NCHL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NCHL1_MOUSE
• UniProt AC: P70232
• Protein Name: Neural cell adhesion molecule L1-like protein
• Gene Name: Chl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1209
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Soluble forms produced by cleavage/shedding also exist.; Processed neural cell adhesion molecule L1-like protein: Secreted, extracellular space, extracellular matrix.
• Protein Description: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane..
• Protein Sequence: MMELPLCGRGLILSLIFLLLKLSAAEIPLSVQQVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPIFSWTKDDKPFDLSDPRIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQRGDLYFANVEENDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENISYQDRGNYRCTANNLLGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQPTIKWRLNGLPIEKHPFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVIDVIPLIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMGKAVITANLDIRNATKLRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLGVPDPPGNLHLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWEELTRVQGEETDVVLSLAPYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYKVSWKPQGAPEEWEEEIVTNHTLRVMTPTVYAPYDVKVQAINQLGSSPDPQPVTLYSGEDYPSTAPVIQRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYKFYLRACTSRGCGKPISEEGATLGEGSKGIRKITEGVNVTQKIHPVEVLVPGAEHIVHLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLILLTICFVKRNRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEKGSVESNGSSTATFPLRA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	N-linked_Glycosylation	DPRIIAANNSGTFKI CCCEEEECCCCCEEC		-
91	Phosphorylation	IAANNSGTFKIPNEG EEECCCCCEECCCCC		22871156
101	Phosphorylation	IPNEGHISHFQGKYR CCCCCCCCEECCEEE		22871156
225	N-linked_Glycosylation	MPMKLTVNSSNSIKQ CCCEEEECCCCHHHC		-
231 (in isoform 2)	Phosphorylation	-		23375375
233 (in isoform 2)	Phosphorylation	-		23375375
234 (in isoform 2)	Phosphorylation	-		23375375
235 (in isoform 2)	Phosphorylation	-		23375375
236 (in isoform 2)	Phosphorylation	-		23375375
299	N-linked_Glycosylation	EKTLKIENISYQDRG ECEEEEECCCCCCCC		-
476	N-linked_Glycosylation	DRYHTHENGTLEIYR CEEEECCCCEEEEEE		-
506	Phosphorylation	AMGKAVITANLDIRN CCCCEEEEECCCCCC		28059163
562	N-linked_Glycosylation	DGEAFEMNGTEDGRI CCCCEEECCCCCCCE		-
580	N-linked_Glycosylation	GAYLTISNITAEDQG CCEEEEECCCHHHCC		-
767	N-linked_Glycosylation	WEEEIVTNHTLRVMT HHHHHHHCCEEEEEC		-
822	N-linked_Glycosylation	IQRVDVMNSTLVKVT EEEEECCCCEEEEEE		-
926	Acetylation	PSFLKVIKVDKDTAT CCEEEEEEECCCCCE		19843315
929	Acetylation	LKVIKVDKDTATLSW EEEEEECCCCCEEEC		19843325
945	N-linked_Glycosylation	LPKKLNGNLTGYLLQ CCCCCCCCCCCEEEE		-
1003	Acetylation	CTSRGCGKPISEEGA HCCCCCCCCCCCCCC		23864654
1019 (in isoform 2)	Acetylation	-		-
1027	N-linked_Glycosylation	RKITEGVNVTQKIHP HHHCCCCCCCCEECC		-
1032 (in isoform 2)	Acetylation	-		-
1128	Phosphorylation	HPDPEVQSAKDETFG CCCHHHCCCCCCCCC		25521595
1133	Phosphorylation	VQSAKDETFGEYSDS HCCCCCCCCCCCCCC		30372032
1137	Phosphorylation	KDETFGEYSDSDEKP CCCCCCCCCCCCCCC		25177544
1138	Phosphorylation	DETFGEYSDSDEKPL CCCCCCCCCCCCCCC		30372032
1140	Phosphorylation	TFGEYSDSDEKPLKG CCCCCCCCCCCCCCH		27742792
1148	Phosphorylation	DEKPLKGSLRSLNRN CCCCCCHHHHHHHCC		25521595
1151	Phosphorylation	PLKGSLRSLNRNMQP CCCHHHHHHHCCCCC		25521595
1159	Phosphorylation	LNRNMQPTESADSLV HHCCCCCCCCCHHHH		21183079
1161	Phosphorylation	RNMQPTESADSLVEY CCCCCCCCCHHHHHH		19060867
1164	Phosphorylation	QPTESADSLVEYGEG CCCCCCHHHHHHCCC		19060867
1168	Phosphorylation	SADSLVEYGEGDQSI CCHHHHHHCCCCCEE		20415495
1174	Phosphorylation	EYGEGDQSIFNEDGS HHCCCCCEEECCCCC		-
1181	Phosphorylation	SIFNEDGSFIGAYTG EEECCCCCEEEEECC		16141072
1194	Phosphorylation	TGAKEKGSVESNGSS CCCCCCCCCCCCCCC		21183079
1197	Phosphorylation	KEKGSVESNGSSTAT CCCCCCCCCCCCCEE		29899451
1200	Phosphorylation	GSVESNGSSTATFPL CCCCCCCCCCEEEEC		29899451
1201	Phosphorylation	SVESNGSSTATFPLR CCCCCCCCCEEEECC		22807455
1202	Phosphorylation	VESNGSSTATFPLRA CCCCCCCCEEEECCC		21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NCHL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NCHL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NCHL1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NCHL1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.