PAR14_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAR14_MOUSE
• UniProt AC: Q2EMV9
• Protein Name: Poly [ADP-ribose] polymerase 14
• Gene Name: Parp14
• Organism: Mus musculus (Mouse).
• Sequence Length: 1817
• Subcellular Localization: Nucleus . Cytoplasm . In steady state cells the protein is mostly nuclear (PubMed:16537510). A minor proportion is detected in the cytoplasm (PubMed:16537510). In macrophages, mainly localizes to the cytoplasm (By similarity).
• Protein Description: ADP-ribosyltransferase. [PubMed: 27796300 By mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and subsequently decreasing STAT-1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to INFG stimulation]
• Protein Sequence: MAASGSFPLLVEGSWGPDPPKNLINKLQVYFQSRKKSGGGECEVVPEPGNPARFRVLFSPEDVRQNVLERGNHELVWQEKGTFKLTVLMPTDPEEASASKKSRKESPEEESKTKEDAVKQGDLDITHSPSSGSEKTEDVPKECENISSMVAFENLPEKVSEMVLTILVENISGLPSDDFKVEVNRDFAVAVVTFQKPIDIKKFIVDCISHRSNQQLQLAPRLLETTNVVRVENLPPGVDEYQLQLFFENPFNGGGRVARVECFPEESSALVEFCDSKVLDTVMAKTHSYNKMPLSVFPYYPSLGTALYGEEKPLIKLPASFQESLDLPLWKFFQKNNHLIEEINNEMRCCHCELTWSEINGKLTIRPAATLVNHRLSIKTWQRDASAVLSGIKSKYGVELFEVCSPVWDIIKHELESGDDRVLVEFEKESLNIAGKSEDVQGMSQKIRELIESTTEKLRREEQSLKEKVAISPGKHYLLHHSGFLKDLSKGFPEMEISYDATAQFLYLKGFRADVYKVKCDIQEKVFSMAQKDVQVSSEVFEFLQQVDSQRLSKSLFEAQNILAIYELKGTALFLVGSSFKDLAEAETKMLSALSHKQIEVEDKEVLISNGWKKKVHPLQKRHSSCATIIVQNELTSETPAKVIVTGCVKEVNEIHRQLFEYLENNMKVERALKIKPSLIVDYLRTDKRLLSKIKKAHVYVHFKPKDNPNSILLTGCKSKVLECMNLVKEIQDSVCVQRFQTDKAGVRHFFKDKESYYKTEIGRQFGCVIELEEDREEKGEEEDGEEEEGEEEGESSINEQKCHLQRDIAPGVKLFVLEEDLSRFPVDVVVNAANENLKHISGLAQALSKAAGPELQTECDQIVKEGGVVLPGNAVISKAGKLPCHHVIHAVGPRWKGDKVLECVSLLKKVVRQSLSLAEEHRCRSIAMPAVSAGIFDFPLELCVANIVSAIKEHFQHKRDTHTLKKIYLVGLPAKVARAFAEAVKTTYKDSLSHTAFPSSLKALVPLGKTPQKQGSLLVSPEGLRIRLVEEGVQNATTHAIVNSISPDLKLNKGPLSQAFLEKAGPKLQEELTRSGQGVSVDVGTILQTSGCNLNSRHVFHVVPPPWKSNNSAWSLKIMKNIIRDCLKTTENLSLQSIAFPAIGTGNLRFPKPEFAKLIISEVLKFSSRNQLKTLQEVQFLLHPKDHENIQAFSDEFDKRNNGDPSDKNPKAEDTQGIYGSLSSPTLGMHEMNIGPILFQVATGNIIKEVADVIVNSTTLTFDLKSGVSKAILEGAGQNVEQECSLLAKQSNHGYIVTGGGLLQCKNIIHVVGGNDVKKSVSCVLEECEQRNYSSICLPAIGTGNAQQDPNVVAKAIIDAIEEFVQKKSVQAVKRVKVVIFQPHILQFFYDNMKEREGSPAPPKQSPAKQSVMSKIASFLGFPKQASPKKNTLVLEKKIEHTVFQVCGSGVDSVNKTISWLKELITKEQLSYTNDDECVSDFDMEEYEKLNEIQKELNITIEMNQKKTSIQVSGISRDVIKARDEIEGMIKSIRLAKEKESQADYISTYVEWQYIDKNITQCFDKMTNMKLEVAWKAKKKDTVVQIHNQDFTVDLSTNTATAPQGQTFTVQRLVKAEAEIPANWSDMKQDKLLLVNLQTSDPEYNMVASAFRQTCSNFFIEKIERIQNPALWRRYQAYKKSMDEKNGNVRNEKHLFHGTEASSLPQLNSNGFNRSYAGKNATAYGKGTYFAVKASYSACDTYSRPDTNGRKYMYYVRVLTGNYTNGNASLIVPPSRDPQNAADLYDTVTDNDKNPSIFVVFYDNQTYPEYLITFRQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	KLQVYFQSRKKSGGG HHHHHHHCCCCCCCC	35.85	30387612
37	Phosphorylation	YFQSRKKSGGGECEV HHHCCCCCCCCCCEE	45.78	30352176
102	Phosphorylation	EASASKKSRKESPEE HHHCCHHHCCCCHHH	52.93	-
106	Phosphorylation	SKKSRKESPEEESKT CHHHCCCCHHHHHCC	40.42	25521595
126	Phosphorylation	KQGDLDITHSPSSGS HHCCCCCCCCCCCCC	18.90	29472430
128	Phosphorylation	GDLDITHSPSSGSEK CCCCCCCCCCCCCCC	20.16	25266776
130	Phosphorylation	LDITHSPSSGSEKTE CCCCCCCCCCCCCCC	50.80	29550500
131	Phosphorylation	DITHSPSSGSEKTED CCCCCCCCCCCCCCC	50.12	29550500
133	Phosphorylation	THSPSSGSEKTEDVP CCCCCCCCCCCCCCC	37.56	27566939
136	Phosphorylation	PSSGSEKTEDVPKEC CCCCCCCCCCCCHHH	33.11	30635358
437	Phosphorylation	SLNIAGKSEDVQGMS HCCCCCCCCCHHHHH	37.80	25338131
444	Phosphorylation	SEDVQGMSQKIRELI CCCHHHHHHHHHHHH	34.84	20531401
734	Phosphorylation	LVKEIQDSVCVQRFQ HHHHHHHHHHHHHHC	10.88	28285833
742	Phosphorylation	VCVQRFQTDKAGVRH HHHHHHCCCCHHHHH	36.43	28285833
976	Ubiquitination	YLVGLPAKVARAFAE EEECCHHHHHHHHHH	34.19	-
1054	Malonylation	SPDLKLNKGPLSQAF CCCCCCCCCHHHHHH	72.79	26320211
1121	Ubiquitination	AWSLKIMKNIIRDCL HHHHHHHHHHHHHHH	48.76	-
1407	Phosphorylation	SPAPPKQSPAKQSVM CCCCCCCCHHHHHHH	32.71	26824392
1412	Phosphorylation	KQSPAKQSVMSKIAS CCCHHHHHHHHHHHH	21.05	-
1419	Phosphorylation	SVMSKIASFLGFPKQ HHHHHHHHHHCCCCC	25.20	22942356
1428	Phosphorylation	LGFPKQASPKKNTLV HCCCCCCCCCCCEEE	34.46	27566939
1443	Phosphorylation	LEKKIEHTVFQVCGS EECCCCCEEEHHHCC	15.38	28576409
1460	Phosphorylation	DSVNKTISWLKELIT HHHHHHHHHHHHHHC	31.42	28059163
1467	Phosphorylation	SWLKELITKEQLSYT HHHHHHHCHHHHCCC	40.95	28059163
1577	Acetylation	MKLEVAWKAKKKDTV CHHHEEEECCCCCEE	40.36	7614175
1761	Phosphorylation	MYYVRVLTGNYTNGN EEEEEEEECCCCCCC	22.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAR14_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAR14_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAR14_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAR10_HUMAN	PARP10	physical	23473667
RAN_HUMAN	RAN	physical	23473667

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.