HHHHHHHCHHHHHHH		10.8522871156
1448PhosphorylationHHMMRNLTAGMAMIT
HHHHHHCCCCHHHHH		25.3924759943
1474PhosphorylationNLKNSFASALRTASP
HCHHHHHHHHHCCCH		26.3129550500
1478PhosphorylationSFASALRTASPQQRE
HHHHHHHCCCHHHHH		32.1329550500
1480PhosphorylationASALRTASPQQREMM
HHHHHCCCHHHHHHH		23.7229550500
1571PhosphorylationDPKQLAVYEEFARNV
CHHHHHHHHHHHHHC		12.2525777480
1584PhosphorylationNVPGFLPTNDLSQPT
HCCCCCCCCCCCCCC		43.4425777480
1588PhosphorylationFLPTNDLSQPTGFLA
CCCCCCCCCCCCCCC		36.6625777480
1591PhosphorylationTNDLSQPTGFLAQPM
CCCCCCCCCCCCCCH		32.6925777480
1648PhosphorylationLLEVVVLSRNSRDAI
HHHHHHHCCCCHHHH		20.1524759943
1700PhosphorylationALQDGRAYGSPWCNK
HHHCCCCCCCHHHCH		19.4428066266
1702PhosphorylationQDGRAYGSPWCNKQI
HCCCCCCCHHHCHHH		11.5328066266
1707UbiquitinationYGSPWCNKQITRCLI
CCCHHHCHHHHHHHH		39.6822790023
1707 (in isoform 4)Ubiquitination-39.6822790023
1708 (in isoform 4)Ubiquitination-28.44-
1932PhosphorylationTMIRAKCYHNLDAFV
HHHHHHHHCCHHHHH		7.9517693683
2168PhosphorylationPRILTNFTGVMPPQF
CHHHHCCCCCCCCHH		30.8221454597
2177UbiquitinationVMPPQFKKDLDSYLK
CCCCHHHHHHHHHHH		65.8922790023
2177 (in isoform 4)Ubiquitination-65.8922790023
2178 (in isoform 4)Ubiquitination-57.19-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CNOT1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CNOT1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CNOT1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CNOT1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CNOT1_MOUSE

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Related Literatures of Post-Translational Modification

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