NU133_MOUSE - dbPTM
NU133_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NU133_MOUSE
UniProt AC Q8R0G9
Protein Name Nuclear pore complex protein Nup133
Gene Name Nup133
Organism Mus musculus (Mouse).
Sequence Length 1155
Subcellular Localization Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.
Protein Description Involved in poly(A)+ RNA transport..
Protein Sequence MFPSVSSPRTPGPGTRRGPLVGIGPTSTPRASRRGLSLGSAVNSPVLFSPAGRRSSVSSRGTPTRIFPHHSISESVNYDVRVFGSSLPVKIMEALTMAEADEQLSVHVDEGGWACLVCTEKLLIWKIAVSPVTKLSVCKELQLPPSDFHGSADLVALSYAATSGEVHSVQAVSVMVATKEGSIRYWPSLAREDTYSDTCVDLGGEKMCRFLTAVQGGSFILSSVGSQLVRLIPESSGKIHQHVLPQGQGMLSGIGRRVSSLFGILSPTSDLMLASVLWDRGGSSFYTLTSSNISKWELDDSSEKQVHSWDVHRTLKESITDAVWGSESNYEAIKEGVNIQYLDLKQNCDGLLILAAAWHLGDSPCLVYYSVITVEDNGNQMSDAVTVEVTQYNPPFQSEDLIACRLMVPNFSSQMTYLYMENAVFVCSTGTGKFSLPQEKIVFDTQGDGILGAGSCAGVPILFSRNSGLVSVTPRENVSLLAEDLEESLTSSVGGRGSESMVFETTTKNETVAHEDKTKLLKAAFLQYCRKDLGRAQIMADELFSSHTDLDSDPELDKAVTQISVDLIDDYPASDPRWAESVPQEAPGLSNTSLIILHQLEDKMKAHCLLVDFLHQVGLFRRLSSYPIRGTPMSTRLLLCEHAEKLSAAITLKNHHSRLPDLVNSAILLALNKRECEVPNSLTPADVFFREVSQVDTICECLLEHEEQVLREVALVSQEWAEVAIDVNTVLKDMLQAATHYRLNKSSMYSQEEVLGKEPEYVPWTATSGPSGIRTAVMRQHGIILKMVYPQADSKLRNVVMEQLVALIDCFLDSYVSQLKSLEKSSDQERYSSLEVEYLQKRSELLSPLLTLGQYPWAASLAEKYCDFDILVQMCEQTDNQARLQRYMTQFADQNFSDFLFRWYLEKGKRGKLLSQPISQHGQLANFLQAHEHLSWLHEINSQELEKAHTTLLGLANMETRYFAKKKTLLGLSKLAALASDISEDRLQEKIEAMAEQERFLLHQETLPEQLLTERQLSLSAMPVLTAPQLISLYICDENRRANEYDFKKALDLLEYIDEEEDVSIDDLKLEILCRALQRDDWSGSDGKDDPIEVSKDSVFVKILQKLIKDGIQLSEYLPEVTDLLRAEQLGSLKSNSYFEFVLKANYEYYVQGQM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MFPSVSSP
-------CCCCCCCC		46.69-
4Phosphorylation----MFPSVSSPRTP
----CCCCCCCCCCC		39.7124759943
6Phosphorylation--MFPSVSSPRTPGP
--CCCCCCCCCCCCC		38.6726643407
7Phosphorylation-MFPSVSSPRTPGPG
-CCCCCCCCCCCCCC		19.0826643407
10PhosphorylationPSVSSPRTPGPGTRR
CCCCCCCCCCCCCCC		35.6624759943
15PhosphorylationPRTPGPGTRRGPLVG
CCCCCCCCCCCCCCC		21.9624759943
17MethylationTPGPGTRRGPLVGIG
CCCCCCCCCCCCCCC		51.4224129315
26PhosphorylationPLVGIGPTSTPRASR
CCCCCCCCCCCCHHH		39.7720469934
27PhosphorylationLVGIGPTSTPRASRR
CCCCCCCCCCCHHHC		39.2825521595
28PhosphorylationVGIGPTSTPRASRRG
CCCCCCCCCCHHHCC		21.1923527152
30MethylationIGPTSTPRASRRGLS
CCCCCCCCHHHCCCC		45.3324129315
32PhosphorylationPTSTPRASRRGLSLG
CCCCCCHHHCCCCCC		24.6429514104
34MethylationSTPRASRRGLSLGSA
CCCCHHHCCCCCCCC		48.1624129315
37PhosphorylationRASRRGLSLGSAVNS
CHHHCCCCCCCCCCC		33.2426824392
40PhosphorylationRRGLSLGSAVNSPVL
HCCCCCCCCCCCCEE		34.0422942356
44PhosphorylationSLGSAVNSPVLFSPA
CCCCCCCCCEEECCC		15.1322942356
49PhosphorylationVNSPVLFSPAGRRSS
CCCCEEECCCCCCCC		15.0726824392
55PhosphorylationFSPAGRRSSVSSRGT
ECCCCCCCCCCCCCC		33.4625263469
56PhosphorylationSPAGRRSSVSSRGTP
CCCCCCCCCCCCCCC		24.9821659605
58PhosphorylationAGRRSSVSSRGTPTR
CCCCCCCCCCCCCCE		19.1021659605
59PhosphorylationGRRSSVSSRGTPTRI
CCCCCCCCCCCCCEE		32.3521659605
62PhosphorylationSSVSSRGTPTRIFPH
CCCCCCCCCCEECCC		22.0021659605
64PhosphorylationVSSRGTPTRIFPHHS
CCCCCCCCEECCCCC		35.9127681418
71PhosphorylationTRIFPHHSISESVNY
CEECCCCCCCCCCCC		25.4426824392
73PhosphorylationIFPHHSISESVNYDV
ECCCCCCCCCCCCEE		27.1728833060
75PhosphorylationPHHSISESVNYDVRV
CCCCCCCCCCCEEEE		14.6328833060
78PhosphorylationSISESVNYDVRVFGS
CCCCCCCCEEEEECC		17.4123984901
130PhosphorylationLIWKIAVSPVTKLSV
HHHHHHCCCCCCHHH		12.4828066266
133PhosphorylationKIAVSPVTKLSVCKE
HHHCCCCCCHHHHHH		29.6528066266
479PhosphorylationVTPRENVSLLAEDLE
ECCHHHHHHHHHHHH		29.2828973931
488PhosphorylationLAEDLEESLTSSVGG
HHHHHHHHHHHCCCC		27.8021082442
490PhosphorylationEDLEESLTSSVGGRG
HHHHHHHHHCCCCCC		28.3825619855
491PhosphorylationDLEESLTSSVGGRGS
HHHHHHHHCCCCCCC		28.4621659604
492PhosphorylationLEESLTSSVGGRGSE
HHHHHHHCCCCCCCE		21.3927087446
498PhosphorylationSSVGGRGSESMVFET
HCCCCCCCEEEEEEE		25.7428973931
500PhosphorylationVGGRGSESMVFETTT
CCCCCCEEEEEEECC		23.1925521595
501OxidationGGRGSESMVFETTTK
CCCCCEEEEEEECCC		3.3417242355
505PhosphorylationSESMVFETTTKNETV
CEEEEEEECCCCCEE		28.4428833060
506PhosphorylationESMVFETTTKNETVA
EEEEEEECCCCCEEC		28.6828833060
507PhosphorylationSMVFETTTKNETVAH
EEEEEECCCCCEECC		39.0128833060
511PhosphorylationETTTKNETVAHEDKT
EECCCCCEECCCHHH		32.1729895711
747PhosphorylationHYRLNKSSMYSQEEV
HHCCCHHHCCCHHHH		24.2929899451
749PhosphorylationRLNKSSMYSQEEVLG
CCCHHHCCCHHHHHC		14.7829899451
757UbiquitinationSQEEVLGKEPEYVPW
CHHHHHCCCCCCCCC		66.97-
786AcetylationRQHGIILKMVYPQAD
HHCCEEEEECCCCCC		18.8623806337
794PhosphorylationMVYPQADSKLRNVVM
ECCCCCCHHHHHHHH		36.2828066266
795AcetylationVYPQADSKLRNVVME
CCCCCCHHHHHHHHH		52.6023954790
824UbiquitinationSQLKSLEKSSDQERY
HHHHHHHCCCCHHHH		61.63-
973PhosphorylationKKTLLGLSKLAALAS
HHHHHHHHHHHHHHC		24.67-
1018PhosphorylationLLTERQLSLSAMPVL
HCCHHCCCHHCCCCC		16.3726745281
1020PhosphorylationTERQLSLSAMPVLTA
CHHCCCHHCCCCCCH		21.1026745281
1045PhosphorylationENRRANEYDFKKALD
CCCCCCCCCHHHHHH		26.87-
1106UbiquitinationVFVKILQKLIKDGIQ
HHHHHHHHHHHCCCC		49.05-
1109UbiquitinationKILQKLIKDGIQLSE
HHHHHHHHCCCCHHH		61.41-
1117PhosphorylationDGIQLSEYLPEVTDL
CCCCHHHHCHHHHHH		24.9526643407
1122PhosphorylationSEYLPEVTDLLRAEQ
HHHCHHHHHHHHHHH		21.1926643407
1132PhosphorylationLRAEQLGSLKSNSYF
HHHHHHCCCCCCCCE		41.0126745281
1135PhosphorylationEQLGSLKSNSYFEFV
HHHCCCCCCCCEEEE		35.9828066266
1137PhosphorylationLGSLKSNSYFEFVLK
HCCCCCCCCEEEEEE		37.9928066266
1138PhosphorylationGSLKSNSYFEFVLKA
CCCCCCCCEEEEEEC		16.0428066266
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NU133_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NU133_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NU133_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NU133_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NU133_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-500, AND MASSSPECTROMETRY.

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