G6PI_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: G6PI_MOUSE
• UniProt AC: P06745
• Protein Name: Glucose-6-phosphate isomerase
• Gene Name: Gpi
• Organism: Mus musculus (Mouse).
• Sequence Length: 558
• Subcellular Localization: Cytoplasm. Secreted.
• Protein Description: Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons..
• Protein Sequence: MAALTRNPQFQKLLEWHRANSANLKLRELFEADPERFNNFSLNLNTNHGHILVDYSKNLVNKEVMQMLVELAKSRGVEAARDNMFSGSKINYTENRAVLHVALRNRSNTPIKVDGKDVMPEVNRVLDKMKSFCQRVRSGDWKGYTGKSITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLASLSPETSLFIIASKTFTTQETITNAETAKEWFLEAAKDPSAVAKHFVALSTNTAKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFLKTPLEKNAPVLLALLGIWYINCYGCETHALLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDHQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRKGLHHKILLANFLAQTEALMKGKLPEEARKELQAAGKSPEDLEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIMWDINSFDQWGVELGKQLAKKIEPELEGSSAVTSHDSSTNGLISFIKQQRDTKLE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAALTRNPQ ------CCCCCCCHH	15.92	-
12	Acetylation	TRNPQFQKLLEWHRA CCCHHHHHHHHHHHH	57.22	-
12	Ubiquitination	TRNPQFQKLLEWHRA CCCHHHHHHHHHHHH	57.22	22790023
25	Acetylation	RANSANLKLRELFEA HHCCCCHHHHHHHHH	45.35	23806337
25	Ubiquitination	RANSANLKLRELFEA HHCCCCHHHHHHHHH	45.35	27667366
25	Succinylation	RANSANLKLRELFEA HHCCCCHHHHHHHHH	45.35	23806337
62	Acetylation	YSKNLVNKEVMQMLV CCCHHCCHHHHHHHH	44.18	22733758
73	Ubiquitination	QMLVELAKSRGVEAA HHHHHHHHHCCHHHH	54.00	22790023
86	Phosphorylation	AARDNMFSGSKINYT HHHHCCCCCCCCCCC	31.24	19854140
88	Phosphorylation	RDNMFSGSKINYTEN HHCCCCCCCCCCCCC	29.21	27742792
89	Ubiquitination	DNMFSGSKINYTENR HCCCCCCCCCCCCCE	38.20	27667366
89	Acetylation	DNMFSGSKINYTENR HCCCCCCCCCCCCCE	38.20	23806337
89	Succinylation	DNMFSGSKINYTENR HCCCCCCCCCCCCCE	38.20	23806337
107	Phosphorylation	HVALRNRSNTPIKVD EEECCCCCCCCCEEC	48.91	23684622
109	Phosphorylation	ALRNRSNTPIKVDGK ECCCCCCCCCEECCE	27.86	27742792
112	Acetylation	NRSNTPIKVDGKDVM CCCCCCCEECCEECH	35.16	23954790
112	Malonylation	NRSNTPIKVDGKDVM CCCCCCCEECCEECH	35.16	26320211
112	Ubiquitination	NRSNTPIKVDGKDVM CCCCCCCEECCEECH	35.16	27667366
116	Ubiquitination	TPIKVDGKDVMPEVN CCCEECCEECHHHHH	42.56	27667366
116	Acetylation	TPIKVDGKDVMPEVN CCCEECCEECHHHHH	42.56	23201123
116	Malonylation	TPIKVDGKDVMPEVN CCCEECCEECHHHHH	42.56	26320211
130	Ubiquitination	NRVLDKMKSFCQRVR HHHHHHHHHHHHHHH	46.23	-
130	Malonylation	NRVLDKMKSFCQRVR HHHHHHHHHHHHHHH	46.23	26320211
131	Phosphorylation	RVLDKMKSFCQRVRS HHHHHHHHHHHHHHC	27.96	29899451
133	S-nitrosocysteine	LDKMKSFCQRVRSGD HHHHHHHHHHHHCCC	3.05	-
133	S-nitrosylation	LDKMKSFCQRVRSGD HHHHHHHHHHHHCCC	3.05	21278135
138	Phosphorylation	SFCQRVRSGDWKGYT HHHHHHHCCCCCCCC	37.94	28542873
142	Acetylation	RVRSGDWKGYTGKSI HHHCCCCCCCCCCCH	46.94	23806337
142	Succinylation	RVRSGDWKGYTGKSI HHHCCCCCCCCCCCH	46.94	23954790
148	Phosphorylation	WKGYTGKSITDIINI CCCCCCCCHHHHEEE	31.87	26643407
150	Phosphorylation	GYTGKSITDIINIGI CCCCCCHHHHEEECC	28.39	26643407
176	Ubiquitination	EALKPYSKGGPRVWF HHCCCCCCCCCCEEE	63.14	27667366
185	Phosphorylation	GPRVWFVSNIDGTHI CCCEEEEECCCCCHH	20.70	-
212	Phosphorylation	LFIIASKTFTTQETI EEEEEECEECCHHHC	24.58	25521595
214	Phosphorylation	IIASKTFTTQETITN EEEECEECCHHHCCC	32.57	25521595
215	Phosphorylation	IASKTFTTQETITNA EEECEECCHHHCCCH	21.88	25521595
220	Phosphorylation	FTTQETITNAETAKE ECCHHHCCCHHHHHH	35.48	28464351
226	Acetylation	ITNAETAKEWFLEAA CCCHHHHHHHHHHHC	64.00	23954790
226	Ubiquitination	ITNAETAKEWFLEAA CCCHHHHHHHHHHHC	64.00	22790023
234	Ubiquitination	EWFLEAAKDPSAVAK HHHHHHCCCHHHHHH	76.77	27667366
234	Acetylation	EWFLEAAKDPSAVAK HHHHHHCCCHHHHHH	76.77	23806337
234	Succinylation	EWFLEAAKDPSAVAK HHHHHHCCCHHHHHH	76.77	23806337
237	Phosphorylation	LEAAKDPSAVAKHFV HHHCCCHHHHHHHHH	45.57	28542873
241	Acetylation	KDPSAVAKHFVALST CCHHHHHHHHHEEEC	30.86	22826441
241	Ubiquitination	KDPSAVAKHFVALST CCHHHHHHHHHEEEC	30.86	22790023
247	Phosphorylation	AKHFVALSTNTAKVK HHHHHEEECCCCCHH	15.18	28542873
248	Phosphorylation	KHFVALSTNTAKVKE HHHHEEECCCCCHHH	37.12	28542873
250	Phosphorylation	FVALSTNTAKVKEFG HHEEECCCCCHHHHC	28.13	25521595
252	Ubiquitination	ALSTNTAKVKEFGID EEECCCCCHHHHCCC	52.37	-
252	Malonylation	ALSTNTAKVKEFGID EEECCCCCHHHHCCC	52.37	26320211
351	Phosphorylation	YMHRFAAYFQQGDME HHHHHHHHHHHCCCC	9.86	-
362	Ubiquitination	GDMESNGKYITKSGA CCCCCCCCEEECCCC	37.42	22790023
366	Succinylation	SNGKYITKSGARVDH CCCCEEECCCCCCCC	37.02	23954790
366	Ubiquitination	SNGKYITKSGARVDH CCCCEEECCCCCCCC	37.02	27667366
366	Malonylation	SNGKYITKSGARVDH CCCCEEECCCCCCCC	37.02	26320211
404	S-nitrosylation	QGTKMIPCDFLIPVQ CCCCEECCCEEEECC	3.90	24926564
404	Glutathionylation	QGTKMIPCDFLIPVQ CCCCEECCCEEEECC	3.90	24333276
404	S-nitrosocysteine	QGTKMIPCDFLIPVQ CCCCEECCCEEEECC	3.90	-
423	Acetylation	IRKGLHHKILLANFL CCCCHHHHHHHHHHH	25.05	22826441
438	Ubiquitination	AQTEALMKGKLPEEA HHHHHHHCCCCCHHH	54.46	22790023
440	Ubiquitination	TEALMKGKLPEEARK HHHHHCCCCCHHHHH	56.18	27667366
447	Ubiquitination	KLPEEARKELQAAGK CCCHHHHHHHHHCCC	70.58	27667366
447	Malonylation	KLPEEARKELQAAGK CCCHHHHHHHHHCCC	70.58	26320211
454	Ubiquitination	KELQAAGKSPEDLEK HHHHHCCCCHHHHHH	59.10	27667366
454	Succinylation	KELQAAGKSPEDLEK HHHHHCCCCHHHHHH	59.10	23806337
454	Malonylation	KELQAAGKSPEDLEK HHHHHCCCCHHHHHH	59.10	26320211
454	Acetylation	KELQAAGKSPEDLEK HHHHHCCCCHHHHHH	59.10	23806337
454	N6-malonyllysine	KELQAAGKSPEDLEK HHHHHCCCCHHHHHH	59.10	-
455	Phosphorylation	ELQAAGKSPEDLEKL HHHHCCCCHHHHHHH	32.38	28542873
461	Acetylation	KSPEDLEKLLPHKVF CCHHHHHHHCCCCCC	63.72	23806337
466	Ubiquitination	LEKLLPHKVFEGNRP HHHHCCCCCCCCCCC	46.83	22790023
466	Acetylation	LEKLLPHKVFEGNRP HHHHCCCCCCCCCCC	46.83	88827
524	Malonylation	LGKQLAKKIEPELEG HHHHHHHHHCHHHCC	46.85	26320211
532	Phosphorylation	IEPELEGSSAVTSHD HCHHHCCCCCCCCCC	13.02	19060867
533	Phosphorylation	EPELEGSSAVTSHDS CHHHCCCCCCCCCCC	37.30	29899451
536	Phosphorylation	LEGSSAVTSHDSSTN HCCCCCCCCCCCCCC	21.76	21183079
537	Phosphorylation	EGSSAVTSHDSSTNG CCCCCCCCCCCCCCH	20.78	21082442
542	Phosphorylation	VTSHDSSTNGLISFI CCCCCCCCCHHHHHH	36.94	24719451
547	Phosphorylation	SSTNGLISFIKQQRD CCCCHHHHHHHHHCC	26.43	28464351

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
185	S	Phosphorylation	Kinase	CK2	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of G6PI_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of G6PI_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR14_MOUSE	Parp14	physical	17875708

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.